Research Organizations Research Articles

Impact of Microsurgery and Postoperative Radiotherapy on Neurological Function in Intramedullary Spinal Cord Gliomas.

To assess the clinical efficacy of combined microsurgery and postoperative radiotherapy for the treatment of intramedullary spinal gliomas and its impact on neurological function. An observational study. Place and Duration of the Study: Department of Neurosurgery, Baoding No.1 Central Hospital, Hebei, China, between January 2020 and 2023. Sixty patients diagnosed with spinal cord intramedullary gliomas were divided equally into an experimental and control group. The control group received microsurgical treatment, and the experimental group received microsurgical treatment combined with postoperative radiotherapy. The treatment effectiveness, neurological function, and follow-up results of the two groups were compared. After treatment, the clinical efficacy of the experimental group treatment was significantly better than that of the control group (p <0.05). The National Institutes of Health Stroke Scale (NIHSS) scores were significantly lower, and the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-30 (EORTC QLQ-C30) scores were significantly higher in the experimental group than in the control group (p <0.05). The 1-3-year survival rate and median survival time of the experimental group were significantly higher than those of the control group (p <0.05). The incidence of complications was 3.33% in the experimental group and 6.67% in the control group, but the difference was not statistically significant (p >0.05). The postoperative recurrence rate was significantly lower in the experimental (0%) than in the control group (13.33%, p <0.05). Combined microsurgery and postoperative radiotherapy was found to be more effective than microsurgery alone. It was also more conducive to the recovery of neurological function and improved the patient's quality of life. Intramedullary spinal cord glioma, Microsurgery, Neurological function, Radiotherapy.

618. A COMPARISON OF HEALTH-RELATED QUALITY OF LIFE AT ONE YEAR FOLLOWING MINIMALLY INVASIVE VERSUS OPEN ESOPHAGECTOMY

Abstract Introduction Minimally invasive esophagectomy (MIE) is being increasingly adopted in the surgical management of esophagogastric cancer. While equivalent clinical and oncological outcomes have been demonstrated in comparison with open resections, differences in health-related quality of life (HR-QOL) between the 2 modalities into survivorship remains unclear. The aim of this study was to determine the differences in HR-QOL between MIE and open esophagectomies (OE) at 1 year post-resection. Methods Consecutive patients undergoing an esophagectomy at a single, U.K based tertiary referral centre for esophagogastric cancer between January 2018 – December 2022 were evaluated. MIE was defined as utilisation of laparoscopic, thoracoscopic or robotic access for at least one phase of an esophagectomy. HR-QOL at 1 year following surgery was measured using the validated European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire (QLQ-C30) and esophagogastric cancer module (QLQ-OG25) and compared between groups. Results A total of 28 patients undergoing MIE and 25 patients undergoing OE were included. No statistical difference was noted in mean global HR-QOL between the OE and MIE cohorts at 1 year (69.33±19.50 vs 64.88±22.05; p=0.66). No statistically significant intergroup differences between OE versus MIE were observed at 1 year in physical functioning (82.67±16.89 vs 79.05±24.39; p=0.97) or role functioning (73.33±29.27 vs 67.86±32.37; p=0.60) domains. Similarly, no difference was observed in symptoms of nausea/vomiting (10.67±18.17 vs 8.93±14.69; p=0.56), pain (29.33±25.56 vs 26.79±33.44; p=0.26) or fatigue (29.78±25.40 vs 37.70±30.44; p=0.44). Conclusion HR-QOL remains comparable between MIE and OE at 1 year. Patient-reported outcomes must be assessed in the long-term to determine if minimally invasive approaches confer HR-QOL improvements well into survivorship.

766. LASTING SYMPTOMS AFTER OESOPHAGEAL RESECTIONAL SURGERY (LASORS): MULTICENTRE VALIDATION COHORT STUDY

Abstract Background As outcomes following curative-intent oesophageal cancer treatment improve, more patients are living with the long-term morbidity of cancer therapies, the symptoms of which are poorly recognised and understood. Existing symptomatology and quality-of-life tools are cumbersome and moreover are not designed specifically for evaluation of post-treatment survivorship. The LASER study and subsequent consultation process identified six key symptoms thought to predict poor health-related quality-of-life (HRQoL) as measured by validated European Organisation for Research and Treatment of Cancer (EORTC) tools. The current study aimed to validate this six-symptom LAsting Symptoms after Oesophageal Resection (LASOR) clinical tool, and assess its clinical utility. Methods In this multi-centre cohort study, patients who underwent oesophagectomy between January 2015 and June 2019 across the United Kingdom, and were disease-free at least one-year post-treatment, were asked to complete LASOR, EORTC-QLQ-C30 and QLQ-OG25 questionnaires. LASOR symptoms (low mood, reduced energy, thoracotomy pain, heartburn, diarrhoea, and bloating after eating) were evaluated using composite scores based on frequency and quality of life impact, and correlated with EORTC HRQoL scores. The ability of the LASOR tool to predict patients with poor HRQoL was validated using receiver operating characteristic (ROC) curve analysis. Patient acceptability of the tool was assessed using a separate questionnaire. Results 263 participants were included. 192 (73%) were males. Surgical technique included open (61%), hybrid (18%), and minimally-invasive (21%). 203 patients (77%) received neoadjuvant chemotherapy or chemoradiotherapy. 148 patients (56%) experienced a post-operative complication. Four LASOR symptoms were associated with significantly lower HRQoL: reduced energy (OR=2.13; 95% CI 1.20-2.87), low mood (OR=1.86; 95% CI 1.45–3.12), diarrhoea (OR=1.48; 95% CI 1.06–2.06), and bloating (OR=1.35; 95%CI 1.03-1.77). In combination, the LASOR symptoms produced an area under the ROC curve of 0.85 (sensitivity = 0.82, specificity = 0.73). Conclusion The six-symptom LASOR tool generated a reliable model for identification of patients with a poor HRQoL, with an overall diagnostic accuracy of over 80%. This is the first clinical symptom tool to be validated in the post-curative-treatment setting for patients with oesophageal cancer. The LASOR tool is straightforward to administer and highly acceptable to patients, and can be used to identify those at risk of high morbidity and poor quality of life in surveillance programmes. In turn, evidence-based survivorship services can be integrated into patient follow-up to alleviate the burden of cancer treatment on oesophagectomy patients.

An analysis of health-related quality of life in children and adolescents after parotidectomy based on patient-reported outcomes.

To assess health-related quality of life (HRQoL) and its influencing factors in these pediatric patients undergoing parotidectomy. This was a cross-sectional study that included 37 children and adolescents (≤ 19years) with parotid gland tumors who were treated in Sichuan Cancer Hospital between January 2006 and November 2021. HRQoL was assessed using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-C30 (EORTC QLQ-C30). The Wilcoxon rank sum test was used to analyze the factors influencing patients' HRQoL. 37 children and adolescents were included in the study, including 22 cases of benign tumors and 15 cases of malignant tumors. All patients underwent surgery, and some patients with malignant tumors received radiotherapy or chemotherapy. Malignancy, permanent facial palsy, and Frey syndrome were associated with worse HRQoL in children and adolescents with parotid gland tumors. Radiotherapy and no cervical lymph node dissection were associated with worse HRQoL in pediatric patients with malignancy. The surgical approach of parotid is not a factor influencing HRQoL. Factors associated with HRQoL in children and adolescents with parotid gland tumors include pathological types, permanent facial palsy, and Frey syndrome. In addition, factors affecting patients with malignancy include lateral lymph node dissection and radiotherapy.

503. HEALTH-RELATED QUALITY OF LIFE FOLLOWING CURATIVE INTENT TREATMENT FOR ESOPHAGEAL CANCER: IMPACT OF TREATMENT PATHWAY ON PATIENT-REPORTED OUTCOMES IN SURVIVORSHIP

Abstract Background Recent improvements in treatment modalities for esophageal cancer have resulted in improved survival outcomes, and optimisation of health-related quality of life (HR-QL) in survivorship is now an increasing focus. This study aimed to compare HR-QL in survivorship following treatment with definitive chemoradiation (dCRT), neoadjuvant chemoradiation and surgery (nCRT), neoadjuvant chemotherapy and surgery (nCT), and surgery only (S). Methods This was a cross-sectional study of patients who underwent oesophageal cancer treatment between 2010 and 2021. A multicomponent questionnaire was distributed to disease-free patients at least one year post completion of treatment. Scores were calculated according to the European Organisation for Research and Treatment of Cancer manual. A mean difference of ten points or more for symptom and function scales was considered clinically significant. One-way ANOVA was performed to detect statistically significant differences between treatment groups. Results Some 125 patients were included. Global HR-QL was similar between treatment groups (mean±SD, dCRT 67.4±20.9, nCRT 71.5±19.6, nCT 80.0±15.0, S 69.0±20.0, P=0.265). Analysis of functional scales found lower emotional functioning (S 71.1±25.5 vs dCRT 87.1±15.6, nCRT 79.6±19.5, nCT 88.9±26.3, P=0.028) and body image scores (S 71.8±29.2 vs dCRT 87.9±22.5, nCRT 83.3±27.8, nCT 91.1±19.8, P=0.056) among patients treated with surgery only. Dysphagia (P=0.034), trouble with coughing (P=0.014) and choking when swallowing (P=0.018) were increased following dCRT as compared with surgical treatment. Following surgical treatment, patients reported more diarrhoea as compared with dCRT (P=0.020), while dCRT was associated with increased constipation (P=0.004). Conclusion Overall HR-QL was similar between groups, but distinct patterns of symptoms were observed in different cohorts. Symptoms related to swallow function were more common in patients treated with dCRT, while patients who underwent surgery exhibited more diarrhoea, possibly reflective of increased dumping syndrome. Interestingly, patients who received surgery upfront reported lower scores for emotional functioning and body image in the long-term after treatment, as compared with other groups. Further research is needed to determine the differential psychological impact of major resectional upper GI surgery among patients presenting with early stage versus locally advanced disease.

Longitudinal assessment of quality of life indicators and prognosis in esophageal cancer patients with curative resection.

The relationship between quality of life and survival outcomes in esophageal cancer patients following curative resection is not well established. This study aimed to longitudinally assess quality of life indicators and their association with overall survival (OS) in these patients. A total of 232 patients were included in the study, and their quality of life was prospectively assessed at different time points using the European Organisation for Research and Treatment of Cancer (EORTC) 30-item core quality of life questionnaire (QLQ-C30) and the disease-specific esophageal module (QLQ-OES18). The scores of QLQ indicators at each time point were summarized, and changes in postoperative assessment were compared with preoperative assessments. The association of deterioration in certain indicators with OS was evaluated at each time point using Cox univariable analysis. Further confirmation of independent variables was carried out using Cox multivariable analysis. The study cohort comprised 62 females (26.7%), and 113 patients (48.7%) aged over 60 years. The median follow-up time was 80 months (range, 8-118 months). At 24 months after discharge, patients reported improvements in role function, fatigue, cognition function, emotional function, social function, insomnia, appetite loss, nausea and vomiting, constipation, financial status, trouble swallowing saliva, and pain related to esophageal cancer. However, physical function, dyspnea, diarrhea, global health status, choking when swallowing, trouble talking, and reflux remained compromised. Multivariable regression analysis revealed deterioration in role function, emotional function, and coughing difficulty at 6 months, and dyspnea, pain, and cognitive function at 24 months post-discharge were identified as independent prognostic factors for OS. Our findings underscore the importance of monitoring quality of life indicators in esophageal cancer patients as they may significantly influence survival outcomes. The identification of specific quality of life indicators as prognostic factors highlights the need for a patient-centered approach in clinical practice to enhance care and potentially improve survival.

437. MEASUREMENT OF FUNCTIONAL, PSYCHOSOCIAL, AND QUALITY OF LIFE IMPACTS OF ROBOTIC VERSUS HYBRID OESOPHAGO-GASTRECTOMY

Abstract Background Since the introduction of Robotic-Assisted Minimally-Invasive Oesophago-gastrectomy (RAMIO), comparisons to other surgical approaches have focussed primarily on peri-operative and oncological outcomes. Few studies have focused on quality-of-life measures once the patient has been discharged home. We sought to compare physical, psychosocial, sleep, pain and employment related measures at six weeks following discharge in patients undergoing RAMIO versus Hybrid Oesophago-gastrectomy. Methods We performed a prospective cohort study comparing RAMIO and Hybrid Oesophago-gastrectomy. Twenty-five consecutive patients on a curative surgical pathway were recruited to each group. Participants were contacted via telephone pre-operatively and six weeks post-operatively. Parameters studied were: physical activity, social activity, sleep, pain control, and employment. Psychological wellbeing was measured using the Hospital Anxiety and Depression Scale, and quality of life with the European Organisation for Research and Treatment of Cancer questionnaires C30 (all cancer patients) and OG25 (patients undergoing oesophago-gastric cancer treatment). Results were analysed using Chi Square and Mann-Whitney-U statistical tests. Results There were no differences in age, ASA, or anaerobic threshold between study groups. At six weeks the RAMIO group was more likely than Hybrid to have returned to pre-operative physical and social activity (physical 7/25 vs. 1/25, p=0.04, social 13/25 vs. 5/25, p=0.03). The RAMIO group stopped regular analgesia earlier, and required fewer opiates. Patients were more likely to return to work in the RAMIO group (7/15 vs. 1/12,p=0.04). The RAMIO group had fewer cases of depression (2 vs. 9, p=0.03), lower QLQ C30 and OG25 scores, and reported higher overall health and quality of life scores (p=0.001). Conclusion We have demonstrated an improvement in physical and social activity, a faster return to work, a reduction in analgesia requirements, lower rates of depression and improved health and quality of life, six weeks post-operatively when comparing RAMIO to Hybrid Oesophago-Gastrectomy. This study has highlighted additional considerations for the selection of surgical modality in oesophago-gastrectomy beyond peri-operative outcomes. Further investigation across a larger sample size and longer time frame to quantify the full spectrum of potential benefits of robotic oesophago-gastric surgery is warranted.

How Academic-Based Survey Research Organizations Inform and Influence the Development of Subnational Public Policy

This field note describes how public polling produced by academic-based survey research organizations provides state and local policymakers with information regarding public preferences. Utilizing a case study from Maryland, we describe how one such organization—the Goucher College Poll—informed the policy response to the COVID-19 pandemic in realtime. Although the American Political Science Association was founded with an eye toward applied research, academic-based survey research organizations are among the few institutions in the discipline that continue to carry out this mission in earnest.

Evaluating D-InSAR performance to detect small water level fluctuations in two small lakes in Sweden

Monitoring lake water level fluctuations is critical for managing water resources, predicting the impacts of climatic change, and preserving ecosystem services lakes provide. However, traditional gauging stations are insufficient to monitor all lakes worldwide due to the large number of existing lakes, the challenges of installation and maintenance, and the remote locations of some. Although satellite altimetry is an alternative for measuring water levels, it cannot monitor small lakes effectively. This study evaluates the potential of Differential Interferometric Synthetic Aperture Radar (D-InSAR) for tracking minor water level changes in small lakes, a method more typically used in wetland studies. We investigate two Swedish lakes using Sentinel-1A and Sentinel-1B data from 2019, generating six-day interferograms and filtering out those with in situ water level changes exceeding one phase cycle. Our results show that D-InSAR can detect small water level changes with Lin’s correlations up to 0.63 and 0.89 and RMSE values of approximately 9 and 4 mm, respectively. These results evidence the potential of future L-band SAR missions with larger wavelengths, such as the NASA-ISRO SAR (NISAR) of the National Aeronautics and Space Administration (NASA) and the Indian Space Research Organisation (ISRO), to track water level changes in lakes and aid water tracking missions such as the SWOT (Surface Water and Ocean Topography).

Introduction to the Special Issue on the Role of Place in Sustainability: Key Trends and Agenda for Future Research

This editorial reviews key themes, trends, and assumptions of organizational research on place and sustainability and introduces the special issue on the “Role of Place in Sustainability.” While recent theorizing has often emphasized global issues such as grand challenges, planetary boundaries, and climate change, this special issue revisits the local by focusing on the role of place in sustainability. We discuss trends and subdomains of research on place and sustainability and identify key assumptions at the interplay between global and local perspectives. Instead of advocating for universal solutions or exclusively context-specific approaches, we highlight the concept of “senses of place,” emphasizing the connections among diverse notions of place and intrinsic links to these locations. We demonstrate how the four insightful articles featured in this special issue provide a broader dialogue on place and sustainability. Finally, we outline a research agenda that identifies underexplored themes in place-based sustainability studies.

Introduction to the Special Issue on Philosophy and Organization Studies: How Does Philosophy Illuminate the Study of Organizations?

Although not always apparent, generating theories about organizational phenomena inevitably involves philosophical questions. The latter are concerned with the meaning of the concepts researchers use to describe, interpret, explain, and, in general, understand organizational phenomena. A philosophical approach to organization studies aims to scrutinize, critique, and clarify key concepts, modes of thinking, research practices, as well as assumptions about reality and ways of justifying knowledge claims. Similar to other institutionalized practices, organizational research legitimates and takes for granted certain ways of engaging with, and talking about, the world, leading inevitably to some closure of meaning. Philosophical inquiry can counteract such closure by questioning commonly accepted meanings and fostering an inquisitive mindset that allows us to perceive the world anew. The aim of this Special Issue is to further develop and critically enhance the existing endeavours that explicitly incorporate philosophical approaches in organization studies. Specifically, the objective is to promote a more philosophically oriented approach in the field, focusing on both critical analysis and the development of innovative conceptual advancements. In this Introduction, we not only introduce the featured papers but, also, reflect on the broader purpose of philosophy, its relationship to organization studies, and how it can inform and enrich the field.

대학 행정직원의 심리적 자본이 직무만족에 미치는 영향 분석:직무순환의 매개효과를 중심으로

Most universities in Korea have regularly introduced and operated a job rotation system. However, not all administrative employees positively evaluate the job rotation system. Some employees use the job rotation system to their advantage, but some believe that the job rotation system lowers the efficiency of their work. This study aims to deal with the process of accepting job rotation by university administrative staff who are introducing the job rotation system more systematically. In this study, the purpose of the following study was proposed. First, the psychological capital of university administrative staff, which is an organization that carries out a regular job rotation system, is identified. Second, the relationship between the psychological capital of university administrative staff and their perception of job rotation is investigated. Third, the relationship between job satisfaction and job satisfaction in the job rotation system is confirmed. Fourth, theoretical and management implications for human resource management and organizational behavior research are presented based on the relationship between employees' psychological capital and the effect of job rotation.

Kidney function assessment for eligibility in clinical cancer trials – Data from the European Organisation for Research and Treatment of Cancer

PurposeThere is no consensus on how to estimate kidney function for the assessment of eligibility in clinical cancer trials. Patients and methodsWe recalculated the creatinine clearance (CrCl)/glomerular filtration rate (GFR) at baseline in a total of 1768 patients enrolled in twelve clinical trials using the Cockcroft-Gault (CG), Modification of Diet in Renal Disease (MDRD), 2021 Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI 2021) and European Kidney Function Consortium (EKFC) formulas. Patients were classified as having renal impairment (RI; CrCl/GFR <60 mL/min) or no renal impairment (NRI; CrCl/GFR ≥60 mL/min) with each of the four formulas, respectively. Furthermore, we analyzed the number of adverse events (AE) per month under study treatment using measures of central tendency, variability and regression models. ResultsUsing CG, EKFC, MDRD and CKD-EPI 2021, 152 (8 %), 140 (8 %), 110 (6 %), and 61 (4 %) patients had RI respectively. Indeed, 47 (3 %) patients had RI using all 4 formulas, while 158 (9 %) had RI by at least one but not all four methods. CG showed the broadest variability and inconsistencies with other methods. All calculation methods performed similarly for excluding patients at risk of severe AE. EKFC demonstrated superior predictive ability for excluding patients at risk of renal and urinary tract AE. ConclusionThis post hoc analysis highlights the importance of choosing accurate and representative methods for kidney function estimation in clinical cancer trials. CG should be replaced by newer methods. While CKD-EPI 2021 may maximize trial accrual, EKFC should be considered for treatment affecting kidney function.

Performances of the e-Nauka Portal in the Republic of Serbia and Its Significance for Researchers

In recent years, digitalization has been recognized as a significant and necessary process that leads to better results, both in the education and in the scientific research. The legal and strategic framework in the Republic of Serbia follows the modern trends of the concept of open science, open knowledge, digital transformation and a unique digital format of scientific production. The Ministry of science, technological development and innovation, in cooperation with the Office for information technology and electronic administration, created the necessary conditions for dynamic the development of the scientific research and innovation system, especially in relation to the digitalization process and the establishment of an information platform, in the form of a unified national information system of scientific research activities: eNauka [eScience]. The concept of eNauka is an innovative tool that improves the efficiency and transparency of scientific processes in Serbia. The eNauka portal in the Republic of Serbia is dedicated to promoting scientific research, innovation and academic achievements within the scientific community of the Republic of Serbia. This portal provides access to scientific articles, research papers and academic publications authored by researchers from Serbia, which enables the spread of knowledge and the encouragement of scientific cooperation within the country. The eNauka portal was opened in full capacity for all active researchers in Serbia on July 3, 2023, and contains data on scientific research organizations in the Republic of Serbia, researchers and their scientific results. The goal of this paper was to bring closer to the academic community the capabilities and performance of the eNauka portal, its structure, the way and importance of data editing, with special reference to issues related to researchers’ profiles and their editing. The paper is methodologically based on a theoretical, preliminary desk analysis of relevant contemporary standpoints in domestic and foreign theory, a normative analysis of current legislative sources, an inductive and deductive approach in researching the operational performance and advantages of the eNauka portal, as well as the quantitative analysis of relevant statistical indicators of relevant parameters regarding the profile that each researcher has on the eNauka portal. The results include the analysis of data related to editing the researcher’s profile and the opportunities offered by the eNauka portal. The conclusion refers to the importance and advantages of the eNauke portal. Finally, it should be noted that one of the key functions of eNauka is the evaluation of scientific results. More precisely, the system provides the possibility of monitoring and evaluating research results, which is of great importance for the academic community.

사회적 연결은 득인가 실인가: 사회적 연결의 이점과 비용에 관한 연구 동향과 과제

Network theory has traditionally focused on social ties as its primary subject of study, investigating patterns of linkages and relationships among actors and the ensuing social structures from various perspectives. This paper reviews the extant literature on both the positive and negative effects of social ties and social networks. It transcends the mainstream research tradition that has predominantly emphasized positive impacts, presenting domestic and international studies that explore the constraints and costs engendered by social ties, including the excessive homogenization they can cause. Specifically, the paper delves into Granovetter’s (1973) “strength of weak ties” theory, Burt’s (1992, 1995) structural hole theory, which addresses both the patterns of connections and relationships between actors and the resultant structures, and Coleman's (1990) concept of network closure, which underscores the overall structure of social networks. In doing so, this paper presents core tenets of these theories and critically evaluates the current state of knowledge as presented in leading domestic and international management and sociology journals. Finally, considering the implications of networks and their social ties for organizational research, alongside the ease with which individuals can now join various networks through the rapid development of online and mobile social networking sites, the paper underscores the importance of focusing on the costs and constraints that actors face when navigating numerous social connections. It also highlights the necessity of being wary of confirmation bias caused by suggestion algorithms embedded in online sites and proposes directions for future research.

Influence Sophistication Technology Information, Support Management Peak and Ability Personal Techniques on Effectiveness System Information Accountancy

The aim of this research is to examine the influence of information technology sophistication, top management support and personal technical capabilities on the effectiveness of accounting information systems. This research was conducted at the Denpasar City Regional Apparatus Organization (OPD), the number of samples used was 40 respondents using a non-probability sampling method using a purposive sampling technique. The collected data was then analyzed using Partial Least Square (PLS). The research results show that the sophistication of information technology, top management support and personal technical abilities have a positive effect on the effectiveness of the accounting information system. The implications of this research include two things, theoretical implications and practical implications. The theoretical implications of this research relate to the development of theories regarding the variables of information technology sophistication, top management support and personal technical abilities that support the Technology Acceptance Model (TAM) theory. The practical implications of this research relate to the contribution of research in Denpasar City Regional Apparatus Organizations (OPD) as material for consideration in improving the effectiveness of accounting information systems.

Determining the effect of longitudinal stiffeners on the deformation of multilayer ellipsoidal shells under non-stationary loads

The object of this study is the deformation of multilayer ellipsoidal shells under non-stationary distributed load. It is proposed to reinforce the shell with longitudinal stiffeners to enhance the strength of it. The application of Timoshenko's theory of shells and cores enabled the investigation of the influence of longitudinal stiffeners on the deformation of multilayer ellipsoidal shells under non-stationary loads with the discrete positioning of the stiffeners. A mathematical model of shell oscillations under various types of short-term non-stationary loads was based on the Hamilton-Ostrogradsky variational principle. The numerical algorithm based on the application of the integral-interpolation approach to the construction of finite difference schemes in spatial coordinates, combined with an explicit finite-difference scheme for the time coordinate, was used to solve the task set. It has been determined that reinforcing stiffeners significantly affect the deformed state of the multilayer ellipsoidal shell. The "shell-stiffeners" relation was taken into account as a base for research. The maximum deformation ε11 of the smooth three-layer ellipsoidal shell was on average 1.4 times greater than the deformation ε11 of the reinforced three-layer ellipsoidal shell throughout the entire studied time interval. It was determined that over time the presence of reinforcing stiffeners has a more significant impact on the deformed state of the reinforced ellipsoidal shell. A distinctive feature of this research is the consideration of the discrete placement of reinforcing stiffeners which made it possible to investigate the impact of longitudinal stiffeners on the deformation of multilayer ellipsoidal shells under non-stationary loads. The results could be used for the investigation of applied problems in research organizations and design bureaus when designing shell structures

Open access in Ukraine: Characteristics and evolution from 2012 to 2021

Abstract This study investigates the development of open access (OA) to publications produced by authors affiliated with Ukrainian universities and research organizations in the period 2012–2021. To get a comprehensive overview we assembled data from three databases: Dimensions, Web of Science (WoS), and Scopus. Our final data set consisted of 186,000 unique records. To determine the OA status of each article, this study utilized Unpaywall data, which was obtained via API. It was determined that 71.5% of all considered articles during the observed period were openly available at the time of analysis. Notably, 60.9% of the OA papers were disseminated through national journals. Furthermore, our findings indicate that the rate of OA papers was highest in the Humanities, at 89.7%, with 74.8% of papers disseminated through national communication channels. The share of OA papers published in national journals surpassed OA papers in foreign journals across all research areas except Natural Sciences. Another noteworthy finding was that Gold OA emerged as the predominant type of OA over the 10-year period of analysis. We underscore the critical importance of ensuring the FAIRness of national scholarly communication infrastructure for monitoring OA uptake and state support of national publishers.

Association between Geriatric 8 frailty and health-related quality of life in older patients with cancer (PROGNOSIS-G8): a Danish single-centre, prospective cohort study

Health-related quality of life (HRQoL) is highly valued among older adults with cancer. The Geriatric 8screening tool identifies individuals with frailty, but its association with HRQoL remains sparsely investigated. Herein, we evaluate whether Geriatric 8frailty is associated with short-term and long-term HRQoL in older patients with cancer. In this Danish single-centre, prospective cohort study, patients aged 70years and older, referred to oncological assessment for solid cancers, were screened with the Geriatric 8. Patients completed the European Organisation for Research and Treatment of Cancer (EORTC) Quality-of-Life Core 30 (QLQ-C30) and Elderly 14(ELD14) questionnaires at baseline, 3months, 6months, 9months, and 12months. Patient characteristics were obtained from medical records. Differences in mean global health status and QoL (GHS), measured using the two seven-point Likert scale questions from the EORTC QLQ-C30 regarding overall health and QoL during the past week, between patients with frailty (defined as a Geriatric 8score of ≤14) and without frailty within 12months were the primary outcome. Secondary outcomes were differences in the mean EORTC Summary Score comprised of all questions from the QLQ-C30 except for those included in the GHS and a question concerning financial difficulties, and five functional (physical, role, and social functioning, maintaining purpose, and family support from the EORTC QLQ-C30 and the EORTC-QLQ-ELD14), and five symptom scales (fatigue, pain, mobility, future worries, and burden of illness from the EORTC-QLQ-C30 and the EORTC-QLQ-ELD14). Analyses were done using linear mixed models. All primary and secondary outcomes were adjusted for gender, treatment intent, and cancer type and the primary outcome was also assessed by means of a responder analysis. Between June 1, 2020and Oct 15, 2021, 1398eligible patients were screened with the Geriatric 8 (908 [65%] with frailty and 490 [35%] without frailty) and provided medical record data. Of these patients, 707 (51%) also provided HRQoL data (437 [62%] with frailty and 270 [38%] without frailty). When adjusted, patients with frailty had poorer GHS(-15·1, 95% CI -18·5to -11·6; p<0·0001) at baseline and throughout follow-up (3 months -7·4, -11·0to -3·7, p=0·0001; 6months -11·7, -15·5to -7·9, p<0·0001; 9months -10·4, -14·3to -6·5, p<0·0001; 12months -10·4, -14·6to -6·2, p<0·0001) compared to patients without frailty. Adjusted summary scores were also poorer for patients with frailty (-9·9, 95% CI -12·1to -7·6; p<0·0001) compared to patients without frailty at baseline and throughout follow-up (3 months -8·2, -10·5to -5·8, p=0·0001; 6months -9·0, -11·4to -6·6, p<0·0001; 9months -9·2, -11·7to -6·8, p<0·0001; 12 months -8·9, -11·5to -6·3, p<0·0001). Patients with frailty had significantly worse physical and role functioning, mobility, and fatigue outcomes, with no differences in family support within 12months, at all timepoints. Older patients with cancer and frailty have significantly poorer HRQoL than those without frailty within the 12months following an oncology referral. Thus, by identifying and treating frailty, we can ultimately improve patient HRQoL. The Danish Cancer Society, Academy of Geriatric Cancer Research (AgeCare), Odense University Hospital, University of Southern Denmark, Dagmar Marshalls Fond, and Agnes and Poul Friis Fond.

Unveiling the nexus: organization inclusion, ethical virtues and organizational citizenship behavior in the hospitality sector

Purpose The purpose of this study is to examine the intricate dynamics within the hospitality service sector, which predominantly employs low-wage and low-skilled workers. These employees frequently encounter challenges related to breaches in their psychological contracts. Despite their critical role in customer service, their experiences are often overlooked in organizational inclusion research. We investigate the relationship between employees’ perceptions of organizational inclusion and their assessments of organizational ethical virtues (OEVs), considering the potential moderating effect of psychological contract breach. Furthermore, it explores how these factors influence customer- and organizationdirected organizational citizenship behaviors (OCBs). Design/methodology/approach Our research design incorporates a two-stage moderated-mediation model to test our proposed hypotheses empirically. A two-source sample of 451 European hotel managers and employees extends the inquiry with the proposed model. Structural Equation Modeling (SEM) was employed to analyze the proposed relationships. Findings Findings reveal that organization inclusion is positively associated with OEV and employee-perceived OEV mediates an indirect link between organization inclusion on customer-oriented OCB. Moreover, psychological contract breach (P CB) attenuates the association between organization inclusion and OEV at the first stage and OEV, and OCB at the second stage. Originality/value The findings robustly corroborate our proposed model. The study findings culminate in a discussion accentuating the extensive implications of our findings for both research and practicality within the hospitality sector. Anchored in empirical revelations, we delineate avenues for future exploration in this pivotal domain.