Outer Shell Research Articles

Spherical ferroelectric solitons.

Spherical ferroelectric domains, such as electrical bubbles, polar skyrmion bubbles and hopfions, share a single and unique feature-their homogeneously polarized cores are surrounded by a vortex ring of polarization whose outer shells form a spherical domain boundary. The resulting polar texture, typical of three-dimensional topological solitons, has an entirely new local symmetry characterized by a high polarization and strain gradients. Consequently, spherical domains represent a different material system of their own with emergent properties drastically different from that of their surrounding medium. Examples of new functionalities inherent to spherical domains include chirality, optical response, negative capacitance and giant electromechanical response. These characteristics, particularly given that the domains naturally have an ultrafine scale, offer new opportunities in high-density and low-energy nanoelectronic technologies. This Perspective gives an insight into the complex polar structure and physical origin of these spherical domains, which facilitates the understanding and development of spherical domains for device applications.

The Effectiveness of Palm Kernell Shell Liquid Smoke (Elaeis Guineensis Jacq) as Antiseptic Against Microbials

Background Bacteria and fungi that enter through the body get intermediaries from the condition of hands that are not washed clean. Alcohol-based antiseptics are usually used for quick and effective hand washing, but repeated use can cause irritation and dryness of the hands. Natural components can be processed to make non-alcoholic substitutes, such as liquid smoke from palm oil's outer shell (Elais guineensis Jacq). It is known that liquid smoke contains antibacterial phenolic chemicals. Methods This research design is true experimental by testing the effectiveness of palm oil outer shell liquid smoke as an antiseptic, which is carried out in vitro using inhibitory tests and in vivo using palm swabs of respondents by looking at the effects before and after use. In vitro results formed the largest inhibition zone size using grade 2 liquid smoke with a concentration of 75%, with an inhibition zone size of Staphylococcus aureus ATCC 25923 of 15.6 mm; Escherichia coli ATCC 25922 of 5.8 mm; Candida albicans ATCC 10231 of 3.3 mm; and Aspergillus flavus ATCC 9643 of 33.3 mm. Results In vivo, results obtained through the respondent's palm swab showed an average value of 89.84% decrease in bacterial colonies and a 77% decrease in fungal colonies after using liquid smoke antiseptic. The results of the organoleptic assessment showed that 92% of respondents liked the color, 75% liked the smell, 75% felt that it did not cause dryness, and 92% felt that there were no side effects of use. Conclusions The liquid smoke of the outer shell of palm oil has the potential as an antiseptic.

Internal interface engineering of yolk-shell structure toward fast and robust potassium storage

Advanced anode materials with stable and fast K-ion storage behavior are of great significance for potassium-ion batteries (PIBs) toward large-scale applications, while it still remains a big challenging due to their intrinsic poor conductivity and large volume variation during cycles. Herein, we develop an internal interfacial engineering by encapsulating core-shell NiS2@C nanoparticles within MOF-derived hollow carbon shell for superior PIB anodes. As-prepared yolk-shell NiS2@C@C composite integrates the structure superiority of abundant interior void space, outer protective carbon shell and internal conductive carbon layer. Comprehensive experimental and theoretical methods illuminate that internal NiS2/C interface is conductive to boost charge transport kinetics, enhance pseudocapacitive behavior, and mitigate mechanical stress in outer carbon shell. As a result, it manifests an ultrahigh capacity of 481 mA h g−1 at 0.2 A g−1, and guarantees the rate capability of 306 mA h g−1 at 20 A g−1. Moreover, it presents excellent cycle stability (358 mA h g−1 after 1600 cycles at 1 A g−1), which is extremely competitive among the best reported conversion anodes for PIBs.

New machaeridian data from the Upper Ordovician of Scotland: Palaeoecological and global palaeobiogeographical implications

New machaeridian material housed in the National Museum of Scotland alongside the type material held in the Natural History Museum London and the Sedgwick Museum of Earth Sciences, Cambridge, is documented here from the Ordovician of Girvan. The specimens are included in four taxa, three of these in open nomenclature. Syntypes and figured specimens of Plumulites scoticus by Nicholson and Etheridge (1879) and Withers (1926) are reviewed and the diagnosis emended. The description of these specimens follows standard terminology and we also introduce here a new terminology for Anterior Outer Shell Plate (AOSP). We also figure for the first time three unpublished letters from Mrs Elizabeth Gray to Thomas Henry Withers, where she criticises the illustrations of machaeridians published by Nicholson and Etheridge (1880) and Reed (1908), recognising issues identifying machaeridian plates and also clarifies a misunderstanding on some of the specimens described and illustrated in Reed (1908), being key for the distribution of Plumulites peachi. We assess the importance of machaeridians as part of the Lower Palaeozoic palaeobenthos and a key element of the palaeo-food chain. A review of the palaeogeographical distribution of the machaeridians is undertaken in the context of the Ordovician biodiversifications.

Effect of fabric properties and glove structure on thermal protective performance of fire gloves under flash fire exposure

The purpose of this study was to analyze the influence of fabric properties and glove structure on the thermal protective performance of fire glove when exposed to a flash fire. Ten types of firefighting glove fabrics were selected, and nine types of gloves with four-layer fabrics were obtained for an orthogonal experiment. Different structures and sizes of gloves were also designed. The burn area and absorbed energy were tested using a flame hand system. Pearson correlations were established to analyze the relationships of fabric properties and absorbed energy, and of shrinkage rate and absorbed energy. The statistical analysis from these obtained data indicated that the thickness of fabric systems had no significant correlation for total absorbed energy ( p > 0.05), while the flame retardancy, air permeability, and shrinkage rate of the outer shell fabric exhibited a strong relation ( p = 0.033, 0.012, and 0.013, respectively). With the increase in glove looseness, the absorbed energy and burn area first decreased and then increased. The thermal protective performance was best at a looseness of 10 mm (by the largest absorbed energy reduction of 24%). It has been found that long gloves provide better thermal protection than short gloves. For short gloves, adding an elastic belt to the wrist can reduce the absorbed energy, while adding an elastic belt to the cuff for long gloves has a negative effect on the thermal protective performance.

SiRNA Delivery against Myocardial Ischemia Reperfusion Injury Mediated by Reversibly Camouflaged Biomimetic Nanocomplexes.

siRNA-mediated management of myocardial ischemia reperfusion (IR) injury is greatly hampered by the inefficient myocardial enrichment and cardiomyocyte transfection. Herein, nanocomplexes (NCs) reversibly camouflaged with a platelet-macrophage hybrid membrane (HM) are developed to efficiently deliver Sav1 siRNA (siSav1) into cardiomyocytes, suppressing the Hippo pathway and inducing cardiomyocyte regeneration. The biomimetic BSPC@HM NCs consist of a cationic nanocore assembled from a membrane-penetrating helical polypeptide (P-Ben) and siSav1, a charge-reversal intermediate layer of poly(l-lysine)-cis-aconitic acid (PC), and an outer shell of HM. Due to HM-mediated inflammation homing and microthrombus targeting, intravenously injected BSPC@HM NCs can efficiently accumulate in the IR-injured myocardium, where the acidic inflammatory microenvironment triggers charge reversal of PC to shed off both HM and PC layers and allow the penetration of the exposed P-Ben/siSav1 NCs into cardiomyocytes. In rats and pigs, BSPC@HM NCs remarkably downregulates Sav1 in IR-injured myocardium, promotes myocardium regeneration, suppresses myocardial apoptosis, and recovers cardiac functions. This study reports a bioinspired strategy to overcome the multiple systemic barriers against myocardial siRNA delivery, and holds profound potential for gene therapy against cardiac injuries.

Heterointerface construction for permalloy microparticles through the surface modification of bilayer metallic organic frameworks: Toward microwave absorption enhancement

Reasonable heterointerface modification can effectively regulate and enhance the microwave absorption of electromagnetic materials. The surface of magnetic permalloy (PM) microparticles is modified herein by coating double-layer metal organic frameworks (MOF), which are composed of a 2-methylimidazole cobalt salt (ZIF-67) layer and a 2-methylimidazole zinc salt (ZIF-8) layer. A stable heterointerface structure with cobalt/carbon (Co/C) and zinc/carbon (Zn/C) layers is formed on the surface of PM microparticles after pyrolysis. These particles include two types of composite particles of PM solely encapsulated by ZIF-67 or ZIF-8, PM@ZIF67 and PM@ZIF8, respectively, and two types of composite PM particles with a double-layered MOF outer shell structure obtained by exchanging the coating sequence (PM@ZIF8@ZIF67 and PM@ZIF67@ZIF8). Furthermore, the thermal decomposition temperature has a significant impact on the surface morphology and magnetic properties of the composite particles. After pyrolyzing at 500 °C, the PM@ZIF67@ZIF8 samples exhibit the highest microwave absorption performance among these samples. Specifically, the minimum reflection loss and effective absorption bandwidth of PM@ZIF67@ZIF8 after pyrolyzing at 500 °C can reach −47.3 dB at a matching thickness of 3.8 mm and 5.3 GHz at a matching thickness of 2.5 mm, respectively. A heterointerface with an electrical field orientation is created in the PM@ZIF67@ZIF8 particles, which effectively enhances the interface polarization and dipole polarization. Furthermore, the formation of a three-dimensional carbon network after pyrolysis is also useful for optimizing impedance matching and enhancing magneto-electric synergism.

Design and key construction technology of steel-concrete-steel sandwich composite pylon for a large span cable-stayed bridge

This paper introduces a new type of steel-concrete composite pylon that has been applied to Nanjing Fifth Yangtze River Bridge (a three-pylon cable-stayed bridge with a main span of 600 m). For this new type of pylon, the steel shells are connected with concrete through PBL shear connectors and studs, and the inner steel shells are connected with the outer steel shells by angle steels. Numerical analysis and full-scale model tests show that the pylon structure exhibits excellent mechanical properties and construction performance. The application of BIM technology, the research and development of special spreaders and construction platforms ensure the precise installation of structures. Highly factory-manufactured modular assembly of the reinforced steel shell structure can effectively reduce the intensity and difficulty of on-site operations, and improve the quality of the project, with low construction risks. Whereas, the successful application of this steel-concrete-steel sandwich composite pylon marks the formation of a complete set of construction technology of steel-concrete-steel sandwich composite pylon, which can be widely used in similar bridges.

Floating photovoltaic systems: photovoltaic cable submersion testing and potential impacts

Background: Floating photovoltaics (FPV) is an emerging technology that is gaining attention worldwide. However, little information is still available on its possible impacts in the aquatic ecosystems, as well as on the durability of its components. Therefore, this work intends to provide a contribution to this field, analysing possible obstacles that can compromise the performance of this technology, adding to an increase of its reliability and assessing possible impacts. The problem under study is related to the potential submersion of photovoltaic cables, that can lead to a degradation of its electrical insulation capabilities and, consequently, higher energy production losses and water contamination. Methods: In the present study, the submersion of photovoltaic cables (with two different insulation materials) in freshwater and artificial seawater was tested, in order to replicate real life conditions, when FPV systems are located in reservoirs or in the marine environment. Electrical insulation tests were carried out weekly to assess possible cable degradation, the physical-chemical characteristics of the water were also periodically monitored, complemented by analysis to detect traces of copper and microplastics in the water. Results: The results showed that the submersion of photovoltaic cables with rubber sheath in saltwater can lead to a cable accelerated degradation, with reduction of its electrical insulation and, consequently, copper release into the aquatic environment. Conclusions: The test results pointed a probable relationship between submersion of cables with rubber outer shell and water freezing temperatures and the occurrence of accelerated degradation of the cable insulation layer. Reduced insulation resistance values were measured in this cable type after the occurrence of such temperatures, both in salt and freshwater, the cable presented visible exterior degradation signs. For this case copper residues were detected in the water.

Thermal Performance and Turbulence Modeling of Combined Multiple Shell-Pass Shell and Tube Heat Exchanger

Abstract This paper investigates the adaptability of different Reynolds-averaged Navier-Stokes (RANS)-based turbulence models for flow behavior and thermal performance of combined multiple shell-pass shell and tube heat exchanger (CMSP-STHE) with unilateral ladder-type helical baffle (ULHB). The presence of ULHB in the outer shell pass of the heat exchanger leads to a complex flow configuration and makes it quite challenging to deal with its computational analysis. The computational fluid dynamic method compares the CMSP-STHE with ULHB with the traditional shell and tube heat exchanger with segmental baffles (SG-STHE). The performance of four turbulence models, namely, realizable k–ɛ, standard k–ɛ, standard k–ω and RNG k–ɛ models are compared with the correlation data. It is observed that the standard k–ω turbulence model more accurately predicts the heat transfer and pressure drop compared to other models. The logarithmic mean temperature difference (LMTD) results for various mass flowrates and thermal performance enhancement factor (TPEF) corresponding to various values of Re are also presented. It is concluded that the TPEF of CMSP (ULHB)-STHE is higher than that of the conventional STHE. The average enhancement is approximately 28% for ULHB STHE than the conventional one. Further, variations in velocity, turbulence kinetic energy, and local Nusselt number along the tube length are examined to understand the thermal performance behavior with CMSP (ULHB)-STHE. It is clear from the results that the CMSP (ULHB)-STHE is a better alternative to the traditional SG-STHEs.

Preparation and dual activation of beta-cyclodextrin derived hollow carbon spheres for highly efficient electro-Fenton

There are many reports related to the hollow carbon nanosphere with the applications in electrochemistry. However, it remains insufficient research in the field of electro-Fenton. In this study, we discovered that hollow carbon spheres can be obtained by the self-assembly of β-cyclodextrin in one step, without using any templates and toxic organic solvents. Meanwhile, activation methods were explored to create more pores and regulate the surface groups in the outer shell of the materials, which are key factors affecting the H2O2 production capability. It is found that H2 carbonization effectively converts a large number of sp2-C bonds on the surface of the materials to sp3-C, providing more active sites for reaction during the electrocatalytic process. The results show that the hollow carbon nanosphere after dual activations has the most H2O2 production rate at 70 mg·L-1·h−1, higher than those of carbon solid spheres and unmodified hollow carbon nanospheres. In the application of electro-Fenton, this material exhibits the degradation efficiency of 95.5 % for 50 mg·L-1p-nitrophenol, fully meeting the needs of environmental remediation. The whole preparation and activation process is simple, environmentally friendly, easy to be scaled up and has broad application prospects. This paper enhanced the understanding of common hollow carbon spheres in the hot research field of electro-Fenton.

Electrostatically reinforced and sealed nanocellulose-based macrosphere by alginate/chitosan multi-layer coatings for delivery of probiotics

Probiotic supplements have been widely employed to change gut microbiome compositions for the treatment of numerous human disorders since gut flora has a tight association with human health and disease. However, the viability of probiotics has been a major barrier to the application of probiotic products. Here, we developed an electrostatically reinforced and sealed nanocellulose-based macrosphere for probiotic encapsulation. The inside porous gel sphere provides abundant and relatively independent porous spaces for probiotics to live in. The introduction of chitosan hydrochloride (CHC) and alginate (ALG) strengthened the gel structure and contributed to the formulation of a multi-layered structure with pH-responsive properties. The mild strengthening and coating processes avoid severe damage to the sensitive probiotics in the processing process, and the synthesized multi-layer macrospheres could protect probiotics from gastric acid and bile salt conditions. In addition, the dissolvability of the outer shell and the stable inner porous skeleton in intestinal conditions allow the gradual release of the entrapped probiotics in targeted environments. Overall, this work suggests the electrostatically reinforced and sealed nanocellulose-based macrospheres are ideal materials for the probiotic delivery application.

Melting and solidification performance investigation of latent heat storage unit designs for low-temperature solar thermal applications

Integrating latent heat storage with solar thermal systems is a promising way to deal with the problem that solar energy is not always available or is only available for short periods of time. An efficient design for latent heat storage is the shell and tube type latent heat storage unit (ST-LHSU). Literature suggests that the performance of ST-LHSU can be improved significantly by modification in design. Therefore, the current article presents a comparative investigation of different horizontal ST-LHSU designs for melting/solidification performances. For this study, four alternative ST-LHSU designs representing the changes in the outer shell's cross-sectional area have been chosen. A validated two-dimensional numerical model for the selected ST-LHSU designs has been formulated and solved using the commercially available CFD solver. In the initial phase, the selected ST-LHSU designs have compared for melting and solidification performance. Complete melting in Design-IV happens 25.5 % and 37.4 % faster than in Design-III and Design-I, respectively. Design-I was the most effective design for entire solidification since it reached complete solidification 3.65 %, 19.57 %, and 45.02 % faster than Designs-II, III, and IV, respectively. In the second phase, the modification in Design-I has been done to reduce its total thermal cycle time. The total thermal cycle time of the modified Design-I is 24.58 % shorter than that of the original Design-I, 37.94 %, and 40.21 % shorter than Design-III and IV, respectively. The utilization of melting/solidification techniques like fins, metal foam, and nanoparticles can be studied in the future with the modified Design-I.

Buckling prevention of a single long NiTi tube compressive elastocaloric regenerator

Superelastic NiTi tubes have been used in elastocaloric coolers due to the good balance between mechanical stability and heat transfer efficiency, and the tube length increase is crucial to the driving force reduction and total cooling power increase of the coolers. The key challenge to adopt long superelastic NiTi tubes in compressive elastocaloric coolers is to prevent long tubes from buckling. In this article, a buckling prevention method of entraining a single long tubular material into a rigid and thick outer shell was proposed. The enhancement in the maximum compression load of a single long tubular material with an outer shell compared with the bare material was derived using the energy method. The proposed buckling prevention method was validated by compression experiments using a single long stainless-steel tube and outer shells of different materials and outer diameters. The buckling prevention method was successfully applied to a single long polycrystalline superelastic NiTi tube (outer diameter 5 mm, wall thickness 1 mm, and initial length 305 mm) in a layered-structured compressive elastocaloric regenerator. Several stress rise-drop-recover processes due to the friction and sliding of the tube were observed in the training, and the dependences of the stress-strain response of the tube on the applied stress and strain rate were also investigated. An elastocaloric cooler based on the single-long-tube compressive elastocaloric regenerator was constructed and it reached the highest temperature span, specific cooling power, and COP values of up to 5.7 K, 150 W∙kg−1, and 4.0, respectively. The results of the article are significant for developing large-power elastocaloric coolers.

Experimental and numerical study on water-filled doubly layered cylindrical shells subjected to lateral impact

A challenging aspect of local loading is that a restricted volume of structure contributes in tolerating external loading and therefore most of the remote zones of the structure remain intact. The present study surveys the effect of using incompressible fluid as a continuum to transfer the impact energy to a broader volume of the structure by employing experimental and numerical approaches. For the experimental study, three classes of doubly layered cylinders with different distances between the layers are fabricated from DIN S235JR steel and pure fresh water is used for filling the space between the layers. Instrumented impactors with different masses and falling heights imparted local dynamic energy on the specimens. The experimental results revealed that by the introduction of the fluid, on average, 25 percent of reduction in local deformation could be observed. Moreover, by implementing a validated numerical procedure, the energy contribution of every layer is scrutinized. It is observed that at a special distance between the layer, fluid contribution in impact energy absorption is maximized. Numerical outcomes illustrated a few percent of improvement in terms of energy contribution in inner and outer shells. Also, the probability of instability of the inner shell has been reported.

Application of Polymeric Micelles for Cancer Treatment: A Review

Polymeric micelles have been considered a promising development in chemotherapies to treat cancer diseases in recent decades. Bearing a structure of hydrophilic outer shell and hydrophobic core, these micelles possess many advantages like their nano-size structure, self-assembly synthesis, physical and chemical stability, biocompatibility, prolonged blood circulation time, and high drug loading and release capacity. The increased availability of building block copolymers that produce polymeric micelles also enables researchers to create the ideal drug delivery system. The formation of these polymeric micelles depends on various non-covalent interactions, the used concentration and temperature, block lengths, and methods of preparation. Among these polymeric micelles, stimuli-sensitive micelles have been developed and begun to attract more attention in recent years for their high on-site specificity and enhanced drug release efficacy. To accommodate the complex microenvironment in tumors, such as the internal changes in pH, reductive responses, and enzyme activities, or the external factors like visible lights, UV irradiations, and temperature, the stimuli-sensitive micelles exhibit strong stability, high drug loading, efficient drug delivery, specific site release, and mild side effects in recent studies. This research also discusses dual or multi-stimuli-sensitive polymeric micelles that are under high research nowadays, dictating a more novel and efficient way of cancer treatments and clinical practices.

Development of a prototype superconducting radio-frequency cavity for conduction-cooled accelerators

The higher efficiency of superconducting radio-frequency (SRF) cavities compared to normal-conducting ones enables the development of high-energy continuous-wave linear accelerators (linacs). Recent progress in the development of high-quality Nb$_3$Sn film coatings along with the availability of cryocoolers with high cooling capacity at 4 K makes it feasible to operate SRF cavities cooled by thermal conduction at relevant accelerating gradients for use in accelerators. A possible use of conduction-cooled SRF linacs is for environmental applications, requiring electron beams with energy of $1 - 10$ MeV and 1 MW of power. We have designed a 915 MHz SRF linac for such an application and developed a prototype single-cell cavity to prove the proposed design by operating it with cryocoolers at the accelerating gradient required for 1 MeV energy gain. The cavity has a $\sim 3$ $\mu$m thick Nb$_3$Sn film on the inner surface, deposited on a $\sim4$ mm thick bulk Nb substrate and a bulk $\sim7$ mm thick Cu outer shell with three Cu attachment tabs. The cavity was tested up to a peak surface magnetic field of 53 mT in liquid He at 4.3 K. A horizontal test cryostat was designed and built to test the cavity cooled with three Gifford-McMahon cryocoolers. The rf tests of the conduction-cooled cavity, performed at General Atomics, achieved a peak surface magnetic field of 50 mT and stable operation was possible with up to 18.5 W of rf heat load. The peak frequency shift due to microphonics was 23 Hz. These results represent the highest peak surface magnetic field achieved in a conduction-cooled SRF cavity to date and meet the requirements for a 1 MeV energy gain.

Device profile of the FlareHawk interbody fusion system, an endplate-conforming multi-planar expandable lumbar interbody fusion cage

ABSTRACT Introduction The FlareHawk Interbody Fusion System is a family of lumbar interbody fusion devices (IBFDs) that include FlareHawk7, FlareHawk9, FlareHawk11, TiHawk7, TiHawk9, and TiHawk11. These IBFDs offer a new line of multi-planar expandable interbody devices designed to provide mechanical stability, promote arthrodesis, and allow for restoration of disc height and lordosis through a minimal insertion profile during standard open and minimally invasive posterior lumbar fusion procedures. The two-piece interbody cage design consists of a PEEK outer shell that expands in width, height, and lordosis with the insertion of a titanium shim. Once expanded, the open architecture design allows for ample graft delivery into the disc space. Areas covered The design and unique features of the FlareHawk family of expandable fusion cages are described. The indications for their use are discussed. Early clinical and radiographic outcome studies using the FlareHawk Interbody Fusion System are reviewed, and properties of competitor products are outlined. Expert opinion The FlareHawk multi-planar expandable interbody fusion cage is unique amongst the many lumbar fusion cages currently on the market. The multi-planar expansion, open architecture, and adaptive geometry set it apart from its competitors.

A closed-ended MXene armor on hollow Sn4P3 nanospheres for ultrahigh-rate and stable sodium storage

The development of sodium-ion batteries has been seriously discouraged by the major limitation in the rate capability and the cycle life of the anode materials. Sn4P3 is recognized as a potential anode for sodium -ion batteries owing to its ultrahigh specific capacity and low cost, but the great volumetric change and low intrinsic electrical conductivity severely limit the cycling performance. Herein, we propose a closed-ended MXene and Sn4P3 hybrid consisting of active Sn4P3 porous hollow nanospheres (Sn4P3 HS) armored by a conductive MXene shell. Notably, the outer MXene shell protects Sn4P3 from direct exposure to the electrolyte and only allows the inward expansion of Sn4P3 into the hollow space, resulting in the formation of a thin solid-electrolyte interphase layer of high stability. As predicted, the hybrids can deliver an extraordinarily high capacity of 302.1 mAh g−1 even at an ultrahigh rate of 10 A g−1 and cycle at 1 A g−1 for 1500 cycles with a capacity retention of 94.9%. Moreover, the Sn4P3 HS@MXene//Na3V2(PO4)3/C full cell exhibits an outstanding energy density of 287.8 Wh kg−1 and good cyclic ability (390.5 mAh g−1 at 1A g−1 after 500 cycles), exhibiting a great potential in practical application.

Tumor-targeted glycogen nanoparticles loaded with hemin and glucose oxidase to promote tumor synergistic therapy

Strategies which are used to address the low levels of intracellular hydrogen peroxide and the development of biocompatible catalysts still need to be fulfilled in tumor chemodynamic therapy. Therefore, a novel tumor-targeted glycogen-based nanoparticle system (GN/He/GOx/HA) was developed to co-deliver hemin (He) and GOx, which can self-supply glucose formed upon degradation of glycogen by α-glycosidase in the lysosome environment, in order to achieve synergistic antitumor therapy. Hyaluronic acid (HA) was selected as the outer shell to protect the activity of GOx, and to increase the uptake by tumor cells via CD44 receptor-mediated endocytosis. GN/He/GOx/HA NPs had a good stability in the blood circulation, but fast release of the therapeutic cargos upon intracellular uptake. Hemin had a cascade catalytic reaction with GOx. Furthermore, GN/He/GOx/HA NPs had the strongest cytotoxicity in Hela cells in a glucose concentration dependent manner. The NPs could efficiently produce reactive oxygen species in tumor cells, resulting in a decrease in the mitochondrial membrane potential and apoptosis of tumor cells. The in vivo results showed that the drug-loaded nanoparticles had good safety, biocompatibility, and efficacious antitumor effect. Therefore, the glycogen-based nanoparticle delivery system provides potential application for self-enhancing CDT, which can be used for effective antitumor therapy.