Following up on a study by Worringham and Beringer (1989) that examined the influence of operator orientation on visual-motor performance, Experiment 1 employed a choice reaction time paradigm in which participants had to make rapid, discrete movements with a lever in response to a discrete stimulus. In Experiment 2, participants had to synchronize rhythmic movements with an oscillating visual display. Operator orientation with respect to stimulus display and response array locations was varied to examine the influence of global spatial relations. Display orientation was varied to examine the influence of spatial configuration. Mapping rules were varied to examine the effects of spatial mapping. In Experiment 1, the spatial mapping that yielded faster responses was dependent upon the stimulus display-response array configuration and the global relation. Under a parallel configuration, participants appeared to code the spatial aspects of the stimulus display and response in a manner that was unaffected by the global spatial relation. Under an orthogonal configuration, spatial mapping effects were dependent upon the global relation. In Experiment 2, the global spatial relation did not have an impact on the uniformity of co-ordination under different configuration or mapping conditions. Spatial configuration influenced whether or not differences between spatial mapping rules emerged. Together, the results speak to the relative nature of stimulus-response coding that underlie compatibility phenomena. In addition, the results have potential importance for the design of human-machine systems that allow flexibility in operator orientation.