Failure Of Osseointegration Research Articles

A translational murine model of aseptic loosening with osseointegration failure.

An in vivo animal model of a weight-bearing intra-articular implant is crucial to the study of implant osseointegration and aseptic loosening caused by osseointegration failure. Osseointegration, defined as a direct structural and functional attachment between living bone tissue and the surface of a load-carrying implant, is essential for implant stability and considered a prerequisite for the long-term clinical success of implants in total joint arthroplasty. Compared to large animal models, murine models offer extensive genetic tools for tracing cell differentiation and proliferation. The 18- to 22-week-old C57BL/6J background mice underwent either press-fitted or loose implantation of a titanium implant, achieving osseointegration or fibrous integration. A protocol was developed for both versions of the procedure, including a description of the relevant anatomy. Samples were subjected to microcomputed tomography and underwent biomechanical testing to access osseointegration. Lastly, samples were fixed and embedded for histological evaluation. The absence of mineralized tissue and weakened maximum pull-out force in loose implantation samples indicated that these implants were less mechanically stable compared to the control at 4 weeks postoperation. Histological analysis demonstrated extensive fibrotic tissue in the peri-implant area of loose implantation samples and excellent implant osseointegration in press-fitted samples at 4 weeks. Both mechanically stable and unstable hemiarthroplasty models with either osseous ingrowth or a robust periprosthetic fibrosis were achieved in mice. We hope that this model can help address current limitations for in vivo study of aseptic loosening and lead to necessary translational benefits.

Evidence-Based Critical Assessment of the Success Rate of Dental Implants in Smokers: An Umbrella Systematic Review.

The aim of this umbrella systematic review is to evaluate the success rate and osseointegration of dental implants in patients with a smoking habit. Electronic database searches of PubMed/Medline, Google Scholar, ScienceDirect, Cochrane Library, and EBSCOhost were done from 2006 until August 2024, using medical subject headings (MeSH) terms. Systematic reviews and meta-analyses (SRMAs) investigating the association between smoking and the rate of success of dental implants based on dental implant failure, marginal bone loss, survival, and peri-implant parameters were deemed eligible. The Assessment of Multiple Systematic Reviews Tool 2 (AMSTAR 2) was used to assess the quality of the included SRMAs. Seventeen systematic reviews have been included. In the reviews, 10 studies included meta-analyses (MAs) that evaluated implant failure rate and marginal bone loss. According to the AMSTAR 2 checklist, one review was scored "high," seven reviews were scored "moderate," seven reviews were scored "low," and two reviews were scored "critically low" quality. The strength of evidence suggests a low level of success and high rate of failure of osseointegration of dental implants in smokers. However, the influence of smoking on the rate of dental implant failure seems to be associated with various factors such as peri-implant inflammatory markers, post-operative infections, etc. Inherently, the conclusion of this review is based on a limited number of systematic reviews.

Mussel-inspired bifunctional coating for long-term stability of oral implants

Peri-implantitis and osseointegration failure present considerable challenges to the prolonged stability of oral implants. To address these issues, there is an escalating demand for a resilient implant surface coating that seamlessly integrates antimicrobial features to combat bacteria-induced peri‑implantitis, and osteogenic properties to promote bone formation. In the present study, a bio-inspired poly(amidoamine) dendrimer (DA-PAMAM-NH2) is synthesized by utilizing a mussel protein (DA) known for its strong adherence to various materials. Conjugating DA with PAMAM-NH2, inherently endowed with antibacterial and osteogenic properties, results in a robust and multifunctional coating. Robust adhesion between DA-PAMAM-NH2 and the titanium alloy surface is identified using confocal laser scanning microscopy (CLSM) and attenuated total reflectance-infrared (ATR-IR) spectroscopy. Following a four-week immersion of the coated titanium alloy surface in simulated body fluid (SBF), the antimicrobial activity and superior osteogenesis of the DA-PAMAM-NH2-coated surface remain stable. In contrast, the bifunctional effects of the PAMAM-NH2-coated surface diminish after the same immersion period. In vivo animal experiments validate the enduring antimicrobial and osteogenic properties of DA-PAMAM-NH2-coated titanium alloy implants, significantly enhancing the long-term stability of the implants. This innovative coating holds promise for addressing the multifaceted challenges associated with peri‑implantitis and osseointegration failure in titanium-based implants. Statement of significanceProlonged stability of oral implants remains a clinically-significant challenge. Peri-implantitis and osseointegration failure are two important contributors to the poor stability of oral implants. The present study developed a mussel-bioinspired poly(amidoamine) dendrimer (DA-PAMAM-NH2) for a resilient implant surface coating that seamlessly integrates antimicrobial features to combat bacteria-induced peri‑implantitis, and osteogenic properties to promote bone formation to extend the longevity of oral implants.

Cranial Sutures as a Cause of Osseointegration Failure in Bone-Anchored Implants : Case Reports

Cranial Sutures as a Cause of Osseointegration Failure in Bone-Anchored Implants : Case Reports

Aptis Distal Radioulnar Joint Implant: Management of Remarkable Complications

Abstract Background The aim of an Aptis distal radioulnar joint (DRUJ) implant is to reconstruct the DRUJ in patients with a destroyed, painful DRUJ, and gross ulnar instability. The literature is scarce regarding the management of (severe) early complications related to the Aptis implant in wrists with more rare conditions, such as rheumatoid arthritis, congenital malformations, or leiomyosarcoma of the distal ulna. Purpose This paper describes the clinical results, (severe) early complications related to the implant, revision surgery, patient satisfaction with the revision surgery, and esthetic appearance of the affected wrist in this specific cohort. Patients and Methods Retrospective evaluation of five consecutive patients with a short-to-medium follow-up time of 32 months (range: 18–53 months) was carried out. Results The follow-up revealed implant osseointegration failure in two cases, periprosthetic fractures in two cases, and acute carpal tunnel syndrome in one case. Three Aptis DRUJ arthroplasties were converted into a proximal Darrach. In four cases (80%), the patient was satisfied with the revision surgery due to pain reduction. In four cases (80%), the esthetic appearance of the affected wrist was found disappointing. Conclusion This study describes remarkable complications related to the Aptis implants in wrists with more rare conditions. The implant is more likely to fail in wrists with poor bone stock, remodeling of the radius, deformation, and malformation of the radius. The range of indications for the usage of the implant to maintain wrist function may be strict. Level of Evidence IV.

Histological Perspectives on Dental Implant Failure: A Case Report and Analysis of Peri-Implant Bone Histology

Peri-implant bone histology plays a crucial role in understanding the mechanisms underlying implant failure. This article presents a case report of a failed dental implant in a 72-year-old male patient, with a focus on the histological evaluation of the peri-implant bone. The patient underwent an All-in-4 implant-based denture treatment plan, which initially showed promising results but later resulted in implant failure. A trephine core biopsy was performed to assess the histology of the failed implant site and determine the cause of failure at the microscopic level. Histological analysis revealed the presence of graft material acting as a scaffold, surrounded by dense fibrosis and chronic inflammatory infiltrate. These findings indicate a failure of osseointegration and suggest possible causes for implant failure, such as inadequate tissue integration and host response. Factors contributing to implant failure, including occlusal overload, peri-implantitis, and systemic conditions, were discussed in the context of the case. Understanding the histological changes associated with implant failure is crucial for improving treatment outcomes and developing preventive strategies. Preoperative assessment, including evaluation of bone density and identification of systemic risk factors, is essential for successful implant placement. Retrieval and histological analysis of failed implants provide valuable insights into tissue responses and areas for improvement in implant design and surgical techniques. This case report highlights the significance of peri-implant bone histology in diagnosing and managing implant failure, with implications for enhancing implant success rates and patient care in implant dentistry. Further research in this field will contribute to advancements in implantology and the development of evidence-based protocols for implant treatment.

Assessment of the Nasopalatine Canal in Patients Requiring Dental Implants in the Maxillary Anterior Region Using Cone Beam Computed Tomography.

To assess the nasopalatine canal in patients requiring dental implants in the maxillary anterior region using cone beam computed tomography (CBCT). About 56 patients requiring dental implants in the maxillary anterior region of either gender reporting to the daily Outpatient Department, Department of Oral Medicine and Radiology aged between 18 and 60 years were selected. They were subjected to a CBCT scan using Newtom Giano CBCT machine (NewTom, Imola, Italy). Newtom New Technologysoftware and a slice thickness of 0.3 mm were used. For assessment of the implant site at the maxillary anterior region, alveolar bone width in the anterior region of the canal at the upper, middle, and lower third, incisive foramen diameter (IFD), nasopalatine canal length (NPCL), canal diameter in the floor of the nasal fossa and nasopalatine canal morphology was determined. Out of 56 patients, males comprised 30 and females 26. The mean bone height in 11 regions was 15.6±3.9, in 12, 16.2±2.7 mm, in 13 was 15.5±2.4 mm, in 21 was 13.7±4.2 mm, in 22 was 14.7±3.6 mm, in 23 was 16.7±1.5 mm. A non-significant difference was observed when comparing the bone height at different implant sites (p>0.05). The mean bone width at 3 mm and 6 mm from an alveolar crest in 11 regions was 4.3 mm and 5.3 mm, in 12 was 5.7 mm and 6.2 mm, in 13 was 3.7 mm and 4.6 mm, in 21 regions was 4.1 mm and 5.5 mm, in 22 regions was 4.6 mm and 5.7 mm and in 23 regions was 4.0 mm and 4.9 mm, respectively. A significant difference was observed when comparing the bone width at 3 mm and 6 mm at different implant sites (p<0.05).Nasopalatine canal type was A in 42 (75%), B in 13 (23.2%), and C in 1 (1.8%) patient. The mean alveolar bone width in the anterior region of the canal at the upper third was 10.1 mm, in the middle third was 7.4 mm, and in the lower third was 5.2 mm. The mean IFD was 4.6 mm, the NPCL was 13.5 mm, and the canal diameter on the floor of the nasal fossawas 3.8 mm. A significant difference was observed in comparing nasopalatine canal type (p<0.05). For the clinician to assess implant placement in the maxillary esthetic zone, CBCT imaging of the nasopalatine canal is crucial. It is possible to prevent intraoperative and postoperative complications such as hemorrhage, sensory impairment, osseointegration failure, and nasopalatine duct cyst formation.

Carbon dots efficiently promote vascularization for enhanced repairing of orthopedic diseases with diabetic mellitus based on nanocatalytic medicine

Insufficient angiogenesis, a prominent characteristic of diabetic mellitus, significantly affected the reparative capacity of orthopedic diseases. Imbalanced redox caused by excessive reactive oxygen species is one of the crucial factors in weakening vascularization. Conditions such as implant osseointegration failure and delayed wound healing in orthopedic diseases are significantly influenced by the vascularization deficits in diabetic mellitus. Promoting angiogenesis by modulating endothelial function is considered as an effective therapy for diabetes, yet current efforts remain insufficient. Nanocatalytic medicine has emerged as promising candidates for therapy. Herein, carbon dots (CDs) with preferable catalytic effect by mimicking both superoxide dismutase (SOD) and catalase (CAT)-like activity were designed and synthesized using anhydrous citric acid and ethane diamine. CDs effectively scavenged superoxide anion (O2•−) and hydrogen peroxide (H2O2) with excellent biocompatibility. Meanwhile, CDs promoted the proliferation, migration, and angiogenesis capacity of human umbilical vein endothelial cells with enhanced SOD and CAT activity in simulated oxidative stress of diabetes. Notably, CDs promoted vascularization by activate PI3K-AKT signaling pathway in impaired endothelial cells, which was demonstrated through transcriptome sequencing, western blot, and reverse transcription-polymerase chain reaction. The therapeutic effect of CDs based on promoting vascularization was found in orthopedic disease models of subcutaneous implant and wound healing of diabetic rat. These findings highlight a promising clinical application for CDs as a nanocatalytic medicine in enhancing vascularization for diabetic mellitus.

Glucose-primed PEEK orthopedic implants for antibacterial therapy and safeguarding diabetic osseointegration

Diabetic infectious microenvironment (DIME) frequently leads to a critical failure of osseointegration by virtue of its main peculiarities including typical hyperglycemia and pathogenic infection around implants. To address the plaguing issue, we devise a glucose-primed orthopedic implant composed of polyetheretherketone (PEEK), Cu-chelated metal-polyphenol network (hauberk coating) and glucose oxidase (GOx) for boosting diabetic osseointegration. Upon DIME, GOx on implants sostenuto consumes glucose to generate H2O2, and Cu liberated from hauberk coating catalyzes the H2O2 to highly germicidal •OH, which massacres pathogenic bacteria through photo-augmented chemodynamic therapy. Intriguingly, the catalytic efficiency of the coating gets greatly improved with the turnover number (TON) of 0.284 s−1. Moreover, the engineered implants exhibit satisfactory cytocompatibility and facilitate osteogenicity due to the presence of Cu and osteopromotive polydopamine coating. RNA-seq analysis reveals that the implants enable to combat infections and suppress pro-inflammatory phenotype (M1). Besides, in vivo evaluations utilizing infected diabetic rat bone defect models at week 4 and 8 authenticate that the engineered implants considerably elevate osseointegration through pathogen elimination, inflammation dampening and osteogenesis promotion. Altogether, our present study puts forward a conceptually new tactic that arms orthopedic implants with glucose-primed antibacterial and osteogenic capacities for intractable diabetic osseointegration.

Use of Individually Designed CAD/CAM Suprastructures for Dental Reconstruction in Patients with Cleft Lip and Palate.

This patient series reports the outcomes of CAD/CAM prosthetic reconstructions in patients with cleft lip and palate (n = 9, aged 27 to 76) who have experienced significant failure with conventional restorative and fixed prosthodontic treatments. The objective of the protocol is to establish a functional and patient-friendly prosthetic structure for individuals with unilateral/bilateral cleft lip and palate (UCLP/BCLP) while minimising the requirement for specialised follow-up care in the cleft unit. The study data were obtained from a retrospective cohort at Helsinki University Hospital. Prosthetic reconstructions were performed using CAD/CAM bar structures by the Atlantis 2in1 system or Createch removable telescope structures, supported by four to eight maxillary dental implants. Out of the nine patients, seven experienced no complications. One prosthesis fracture occurred after 16 months due to a design error in the original framework, and one patient experienced failure of osseointegration in a dental fixture (specifically, one fixture out of the eight maxillary implants in this patient). In total, 56 implants were successfully placed. The maxillary dentition of elderly patients with cleft lip and palate often poses challenges due to periodontal and reconstructive issues. An implant-supported CAD/CAM bar with a removable telescope suprastructure offers an easily maintained and functional solution for dental rehabilitation.

Complication rates and modes of short and medium-term failure in Motec total wrist arthroplasty: an international cohort study.

The aim of this study was to analyse the short- and medium-term complications of the Motec total wrist arthroplasty (TWA). Identifying exact modes of failure and their causes should allow surgeons to avoid or mitigate these risks in the future. Retrospective analysis of prospectively collected data from six hand surgeons at five international centres provided details of 171 Motec TWAs. The mean follow-up was 5.8 years (range 18 months to 12 years). There were 33 (19%) complications within our cohort, with a revision rate of 8.2% (14 revisions). There was no difference in complication rates between metal-on-metal and metal-on-polymer articulations. Failure of osseointegration was the most common complication. Problems with soft tissue balancing, implant impingement related osteolysis, bony impingement and metacarpal fracture were found to be other preventable causes of failure in this series. Elimination of these preventable complications will improve survival rates for this implant.Level of evidence: IV.

Dental implants developing peri-apical disease: a case report

Dental implants are a treatment option for edentulous spaces. Placing implants involves a surgical procedure requiring a high level of attention to detail. There are risks associated with implants, such as peri-implantitis, failure of osseo-integration and peri-apical implantitis. The latter condition can present after implant placement, and presents radiographically as a radiolucency around the apical part of the implant, similar in appearance to a peri-apical lesion of a non-vital tooth. The aetiology of this condition remains controversial. This article presents some of the current literature and the case report demonstrates the successful surgical management of peri-apical implantitis. CPD/Clinical Relevance: The presentation, potential aetiologies and the successful clinical management of peri-apical implantitis can be useful to clinicians.

Preparation of Gelatin-Quaternary Ammonium Salt Coating on Titanium Surface for Antibacterial/Osteogenic Properties.

Titanium (Ti) and its alloys are widely used in medical treatment, engineering, and other fields because of their excellent properties including biological activity, an elastic modulus similar to that of human bones, and corrosion resistance. However, there are still many defects in the surface properties of Ti in practical applications. For example, the biocompatibility of Ti with bone tissue can be greatly reduced in implants due to a lack of osseointegration as well as antibacterial properties, which may lead to osseointegration failure. To address these problems and to take advantage of the amphoteric polyelectrolyte properties of gelatin, a thin layer of gelatin was prepared by electrostatic self-assembly technology. Diepoxide quaternary ammonium salt (DEQAS) and maleopimaric acid quaternary ammonium salt (MPA-N+) were then synthesized and grafted onto the thin layer. The cell adhesion and migration experiments demonstrated that the coating has excellent biocompatibility, and those grafted with MPA-N+ promoted cell migration. The bacteriostatic experiment showed that the mixed grafting with two ammonium salts had excellent bacteriostatic performance against Escherichia coli and Staphylococcus aureus, with bacteriostasis rates of 98.1 ± 1.0% and 99.2 ± 0.5%, respectively.

Applications of Polydopamine in Implant Surface Modification.

There has been great clinical demand for orthopedic and dental implant surface modification methods to prevent osseointegration failure and improve implant biological functions. Notably, dopamine (DA) can be polymerized to form polydopamine (PDA), which is similar to the adhesive proteins secreted by mussels, to form a stable bond between the bone surface and implants. Therefore, PDA has the potential to be used as an implant surface modification material with good hydrophilicity, roughness, morphology, mechanical strength, biocompatibility, antibacterial activity, cellular adhesion and osteogenesis. In addition, PDA degradation releases DA into the surrounding microenvironment, which has been found to play an important role in regulating DA receptors on both osteoblasts and osteoclasts during the bone remodeling process. Furthermore, the adhesion properties of PDA suggest its use as an intermediate layer in assisting other functional bone remodeling materials, such as nanoparticles, growth factors, peptides and hydrogels, to form "dual modifications". The purpose of this review is to summarize the recent progress in research on PDA and its derivatives as orthopedic and dental implant surface modification materials and to analyze the multiple functions of PDA. This article is protected by copyright. All rights reserved.

A Model Study to Evaluate Osseointegration and Fracture Healing Following Open Reduction and Internal Fixation (ORIF) in Diabetic Lewis Rats

There is a higher risk of implant osseointegration failure after open reduction and internal fixation (ORIF) in patients with diabetes due to increased inflammatory conditions, associated metallic corrosion and infection. While it is possible to avoid elective osseous surgery in patients with diabetes, it may not be the case in nonelective cases, such as ORIF ankle fractures. A total of 30 male Lewis rats (12-15 weeks old) were distributed into diabetic (D) and nondiabetic (ND) groups. Fracture healing and osseointegration were evaluated at 2-, 10-, and 21-day time points. Microtomographic and histological analysis depicted distinct differences in fracture healing and osseointegration between D and ND animals. Immunohistochemical analysis exhibited elevated proliferation (PCNA) and osteogenic (Runx2) cells for ND animals, while HMGB1 (inflammatory marker) was elevated for D animals during healing. Bone resorption marker CTX-1 was elevated in the plasma of D animals at 2 days, while bone formation marker P1NP was higher for ND animals at 10 days. Overall, this model resulted in delayed implant osseointegration and fracture healing in diabetic animals, highlighting the importance of developing new biomaterials or implant coatings that can improve bone healing outcomes in this patient population.

ERYTHROMYCIN-DOPED NANOFIBRE COATING ENHANCES OSSEOINTEGRATION AND INHIBITS STAPHYLOCOCCUS AUREUS-INDUCED OSTEOLYSIS

Failure of osseointegration and periprosthetic joint infection (PJI) are the two main reasons of implant failure after total joint replacement (TJR). Nanofiber (NF) implant surface coating represents an alternative local drug eluting device that improves osseointegration and decreases the risk of PJI. The purpose of this study was to investigate the therapeutic efficacies of erythromycin (EM)-loaded coaxial PLGA/PCL-PVA NF coating in a rat S. aureus-infected tibia model.NF coatings with 100mg and 1000mg EM were prepared. NF without EM was included as positive control. 56 Sprague Dawley rats were divided into 4 groups. A titanium pin (1.0-mm x 8 mm) was placed into the tibia through the intercondylar notch. S. aureus (SA) was introduced by both direct injection of 10 μl broth (1 × 104 CFU) into the medullary cavity and single dip of Ti pins into a similar solution prior to insertion. Rats were sacrificed at 8 and 16 weeks after surgery. The outcome measurements include μCT based quantitative osteolysis evaluation and hard tissue histology.Results: EM-NF coating (EM100 and EM1000) reduced osteolysis at 8 and 16 weeks, compared to EM0 and negative control. The effective infection control by EM-NFs was further confirmed by hard tissue section analysis. The Bone implant contact (BIC) and bone area fraction Occupancy (BAFO) within 200 µm of the surface of the pins were used to evaluate the osseointegration and new bone formation around the implants. At 16 weeks, the bone implant contact (BIC) of EM 100 (35.08%) was higher than that of negative control (3.43%) and EM0 (0%). The bone area fraction occupancy within 200 µm (BAFO) of EM100 (0.63 mm2) was higher than that of negative control (0.390 mm2) and EM0 (0.0 mm2). The BAFO of EM100 was also higher than that of EM1000 (0.3mm2).There was much less osteolysis observed with EM100 and EM1000 NF coatings at 16 weeks, as compared to EM0 positive control, p=0.08 and p=0.1, respectively. Osseointegration and periprosthetic bone formation was enhanced by EM-NFs, especially EM100. Data from this pilot study is promising for improving implant surface fabrication strategies.

Implant survival rate of patients in Dental Hospital Hasanuddin University: 8 years evaluation

Data on dental implant treatment's success and survival rate are still limited. Meanwhile, the data on the success and survival after implant placement and restoration can be used to evaluate materials, improve the dental implant treatment, and enhance the service quality at Hasanuddin University Dental Hospital. The purpose of this study is to analyze the dental implant survival rate, the contributing factors that enhance the survival rate, and the factors causing the failure of the dental implants at the Prosthodontic Clinic of Dental and Oral Hospital, Hasanuddin Uni-versity. The final study group consisted of 11 patients with 20 implants. Implant failure was categorized based on implant loss, mobility, or removal due to severe peri-implant infection or implant fracture. Implant survival rates were grouped based on sex, age, smoking habit, placement location, diameter, length, and placement time. The value of implant survival rate was assessed based on the presentation of successful implants. Of all 20 cases, five implants failed, indicating a cumulative implant survival rate of 75%. Based on the failure period, there are initial failure cases before loading and late failure cases after loading. One implant failed within the first six months, and two implants failed 2 years after insertion of the superstructure. The leading cause of implant failure before loading is osseointe-gration failure. In the case of implants that failed after installing the superstructure, peri-implantitis occurs continous-ly. It was concluded that the implant survival rate for patients at the Hasanuddin University Dental Hospital is 75%. Dental implant survival rates include gender, age, implant placement location, smoking habits, implant diameter, length, and immediate or delayed implant placement. The factors causing the failure of the implant in this study were osseointegration failure and peri-implantitis

The Effect of Proton Pump Inhibitors on Early Implant Failure A Retrospective Cohort Study

Background and Objectives: Maintenance of a firm and long-term stable osseointegration is the primary goal of implant dentistry. Time is used to define implant failure characteristics. Early implant failure (EIF) occurs up to one year after loading. Recent studies indicated an association between proton pump inhibitors (PPI) therapy and failure of osseointegration. The present study assessed whether the use of PPIs is a risk factor to EIF. Materials and methods: A retrospective cohort study including 687 patients and 2971 dental implants. The study group (PPIs users) comprised 17.3% (119) individuals and 18.7% (555) implants. The remaining cohort (82.7% (568) individuals and 81.3% (2416) implants) served as control. The information was taken from the patients' files. The following information was collected: age, gender, physical status, systemic diseases, HbA1C values before and after implant-supported prosthesis delivery in cases of diabetes mellitus, smoking, implant location, number of implants per individual, bone augmentation, implant brand, length and width, and EIF. EIF was defined as implant removal within a period of up to 12 months from loading. Results: EIF in PPIs vs. non-PPIs users was 19.3% vs. 14.3% (p = 0.16) at patient level and 5.4% vs. 3.5% at implant level (p = 0.03). Univariate analysis yielded factors significantly associated with PPIs use, including older age, physical status of the American Society of Anesthesiology (ASA) 3, hypertension, hyperlipidemia, diabetes mellitus, osteoporosis, cardiovascular accident (CVA), location (anterior mandible), shorter and narrower implants, and higher number of implants per individual. Multivariate analysis yielded statistically significant OR of 1.91; p = 0.01 for EIF following PPIs use and 2.3; p < 0.001 for location in anterior mandible. Conclusions: Patients and their healthcare providers are advised to carefully consider the potential risks of taking PPIs prior to dental implant surgery. Further research is needed to confirm these risks and elucidate systemic and local factors that may be involved in such outcomes.

Cementless Total Knee Arthroplasty Over the Past Decade: Excellent Survivorship in Contemporary Designs

BackgroundCementless fixation in total knee arthroplasty (TKA) is re-emerging due to improvements in biomaterials, surgical technique, and implant design. Albeit rare, failure of osseointegration typically occurs within the first 2 years, and limited data exist on survivorship of the modern cementless TKA designs. This study evaluated clinical survivorship of 2 contemporary cementless TKA designs at minimum 2-year follow-up. MethodsA total of 627 cementless TKAs were performed up to July 2022. Three hundred thirty-nine cases were eligible for 2-year follow-up. Indications centered around bone quality and involved predominantly younger patients. The 2 designs consisted of tibial components with a highly porous titanium ingrowth surface, a central keel, and peripheral cruciform pegs with a porous cobalt-chromium femur. Survivorship estimates were calculated using right-censored non-parametric Kaplan–Meier methodologies. A total of 226 TKAs obtained minimum 2-year follow-up with a mean of 3.6 years (range, 2 to 10). ResultsThe all-cause revision rate was 2.4% (8 of 339). The revision rate due to aseptic loosening was 0.6% (2 of 339) consisting of 2 femoral components. No tibial components were revised for aseptic loosening. Kaplan–Meier survivorship free from aseptic loosening was 99% (95% confidence interval 98 to 100) at a maximum of 10 years. ConclusionThese results demonstrate encouraging survivorship of cementless fixation in primary TKA with use of contemporary ingrowth biomaterials and modern implant designs. This particular tibial implant design with a highly porous titanium fixation surface, central keel, and peripheral cruciform pegs demonstrated excellent clinical survivorship without failure which may portend superior fixation. Level of EvidenceIV–case series, no control group/historical control group.

The Influence of Radiation Therapy on Dental Implantation in Head and Neck Cancer Patients

Radiotherapy is used to treat patients with head and neck cancers as a primary therapy or as an adjuvant to surgery or chemotherapy. Irradiation results in several complications that can be very overwhelming to the patient. Frequently there is loss of function due to tooth loss, compromised aesthetics, pain and discomfort from xerostomia and mucositis, it also significantly impacts the quality of life.&#x0D; A major advance in dentistry is the successful rehabilitation and replacement of lost teeth by osseointegrated implants. However, the risk of osteoradionecrosis and failure of osseointegration are barriers to implant therapy for those irradiated patients.&#x0D; The aim of this review article is to primarily find out whether the radiotherapy used in the treatment of head and neck cancer patients can affect the success and survival of dental implants according to different studies, and also, to highlight some other pertinent factors that may concurrently influence these implantation.&#x0D; The primary outcome measure shows implants survival in irradiated patients. Most of the studies reported that dental implants can osseointegrate and remain functionally stable in irradiated patients following oral cancer surgery. Accordingly, rehabilitation using dental implants is a viable option for head and neck cancer patients receiving radiotherapy. However, all studies included indicated that survival was significantly higher in non-irradiated patients.&#x0D; Factors such as the mode of radiation therapy delivery, gender, age, implant site and radiation dose at the implant site can affect the survival of dental implant.&#x0D; More research and randomized controlled trails are needed for more accurate judgment.