This contribution considers causes of dementia not discussed elsewhere in the chapter. Within this broad grouping are disorders that would be categorized as the potentially ‘treatable’ dementias as well as other neurodegenerative conditions. Meta-analyses of studies describing populations referred to specialist out-patient services give prevalence rates of potentially reversible dementia of 13–15%, though community studies are likely to yield lower rates. Many ‘reversible’ dementias may be better described as sub-acute confusional states (with a shorter and fluctuating history), focal brain syndromes or mild cognitive disturbance; this is particularly the case for drug-induced states as well as space-occupying lesions, metabolic and endocrine disorders, normal-pressure hydrocephalus (NPH) and the cognitive impairment associated with depression. The important treatable dementias, in particular NPH, hypothyroidism, hyperparathyroidism, alcohol dementia, and B12 and folate deficiency are considered in detail. Depression is not discussed as this is essentially a mimic rather than a dementia. Other important causes of dementia are the extrapyramidal diseases that are frequently associated with cognitive disorders, namely Parkinson's disease, multiple system atrophy, progressive supranuclear palsy (PSP), corticobasal degeneration and Huntington's disease. The symptoms of subcortical dementia – with slowing of cognition, forgetfulness (but an ability to respond to cues), executive dysfunction and decreased verbal fluency – are common to a number of these conditions, namely PSP, Huntington's disease, NPH and some cases of Parkinson's.
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