In this study, an investigation is conducted to examine various methods for measuring the two-phase flow of water and air. The two-phase flow loop and its equipment, including the orifice flow meter, were designed and manufactured in accordance with relevant standards. By employing the orifice flow meter in the two-phase flow loop and determining the total mass flow rate of the two-phase flow passing through it, the pressure drop of the orifice flow meter was determined for different values of the flow rate and volume fractions of the water and air phases in the two-phase flow. The Reynolds number of the two-phase flow ranged from 700 to 11000, while the air volume fraction ranged from 10% to 45%. We observed that, for the orifice flow meter, the slope of the discharge coefficient variation in relation to the two-phase flow Reynolds number was higher at low Reynolds numbers, where a laminar flow pattern was established. As the two-phase flow Reynolds number increased, the flow pattern transitioned from laminar to plug flow, resulting in a decrease in the slope. The orifice flow meter under two-phase flow conditions was simulated using computational fluid dynamics (CFD) with different turbulence models. The results indicated that the k-epsilon RNG turbulence model yielded more accurate results compared to other turbulence models. This study provides a foundation for the measurement of two-phase flows in the oil and gas industries.