Orthopaedic Hospital Research Articles

STABLE REDUCED HIP AFTER OPEN REDUCTION IN DEVELOPMENTAL DYSPLASIA OF THE HIP

Introduction: Developmental dysplasia of the hip (DDH) has a wide spectrum of conditions and treatment plans. Our aim in this study is to investigate related and controllable factors that can lead to secondary redislocation, and use them to foresee a concomitant pelvic osteotomy requirement. Methods: This is a retrospective case-control study on DDH cases reduced via an anterior approach without pelvic osteotomy in our orthopedics hospital from 2019 to 2021. After 24 months, we compared clinical and radiological findings between the failure and successful groups. Results: We reduced 49 hips (38 cases) using an anterior approach without osteotomy. The success rate was 89.8% (five cases re-dislocated), which is accountable for favorable odds. We found no statistically significant correlation between re-dislocation and bilaterality (p = 0.64), gender (p = 0.27) or age (p = 0.82), or the AI before reduction (p = 0.19). Conclusion: When the reduction has a wide safe zone in the operating room, the reduction of the hip without osteotomy can have satisfactory results, so based on the findings of our study, invasive procedures such as osteotomy will not be necessary if the hip is stable after the open reduction in the operating room.

Socioeconomic Factors and Risk of Knee Osteoarthritis: A Case-Control Study

Background: The risk factor for knee osteoarthritis (knee OA) is multifactorial. Socioeconomic status is a risk factor that is commonly underreported. The study aims to find the relationship between socio-economic factors and knee OA, and the influence of these on gender. Methods: This is a case-control study conducted at Orthopaedic Hospital Wamakko, Sokoto, North-Western Nigeria between January 2022 and December 2022. Adult patients aged >40 years with knee OA were included in the study. The data was collected via participants’ interviews through a self-administered questionnaire. The risk factors for knee OA under consideration were occupation, educational level, and monthly income. Data were analysed using the SPSS version 23. The significant level was set at less than 5%. Results: There were a total of 372 patients in the study, with 124 cases and 248 controls in a ratio of 1:2. The average age was 53.7±10.8 (range 40 to 88 years). There were 165(44.4%) males and 207(55.6%) females. For occupation, 201(53.7%) were unemployed, 60(16%) on business, 61(16.3%) were civil servants and 50(13.4%) worked as farmers. For education, 250(66.8%) had non-formal education, and 122(32.6%) had formal education. Most patients (237/57.8%) were high-income earners and 135 (41.7%) were low-income earners. The knee OA prevalence was 13.17% for males and 20.16% for females. In the case group, the majority were unemployed with 63 (50.8%) patients and the least were farmers with only 16 (12.9%). Non-formal education was the most common educational level among the cases with 89(71.8%), and low-income earners are also more common with 74(59.7%) compared with high-income earners with 61 (40.3%). There was a statistically significance result between socioeconomic status and knee OA (OR=0.334, CI=0.214-0.521, and P<0.0001). The odd ratio (OR) for low-income earners among females is 2.238 (CI=1.878-2.666) and p value<0.0001. The OR for non-formal education in low-income earners is 2.332 (CI=1.466-3.709) and p value<0.0001. Conclusion: Low-income level was the most important predictor of knee OA in the study, and the female gender has the lowest income with higher knee OA risk and ....

The Role of the Sagittal Pars Inclination Angle in the Development of a Spondylolysis

Background and Aims: Spondylolysis refers to a stress fracture of the pars interarticularis. We investigated if there is a correlation between a novel measurement, the sagittal pars inclination angle and the incidence of spondylolysis (pars defect) in adolescent and young adult patients. Methods: A retrospective cohort study was conducted at the Royal Orthopaedic Hospital, UK (a tertiary referral orthopaedic centre) over two years identifying 37 Adult patients under the age of 30 years who had a computed tomography (CT) scan of the lumbar spine. In total 255 pars interarticularis, from levels L2 to L5, were analysed in 37 patients (19 male, 18 female). The pars interarticularis were divided into two groups: (1) pars intact ( N = 217) and (2) pars defect ( N = 38). Statistical analysis of each group and vertebral level was performed including load measurements. Results: In the pars intact group ( N = 217), the sagittal mean ± standard deviation (SD) pars inclination angle for the pars intact group was 17.91 ± 5.62°. In the pars defect group ( N = 38), the mean ± SD sagittal pars inclination angle was 35.95 ± 6.42°. A two-tailed P value was less than .0001. There was an increase in the normal sagittal pars angle from L2 to L5. Conclusion: In this study, an increased sagittal pars inclination angle demonstrated a significant association with spondylolysis. Its implications in the management of athletic individuals, surgical planning and indeed a true causative relationship are yet to be evaluated in future studies.

Survivorship and Outcomes of Hip Arthroplasty for Elective Care Versus Fracture in Patients Who Have Solid Organ Transplant: Lung Transplant Patients Do Worse.

With continued improvement in patient outcomes following solid organ transplant (SOT), more SOT recipients may benefit from hip arthroplasty. This study sought to compare the perioperative complications and survivorship of SOT recipients undergoing hip arthroplasty for elective care versus for fracture. A single-institution retrospective review yielded 95 hip arthroplasty procedures (80 patients) performed between August 2016 and May 2023 with a mean follow-up of 35 months. The most common SOT was liver (47%), followed by kidney (31%) and lung (23%). Cases with an elective indication (69 hips) were compared to those with traumatic indications (26 hips). Perioperative complications and patient survivorship were compared between groups and by transplant type. Patient mortality at one year was 19.2% for the fracture group compared to 1.4% for the elective group (P = 0.006). For elective care, lung transplant recipients had a higher incidence of postoperative mortality at final follow-up (27%) when compared to the liver (7%) and renal (0%) (P = 0.044). Hospital length of stay was less in the elective group (2.7 ± 3.1 versus 16.3 ± 21.2 days, P = 0.002), and more elective patients were discharged to home (85 versus 42%, P < 0.001), but there was no difference in the rate of 90-day hospital readmission (P = 0.91) or orthopaedic complication (13 versus 12%, P = 1.0). For fracture care, a preoperative surgical delay greater than 48 hours was more frequently observed for lung compared to liver transplant recipients (83 versus 13%, P = 0.010). Recipients of SOT undergoing hip arthroplasty for fracture experience longer hospitalizations and increased 1-year mortality compared to elective cases with a similar rate of orthopaedic complications and hospital readmissions. When evaluating by SOT type, lung transplant patients may have increased surgical delays for fracture care and postoperative mortality for elective care.

Bone lesion cryotherapy: pictorial review and review of current evidence.

Over the last two decades the development of small probes has enabled percutaneous use of cryotherapy. Cryotherapy, also known as cryoablation, enables the treatment of much larger lesions than other thermal ablation techniques, particularly when using multiple evenly spaced probes. Using rapid cooling to as low as -200 degrees Celsius (at the tip of the probe), reliable, and predictable necrosis can be induced. Probes are usually percutaneously inserted under computed tomography (CT) guidance under sedation or general anaesthesia, often as a day case. The procedure is safe with severe complications occurring rarely; the commonest complication is neural injury in lesions closely related to neurovascular bundles. Cryotherapy has been applied to the symptomatic and occasionally curative treatment of bone metastases and a range of primary bone lesions. This review summarises the published evidence base for the use of cryotherapy in metastatic and primary bone lesions and describes the experience with cryotherapy at the Royal Orthopaedic Hospital, Birmingham, a quaternary bone tumour referral hospital, where cryotherapy has been used for 3 years.

Characterization and variability of PROMIS-10 scores with physical therapy in knee osteoarthritis: A retrospective review.

Knee osteoarthritis (OA) and its impairments affect patients' physical and mental health. Radiographically severe knee OA is believed to respond less to conservative treatments including physical therapy (PT) but has not been compared specifically with Patient-Reported Outcomes Measurement Information System (PROMIS)-10. To correlate baseline PROMIS-10 physical and mental health scores in patients undergoing PT for knee OA, subgrouped by radiographic severity (Kellgren-Lawrence [KL] grade and number of knee compartments involved). Additionally, to describe the relationship between radiographic severity of knee OA and the change in PROMIS-10 scores post-PT. Retrospective review. Outpatient musculoskeletal clinics at an orthopedic specialty hospital. One hundred nine patients (age ≥ 18 years) who presented for evaluation of knee OA from April 1, 2019 to August 1, 2021, had baseline radiographs, underwent PT, and completed PROMIS-10 at baseline and follow-up. PT. PROMIS-10 physical and mental health scores. Participants were 60% female; average age was 66.6 ± 10.0 years. Baseline PROMIS-10 physical and mental health scores averaged 44.4 ± 7.2 and 52.8 ± 9.0. Post-PT PROMIS-10 physical and mental health scores averaged 44.7 ± 6.7 and 52.6 ± 8.7. Physical health scores improved in 39% of patients; mental health scores improved in 36% of patients (no statistical significance). There was no relationship between post-PT PROMIS-10 scores and radiographic severity of knee OA. Females exhibited osteoarthritic changes in all compartments in 72% of cases compared to 55% of males (p = .020). Females demonstrated a higher predisposition for lateral compartment involvement (83% vs. 64%; p = .021) and a higher proportion of severe OA, radiographically, with a KL grade 3-4 (92% vs. 80%; p = .051). More than one third of patients with knee OA reported improved physical and mental health post-PT. The degree of benefit did not relate to radiographic severity. Although OA is characterized by radiographic measurements, there are variables beyond the radiographic imaging that may affect patient outcomes.

Comparison and Validation of Methods for Restoring Neck Length in Hip Arthroplasty That Can Be Applied for Femoral Neck Fracture.

Background: Restoring leg length during total hip arthroplasty (THA) for femoral neck fracture is challenging due to the lack of an intact femoral neck on the fractured side. Thus, templating methods typically use size of the intact contralateral hip to estimate length. Common reference points include the distance from the lesser trochanter to the center of the femoral head (LTC) and femoral head diameter (FHD). Objectives: We sought to (1) investigate the LTC:FHD ratio as a preoperative templating method and (2) compare this method with calibrated LTC measurements. Methods: We performed a retrospective review of patients undergoing primary THA between 2021 and 2022 with recorded intraoperative measurements of LTC and FHD at a single academic orthopedic specialty hospital. Preoperative hip X-rays were used to determine the "predicted LTC length" with 2 separate methods: the LTC:FHD ratio yielding the "Ratio Predicted LTC" and the calibrated measurements method yielding the "Calibrated Predicted LTC." These measurements were compared with intraoperative measurements of the LTC length to determine accuracy. Results: Sixty-two hips in 59 patients were studied. The ratio predicted LTC and contralateral ratio predicted LTC length showed no significant difference from the intraoperative LTC length with a strong correlation between the 2 measurements (correlation coefficient = 0.77 and 0.80). The calibrated predicted LTC lengths were significantly different from the intraoperative LTC lengths (mean difference, 3.0 mm; 95% confidence interval [CI] = [2.2, 3.8]). Conclusions: This retrospective review suggests the LTC:FHD ratio multiplied by intraoperative FHD may be an accurate method for restoring anatomic femoral head height in THA (LTCa = [LTCr/FHDr] × FHDa). This method may be useful in hip fracture populations with distorted proximal femoral anatomy.

Predictive Factors of Inpatient Rehabilitation Stay and Post-Discharge Burden of Care After Joint Replacement for Hip and Knee Osteoarthritis: A Retrospective Study on 1678 Patients

The global demand for end-stage hip and knee osteoarthritis surgical treatment is rising, as is the need of optimal postoperative rehabilitation. Patient stratification is key to provide rehabilitation professionals and policy makers with real-life data in support of early discharge planning and continuous care provision. The aim of this retrospective, observational study was to investigate which factors can predict the burden of care at discharge (BCD) and the inpatient rehabilitation length of stay (LOS) based on a set of demographic, societal, clinical and organizational data collected from a high-volume orthopedic hospital. We included 45.306 variables from 1678 patients. All variables were initially tested individually using a linear regression model for inpatient rehabilitation LOS and a logistic regression model for BCD. Variables that resulted significant (p &lt; 0.05) were subsequently considered in a single, comprehensive linear regression model, or a single, logistic regression model, respectively. Age, living with a family, occupational status, baseline Barthel Index and duration of surgery were predictors of inpatient rehabilitation LOS and BCD. Sex, primary or secondary osteoarthritis, American Society of Anesthesiologists score, body mass index, transfusion, biological risk, type of anesthesia, day of surgery, numeric pain rating scale and baseline cognitive function at baseline were not. Including specific patient comorbidities, surgical access technique and chronic use of pharmacological therapy can improve the predictive power of the model.

Effectiveness of a new thermal insulation blanket in the control of inadvertent perioperative hypothermia and comfort: a randomized controlled trial

BackgroundDisturbances in the thermoregulatory system can precipitate inadvertent hypothermia in patients undergoing surgeries lasting over 60 min, causing serious complications in the recovery process. Cutaneous thermal protection is relevant for the control of temperature of patients in the perioperative setting. The standard thermal protection widely utilized is an electric forced warm air blanket. This study compared a new layered textile blanket with the standard protection. The hypothesis posited that the textile blanket could provide cutaneous thermal protection comparable to that of the standard protection (forced-air warming blanket), in terms of temperature variation and safety.MethodsThis randomized controlled trial was conducted at a Portuguese orthopedic hospital from October 2018 to January 2019, comprising 124 adult patients undergoing elective total knee arthroplasty. Participants were randomly allocated to either the intervention group, receiving the textile blanket, or to the control group, receiving standard measures. Tympanic temperature, shivering, and thermal comfort perception were evaluated at six time points. Comfort dimensions and ergonomic aspects were also assessed. Parametric statistics were performed, and independent samples t-tests and repeated measures were used to compare temperature variations and thermal comfort.ResultsNo statistically significant differences were found between groups in mean temperature variation, visual perception of thermal comfort, and thermal and perioperative comfort scales. The intervention group (n = 65) scored significantly higher in ergonomic evaluations compared to the control group (n = 59) for: fit to body and general comfort (p = 0.004), touch (p = 0.005), and feeling of comfort with the inner layer texture and shape (p < 0.001).ConclusionThe tested blanket had a comparable performance to the standard protection, suggesting it as a potential sustainable alternative to the recommended measures for thermal protection. However, further investigations across diverse contexts and populations are needed to validate these findings.

Staff education compared with active real-time waste segregation to reduce the environmental impact of hip and knee arthroplasty.

Arthroplasty has been shown to generate the most waste among all orthopaedic subspecialties, and it is estimated that hip and knee arthroplasty generate in excess of three million kg of waste annually in the UK. Infectious waste generates up to ten times more CO2 compared with recycled waste, and previous studies have shown that over 90% of waste in the infectious stream is misallocated. We assessed the effect of real-time waste segregation by an unscrubbed team member on waste generation in knee and hip arthroplasty cases, and compared this with a simple educational intervention during the 'team brief' at the start of the operating list across two sites. Waste was categorized into five categories: infectious, general, recycling, sharps, and linens. Each category was weighed at the end of each case using a digital weighing scale. At Site A (a tertiary orthopaedic hospital), pre-intervention data were collected for 16 total knee arthroplasy (TKA) and 15 total hip arthroplasty (THA) cases. Subsequently, for ten TKA and ten THA cases, an unscrubbed team member actively segregated waste in real-time into the correct streams. At Site B (a district general hospital), both pre- and post-intervention groups included ten TKA and ten THA cases. The intervention included reminding staff during the 'team brief' to segregate waste correctly. Active real-time waste segregation reduced infectious waste by a mean of 2.51 kg (95% CI 1.492 to 3.542) in TKA, and 1.83 kg in THA cases (p = 0.004). Educational intervention reduced infectious waste by a mean of 3.52 kg in TKA and 2.09 kg in THA cases (p = 0.026). Total waste was significantly reduced in both groups post-intervention for TKA cases. Simple educational measures alone can significantly reduce the amount of infectious waste. Extrapolated nationally, our results would yield a reduction of approximately 315,004 kg to 594,577 kg of CO2 annually, which equates to 70 to 132 gasoline-powered passenger vehicles driven for a year.

Impact of Paper Consumption in Radiology Departments on Carbon Footprint and Climate Change: A Retrospective Analysis and Future Projections

Abstract Introduction Climate change and global warming have major contributions from greenhouse gas emissions. Despite the introduction of digitalized systems, many health care systems still rely heavily on paper. The purpose of this study is to investigate paper usage in the radiology department of a single hospital institution over the last 3 years to forecast paper usage up to 2050. Methodology This retrospective study was performed in the radiology department of our tertiary orthopaedic hospital. The study included forms used for diagnostic and interventional procedures in various departmental modalities. Diagnostic procedures require one to three forms and interventional procedures require three forms each. Based on the established ratio that 1.2 trees are cut for every 10,000 sheets of papers used, the study calculated the number of trees cut annually over the past 3 years and projected paper usage and tree loss until 2050. Results Paper usage was distributed between diagnostic and interventional procedures, with 67% used in diagnostics and 33% in interventions. The corresponding number of trees cut during this period amounted to 53.729 trees, with 47.4 trees for diagnostic procedures and 6.4 trees for interventional procedures. A total of 57.8 trees for diagnostic procedures and 11.7 trees for interventional procedures were forecasted to be cut annually from 2024 to 2050, cumulatively being 1,227 trees by the year 2050. Conclusion Our individual department had a significant contribution from paper usage in the carbon footprint of the department. Adoption of digitalized appointment, prescribing, and patient records is important in reducing this and achieving the NHS net zero targets.

Association Between Anterior Knee Pain and Soft Tissue Gliding of the Anterior Knee Region After Total Knee Arthroplasty: A Cross-Sectional Study.

To investigate the relationship between impaired gliding in the anterior knee region and anterior knee pain (AKP) in patients after total knee arthroplasty (TKA). Cross-sectional study. Orthopedic hospital. Patients aged >60 years who underwent TKA between June and September 2023 without abnormal components or postoperative infections. Not applicable. Ultrasonography visualized the anterior knee soft tissues (subcutaneous tissue [SC], patellar tendon [PT], and infra-patellar fat pad [IFP]) during maximal voluntary isometric knee extension. Particle image velocimetry analyzed the SC, PT, and IFP flow velocities, organized into time-series data. Correlation coefficients of flow velocity between the SC and PT and between the PT and IFP were calculated to define the gliding coefficient. We measured AKP during walking and stair ascent and descent. Furthermore, we investigated the correlations between gliding coefficients and AKP and identified factors contributing to AKP using multiple regression analysis. The relationship between gliding coefficients and patient-reported outcomes was explored. In total, 20 patients (mean age, 72.9years; postoperative period, 14.9weeks) were included. A significant positive correlation was observed between the SC-PT gliding coefficients and AKP. Multiple regression analysis identified the SC-PT gliding coefficient as a significant independent variable associated with AKP during stair descent. Additionally, the SC-PT gliding coefficients were found to have a significant negative correlation with patient-reported outcomes. The impaired gliding between the SC and PT may contribute to AKP, specifically during stair descent. This finding suggests that soft tissue gliding plays a significant role in postoperative pain and activity limitations in patients who underwent TKA.

Evaluating the Compliance to 24-Hour Venous Thromboembolism Risk Re-assessment Following Orthopaedic Surgery at a Tertiary Center: A Closed-Loop Clinical Audit.

Introduction Venous thromboembolism (VTE) is a preventable cause of patient morbidity and mortality among hospitalised patients. VTE events have a high incidence among orthopaedic patients, who routinely receive chemical thromboprophylaxis in the form of heparin, warfarin, antiplatelet agents or direct oral anticoagulants. These can be associated with adverse events, most commonly bleeding or heparin-induced thrombocytopenia. A VTE risk reassessment following 24 hours of admission or a change in clinical condition like surgery is recommended to avoid such complications. We evaluated the compliance to completion of these reassessments following surgery at a tertiary elective orthopaedic hospital. Methods A closed-loop audit was undertaken for all elective orthoapedic specialties. First loop was conducted between 01/07/2022 and 25/05/2023, whilst the second loop was done between 01/01/2024 and 01/02/2024. Insight, an online database was used to collect data on initial VTE assessment forms completed at admission and VTE reassessment forms completed within 24 hours of surgery, as agreed with orthopaedic teams. Audit standards were derived from National Institute for Health and Care Excellence (NICE) guidelines on venous thromboembolism in over 16s. A target compliance was agreed at 100%. Paediatric patients, day case procedures and medical admissions comprised the exclusion criteria. Results For the first audit loop, only 6/4780 (0.13%) patients had completed VTE reassessment forms within 24 hours following surgery. Following implementation of a system prompt on Electronic Patient Medication Administration (EPMA) to serve as a reminder for VTE reassessment completion, the second audit loop found 112/156 (74%) patients had completed forms (p<0.001). Conclusion VTE risk reassessment following surgery is recommended by NICE guidelines in order to assess and potentially minimize complications like bleeding and heparin-induced thrombocytopenia. A simple intervention such as a system reminder can serve to improve compliance. This can be implemented at a large scale given most hospitals use integrated electronic medication administration systems where initial VTE risk assessments are completed as part of the initial patient admission process.

A comparison of patients receiving vertebral body tethering for adolescent idiopathic scoliosis in the public and private hospital setting

PurposeVertebral body tethering (VBT) is a new growth-modulating surgery for adolescent idiopathic scoliosis (AIS) requiring a distinct skillset and intraoperative setup. We compared perioperative details and outcomes of VBTs performed in a public pediatric orthopedic hospital and a general private hospital setting.MethodsWe identified all patients receiving VBT for AIS from 1/2020 to 12/2023 with ≥ 6 months post-operative follow-up, with surgeries performed by the same senior surgeons. Clinical, radiological, and surgical details were retrieved.Results24 VBTs were performed in the private setting and 16 in the public setting. Average age at operation was 11.9 ± 1.1 at a Sanders staging of 3.8 ± 1.2 when the major curve Cobb angle was 50.5 ± 8.0°. Tethered curves were most often thoracic in location (23/40) followed by thoracolumbar/lumbar curves (10/40) and double curve tethers (7/40). Overall correction ratio of 68.0 ± 19.0% was achieved. Time from booking to operation (82.2 ± 39.2 vs 63.1 ± 34.4 days, p = 0.112) and operation time (310 ± 86.4 min vs. 289 ± 87.4 min, p = 0.054) were longer in the public and private setting respectively but failed to reach statistical significance. Time to chest drain removal (1.5 ± 0.8 vs. 3.5 ± 1.7 days, p < 0.001) and length of stay (4.3 ± 0.9 vs. 6.6 ± 1.8 days, p < 0.001) were significantly shorter in the private setting, whilst complication rates remained similar (7/24 vs. 3/16, p = 0.456).ConclusionExpertise, resource availability, and costs differ in the public and private healthcare setting. With regards to VBT, the conditions for referral and surgical outcomes remained similar. Earlier drain removal and discharge for patients managed in the private setting was not associated with an increase in complication rate.

Psychometric properties of the WHODAS 2.0 in patients with orthopedic injuries from road traffic crashes in Bangladesh

Purpose Road traffic injuries (RTIs) are a leading cause of disability in low- and middle-income countries. This study assesses the psychometric properties of 12-item World Health Organization Disability Assessment Schedule (WHODAS) 2.0 among patients with orthopedic injuries from road traffic crashes in Bangladesh across two timepoints after hospital discharge. Materials and methods Confirmatory factor analysis (CFA) assessed WHODAS 2.0 construct validity and investigated measurement invariance among a sample of RTI patients at an orthopedic hospital one month and three months post-discharge. Cronbach’s alpha measured reliability. Results A single-factor structure was identified in CFA for the one-month sample (χ2(53)=894.337, p < 0.001; CFI = 0.989, TLI = 0.986; SRMR = 0.052, RMSEA = 0.151) and the three-month sample (χ2(53)=630.119, p < 0.001; CFI = 1.000, TLI = 1.000; SRMR = 0.022, RMSEA = 0.130). Measurement invariance was supported, and internal consistency was excellent (α > 0.9) at each timepoint. Mean disability score decreased from 37.89 (out of 48, SD = 10.44) one-month post-discharge to 27.19 (SD = 18.10, p < 0.001) three months post-discharge indicating improvement in functional status over time. Conclusions WHODAS 2.0 is valid and reliable for measuring disability among patients with RTIs in Bangladesh and has validity for making meaningful comparisons in disability level over time. Future research should include samples with different types of RTIs to strengthen the evidence supporting the use of the instrument.

Indoor Air Quality in an Orthopedic Hospital from Romania.

Inside hospitals, there is a trend of increasing levels of air pollutants. However, only the indoor air quality in operating theaters is carefully monitored. Therefore, we set the goal of this study to evaluate the indoor air quality in areas of an orthopedics department and to compare the indoor air quality indices that characterize these areas. We used a monitoring system based on the Internet of Things with uRADMonitor model A3 sensors, with which we prospectively measured indoor air quality in the facilities of the orthopedic emergency hospital of Targu Mures in Romania, between 1 February 2023, and 31 January 2024. The primary target pollutants investigated in the emergency room, outpatient room and ward were carbon dioxide (CO2), nitrogen dioxide (NO2), volatile organic compounds (VOCs) and particles with a diameter smaller than 2.5 μm (PM2.5). We compared the effectiveness of the intervention for emergency rooms where air purifiers were working or not. The concentrations of CO2, VOCs and PM2.5 were significantly higher in the emergency room than in the outpatient room or ward. The indoor air quality was worst in winter, when the CO2, NO2 and VOC concentrations were at their highest. Air purifiers can help reduce the concentration of PM2.5 in emergency rooms. Medical staff and patients in orthopedic hospitals, especially in emergency rooms, are frequently exposed to polluted ambient air, which can affect their health. Orthopedic medical practice guidelines should address issues relating to the protection of personnel through the application of measures to improve indoor air quality.

Epidemiology of International Patients with Lower-Limb Deficiencies Treated at a United States–Based Pediatric Prosthesis Clinic

ABSTRACT Introduction Limited epidemiological or clinical research exists describing pediatric lower-limb deficiency (LLD) patients born outside the United States (US). Objectives The purpose of this study was to characterize a cohort of international patients treated at a single tertiary care orthopedic hospital. We set out to quantify the prevalence of international patients within a broader cohort of pediatric limb deficiency patients. In addition, we evaluated similarities and differences between adopted and nonadopted internationally born patients as well as their US-born counterparts. Study Design Retrospective chart review was performed on patients born outside the US between 1995 and 2020. Methods Patients were divided into groups based on place of birth, country of residence, and adoption status. Statistical analysis was performed using χ2 and t-test. Results A total of 111/579 (19.2%) patients seen in our limb difference clinic were born outside the US, with 39.6% adopted. Geographically, patients represented 32 countries, and 96.4% were born in low- or middle-income countries (LMICs). The most common causes of LLD were congenital malformations (72.1%), trauma (17.1%), and tumor (5.4%). Syme was the most common amputation level (26.6%), followed by knee disarticulation (23.7%) and transtibial (18.7%). Congenital diagnoses were more frequent in adoptees (93.1% vs. 58.2%), whereas nonadoptees often had trauma (25.4%) or tumor (8.9%) diagnoses leading to amputation (P = 0.0003). A total of 23/60 (38.3%) international patients with preexisting lower-limb amputations had never worn a prosthesis at the time of initial presentation. Conclusions Many pediatric patients with prosthetic needs presenting for care in the US were born in LMIC. Adopted and nonadopted internationally born patients had significant differences in clinical etiologies of their LLD. Clinical Relevance Statement Internationally born patients may constitute a substantial percentage of US-based specialty clinics treating children with lower-limb differences, particularly from low- or middle-income countries where access to orthopedic and prosthetic care may be limited. This study highlights the importance of multidisciplinary health care providers addressing these children’s distinct clinical needs for improved patient-centered care.

Pain Control and Opioid Consumption in Patients Undergoing Total Hip or Knee Arthroplasty Receiving a Preoperative Low Dose of Gabapentin

Background: Meta-analyses and randomized controlled trials were inconclusive regarding the role of gabapentinoids in patients undergoing joint arthroplasties. The aim of the present study was to investigate the effect of a preoperative low dose of gabapentin in patients undergoing total hip (THA) and knee arthroplasties (TKA). Methods: A retrospective observational study was conducted on 135 patients undergoing THA and TKA at the National Orthopedic Hospital Cappagh, Dublin, from July to December 2022. The primary outcome was the assessment of numerical rating scores (NRS) for postoperative pain at various time intervals. Results: During the observation period, 55 patients received a preoperative dose of gabapentin, while 80 patients did not. Statistically significant differences in numerical rating scores (NRS) were found at 6 (3 vs. 0, p &lt; 0.001), 12 (4 vs. 2, p &lt; 0.001), 18 (4 vs. 3, p &lt; 0.001), and 24 h (4 vs. 3, p = 0.010) after surgery, in favor of the group receiving gabapentin. A reduction in opioid consumption, measured as morphine equivalents, was also noted in the gabapentin group (40 vs. 30 mg, p = 0.040). Conclusions: A low preoperative dose of gabapentin was associated with reduced postoperative pain and opioid consumption in patients undergoing TKA and THA, without impacting hospital stay. Prospectively designed trials are encouraged to assess the safety and effect on pain control of a preoperative low dose of gabapentin.

RNA-First Approach Identifies Deep Intronic PHEX Variants in X-Linked Hypophosphatemic Rickets.

Up to 20% of patients with X-linked hypophosphatemic rickets (XLH) have no causative variant identified on routine molecular diagnostic testing. To identify intronic variants causing PHEX mis-splicing in patients with XLH. The metabolic bone clinic of a paediatric orthopedic hospital. Four patients (age 6 to 12 years; 3 girls) with clinically diagnosed XLH and no PHEX variant on routine testing. RNA and DNA sequence analysis of PHEX. Urine-derived cells were cultured, and mRNA was extracted and transcribed to cDNA. PHEX cDNA was amplified by PCR, followed by sequencing of PCR products. Sequencing of PHEX intronic DNA regions was performed to identify variants causing mis-splicing observed on RNA analysis. PHEX mis-splicing was identified in 3 of the 4 participants, and an intronic variant was identified in all 3 cases. In a 12-year-old boy, transcript analysis showed skipping of PHEX exon 13, while sequencing of PHEX intronic regions revealed a de novo 18 bp deletion in intron 13. In a 7-year-old girl, a pseudoexon in PHEX intron 17 was found, associated with a de novo deep intronic variant (c.1768+173A>G) that activated a cryptic splice donor site. Finally, an 84 bp pseudoexon in PHEX intron 21 caused by a recurrent de novo deep intronic variant (c.2147+1197A>G) was identified in an 11-year-old girl. Analysis of RNA from urine-derived cells combined with sequencing of PHEX introns can identify deep intronic variants in individuals with XLH without a detectable PHEX variant in routine exon-centric molecular diagnosis.

Can the lung ultrasound score predict pulmonary complications after non-thoracic surgery in patients with blunt thoracic trauma: A single-center observational study

Study objectivePatients with blunt thoracic trauma have a high risk of developing postoperative pulmonary complications (PPCs). In this study, we aimed to identify the risk factors for PPCs after non-thoracic surgery in patients with blunt thoracic trauma and investigate the efficacy of perioperative lung ultrasound scores in predicting PPC occurrence. DesignProspective observational study. SettingA Chinese tertiary orthopedic hospital. ParticipantsThis observational study included 369 patients with blunt thoracic trauma who underwent surgery for pelvic and upper or lower extremity fractures. InterventionsLung ultrasonography was performed pre- and postoperatively. MeasurementsPatients were followed up for 1 week to assess PPCs and assigned to the PPC or non-PPC groups. We identified risk factors for PPCs using univariate and multivariate logistic regression analyses. The predictive value of these risk factors was evaluated using receiver operating characteristic (ROC) curves. Main resultsPPCs incidence was 36.58 %. The two groups differed significantly in Injury Severity Scores, American Society of Anesthesiologists (ASA) classification, chronic obstructive pulmonary disease, hydrothorax, preoperative hypoxemia, lung ultrasound score, preoperative hemoglobin level, intraoperative infusion volume, and Assess Respiratory Risk in Surgical Patients in Catalonia (ARISCAT) scores (P < 0.05). Independent risk factors for PPCs included ASA classification III, higher postoperative lung ultrasound scores, preoperative anemia, higher intraoperative infusion volume, and higher ARISCAT scores. ROC curve analysis revealed that postoperative lung ultrasound score (area under the curve [AUC]: 0.810, cutoff: 10), preoperative hemoglobin level (AUC: 0.627, cutoff: 97), intraoperative infusion volume (AUC: 0.701, cutoff: 886.51 mL/h) and ARISCAT score (AUC: 0.718, cutoff: 33) predicted postoperative outcomes effectively. ConclusionsPostoperative lung ultrasound scores reliably predicted pulmonary complications after non-thoracic surgery in patients with blunt thoracic trauma. ASA classification III, preoperative anemia, excessive intraoperative fluid infusion, higher ARISCAT, and postoperative lung ultrasound scores were significant risk factors associated with PPCs.Trial registration: Clinical Trial Number: 1900023408. Registered on May 26, 2019.