We discuss the effect of the dynamics of D-branes on moduli stabilization in type IIB string theory compactifications, with reference to a concrete toy model of [Formula: see text] orientifold compactification with fractional D3-branes and anti-D3-branes at orbifold fixed points. The resulting attractive forces between anti-D3-branes and D3-branes, together with the repulsive forces between anti-D3-branes and O3-planes, can affect the stability of the compact space. There are no complex structure moduli in [Formula: see text] orientifold, which should thus capture some generic features of more general settings where all complex structure moduli are stabilized by three-form fluxes. The simultaneous presence of branes and anti-branes brings along the breaking of supersymmetry. Non-BPS combinations of this type are typical of “brane supersymmetry breaking” and are a necessary ingredient in the KKLT scenario for stabilizing the remaining Kähler moduli. The conclusion of our analysis is that, while mutual D-brane interactions sometimes help Kähler moduli stabilization, this is not always the case.