<abstract> <p>Under the influence of global climate change, the climatic conditions of China's major agricultural regions have changed significantly over the last half-century, affecting regional grain production levels. With its favorable conditions for agricultural activities, China's central region has been a strategic location for grain production since ancient times and has assumed an essential responsibility for maintaining national grain security. However, the key concerns of this study are whether the national grain security pattern is stable and whether it might be affected by global climate change (especially climate instability and increased risks in recent years). Therefore, the present study collected grain production data and used descriptive statistical and geospatial analyses to reveal the trend and spatiotemporal pattern of grain production in China's central region from 2010 to 2020. Then, a further analysis was conducted by combining meteorological data with a geographically weighted regression (GWR) model to investigate the relationship between spatial differences in the output per unit of the grain sown area (OPUGSA). The findings were as follows: (1) The overall development trend of grain production in China's central region from 2010 to 2020 revealed a positive overall trend in grain production, with notable differences in growth rates between northern and southern provinces. (2) Most regions in the southern part of the central region from 2015 to 2020 showed varying degrees of total output of grain (TOG) and OPUGSA reduction, possibly affected by the effects of the anomalies for global climate change and a strong El Niño effect in 2015. (3) Low-low (L-L) clusters of TOG and OPUGSA indicators were consistently in the northwest part (Shanxi) of the central region, and high-high (H-H) clusters of TOG were consistently in the central part (Henan and Anhui) of the central region, but H-H clusters of OPUGSA were not stably distributed. (4) The fitting results of the GWR model showed a better fit compared to the ordinary least squares (OLS) model; it was found that the annual average temperature (AAT) had the greatest impact on OPUGSA, followed by annual sunshine hours (ASH) and annual precipitation (AP) last. The spatiotemporal analysis identified distinct clusters of productivity indicators. It suggested an expanding range of climate impact possibilities, particularly in exploring climate-resilient models of grain production, emphasizing the need for targeted adaptation strategies to bolster resilience and ensure agricultural security.</p> </abstract>