The need to identify the main determinants of occupational burnout gained new attention with the release of management of psychosocial standards. Based on the JD-R model and COR theory, the article compares demands and resources interactions and their effects on high levels of burnout. Employees in Israel ( N = 2010) reported job demands and organizational and personal resources. One year later, 1201 of them reported their burnout. The interactions effects on next-year burnout levels were analyzed using logistic regression. The enhancing interaction better predicts next-year burnout. Each additional stressor increases the risk for very high burnout (above 4) a year later (odds ratio = 1.76; 95% confidence interval: 1.55-2.00). The cumulative interaction of stressors predicts next-year burnout levels. Moreover, we used concrete comparable values of the measures that may initiate a standardization process for organizational stressors.