Orientation Bias Research Articles

Flow Orientation Analysis for Major Activity Regions Based on Smart Card Transit Data

Analyzing public movement in transportation networks in a city is significant in understanding the life of citizen and making improved city plans for the future. This study focuses on investigating the flow orientation of major activity regions based on smart card transit data. The flow orientation based on the real movements such as transit data can provide the easiest way of understanding public movement in the complicated transportation networks. First, high inflow regions (HIRs) are identified from transit data for morning and evening peak hours. The morning and evening HIRs are used to represent major activity regions for major daytime activities and residential areas, respectively. Second, the directional orientation of flow is then derived through the directional inflow vectors of the HIRs to show the bias in directional orientation and compare flow orientation among major activity regions. Finally, clustering analysis for HIRs is applied to capture the main patterns of flow orientations in the city and visualize the patterns on the map. The proposed methodology was illustrated with smart card transit data of bus and subway transportation networks in Seoul, Korea. Some remarkable patterns in the distribution of movements and orientations were found inside the city. The proposed methodology is useful since it unfolds the complexity and makes it easy to understand the main movement patterns in terms of flow orientation.

Optical Coherence Tomography Angiography Reveals Spatial Bias of Macular Capillary Dropout in Diabetic Retinopathy.

Our purpose is to evaluate the spatial bias of macular capillary dropout accompanying diabetic retinopathy (DR) using optical coherence tomography angiography (OCTA). This study included 47 patients with diabetes and 29 healthy individuals who underwent OCTA. Retinal capillary flow density (FD) of 2.6 × 2.6 or 5.2 × 5.2 mm foveal area as well as the four divided areas (superior, inferior, temporal, nasal) without a foveal avascular zone (FAZ) at the superficial capillary plexus and deep capillary plexus (DCP) were measured respectively using ImageJ and NI Vision. Spatial biases of FD (orientation bias ratio and hierarchical bias ratio) and the correlation between FAZ and FD were examined. OCTA showed focal capillary dropout in DR patients. The orientation bias of FD was significantly higher in NPDR compared to NDR in the DCP (P = 0.03). The hierarchical bias of FD was significantly shifted to a DCP dominance with progression of DR (P < 0.01). In addition, the FD and FAZ area were significantly inversely correlated in both plexus in DR patients but not in healthy subjects (P < 0.01). Area-divided OCTA quantification shows the appearance of spatial biases of macular capillary dropout with the onset of DR, suggesting that DR-related macular capillary dropout occurs locally and randomly. Future studies are necessary to determine the clinical relevance of the spatial pattern of capillary dropout in DR.

An error-based micro-sensor capture system for real-time motion estimation**Research supported by the National Natural Science Foundation of China (Nos. 61431017, 81272166).

A wearable micro-sensor motion capture system with 16 IMUs and an error-compensatory complementary filter algorithm for real-time motion estimation has been developed to acquire accurate 3D orientation and displacement in real life activities. In the proposed filter algorithm, the gyroscope bias error, orientation error and magnetic disturbance error are estimated and compensated, significantly reducing the orientation estimation error due to sensor noise and drift. Displacement estimation, especially for activities such as jumping, has been the challenge in micro-sensor motion capture. An adaptive gait phase detection algorithm has been developed to accommodate accurate displacement estimation in different types of activities. The performance of this system is benchmarked with respect to the results of VICON optical capture system. The experimental results have demonstrated effectiveness of the system in daily activities tracking, with estimation error 0.16 ± 0.06 m for normal walking and 0.13 ± 0.11 m for jumping motions.

Design of steel fiber reinforced concrete beams for shear using inverse analysis for determination of residual tensile strength

The behavior of steel fiber reinforced concrete (SFRC) has been extensively investigated in the last four decades. For the most part, however, existing design models for shear are based on empirical equations where fiber–concrete is considered as a unique material and fibers and concrete components to shear are considered collectively, or where the concrete and fiber components to shear are considered separately and each are derived independently. As demonstrated in this paper, the problem with this latter approach is that the influence of the concrete and the fiber components are each affected by the other—that is, they are coupled. In this paper, a rational model is outlined for determining one‐way shear strength of SFRC beams and slabs. The model is developed from the modified compression field approach with due consideration given to the inter‐relationship between the concrete–steel–fiber components to the shear resistance. Introduced into the model is an inverse analysis method for determining the post‐cracking residual tensile strength of SFRC from prism bending tests, a core materials property needed for design. In determining this strength, due attention is provided to the influences of notches, specimen boundaries and bias in fiber orientation that occurs as part of the casting process. The results of the design model predictions are compared with a dataset of test specimens collected from the literature, with very good correlation observed.

Statistical methods of fracture characterization using acoustic borehole televiewer log interpretation

AbstractAcoustic borehole televiewer (BHTV) logs provide measurements of fracture attributes (orientations, thickness, and spacing) at depth. Orientation, censoring, and truncation sampling biases similar to those described for one‐dimensional outcrop scanlines, and other logging or drilling artifacts specific to BHTV logs, can affect the interpretation of fracture attributes from BHTV logs. K‐means, fuzzy K‐means, and agglomerative clustering methods provide transparent means of separating fracture groups on the basis of their orientation. Fracture spacing is calculated for each of these fracture sets. Maximum likelihood estimation using truncated distributions permits the fitting of several probability distributions to the fracture attribute data sets within truncation limits, which can then be extrapolated over the entire range where they naturally occur. Akaike Information Criterion (AIC) and Schwartz Bayesian Criterion (SBC) statistical information criteria rank the distributions by how well they fit the data. We demonstrate these attribute analysis methods with a data set derived from three BHTV logs acquired from the high‐temperature Rotokawa geothermal field, New Zealand. Varying BHTV log quality reduces the number of input data points, but careful selection of the quality levels where fractures are deemed fully sampled increases the reliability of the analysis. Spacing data analysis comprising up to 300 data points and spanning three orders of magnitude can be approximated similarly well (similar AIC rankings) with several distributions. Several clustering configurations and probability distributions can often characterize the data at similar levels of statistical criteria. Thus, several scenarios should be considered when using BHTV log data to constrain numerical fracture models.

Medical School Factors Associated with Changes in Implicit and Explicit Bias Against Gay and Lesbian People among 3492 Graduating Medical Students.

Implicit and explicit bias among providers can influence the quality of healthcare. Efforts to address sexual orientation bias in new physicians are hampered by a lack of knowledge of school factors that influence bias among students. To determine whether medical school curriculum, role modeling, diversity climate, and contact with sexual minorities predict bias among graduating students against gay and lesbian people. Prospective cohort study. A sample of 4732 first-year medical students was recruited from a stratified random sample of 49 US medical schools in the fall of 2010 (81% response; 55% of eligible), of which 94.5% (4473) identified as heterosexual. Seventy-eight percent of baseline respondents (3492) completed a follow-up survey in their final semester (spring 2014). Medical school predictors included formal curriculum, role modeling, diversity climate, and contact with sexual minorities. Outcomes were year 4 implicit and explicit bias against gay men and lesbian women, adjusted for bias at year 1. In multivariate models, lower explicit bias against gay men and lesbian women was associated with more favorable contact with LGBT faculty, residents, students, and patients, and perceived skill and preparedness for providing care to LGBT patients. Greater explicit bias against lesbian women was associated with discrimination reported by sexual minority students (b=1.43 [0.16, 2.71]; p=0.03). Lower implicit sexual orientation bias was associated with more frequent contact with LGBT faculty, residents, students, and patients (b=-0.04 [-0.07, -0.01); p=0.008). Greater implicit bias was associated with more faculty role modeling of discriminatory behavior (b=0.34 [0.11, 0.57); p=0.004). Medical schools may reduce bias against sexual minority patients by reducing negative role modeling, improving the diversity climate, and improving student preparedness to care for this population.

New insights from a high-resolution look at gastrulation in the sea urchin, Lytechinus variegatus

BackgroundGastrulation is a complex orchestration of movements by cells that are specified early in development. Until now, classical convergent extension was considered to be the main contributor to sea urchin archenteron extension, and the relative contributions of cell divisions were unknown. Active migration of cells along the axis of extension was also not considered as a major factor in invagination. ResultsCell transplantations plus live imaging were used to examine endoderm cell morphogenesis during gastrulation at high-resolution in the optically clear sea urchin embryo. The invagination sequence was imaged throughout gastrulation. One of the eight macromeres was replaced by a fluorescently labeled macromere at the 32 cell stage. At gastrulation those patches of fluorescent endoderm cell progeny initially about 4 cells wide, released a column of cells about 2 cells wide early in gastrulation and then often this column narrowed to one cell wide by the end of archenteron lengthening. The primary movement of the column of cells was in the direction of elongation of the archenteron with the narrowing (convergence) occurring as one of the two cells moved ahead of its neighbor. As the column narrowed, the labeled endoderm cells generally remained as a contiguous population of cells, rarely separated by intrusion of a lateral unlabeled cell. This longitudinal cell migration mechanism was assessed quantitatively and accounted for almost 90% of the elongation process. Much of the extension was the contribution of Veg2 endoderm with a minor contribution late in gastrulation by Veg1 endoderm cells. We also analyzed the contribution of cell divisions to elongation. Endoderm cells in Lytechinus variagatus were determined to go through approximately one cell doubling during gastrulation. That doubling occurs without a net increase in cell mass, but the question remained as to whether oriented divisions might contribute to archenteron elongation. We learned that indeed there was a biased orientation of cell divisions along the plane of archenteron elongation, but when the impact of that bias was analyzed quantitatively, it contributed a maximum 15% to the total elongation of the gut. ConclusionsThe major driver of archenteron elongation in the sea urchin, Lytechinus variagatus, is directed movement of Veg2 endoderm cells as a narrowing column along the plane of elongation. The narrowing occurs as cells in the column converge as they migrate, so that the combination of migration and the angular convergence provide the major component of the lengthening. A minor contributor to elongation is oriented cell divisions that contribute to the lengthening but no more than about 15%.

PREJUDICE AND DISCRIMINATION IN SEASIDE RETAILING. COMPARATIVE ANALYSES BETWEEN BRAZIL AND ITALY

This paper focuses on the phenomena of prejudice and discrimination among the interactions of frontline employees and customers in retailing spatial environments. The aim is to identify if there is perception of prejudice and discrimination related to Ageism, Sexism, Lookism (ASL) and Sexual Orientation bias (SO) against customers in Brazil and Italy Seaside Retailing. Through quantitative research and descriptive study, data from Curitiba-Parana-Brazil and Urbino-Marche-Italy are collected, using sampling by convenience. Likert Scales have been used to evaluate ASL+SO. Findings: One statement (4.2 “The frontline male employees are nicer to younger female customers”), out of 15 shows that the interviewees from both countries had presented a highly agreement perception, which is the reinforcement that they had perceived that gender, age and appearance have influence on frontline employees’ behaviour. However, considering the results of the majority of the statements, an overall conclusion can highlight that the respondents do not perceive ageism, sexism, lookism or sexual orientation bias against customers when the seaside retail companies provide face-to-face services. A theoretical contribution of this paper can be drawn for the development of protocols that can be useful to identify and to evaluate ASL+SO phenomena in retailing. Its format and its methodology can be used to research different kinds of organisations, especially in the retail and services industries. The managerial implications are in the importance of developing T&D to reduce ASL+SO practices against customers and to include these issues as subjects in the organisation’s strategic statements. Also it would be suitable designing more efficient procedures of queueing management. These practices could avoid that dissatisfied customers reduce purchasing and consequent falling sales and profits. Classification-JEL: Keywords: prejudice, discrimination, seaside retailing, ageism, sexism, lookism, sexual orientation bias.

Sequence motifs capable of forming DNA stem-loop structures act as a replication diode.

Calculating peak‐height ratios between single‐nucleotide polymorphisms (SNP) alleles in sequencing chromatograms is a practical method for estimating their copy number proportions (CNPs). However, it is surprising that sequencing DNA from different directions might yield different results. We analyzed three adjacent SNPs within the ovine period circadian‐clock 2 (PER2) gene that displayed such behavior. We compared Sanger and DNA‐seq sequencing for this locus and applied high‐resolution melt and MFOLD analyses to point to the DNA secondary structure that underlined this phenomenon. A synthetic system of oligonucleotides cloned into plasmids was used to further test the effect of such structures on sequencing. Our analyses indicated that a stem–loop structure capable of G–T pairing mediated the orientation bias by stabilizing this structure for specific alleles in heterozygous situations. We propose that this wobble‐like pairing hinders DNA polymerase passage on one strand while, on the complementary strand, the nonpaired A–C nucleotide counterparts allow unobstructed replication. Experimentation with synthetic amplicons that form similar stem–loop structures supported our hypothesis. We coined the term ‘replication diode’ for this effect and demonstrated that we can minimize it by lowering DNA and salt concentration. We also demonstrated that common genomic palindromes might induce the replication diode effect by applying bidirectional sequencing to an amplicon containing the palindrome within the human miRNA 1‐1 gene. Hence, to obtain reliable peak‐height ratios, bidirectional sequencing should be practiced at the lowest possible ionic strength whenever estimating CNPs. Further research is needed to determine whether the observed variable stem–loop structures affect PER2 regulation in vivo.

Social and Psychological Background for Emergence of Hypochondriacal Personality Disorders

Abstract Introduction. A hypochondriacal disorder is among the least extensively studied psychopathological phenomena. It is, above all, characterized by the excessive concentration on the person’s own psychosomatic feelings. Hypochondriacal attitude causes various age crises generated by the weakening of psychophysical functions, reduction of abilities, change of the major activity and social status. The present requires new approaches towards the realization of the national policies in the sphere of maintenance of optimal functioning and efficiency of the Ukrainian society. Aim. The aim of the study was to emphasize the preconditions for the emergence of hypochondriacal personality disorders in sociometric dimension, as well as people’s professional tolerance to the disease. Material and methods. The study involved 236 teachers of rural and urban schools, of which 78% were women and 22% (52 respondents) were men. The teachers were asked about the level of their job satisfaction. Results. Quite a large proportion of respondents – 56% (132) is satisfied with their professional activity. Nevertheless, the teaching conditions, especially in rural schools, block up their professional advancement. According to the results of the research, about a third of the respondents (75 people, or 32%) is partially satisfied with their job, while those not satisfied made up 12% (28 respondents). Such level of job satisfaction testifies that a crucial problem nowadays is not a pedagogical job placement, but on the contrary, an improper professional orientation, wrong choice of qualification, biased personality orientation. Other complaints made in the survey included statements concerning poor salaries, unhealthy socio-psychological atmosphere among the teaching staff, teachers’ own poor health, etc. Conclusions. Decoding a hypochondriacal “message” is only possible through the analysis of the defective transactions between the individual and his/her family or social environment. The absolute self-activation of a individual is realized through the interaction between the personal potentials determined by the state of the optimal functioning of a person and social recognition as a factor of maintaining teacher’s spirituality in the form of professional self-consciousness.

High-resolution cryo-EM proteasome structures in drug development.

With the recent advances in biological structural electron microscopy (EM), protein structures can now be obtained by cryo-EM and single-particle analysis at resolutions that used to be achievable only by crystallographic or NMR methods. We have explored their application to study protein-ligand interactions using the human 20S proteasome, a well established target for cancer therapy that is also being investigated as a target for an increasing range of other medical conditions. The map of a ligand-bound human 20S proteasome served as a proof of principle that cryo-EM is emerging as a realistic approach for more general structural studies of protein-ligand interactions, with the potential benefits of extending such studies to complexes that are unfavourable to other methods and allowing structure determination under conditions that are closer to physiological, preserving ligand specificity towards closely related binding sites. Subsequently, the cryo-EM structure of the Plasmodium falciparum 20S proteasome, with a new prototype specific inhibitor bound, revealed the molecular basis for the ligand specificity towards the parasite complex, which provides a framework to guide the development of highly needed new-generation antimalarials. Here, the cryo-EM analysis of the ligand-bound human and P. falciparum 20S proteasomes is reviewed, and a complete description of the methods used for structure determination is provided, including the strategy to overcome the bias orientation of the human 20S proteasome on electron-microscope grids and details of the icr3d software used for three-dimensional reconstruction.

Mean-intercept anisotropy analysis of porous media. I. Analytic formulae for anisotropic Boolean models.

Structure-property relations, which relate the shape of the microstructure to physical properties such as transport or mechanical properties, need sensitive measures of structure. What are suitable fabric tensors that quantify the shape of anisotropic heterogeneous materials? The mean intercept length is among the most commonly used characteristics of anisotropy in porous media, for example, of trabecular bone in medical physics. We analyze the orientation-biased Boolean model, a versatile stochastic model that represents microstructures as overlapping grains with an orientation bias towards a preferred direction. This model is an extension of the isotropic Boolean model, which has been shown to truthfully reproduce multi-functional properties of isotropic porous media. We explain the close relationship between the concept of intersections with test lines to the elaborate mathematical theory of queues, and how explicit results from the latter can be directly applied to characterize microstructures. In this series of two papers, we provide analytic formulas for the anisotropic Boolean model and demonstrate often overlooked conceptual shortcomings of this approach. Queuing theory is used to derive simple and illustrative formulas for the mean intercept length. It separates into an intensity-dependent and an orientation-dependent factor. The global average of the mean intercept length can be expressed by local characteristics of a single grain alone. We thus identify which shape information about the random process the mean intercept length contains. The connection between global and local quantities helps to interpret observations and provides insights into the possibilities and limitations of the analysis. In the second paper of this series, we discuss, based on the findings in this paper, short-comings of the mean intercept analysis for (bone-)microstructure characterization. We will suggest alternative and better defined sensitive anisotropy measures from integral geometry.

MODERNISASI PESANTREN: PERGESERAN TRADISI DAN PUDARNYA KYAI

This article is aimed at studying the bias of the pesantren orientation, pesantren transformation and its implication on the institutional development of the pesantren. The findings give indication that this educational institution has, slowly but surely, been unable to realize its identity as the agent of social changes. At the same time, young generation who are graduates of both general and Islamic high schools and universities have begun to play a strategic role in the management and leadership of pesantren in particular and ummah in general. Therefore, it is essential for pesantren to understand the basic idea of modernization in education. With this knowledge, pesantren will be able to make some revision toward the ideal form of pesantren in the future.

Correlates of Perceptual Orientation Biases in Human Primary Visual Cortex.

Vision can be considered as a process of probabilistic inference. In a Bayesian framework, perceptual estimates from sensory information are combined with prior knowledge, with a stronger influence of the prior when the sensory evidence is less certain. Here, we explored the behavioral and neural consequences of manipulating stimulus certainty in the context of orientation processing. First, we asked participants to judge whether a stimulus was oriented closer to vertical or the clockwise primary oblique (45°) for two stimulus types (spatially filtered noise textures and sinusoidal gratings) and three manipulations of certainty (orientation bandwidth, contrast, and duration). We found that participants consistently had a bias toward reporting orientation as closer to 45° during conditions of high certainty and that this bias was reduced when sensory evidence was less certain. Second, we measured event-related fMRI BOLD responses in human primary visual cortex (V1) and manipulated certainty via stimulus contrast (100% vs 3%). We then trained a multivariate classifier on the pattern of responses in V1 to cardinal and primary oblique orientations. We found that the classifier showed a bias toward classifying orientation as oblique at high contrast but categorized a wider range of orientations as cardinal for low-contrast stimuli. Orientation classification based on data from V1 thus paralleled the perceptual biases revealed through the behavioral experiments. This pattern of bias cannot be explained simply by a prior for cardinal orientations.SIGNIFICANCE STATEMENT Our perception of the world around us is biased through prior expectations rather than necessarily reflecting the true state of our environment. Here, we investigate biases in the visual processing of spatial orientation to understand how prior expectations and current sensory information interact to generate a percept. By degrading visual input in various ways, we are able to quantify the extent to which prior experience affects both perceptual judgments and neural responses in the human visual system. We observe systematic biases in the perception of orientation that correlate with the pattern of activity in the primary visual cortex of the human brain. These results indicate that prior expectations influence neural processing right from the earliest stage of the cortical hierarchy.

Distribution of content in recently-viewed scenes whitens perception.

Anisotropies in visual perception have often been presumed to reflect an evolutionary adaptation to an environment with a particular anisotropy. Here, we adapt observers to globally-atypical environments presented in virtual reality to assess the malleability of this well-known perceptual anisotropy. Results showed that the typical bias in orientation perception was in fact altered as a result of recent experience. Application of Bayesian modeling indicates that these global changes of the recently-viewed environment implicate a Bayesian prior matched to the recently experienced environment. These results suggest that biases in orientation perception are fluid and predictable, and that humans adapt to orientation biases in their visual environment "on the fly" to optimize perceptual encoding of content in the recently-viewed visual world.

Boundary Layer Effect on Behavior of Discrete Models.

The paper studies systems of rigid bodies with randomly generated geometry interconnected by normal and tangential bonds. The stiffness of these bonds determines the macroscopic elastic modulus while the macroscopic Poisson’s ratio of the system is determined solely by the normal/tangential stiffness ratio. Discrete models with no directional bias have the same probability of element orientation for any direction and therefore the same mechanical properties in a statistical sense at any point and direction. However, the layers of elements in the vicinity of the boundary exhibit biased orientation, preferring elements parallel with the boundary. As a consequence, when strain occurs in this direction, the boundary layer becomes stiffer than the interior for the normal/tangential stiffness ratio larger than one, and vice versa. Nonlinear constitutive laws are typically such that the straining of an element in shear results in higher strength and ductility than straining in tension. Since the boundary layer tends, due to the bias in the elemental orientation, to involve more tension than shear at the contacts, it also becomes weaker and less ductile. The paper documents these observations and compares them to the results of theoretical analysis.

Anisotropy in finite continuum percolation: threshold estimation by Minkowski functionals

We examine the interplay between anisotropy and percolation, i.e. the spontaneous formation of a system spanning cluster in an anisotropic model. We simulate an extension of a benchmark model of continuum percolation, the Boolean model, which is formed by overlapping grains. Here we introduce an orientation bias of the grains that controls the degree of anisotropy of the generated patterns. We analyze in the Euclidean plane the percolation thresholds above which percolating clusters in x- and in y-direction emerge. Only in finite systems, distinct differences between effective percolation thresholds for different directions appear. If extrapolated to infinite system sizes, these differences vanish independent of the details of the model. In the infinite system, the uniqueness of the percolating cluster guarantees a unique percolation threshold. While percolation is isotropic even for anisotropic processes, the value of the percolation threshold depends on the model parameters, which we explore by simulating a score of models with varying degree of anisotropy. To which precision can we predict the percolation threshold without simulations? We discuss analytic formulas for approximations (based on the excluded area or the Euler characteristic) and compare them to our simulation results. Empirical parameters from similar systems allow for accurate predictions of the percolation thresholds (with deviations of <5% in our examples), but even without any empirical parameters, the explicit approximations from integral geometry provide, at least for the systems studied here, lower bounds that capture well the qualitative dependence of the percolation threshold on the system parameters (with deviations of –). As an outlook, we suggest further candidates for explicit and geometric approximations based on second moments of the so-called Minkowski functionals.

Handedness and Graspability Modify Shifts of Visuospatial Attention to Near-Hand Objects.

We examined how factors related to the internal representation of the hands (handedness and grasping affordances) influence the distribution of visuospatial attention near the body. Left and right handed participants completed a covert visual cueing task, discriminating between two target shapes. In Experiment 1, participants responded with either their dominant or non-dominant hand. In Experiment 2, the non-responding hand was positioned below one of two target placeholders, aligned with the shoulder. In Experiment 3 the near-monitor hand was positioned under the placeholder in the opposite region of hemispace, crossed over the body midline. For Experiments 2 & 3, in blocked trials the palmar and back-of hand surfaces were directed towards the target placeholder such that targets appeared towards either the graspable or non-graspable space of the hand respectively. In Experiment 2, both left and right handers displayed larger accuracy cueing effects for targets near versus distant from the graspable space of the right hand. Right handers also displayed larger response time cueing effects for objects near the graspable versus non-graspable region of their dominant hand but not for their non-dominant hands. These effects were not evident for left-handers. In Experiment 3, for right handers, accuracy biases for near hand targets were still evident when the hand was crossed over the body midline, and reflected hand proximity but not functional orientation biases. These findings suggest that biased visuospatial attention enhances object identity discrimination near hands and that these effects are particularly enhanced for right-handers.

Spatial scale and distribution of neurovascular signals underlying decoding of orientation and eye of origin from fMRI data.

Multivariate pattern analysis of functional magnetic resonance imaging (fMRI) data is widely used, yet the spatial scales and origin of neurovascular signals underlying such analyses remain unclear. We compared decoding performance for stimulus orientation and eye of origin from fMRI measurements in human visual cortex with predictions based on the columnar organization of each feature and estimated the spatial scales of patterns driving decoding. Both orientation and eye of origin could be decoded significantly above chance in early visual areas (V1-V3). Contrary to predictions based on a columnar origin of response biases, decoding performance for eye of origin in V2 and V3 was not significantly lower than that in V1, nor did decoding performance for orientation and eye of origin differ significantly. Instead, response biases for both features showed large-scale organization, evident as a radial bias for orientation, and a nasotemporal bias for eye preference. To determine whether these patterns could drive classification, we quantified the effect on classification performance of binning voxels according to visual field position. Consistent with large-scale biases driving classification, binning by polar angle yielded significantly better decoding performance for orientation than random binning in V1-V3. Similarly, binning by hemifield significantly improved decoding performance for eye of origin. Patterns of orientation and eye preference bias in V2 and V3 showed a substantial degree of spatial correlation with the corresponding patterns in V1, suggesting that response biases in these areas originate in V1. Together, these findings indicate that multivariate classification results need not reflect the underlying columnar organization of neuronal response selectivities in early visual areas.NEW & NOTEWORTHY Large-scale response biases can account for decoding of orientation and eye of origin in human early visual areas V1-V3. For eye of origin this pattern is a nasotemporal bias; for orientation it is a radial bias. Differences in decoding performance across areas and stimulus features are not well predicted by differences in columnar-scale organization of each feature. Large-scale biases in extrastriate areas are spatially correlated with those in V1, suggesting biases originate in primary visual cortex.

Acute peripheral vestibular deficit increases redundancy in random number generation

Unilateral peripheral vestibular deficit leads to broad cognitive difficulties and biases in spatial orientation. More specifically, vestibular patients typically show a spatial bias toward their affected ear in the subjective visual vertical, head and trunk orientation, fall tendency, and walking trajectory. By means of a random number generation task, we set out to investigate how an acute peripheral vestibular deficit affects the mental representation of numbers in space. Furthermore, the random number generation task allowed us to test if patients with peripheral vestibular deficit show evidence of impaired executive functions while keeping the head straight and while performing active head turns. Previous research using galvanic vestibular stimulation in healthy people has shown no effects on number space, but revealed increased redundancy of the generated numbers. Other studies reported a spatial bias in number representation during active and passive head turns. In this experiment, we tested 43 patients with acute vestibular neuritis (18 patients with left-sided and 25 with right-sided vestibular deficit) and 28 age-matched healthy controls. We found no bias in number space in patients with peripheral vestibular deficit but showed increased redundancy in patients during active head turns. Patients showed worse performance in generating sequences of random numbers, which indicates a deficit in the updating component of executive functions. We argue that RNG is a promising candidate for a time- and cost-effective assessment of executive functions in patients suffering from a peripheral vestibular deficit.