Sclerosing Stromal Tumor Of Ovary Research Articles

Ovarian sclerosing stromal tumor - benign neoplasm of the young. A case study with literature review

Sclerosing stromal tumor (SST), located in the ovary, is a very rare disease entity. To date, only a few hundred cases of ovarian SST have been confirmed worldwide. Preoperative diagnosis of stromal tumor is difficult, as clinically and radiologically it resembles other types of ovarian tumors. These tumors present nonspecific symptoms, with irregular menstrual bleeding, lower abdominal pain and palpable pelvic lesions being the most common. Differentiation and diagnosis is possible only thorough histopathological examination and immunophenotyping. In the present study, we presented a case report of a young, 20-year-old patient with an oligosymptomatic ovarian stromal tumor. We compared and summarized the diagnostic and therapeutic process, as well as the tumor immunophenotypes, with recent cases reported in the literature.

Review of Sclerosing stromal tumor: A relatively rare ovarian neoplasm

Abstract Introduction/Objective Sclerosing stromal tumor (SST) is sex cord stromal tumor which is rare primary ovarian neoplasm. Because its clinical presentation and imaging findings accurate preoperative clinical diagnosis can be difficult. We report three cases of a sclerosing stromal tumor of ovary and histopathological presentation. Methods/Case Report Our patients had an age ranged from 27-40 years with primary ovarian neoplasm and as incidental in 64-year-old patient. Radiologically lobulated and heterogeneously enhancing, partially calcified masses with nodular rind of avid enhancement about the periphery of the lesion with high risk malignancy were seen. Grossly the masses had firm tan-white, solid, lobulated cut surfaces with patchy calcifications Results (if a Case Study enter NA) Microscopically all the three tumors showed a hyalinized, well-circumscribed nodule with few scattered trabeculae of spindled to plump cells with pale grey cytoplasm within a sclerotic stroma with few staghorn- like blood vessels around the periphery. Scattered calcifications were identified. No mitoses are identified. The reticulin stain showed pericellular focal nested staining pattern. There was no necrosis, pleomorphism, or features of malignancy were identified. Findings were consistent with a sclerosing stromal tumor. Conclusion Ovarian sex cord-stromal tumors are relatively infrequent neoplasms of all primary ovarian tumors. Clinical and sonographic findings alone do not predict the presence of this tumor. SSTs should be considered in differentials in young females with unilateral masses with cystic and solid masses. These tumors carry a good prognosis. Histopathological features along with immunohistochemsitry establish the diagnosis.

Ovarian collision tumor consisting of sclerosing stromal tumor and mature cystic teratoma complicated with Meigs syndrome: A case report.

Ovarian collision tumors are uncommon and reports of their radiological appearance are even less frequent. The present study reported the world's first case of an ovarian collision tumor consisting of an ovarian sclerosing stromal tumor and a mature cystic teratoma and its imaging presentation. When a cystic solid ovarian mass combined with ascites and elevated CA125 is encountered it is frequently diagnosed as a malignant tumor, but the present case was a benign tumor. Therefore, when encountering similar cases, clinicians should not limit the diagnosis to malignant tumors to avoid rashly expanding the surgery and causing unnecessary harm to the patient. The combination of computed tomography, magnetic resonance imaging and pathology findings presented in the current study enable radiologists to learn about this disease and further assist clinicians in developing the best treatment plan.

Ovarian sclerosing stromal tumor uncommonly presenting in an infant

Sclerosing stromal tumor (SST) is a rare subset of ovarian sex cord-stromal tumors. It is even rarer among the pediatric population. As such its characterization in case reports holds particular value. We report a case of SST in an 8-month old who presented with abdominal distension and for whom exploratory laparotomy and surgical excision of the tumor was done. To our knowledge this is only the second reported case of SST presenting in an infant.

Imaging characteristics of ovarian sclerosing stromal tumor

ObjectivesThis study was designed to evaluate the specific imaging features of ovarian sclerosing stromal tumor (SST), improve its accuracy as well as the specificity of imaging diagnosing, and prevent overestimation of malignancy to reduce unnecessary surgical procedures.MethodsEight patients with magnetic resonance imaging (MRI) and six with computed tomography (CT) images were analyzed in this retrospective observational study. All the cases were confirmed by postoperative pathological examination as those of ovarian SST. Imaging and pathological features were also evaluated.ResultsAll the 14 masses displayed cystic and solid components with outer surface of tumors contained a capsular and complete smooth rim. Eight tumors of MRI exhibited “lake-island” sign on T2 weighted imaging (T2WI). Two of the 6 CT cases displayed a flaky calcification. One case showed as a multiloculated cystic mass with irregularly thickened septae and the tumor wall. The solid components in other 13 masses were comb- or wheel-like enhanced. After injection of contrast agent, the solid components in 8 cases (57.1%) appeared as early enhancement, whereas the other 6 cases (42.9%) appeared as progressive enhanced, and the cystic components of all the cases had no enhancement in the whole course. Vascular flow signals or/and marked enhancement of the blood vessels were found in 12 lesions (85.7%). Pathological examination demonstrated pseudolobule patterns, round to spindle shaped cells, collagenous areas, edematous hypocellular areas and prominent vasculatures.ConclusionsThe results demonstrated that MRI with “lake-island” signs on T2WI and MRI/CT dynamic enhancement could potentially play a critical role in facilitating appropriate diagnosis preoperatively.

Rare Case report of Sclerosing Stromal Cell Ovarian tumor in adolescent age group

Introduction :Sclerosing stromal cell tumor (SST) is an extremely rare benign ovarian tumor which is a subtype of ovarian stromal tumor of sex cord-stromal origin . So far about 208 cases throughout the world .These tumors occur predominantly in the second and third decade of life. Case report :We report a case of sclerosing stromal cell tumor of ovary in 14 year old girl for its rarity who presented with mass abdomen and menstural irregularity with Inhibin B elevated .CECT abdomen showed features suggestive of left ovarian solid mass lesion with internal clear cystic areas drained by left ovarian and internal iliac veins -possibly malignant mass (?Dysgerminoma).Patient was planned for laprotomy and proceed .Surprisingly histopathological examination revealed Sclerosing stromal tumor of ovary .

Sclerosing Stromal Tumour of Ovary- A Case Report

Sclerosing stromal tumor (SST) is an extremely rare and distinctive sex cord stromal tumor, which occurs predominantly in the second and third decades of life. Approximately 100 cases reported since first described in 1973. It typically present with pelvic/abdominal pain and tenderness, mass, and/or abnormal menses, and with hormonal activity reported predominantly in postmenarchal females. Only 5 cases of these tumors have been reported in premenarchal girls.We report a case of a 18-year-old girl who developed a sclerosing stromal tumor of ovary and presented with excessive menstruation, pelvic pain and increased frequency of menstruation. Her hormonal status was normal. She was suspected to have a malignant tumor on computed tomography and underwent unilateral salpingo-oopherectomy. It is therefore, necessary to keep in mind the possibility of sclerosing stromal tumor in a young womanBangladesh J Obstet Gynaecol, 2015; Vol. 30(1) : 56-58

A rare case of sclerosing stromal tumor of ovary with Meigs syndrome presenting with torsion

A young primi para presented with a large solid ovarian mass with ascites and hydrothorax. She had raised CA 125 levels. She developed torsion of the mass after admission. At laparotomy the tumor was subjected to frozen section. The tumor was benign sclerosing stromal tumor of ovary. Uterus and normal ovary could be conserved. DOI: http://dx.doi.org/10.3126/ajms.v5i4.9518 Asian Journal of Medical Sciences 2014 Vol.5(4); 116-118

Sclerosing stromal tumor of the ovary: A rare entity with distinctive features

Sclerosing stromal tumor (SST) is an extremely rare ovarian sex cord-stromal tumor with distinctive pathological featuresand benign nature. Awareness of such entity is crucial because of its histopathologic similarity with other neoplastic andnon-neoplastic lesions of the ovary. In this report, a 29-year-old woman was presented with menstrual irregularities andpelvic pain. She underwent unilateral oophorectomy after detecting a right ovarian mass by ultrasonography. The case wasdiagnosed as ovarian sclerosing stromal tumor based on clinicopathologic and immunohistochemical features. Differentialdiagnosis is discussed with review of the literature data.

Sclerosing stromal tumor of the ovary: A case report

Sclerosing stromal tumors are benign ovarian neoplasms of the sex cord-stromal category, occurring predominantly in the second and third decades of life. Herein, we report a 23-year-old female who presented with pelvic pain, irregular menses but normal hormonal status and was diagnosed as having a right ovarian tumor. A right oophorectomy was performed, and microscopic examination revealed a sclerosing stromal tumor of the right ovary. We stress the importance of being familiar with sclerosing stromal tumors when evaluating ovarian neoplasms in young women, in order to contribute to the appropriate clinical management, preventing extensive and unnecessary surgery, and preserving fertility.

Sclerosing stromal cell tumor of the ovary in pregnancy: A case report and review of the literature

A sclerosing stromal tumor of the ovary is an extremely rare benign tumor in pregnant women. Only 9 reports of sclerosing stromal tumor of the ovary during pregnancy have been presented. A 26-year-old woman at the 10th week of gestation was explored via laparoscopic surgery. She had non-specifi c symptoms but high levels of the tumor marker. The pathological diagnosis was sclerosing stromal tumor of the right ovary. We report a case of sclerosing stromal tumor in a 26-year-old woman who was admitted to confi rm pregnancy with a review of the literature.

Sclerosing Stromal Tumor of Ovary: A Case Report

Sclerosing stromal tumor (SST) is an extremely rare and distinctive sex cord stromal tumor which occurs predominantly in the second and third decades of life. We report a case of a 32-year-old woman who developed a sclerosing stromal tumor of ovary and presented with irregular menstruation and pelvic pain. Her hormonal status was normal but CA-125 was raised. She was suspected to have a malignant tumor on computed tomography and underwent bilateral salpingo-oopherectomy. It is therefore necessary to keep in mind the possibility of sclerosing stromal tumor in a young woman.

Meigs’ syndrome with elevated serum cancer antigen 125 levels in a case of ovarian sclerosing stromal tumor

Objective Meigs’ syndrome presenting as an ovarian tumor with elevated serum cancer antigen 125 (CA 125) levels is unusual. Only 37 cases have been reported, including three cases of ovarian sclerosing stromal tumor (SCT). Many reports have suggested that the presence of ascites is the major factor inducing mesothelial expression of CA 125. Case Report An 18-year-old woman presented with massive ascites, elevated serum CA 125 levels, and radiographic evidence of ovarian tumor. The histological and immunohistochemical examinations revealed a benign SCT. Conclusion SCT is a benign ovarian tumor and complete excision is curative. We also review all 37 cases and discuss possible mechanisms of Meigs’ syndrome and elevated serum CA 125 level.

Sclerosing stromal tumor of the ovary in a 4-year-old girl with characteristics of an ovarian signet-ring stromal tumor

Ovarian sclerosing stromal tumor (OSST) is an extremely rare neoplasm that primarily affects young women. Signet-ring stromal tumor is another rare non-functioning benign ovarian stromal neoplasm. We report a case of a right OSST with prominent characteristics of signet-ring stromal tumor in a 4-year-old girl with symptoms of premature thelarche. We describe the clinical, histopathological, and immunohistochemical findings and review the literature. To our knowledge, the 4-year-old patient presented here is the youngest case of OSST reported in premenarchal children. The presence of non-mucin/non-lipid obvious signet-ring-like cells in this case suggests a possible relationship between OSST and signet-ring stromal tumor of the ovary.

Study of an Ovarian Sclerosing Stromal Tumor Presenting as Vaginal Bleeding in a 7-Month-Old

This communication describes the histological, immunohistochemical, ultrastructural, and cytogenetic study of an ovarian sclerosing stromal tumor resected from a 7-month-old girl who presented with vaginal bleeding. The tumor is very rare, its pathogenesis is not clear, and its hormonal activity has been subject to debate. In addition, it has been rarely seen in children and never in infants, with the youngest patient reported being 10 years of age. Histological study of the tumor showed a process of multinodular asynchronous growth followed by gradual loss of cells, hyalinization, and eventual transformation into corpora albicantia-like structures, thus indicating that the process may be more akin to an ovarian nodular follicular hyperplasia than to a classical neoplasm. The study also documented an elevated proliferative MIB-1 index in the process, which had not been investigated in earlier reports, and illustrated the immunohistochemical reactivity of some of its stromal cells to progesterone receptors.

Laparoscopic Management Of Sclerosing Stromal Tumor Of Ovary: A Case Report

Sclerosing stromal tumor of ovary is a benign tumor occurring predominantly in young women in secondthird decade which is amicable to treatment by minimally invasive surgery. This case study demonstrates laparoscopic removal of sclerosing stromal tumor of ovary in two young women.

Ovarian sclerosing stromal tumor presenting as Meigs’ syndrome with elevated CA‐125

Meigs' syndrome caused by sclerosing stromal tumor is extremely rare and only two cases have been reported to date. An elevated serum level of CA-125 is also unusual and it has been thought that it is the consequence of physical irritation and inflammation. In this report, we present the case of a 50-year-old postmenopausal woman with a sclerosing stromal tumor presenting with Meigs' syndrome and an elevated CA-125 level (1476.8 IU/mL). This case highlights the difficulty in discerning the diagnosis of Meigs' syndrome from that of an ovarian malignancy and it should be considered in the differential diagnosis in postmenopausal patients with pelvic mass, ascites, pleural effusions and elevated serum CA-125.

Sclerosing Stromal Tumor of the Ovary with Torsion. MRI features

Sclerosing stromal tumors are rare benign ovarian neoplasms that are usually diagnosed in the second or third decade of life. Most patients with these tumors present with menstrual irregularities and pelvic pain. We present the magnetic resonance imaging (MRI) findings of a left ovarian sclerosing stromal tumor with torsion that was located in the right parauterine area, and discuss the differential diagnosis for this entity based on MRI findings. In this case, MRI demonstrated a well-defined, predominantly solid mass with a pseudolobular pattern, and showed a shift of the uterus to the left. The surgical and histopathologic aspects of the case are also described.

Sclerosing stromal tumor of the ovary associated with endometrial adenocarcinoma: A case report

The first case of ovarian sclerosing stromal tumor associated with endometrial adenocarcinoma in a 44-year-old woman is presented. By ultrastructural study, typical steroidsecreting type theca cells and various transitional tumor cells from fibroblast-like cells to theca-like cells were observed in the ovarian tumor. The clinical history of the patient and the ultrastructural study of this tumor suggested hormonal activity, but no apparent evidence of active hormone secretion was detected by plasma analysis for steroid hormones.