Organosilicon Research Articles

Silylation of piroxicam with some silylating reagents, and characterization of them to improve some properties of this drug

In this work, we synthesized some organosilicon derivatives of piroxicam. Due to some properties of organosilicon compounds, including increased lipophilicity and thermal stabilization and prodrug for drugs, some silyl ethers of this drug were synthesized and characterized. Increasing of the lipophilic properties of this drug can be very important in the rate of absorption and its effectiveness. We synthesized silyl ethers of this drug, in the next step some copolymers this drug was synthesized. All of compounds were identified by spectroscopic methods.

High hydrophobic silanized paper: Material characterization and its biodegradation through brown rot fungus.

Modifying natural polymers with silicones gives new possibilities for packaging products and waste management. In this study, the innovative papers produced were altered following the reaction of polysaccharides and organosilicon compounds. The susceptibility of the studied material to biodegradation caused by a brown-rot fungus was assessed. Strength properties by tensile strength and dynamic mechanical analysis and hydrophobic properties by water uptake test and water contact angle analysis were evaluated. Moreover, elemental analysis by ICP method was controlled. The durability against fungi and the hydrophobic properties were increased by the modification. The fungal decay resistance of the silanized paper was reduced by water storage, which allows for managing paper waste. Cellulose-based paper treated with starch-modified methyltrimethoxysilane showed potential as a packaging material due to its reduced water uptake. Possible application areas could be corrugated boxes, cellulose thermoformed products for electronics, and food packaging. However, the water-repellent effect is limited to short-term exposure in humid conditions.

Selection of precursors of safe silica-based fireproof coatings for textile materials

The selection of the inorganic precursor SiO2 as the main component of the simplified safe technology for obtaining flame-retardant coatings on textile materials was carried out. By thermo-graphic research of organic and inorganic SiO2 precursors, performed on an OD-102 deri-vatograph under conditions of heating at a rate of 10ºС/min in an air environment, the processes of decomposition of the coating that occur during the action of fire were investigated. Gels based on inorganic precursors produced by industry (silica sol, silica gel) and silicic acid, which was obtained by the exchange reaction of an aqueous solution of sodium silicate of liquid glass and acetic acid, were studied for the comparative characteristics of thermal destruction of coatings. As organic precursors of SiO2, gels of ethyl silicate-32 and methyltriethoxysilane were studied, which were obtained by hydrolysis of organosilicon compounds in an acidic water-alcohol medi-um with subsequent polycondensation of the hydrolysis products. The effect of temperature on the nature of thermal destruction of silica gel, silica sol, silicic acid and organosilicon gels of ethyl silicate and methylotriethoxysilane was investigated. It is shown that inorganic precursors differ favorably from organosilicon precursors in terms of the overall thermal effect during their de-composition, mass loss during heat treatment, and the rate of change of this parameter. Consider-ing that, in addition to total mass loss, the increase in mass loss during heating is less than 1 % in compositions based on inorganic precursors, it is possible to use all three types of inorganic pre-cursors, but from the point of view of acidity and safety of impregnation compositions, prefer-ence is given to silicic acid obtained by the exchange reaction of silicate sodium liquid glass with acetic acid.

Effect of Non-Functional Polyorganosiloxane Additives on the Hydrophysical Properties of Cement Systems

A research on the influence of non-functional organosilicon compounds (OSC) - polyorganosiloxanes on the hydrophysical properties of cement systems has been carried out. Two groups of polyorganosiloxanes with the most typical structure (linear, cyclolinear, and three-dimensional) have been studied: polyorganylsilsesquioxanes and polydiorganylsiloxanes. Within the group of polyorganylsilsesquioxanes the polyphenylsiloxane (PPS) and polyvinylsiloxane (PVS) differing in the type of radical and degree of structure completion were studied. Within the group of polydiorganylsiloxanes the polydimethylsiloxane liquid (PMS-6) and dimethylsiloxane rubber (SKTN) differing in molecular weight were studied.It has been established that non-functional organosilicon compounds (polydiorganylsiloxanes, polyorganylsilsesquioxanes) are able to hydrophobize the cement systems when introduced by the method of mechanical activation. At the same time, SKTN is a powerful agent for efflorescence formation, preventing the removal of calcium hydroxide Ca (OH)2 out of the cement stone.

Rhenium-Catalyzed Decarboxylative Coupling of Cyclic Enol Carbonates with Silyl Enol Ethers and Ketene Silyl Acetals

The Lewis acid-catalyzed decarboxylative coupling of cyclic enol carbonates, prepared by the fixation of carbon dioxide onto propargyl alcohols, with silyl enol ethers including ketene silyl acetals, was developed to afford 1,4-dicarbonyl compounds in good-to-high yields. As the plausible reaction mechanism, it was proposed that the decarboxylative formation of an oxyallyl cation intermediate or its equivalent and the sequential nucleophilic addition of silyl enol ethers proceeded to afford 1,4-dicarbonyl products. In addition, the synthetic utility of the obtained-1,4-dicarbonyl compounds was also demonstrated by applying them to the construction of multisubstituted heterocycles.

Base-Mediated Radio-Iodination of Arenes by Using Organosilane and Organogermane as Radiolabelling Precursors.

The radio-iodination of arenes is investigated from organosilane and organogermane precursors using ipso-electrophilic halogenation (IEH). Discovery of a mild base mediated process allows radio-iodination in HFIP (1,1,1,3,3,3-hexafluoro-2-propanol) of either aryl silane or germane, with germanes being more reactive. Clinical potential of arylgermanes as radio-iodination precursors is demonstrated through the labelling of [125 I]IMTO (iodometomidate) and [125 I]MIBG (meta-iodobenzylguanidine) thus offering an alternative to radio-iododestannylation processes using non-toxic precursors.

Retinal Toxicity of Silicone Oil

Polydimethylsiloxane, known as silicone oil, belongs to a group of polymeric organosilicon compounds and is widely used in vitreoretinal surgery.

One-Pot Synthesis of Dihydropyrans via CO2 Reduction and Domino Knoevenagel/oxa-Diels-Alder Reactions.

Catalytic CO2 reduction with phenylsilane under solvent-free conditions was linked with the one-pot synthesis of 3,4-dihydropyrans from β-dicarbonyl compounds and styrenes. The synthesis includes three processes: (1) bis(silyl)acetal formation from CO2 and phenylsilane and a domino reaction of (2) Knoevenagel condensation and (3) inverse-electron-demand oxa-Diels-Alder reaction. The first process was catalyzed by a pentanuclear ZnII complex (0.07 mol %) to generate bis(silyl)acetals, which were hydrolyzed into formaldehyde to be used in the second step.

Organocatalytic DYKAT of Si-Stereogenic Silanes.

Chiral organosilanes do not exist in nature and are therefore absent from the "chiral pool". As a consequence, synthetic approaches toward enantiopure silanes, stereogenic at silicon, are rather limited. While catalytic asymmetric desymmetrization reactions of symmetric organosilicon compounds have been developed, the utilization of racemic silanes in a dynamic kinetic asymmetric transformation (DYKAT) or dynamic kinetic resolution (DKR) would significantly expand the breadth of accessible Si-stereogenic compounds. We now report a DYKAT of racemic allyl silanes enabled by strong and confined imidodiphosphorimidate (IDPi) catalysts, providing access to Si-stereogenic silyl ethers. The products of this reaction are easily converted into useful enantiopure monohydrosilanes. We propose a spectroscopically and experimentally supported mechanism involving the epimerization of a catalyst-bound intermediate.

Dinitrogen Functionalization Affording Chromium Diazenido and Side-on η2-Hydrazido Complexes.

Isolation of key intermediate complexes in dinitrogen functionalization is crucial for elucidating the mechanistic details and further investigation. Herein, the synthesis and characterization of (μ-η1:η1-N2)(η1-N2)-Cr(I) 3 and (η1-N2)2-Cr(0) complexes 4 supported by Cp* (Cp* = C5Me5) and NHC ligands were reported. Further functionalization of Cr(0)-N2 complex 4 with silyl halides delivered the key intermediates in the alternating pathway, the chromium diazenido complex 5 and the chromium side-on η2-hydrazido complex 6. Protonation of 6 led to the quantitative formation of N2H4. Moreover, the [η2-Me3SiNNSiMe3]2- unit in 6 enabled N-C bond formation reactions with CO2 and tBuNCO, giving the corresponding N,O-chelating hydrazidochromium complexes 7 and 8, respectively.

Enantioselective Synthesis of Chiral Organosilicon Compounds by Organocatalytic Asymmetric Conjugate Addition of Boronic Acids to β-Silyl-α,β-Unsaturated Ketones.

Herein, we report (R)-3,3'-(3,5-(CF3)2-C6H3)2-BINOL-catalyzed enantioselective conjugate addition of organic boronic acids to β-silyl-α,β-unsaturated ketones, furnishing moderate to excellent yields of the corresponding β-silyl carbonyl compounds with stereogenic centers in excellent enantioselectivities (up to 98% ee). Moreover, the catalytic system features mild reaction conditions, high efficiency, broad substrate scope, and easy scale-up.

Diverse Alkyl-Silyl Cross-Coupling via Homolysis of Unactivated C(sp3)-O Bonds with the Cooperation of Gold Nanoparticles and Amphoteric Zirconium Oxides.

Since C(sp3)-O bonds are a ubiquitous chemical motif in both natural and artificial organic molecules, the universal transformation of C(sp3)-O bonds will be a key technology for achieving carbon neutrality. We report herein that gold nanoparticles supported on amphoteric metal oxides, namely, ZrO2, efficiently generated alkyl radicals via homolysis of unactivated C(sp3)-O bonds, which consequently promoted C(sp3)-Si bond formation to give diverse organosilicon compounds. A wide array of esters and ethers, which are either commercially available or easily synthesized from alcohols participated in the heterogeneous gold-catalyzed silylation by disilanes to give diverse alkyl-, allyl-, benzyl-, and allenyl silanes in high yields. In addition, this novel reaction technology for C(sp3)-O bond transformation could be applied to the upcycling of polyesters, i.e., the degradation of polyesters and the synthesis of organosilanes were realized concurrently by the unique catalysis of supported gold nanoparticles. Mechanistic studies corroborated the notion that the generation of alkyl radicals is involved in C(sp3)-Si coupling and the cooperation of gold and an acid-base pair on ZrO2 is responsible for the homolysis of stable C(sp3)-O bonds. The high reusability and air tolerance of the heterogeneous gold catalysts as well as a simple, scalable, and green reaction system enabled the practical synthesis of diverse organosilicon compounds.

Direct Synthesis of Silicon Compounds—From the Beginning to Green Chemistry Revolution

This paper discusses the historical beginnings and the current state of knowledge of the synthesis of organosilicon compounds and chlorine derivatives of silicon. The key importance of these compounds for modern industry, including the semiconductor industry (photovoltaic cells, microprocessors, memory chips and many other electronic elements) is highlighted. Significant environmental threats related to the production of these compounds and the research challenges aimed at their elimination are discussed. The complexity of the catalytic mechanism of direct reaction of silicon with CH3Cl and alcohols is presented in an accessible way. In the last part of the work, the directions of the development of direct synthesis technology in line with the principles of green chemistry are indicated.

Improving the Dispersibility of TiO2 in the Colloidal System Using Trifunctional Spherosilicates

Titanium dioxide is a commonly used ingredient in cosmetics acting as a thickening agent and inorganic UV filter. However, TiO2 is difficult to disperse, which causes problems in spreading the formulations. The solution to this problem is to modify the titanium dioxide surface to change its properties by creation of the new type of hybrid inorganic-organic UV filter. Therefore, this study aimed to functionalize titanium dioxide with organosilicon compounds and determine how this modification will affect the dispersibility of TiO2 in the colloidal system and the stability of emulsions. First, the functionalized octaspherosilicates were obtained and characterized. Next, the synthesized compounds were applied as modifiers for titanium dioxide and were analyzed by FT-IR, UV-Vis, and laser diffraction. Furthermore, the hydrophilic-hydrophobic character was assessed by measuring the contact angle. The new materials were introduced into emulsions and the formulations were analyzed in terms of particle size distribution and stability by multiple light scattering. It was found that the modification of titanium dioxide with spherosilicates significantly improved both the stability of emulsion and the dispersibility of novel materials in the colloidal system compared to nonmodified TiO2. The covalent binding of the modifier with the titanium dioxide had an impact on the stability of the emulsion.

Dearomative triple elementalization of quinolines driven by visible light

Organoboron and organosilicon compounds are used not only as synthetic building blocks but also as functional materials and pharmaceuticals, and compounds with multiple boryl and silyl groups are beginning to be used for these purposes. Especially in drug discovery, methodology providing easy stereoselective access to aliphatic nitrogen heterocycles bearing multiple boryl or silyl groups from readily available aromatic nitrogen heterocycles would be attractive. However, such transformations remain challenging, and available reactions have been mostly limited to dearomative hydroboration or hydrosilylation reactions. Here, we report the dearomative triple elementalization (carbo-sila-boration) of quinolines via the addition of organolithium followed by photo-boosted silaboration, affording the desired products with complete chemo-, regio-, and stereoselectivity. The reaction proceeds via the formation of silyl radicals instead of silyl anions. We also present preliminary studies to illustrate the potential of silaboration products as synthetic platforms.

Metal-catalyst- and fluoride-free oxidative desilylation of arylsilanes and its application

A general and practical approach has been developed to construct aryloxy acrylates, esters, sulfonates, and ethers. This strategy performs smoothly to form the phenol intermediate through metal-catalyst- and fluoride-free oxidative desilylation of arylsilane, followed by Michael addition and nucleophilic substitution. This cascade reaction is characterized by its simple setup and broad functional group compatibility. Further transformation of the formed aryloxy acrylate demonstrated the rich chemistry of oxidative desilylation of organosilicon compounds.

Copper-Catalyzed Electrophilic Amination: An Umpolung Strategy for New C–N Bond Formations

Abstract The nitrogen atom is ubiquitous in bioactive molecules and functional materials, and the development of new C–N bond forming strategies is thus one of the long-standing research subjects in the synthetic community. This account describes the nitrogen-umpolung-enabled copper-catalyzed highly chemo- and stereoselective amination protocols developed by the author’s research group. Starting from the C–H amination, electrophilic amination of stable organoboron and organosilicon compounds, aminoboration/hydroamination of alkenes, and their applications to the synthesis of functionality-rich alkylamines are shown. The reaction design, concept, and substrate scope are briefly summarized.

Malcolm E. Kenney

Malcolm E. Kenney, 94, died Nov. 28, 2022, in Cleveland Heights, Ohio. “Malcolm’s extensive research career focused on phthalocyanines for applications as photodynamic therapy cancer treatments, organosilicon compounds for new materials, and silicates as sulfur dioxide adsorbents for coal gas emissions remediation. He received the R. Patrick Linstead Award in Phthalocyanine Chemistry in 2000. Malcolm published 30 patents and 200 papers and mentored numerous PhD students. He was an avid traveler, especially to Europe to visit sites of scientific interest. In addition to his scientific achievements, Kenney was a generous benefactor to the Cleveland Museum of Art and the Cleveland Orchestra, as well as the Open Doors Academy.”—John Protasiewicz, colleague and friend Most recent title: Hurlbut Professor Emeritus of Chemistry, Case Western Reserve University Education: BS, chemistry, University of Redlands, 1950; PhD, inorganic chemistry, Cornell University, 1953 To recognize your late loved one or colleague, submit obituary information at cenm.ag/obits

Characterization of spherical silica–titania mixed oxide particles synthesized by using a dry process

Silica–titania mixed oxides have excellent properties, such as a low thermal expansion coefficient and a refractive index that can be adjusted by changing the Ti content. However, when the Ti content increases, silica and titania phases in silica–titania mixed oxides can separate. This phase separation leads to the precipitation of the titania component as rutile or anatase crystals. When silica–titania mixed oxides undergo phase separation, their properties become unstable; for example, the refractive index of the particles becomes non-uniform. Therefore, it is preferable to synthesize silica–titania mixed oxides in an amorphous state without causing phase separation. Based on our previous studies on particle size control in silica synthesis, we employed a dry process using organosilicon compounds to synthesize silica–titania mixed oxides. In this study, spherical amorphous silica–titania mixed oxide particles were obtained via flame synthesis using organosilicon and organotitanium compounds. The purpose of this study was to characterize the obtained powder and explore the possibility of controlling particle size during synthesis. By studying the dry process synthesis of spherical silica–titania mixed oxide particles, we confirmed the relationships: between the Si/Ti molar ratio and the obtained crystal structure and between the adiabatic flame temperature and the particle size.

Hydro- and Icephobic Properties and Durability of Epoxy Gelcoat Modified with Double-Functionalized Polysiloxanes.

Anti-icing coatings have provided a very good alternative to current, uneconomic, active deicing methods, and their use would bring a number of significant benefits to many industries, such as aviation and energy. Some of the most promising icephobic surfaces are those with hydrophobic properties. However, the relationship between hydrophobicity and low ice adhesion is not yet clearly defined. In this work, chemical modification of an epoxy gelcoat with chemical modifiers from the group of double organofunctionalized polysiloxanes (generally called multifunctionalized organosilicon compounds (MFSCs)) was applied. The anti-icing properties of manufactured coatings were determined by means of measurements of shear strength between the ice layer and the modified surface, conducted using a tensile machine. In the work, tests were also performed on the roughness, wettability, and durability of the properties in an aging chamber. It was found that the performed modifications of the coating's chemical composition by the addition of polysiloxanes enabled us to reduce ice adhesion by 51% and to increase the water contact angle by 14% in comparison to the neat gelcoat. A reduction in ice adhesion was also observed with the increasing water contact angle and with decreasing surface roughness. In addition, only one modification recorded an increase in ice adhesion after exposure in the aging chamber.