Microplastics are emerging pollutants with sizes less than 5 mm, and they are ubiquitous. The occurrence of algal blooms has become a major problem affecting water quality in Chaohu Lake. To understand the relationship between the microplastic distribution and algal bloom density from a macroscopic point of view in Chaohu Lake, we collected microplastic samples from water and sediments during the wet and dry seasons and collected satellite remote sensing images of the algae density in recent years. The research results showed that the spatial and temporal distributions of microplastics were uneven and varied greatly. The average abundances of microplastics in the water samples were 2133 ± 1534 n•m−3 in the dry season and 1679 ± 1577 n•m−3 in the wet season, and the average abundance of microplastics in sediments was 308 ± 231 n•kg−1. The abundance of microplastics in the estuaries was higher than those in other locations, and it was higher in the western part of the lake than in the eastern part. The microplastics in water and sediments presented different sizes, colors, shapes and compositions. The abundance, distribution and migration of microplastics were mainly affected by population density, rainfall, runoff, hydrodynamic force and wind direction. At a more macroscopic level, the distribution of microplastics was similar to that of algal blooms, TN and TP to some extent, especially in the early stage of algal bloom outbreaks, and the algal density was significantly positively correlated with the flux of microplastics into the lake. Microplastics, as carriers of algae, could promote the growth of algae blooms in the early stage, while in the later stage, microplastics and algal blooms could aggregate and coprecipitate through adsorption or adhesion and then inhibit the growth of algae.