Organs Of Human Body Research Articles

Biomarkers: Acute kidney injury

Biomarkers can be measured objectively and can assess physiological as well as pathological process or pharmacological response or helps in deciding therapeutic intervention or prognostication of disease. Biomarkers can be clinical as well as molecular. Kidney is one of the vital organs of human body and has mainly excretory functions. Acute kidney injury is independent risk factor for morbidity and mortality and early intervention has better prognosis. Defining acute kidney injury is still a big issues and various classifications have been proposed but none is suitable to define or identify sub-acute injury to such a vital organ. Measurement of serum creatinine and urine output have been used in almost all definitions but do not pick up early sub-clinical damage associated with normal serum creatinine and urine output. Recently study of general and novel biomarkers have helped in defining the sub-clinical damage, early therapeutic intervention and prognosis of child with acute kidney injury.

Diabetic Retinopathy: Present and Past

Diabetes, a chronic disease affects various organs of human body including the retina. Diabetic Retinopathy (DR) results from the Diabetes Mellitus (DM). In literature various machine learning algorithms have been applied in detection of DR. This involves two steps; Feature extraction and Classification. This paper reviews the various techniques used for detecting DR based on the features like blood vessels, microaneurysms, haemorrhages etc. In most of the experiments retinal fundus images were used in which images of retina were captured by fundus camera. This review bifurcates the detection of DR into two approaches; Blood vessels segmentation and Identification of lesions. This paper compares the experimental results of various machine learning techniques based on parameters like sensitivity, specificity, Area Under Curve (AUC), Accuracy. The results are also compared with the deep neural networks and analysis of best technique has been provided.

PENERAPAN MULTIMEDIA PEMBELAJARAN ILMU PENGETAHUAN ALAM FUNGSI ORGAN TUBUH MANUSIA DAN HEWAN BERBASIS FLSAH UNTUK KELAS V SEKOLAH DASAR

The purpose of this study is to improve the learning outcomes of science of human body and animal 5th grade animal organ function through the application of interactive model based on flash. This form of research is a classroom action research of 2 cycles. Each cycle consists of 4 stages: planning, action implementation, observation and reflection. The subjects of the study were the 5th graders of SDN 05 Dagen as many as 20 students. Data collection techniques use observation, interview, test and documentation. Data analysis technique used is interactive analysis model which has three component that is data reduction, data presentation and conclusion drawing. Based on the results of research that is with the implementation of learning in the cycle I and cycle II can be concluded that there is an increase in learning outcomes by applying interactive multimedia based flash. This can be demonstrated by the increased ability of students from before and after action.

Recent Developments in Graphene‐Based Tactile Sensors and E‐Skins

AbstractHuman skin, the largest organ of human body, can perceive tactile sensations, temperature, humidity, and other complex environmental stimulations. To mimic the capabilities of human skin, graphene provides great potential in building wearable electronic skins (E‐skins), which hold broad applications in advanced robotics, healthcare monitoring, artificial intelligence, human–machine interfaces, etc. Herein, the recent progress in flexible tactile sensors and E‐skins based on graphene material is presented. A brief introduction of the main approaches to prepare graphene nanosheets is provided. The main developments on the functions and mechanisms of bionic functional devices in E‐skins including tactile sensors, temperature sensors, and humidity sensors are then highlighted. The current and future applications for graphene‐based E‐skins, such as multifunctional biomimetic E‐skins, healthcare monitoring, and interactive human–machine interface, are also described. Finally, the existing challenges and future development trends for graphene‐based E‐skins are discussed.

Assessment of Heavy Metals on Occupationally Exposed Workers from Hair Analysis

The use of human hair as a tool in assessing changes and abnormalities in human bodies has been increasing for last decades since it may reflect the health status or environmental condition of habitation or working place of individuals as well as population groups. Compared to other body tissue or fluids, hair provides an ease of elemental analysis especially in reflecting the long-term exposure. This research was conducted to determine the elemental content especially heavy metals, since they are bioaccumulated in human body organs and impact human health, in hair of workshop workers and traffic services officers as exposed groups and its comparison with control group and references data for assessing of occupational exposure. Thirty-five automotive workshop workers and 32 traffic services officers’ hair specimens were collected in Bandung, while hair specimens of the control group were collected from 43 healthy individuals. The elemental concentrations in hair specimen were analyzed using neutron activation analysis (NAA) for mercury and chromium, and atomic absorption spectrometry (AAS) for lead and arsenic. The accuracy of the method was evaluated using GBW 07601 human hair certified reference material (CRM) and it was found to give good results in accordance with the certificate values. It was found that chromium , lead, and arsenic hair concentration in exposed groups (0.88, 10.7, and 0.051 mg/kg, respectively) were higher than in control group (0.27, 4.52, and 0.045 mg/kg, respectively), w hile mercury hair concentration of traffic services officers were higher than control group but mercury hair concentration of automotive workshop workers were lower than in control group (1.41 mg/kg) . The t-test statistical results shown that mercury concentrations in one exposed group did not differ significantly from the control , but other exposed groups showed otherwise. The level of mercury in hair is strongly attributed not only to environmental exposure, but also to lifestyle and dietary habit s , w hile t-test statistical results of chromium and lead differ significantly with p value < 0.05. These results indicate that heavy metal hair concentrations were well quantified to show the abnormalities of elemental concentration in human hair for evaluating the occupational exposure .

A Microfluidic Device for Culturing an Encapsulated Ovarian Follicle.

Microfluidic chips have been proved effective in mimicking different organs of human body. Simulating human ovarian follicles by microfluidic device will be useful in exploring the mechanism of folliculogenesis and related diseases. In this paper, a microfluidic chip was designed to culture a single human pre-antral follicle. Ovarian follicles were first encapsulated in 3D calcium alginate hydrogel beads and then cultured on chip and in dish under same conditions. The diameters of cultured ovarian follicles were measured, and the same amount of medium was collected from microfluidic device or dish per two days for measuring the estradiol and androgen concentrations. The results confirmed the successful growth of ovarian follicles on chip with their hormonal trends and diameters increase, which were similar to ovarian follicles cultured in dish. It is concluded that this microfluidic chip can be used to culture a single human ovarian follicle, which provides a useful tool to explore the hormonal changes and their interactions during folliculogenesis.

Determination of qualitative composition and quantitative content of amino acids in garlic bulbs and leaves

Introduction. Plant amino acids have an important impact on functioning of various systems and organs of human body. In addition, they possess a wide range of pharmacotherapeutic properties, improve the digestion and potentiate the activity of biologically active compounds present in plants. Thus, the search of plant species that contain a large complex of plant amino acids and are used as food is of current interest. Garlic (Allium sativum L.) from Alliaceae family is one of such plants, and has been used since ancient times for the treatment of various disorders.The aim of the study – to determine the composition and quantitative content of free and bound amino acids of garlic bulbs and leaves.Research methods. The amino acid composition was determined using the high-performance liquid chromatography (HPLC) method.Results and Discussion. 16 amino acids were detected in garlic bulbs as a result of the experiment. Arginine (3.04 %) and proline (1.56 %) were found to be accumulated infree state, while glutamic acid (10.59 %), aspartic acid (6.06 %) and arginine (5.94 %) prevailed in bound state. 15 free and 16 bound amino acids were identified and quantified in garlic leaves. Glutamic acid (2.11 %), leucine (1.79 %), valine (1.77 %), isoleucine (1.52 %), treonine and phenylalanine (1.44 %) dominated infree state, and glutamic acid (28.49 %), aspartic acid (12.90 %) and leucine (7.61 %) prevailed in bound state. Methionine was found only in bound state in garlic leaves.Conclusions. The amino acid composition of garlic bulbs and leaves was studied using the HPLC method. 16 amino acids in both free and bound state were detected and their content was determined in garlic bulbs, while in garlic leaves – 15 free and 16 bound amino acids. The results of the experiment showed that methionine is present only in bound state in garlic leaves.

Automated technique for coronary artery disease characterization and classification using DD-DTDWT in ultrasound images

Abstract Heart is one of the important as well as hardest working organ of human body. Cardiac ischemia is the condition where sufficient blood and oxygen will not reach the heart muscle due to narrowed arteries of the heart. This condition is called coronary artery disease. Several non-invasive diagnostic tests fail to reveal exact impact of coronary artery disease on myocardial segments. The ultrasound images can explore major impact on ventricular muscle segments due to ischemia and complication of acute coronary syndrome. Computer aided diagnosis tools can predict coronary artery disease in its early stage so that patients can undergo treatment and save their life. This paper presents a novel computer aided diagnosis system for the automated detection of coronary artery disease using echocardiography images taken from four chamber heart. Proposed method uses double density-dual tree discrete wavelet transform (DD-DTDWT) to decompose the images into different frequency sub-bands. Then various entropy features are extracted from these sub-bands. The obtained dimension of the features is reduced using marginal fisher analysis (MFA) and optimal features are selected using feature ranking methods. The proposed method achieved promising accuracy of 96.05%, sensitivity of 96.12%, and specificity of 96.00% for linear discriminant classifier using entropy ranking method with twelve features. We have also proposed coronary artery disease risk index (CADRI) to categorize diseased subjects from normal subjects using a single value. Thus, it can be used as a diagnosis tool in hospitals and polyclinics for confirming the findings of clinicians.

Research progress of senescence-associated secretory phenotype and vascular aging

Vascular senescence is associated with aging and disease in various organ and systems of the human body, and is one of the main pathogenesis of chronic diseases such as heart, brain, kidney and others.Vascular cell senescence expresses a senescence-associated secretory phenotype (SASP), including proinflammatory cytokines, growth factors, chemokines and proteases.These factors accelerate the changes in vascular structure and function, and lead to vascular aging.This study focuses on the latestresearchprogressions of the mechanism, biological effects of SASP, relationship between SASP and vascular aging, and intervention on SASP. Key words: Aging; Blood vessels

Biological/pathological functions of the CXCL12/CXCR4/CXCR7 axes in the pathogenesis of bladder cancer.

CXC chemokine ligand 12 (CXCL12) is an important member of the CXC subfamily of chemokines, and has been extensively studied in various human body organs and systems, both in physiological and clinical states. Ligation of CXCL12 to CXCR4 and CXCR7 as its receptors on peripheral immune cells gives rise to pleiotropic activities. CXCL12 itself is a highly effective chemoattractant which conservatively attracts lymphocytes and monocytes, whereas there exists no evidence to show attraction for neutrophils. CXCL12 regulates inflammation, neo-vascularization, metastasis, and tumor growth, phenomena which are all pivotally involved in cancer development and further metastasis. Generation and secretion of CXCL12 by stromal cells facilitate attraction of cancer cells, acting through its cognate receptor, CXCR4, which is expressed by both hematopoietic and non-hematopoietic tumor cells. CXCR4 stimulates tumor progression by different mechanisms and is required for metastatic spread to organs where CXCL12 is expressed, thereby allowing tumor cells to access cellular niches, such as the marrow, which favor tumor cell survival and proliferation. It has also been demonstrated that CXCL12 binds to another seven-transmembrane G-protein receptor or G-protein-coupled receptor, namely CXCR7. These studies indicated critical roles for CXCR4 and CXCR7 mediation of tumor metastasis in several types of cancers, suggesting their contributions as biomarkers of tumor behavior as well as potential therapeutic targets. Furthermore, CXCL12 itself has the capability to stimulate survival and growth of neoplastic cells in a paracrine fashion. CXCL12 is a supportive chemokine for tumor neovascularization via attracting endothelial cells to the tumor microenvironment. It has been suggested that elevated protein and mRNA levels of CXCL12/CXCR4/CXCR7 are associated with human bladder cancer (BC). Taken together, mounting evidence suggests a role for CXCR4, CXCR7, and their ligand CXCL12 during the genesis of BC and its further development. However, a better understanding is still required before exploring CXCL12/CXCR4/CXCR7 targeting in the clinic.

Cytoprotective Effects of Pumpkin (Cucurbita Moschata) Fruit Extract against Oxidative Stress and Carbonyl Stress.

Background Diabetes mellitus is a chronic endocrine disorder that is associated with significant mortality and morbidity due to microvascular and macrovascular complications. Diabetes complications accompanied with oxidative stress and carbonyl stress in different organs of human body because of the increased generation of free radicals and impaired antioxidant defense systems. In the meantime, reactive oxygen species (ROS) and reactive carbonyl species (RCS) have key mediatory roles in the development and progression of diabetes complications. Therapeutic strategies have recently focused on preventing such diabetes-related abnormalities using different natural and chemical compounds. Pumpkin (Cucurbita moschata) is one of the most important vegetables in the world with a broad-range of pharmacological activities such as antihyperglycemic effect. Methods In the present study, the cytoprotective effects of aqueous extract of C. moschata fruit on hepatocyte cytotoxicity induced by cumene hydroperoxide (oxidative stress model) or glyoxal (carbonylation model) were investigated using freshly isolated rat hepatocytes. Results The extract of C. moschata (50 μg/ml) excellently prevented oxidative and carbonyl stress markers, including hepatocyte lysis, ROS production, lipid peroxidation, glutathione depletion, mitochondrial membrane potential collapse, lysosomal damage, and cellular proteolysis. In addition, protein carbonylation was prevented by C. moschata in glyoxal-induced carbonyl stress. Conclusion It can be concluded that C. moschata has cytoprotective effects in oxidative stress and carbonyl stress models and this valuable vegetable can be considered as a suitable herbal product for the prevention of toxic subsequent of oxidative stress and carbonyl stress seen in chronic hyperglycemia.

The Unwanted Cell Migration in the Brain: Glioma Metastasis.

Cell migration is identified as a highly orchestrated process. It is a fundamental and essential phenomenon underlying tissue morphogenesis, wound healing, and immune response. Under dysregulation, it contributes to cancer metastasis. Brain is considered to be the most complex organ in human body containing many types of neural cells with astrocytes playing crucial roles in monitoring both physiological and pathological functions. Astrocytoma originates from astrocytes and its most malignant type is glioblastoma multiforme (WHO Grade IV astrocytoma), which is capable to infiltrate widely into the neighboring brain tissues making a complete resection of tumors impossible. Very recently, we have reviewed the mechanisms for astrocytes in migration. Given the fact that astrocytoma shares many histological features with astrocytes, we therefore attempt to review the mechanisms for glioma cells in migration and compare them to normal astrocytes, hoping to obtain a better insight into the dysregulation of migratory mechanisms contributing to their metastasis in the brain.

Dental enamel as biomarker for environmental contaminants in relevant industrialized estuary areas in São Paulo, Brazil.

Heavy metal contamination is a long-standing and very well-known public health problem, and its exposure can cause damage to several organs of human body, especially on the central nervous system of young children and teenagers. The aim of this article is to evaluate lead, cadmium, and manganese contamination in 125 children from 6 to 13years old living in contaminated areas during the period from 2006 to 2009 (São Vicente, Cubatão Downtown, Bertioga and Cubatão Pilões/Água Fria). This estuary area is the most important example of environmental degradation by chemicals from industrial sources. This is a cross-sectional study through clinical examinations and dental enamel tests. All mothers from these children lived in the area since before the pregnancy. Lead, cadmium, and manganese levels (μg/g) were measured on dental enamel samples through graphite furnace atomic absorption spectrometry, searching for the occurrence of heavy metals. The mean lead concentrations were 139.48μg/g in Cubatão Pilões/Água Fria, 170.45μg/g in Cubatão Downtown, 213.52μg/g in São Vicente, and 151.89μg/g in Bertioga. The mean cadmium concentrations were 10.83μg/g in Cubatão Pilões/Água Fria, 12.58μg/g in Cubatão Downtown, 10.92μg/g in São Vicente, and 14.57μg/g in Bertioga. The mean manganese concentrations were 23.49μg/g in Cubatão Pilões/Água Fria, 30.90μg/g in Cubatão Downtown, 41.46μg/g in São Vicente, and 42.00μg/g in Bertioga. Dental surface enamel may be used as an efficient biomarker of past environmental exposure to lead, manganese, and cadmium which are associated to well-known sources of heavy metal contamination. The results suggest that the evaluated children were exposed to sources of lead, cadmium, and manganese since before their conceptions. Although Bertioga initially was chosen as a control area of this study, it was also was verified to have heavy metal contamination on examined children.

Modeling the effect of tilting, passive leg exercise, and functional electrical stimulation on the human cardiovascular system.

Long periods of bed rest negatively affect the human body organs, notably the cardiovascular system. To avert these negative effects and promote functional recovery in patients dealing with prolonged bed rest, the goal is to mobilize them as early as possible while controlling and stabilizing their cardiovascular system. A robotic tilt table allows early mobilization by modulating body inclination, automated passive leg exercise, and the intensity of functional electrical stimulation applied to leg muscles (inputs). These inputs are used to control the cardiovascular variables heart rate (HR), and systolic and diastolic blood pressures (sBP, dBP) (outputs). To enhance the design of the closed-loop cardiovascular biofeedback controller, we investigated a subject-specific multi-input multi-output (MIMO) black-box model describing the relationship between the inputs and outputs. For identification of the linear part of the system, two popular linear model structures-the autoregressive model with exogenous input and the output error model-are examined and compared. The estimation algorithm is tested in simulation and then used in four study protocols with ten healthy participants to estimate transfer functions of HR, sBP and dBP to the inputs. The results show that only the HR transfer functions to inclination input can explain the variance in the data to a reasonable extent (on average 69.8%). As in the other input types, the responses are nonlinear; the models are either not reliable or explain only a negligible amount of the observed variance. Analysis of both, the nonlinearities and the occasionally occurring zero-crossings, is necessary before designing an appropriate MIMO controller for mobilization of bedridden patients.

TWO-DIMENSIONAL FINITE ELEMENT MODEL TO STUDY THERMO BIOMECHANICS IN PERIPHERAL REGIONS OF HUMAN LIMBS DUE TO EXERCISE IN COLD CLIMATE

Human beings are equipped with thermo sensitivity, thermoregulation and thermo protection for maintaining the structure and function of their body organs. The thermoregulatory responses and disturbances caused by physical activity in thermo biomechanics of human body organs are not well understood. The mechanism of thermoregulation exhibits a beautiful coordination of biophysical process in order to balance distribution caused by a biothermal system due to physical exercise and other abnormal conditions. In view of above, a model has been developed to study the thermal dynamics in peripheral region of human limbs immediately after exercise under cold climatic conditions. The human limb is assumed to be of cylindrical shape. The peripheral region of limb is divided into three natural components namely epidermis, dermis and subdermal tissues. Appropriate boundary conditions have been framed based on the physical condition of the problem. Finite difference has been employed for time variable and the finite element method is employed along radial and angular direction. The numerical results have been used to obtain temperature profiles in the peripheral region immediately after continuous exercise for a two-dimensional unsteady state case. These results have been used to analyze the thermal disturbances caused by the different intensities of physical exercise in the peripheral region of human limbs. Such a model can be developed to study the generated thermal information which can be useful to biomedical science to analyze the impact of thermal stress on mechanism of thermoregulation causing thermal injuries like heat cramps, heat exhaustion and heat stroke. The results give the idea about the capacity of biothermo mechanisms of human limbs in counting balance. The thermal stress is caused by different intensities of physical exercise. These results can be useful for the biomedical scientists to understand the thermal discomfort caused by different intensities of physical exercise and the time period of rest required to overcome discomfort. Further, the result can be useful to biomedical scientists for developing protocols for physical exercise and rest required by the subject for different intensities of physical exercise and prevent thermal injuries in the workers and sportsmen.

Effect of Glycine, Pyruvate, and Resveratrol on the Regeneration Process of Postischemic Intestinal Mucosa.

Background Intestinal ischemia is often caused by a malperfusion of the upper mesenteric artery. Since the intestinal mucosa is one of the most rapidly proliferating organs in human body, this tissue can partly regenerate itself after the onset of ischemia and reperfusion (I/R). Therefore, we investigated whether glycine, sodium pyruvate, and resveratrol can either support or potentially harm regeneration when applied therapeutically after reperfusion injury. Methods I/R of the small intestine was initiated by occluding and reopening the upper mesenteric artery in rats. After 60 min of ischemia and 300 min of reperfusion, glycine, sodium pyruvate, or resveratrol was administered intravenously. Small intestine regeneration was analyzed regarding tissue damage, activity of saccharase, and Ki-67 positive cells. Additionally, systemic parameters and metabolic ones were obtained at selected periods. Results Resveratrol failed in improving the outcome after I/R, while glycine showed a partial beneficial effect. Sodium pyruvate ameliorated metabolic acidosis, diminished histopathologic tissue injury, and increased cell proliferation in the small intestine. Conclusion While glycine could improve in part regeneration but not proliferation, sodium pyruvate seems to be a possible therapeutic agent to facilitate proliferation and to support mucosal regeneration after I/R injury to the small intestine.

Quantitative Study of Thermal Disturbances Due to Nonuniformly Perfused Tumors in Peripheral Regions of Women's Breast.

BACKGROUNDMathematical modeling of biothermal processes is widely used to enhance the quantitative understanding of thermoregulation system of human body organs. This quantitative knowledge of thermal information of various human body organs can be used for developing clinical applications. In the past, investigators have studied thermal distribution in hemisphere-shaped human breast in the presence of sphere-shaped tumor. The shape and size of the breast as well as tumor may also affect thermal distribution which can have serious implications in thermography. In this article, a model of thermal disturbances in peripheral regions of ellipsoid-shaped human breast involving ellipse-shaped nonuniformly perfused tumor has been developed for a 2-dimensional steady-state case. The modeling study will provide biomedical scientists vital insights of thermal changes occurring due to the shape and size of breast and tumor which can influence the development of protocols of thermography for diagnosis of tumors in women’s breast.METHODWe have incorporated the significant parameters such as blood flow, metabolic activity, and thermal conductivity in the thermal model for normal and malignant tissues. The controlled metabolic activity has been incorporated for normal tissues, and uncontrolled metabolic activity has been incorporated for tumor regions. The peripheral regions of breast are divided into 3 major layers, namely, epidermis, dermis, and subdermal tissues. An ellipse-shaped nonuniformly perfused tumor is assumed to be present in dermal layers. The nonuniformly perfused tumor is divided into 2 natural components, namely, the necrotic core and tumor periphery. The outer surface of the breast is assumed to be exposed to the environment, and the heat loss takes place by conduction, convection, radiation, and evaporation. The finite element approach is used to obtain the solution. The numerical results have been used to study the effect of shape and size of tumor on temperature distribution in matured breast of different shapes.RESULTSBy selecting appropriate model parameters, we have shown the spatial thermal variation in matured breast of different shapes which could be replicated by the proposed model. We have also shown the thermal disturbances caused by different shapes and sizes of tumors by selecting appropriate values of parameters. In addition, the thermal information from our model provides us the basis for prediction of shape and size of tumors in terms of change of the slope of temperature profiles at the junction of tumor and normal tissues and tumor periphery and tumor core.CONCLUSIONSThe proposed model was successfully used to study the impact of different sizes and shapes of nonuniformly perfused tumor on thermograms in peripheral regions of ellipse-shaped woman’s breast. The proposed model is more realistic in terms of shape and size of tumors and woman’s breast in comparison with earlier models reported in the literature. The finite element discretization of breast into large number of triangular ring elements effectively models the heterogeneity of region. The changes in slope of the thermal curves at the junctions of various peripheral and tumor layers are due to the nonhomogeneous nature of the region. The location of major thermal disturbances in the tissues indicates the presence of tumor. The change in the slope of the thermal curves gives us idea about the position, type, and size of the tumors in the peripheral tissues. This thermal information can be exploited for detection of tumors by thermographic techniques.

Thermal Patterns in Peripheral Regions of Breast during Different Stages of Development

Background: Mathematical modelling of bio thermal processes is widely used to enhance the quantitative understanding of thermoregulation system of human body organs. This quantitative knowledge of thermal information of various human body organs can be used for developing clinical applications. In the past the investigators have studied thermal distribution in hemispherical shaped human breast in presence of spherical shaped tumor. The shape and size of the breast as well as tumor may also affect thermal distribution which can have serious implications in thermography. In the present paper a model of thermal disturbances in peripheral regions of ellipsoidal shaped breast for two dimensional steady state case. The modelling study will provide biomedical scientist vital insights of thermal changes occurring due to shape and size of breast which can influence the development of protocols of thermography for diagnosis and treatment of tumors in women’s breast. Method: We have incorporated the significant parameters like blood flow, metabolic activity and thermal conductivity in the thermal model for normal and malignant tissues. The controlled metabolic activity has been incorporated for normal tissues. The peripheral regions of breast are divided into three major layers mainly epidermis, dermis and sub dermal tissues. The outer surface of the breast is assumed to be exposed to the environment and the heat loss takes place by conduction, convection, radiation and evaporation. The finite element approach is employed to obtain the solution. Results: By selecting appropriate model parameters we have shown the spatial thermal variation in different stages of breast according to their shapes which could be replicated by the proposed model. Conclusions: The proposed model was successfully employed to study the impact of different sizes and shapes in peripheral regions of elliptical shaped woman’s breast. The proposed model is more realistic in terms of shape and size of woman’s breast in comparison to earlier models reported in the literature. The changes in slope of the thermal curves at the junctions of various peripheral layers are due to the non homogenous nature of the region.

Numerical Study of the Effects of Aneurysm and Stenosis in the Left Coronary Artery on the Human Blood Stream

The heart is the most important muscular organ in human's body, which pumps blood through the arteries to supply the body with oxygen and nutrients. The heart is supplied by the coronary blood vessel; therefore, the effect of aneurysm and stenosis in left coronary artery on the velocity of blood, wall shear stress of artery and mass flow rate of blood have been investigated in this study. The simulation program (ANSYS Fluent) was used to execute the numerical study. Typical geometry of left coronary artery and physiological parameters of human blood values were obtained from measured values reported in literature. The problem of the effect of the aneurysm and stenosis on the human blood stream has been solved numerically under three conditions, healthy artery and two infected cases (30%, 50%) percentage of aneurysm in left main stem (LMS) and stenosis in left anterior descending (LAD). It has been shown, in stenosis region that the velocity of blood will suffer fast flowing and an increase in the shear stress on the artery wall, in contrast with the aneurysm case, blood velocity becomes slow and low wall shear stress. Also irregularity was shown in mass flow rate of blood in the left coronary artery which suffers from aneurysm and stenosis compared with healthy artery.

Medical Palmistry: An Artistic Analysis and Future beyond Lexical Meaning

Palmistry, the HAST SAMUDRIKA is a part of science, known as SAMUDRIKA SHASTRA. This science forecasts a person’s future by observing his hand geometry and palm prints. Medical Palmistry, the major branch of Palmistry facilitates the diagnosis of diseases on keenly focusing one’s palm. The texture, shape and color of palm and nails are reflecting the health condition of a person. The positions of lines, mounts and some special symbols are exhibiting several medical features of internal organs of human body and thus lead to diagnose various diseases. In this survey, we bring the collective ideas of the research works that attempt to analyze different dimensions of Medical Palmistry. We have examined the works under five different categories of diseases based on the nature and outcome of the works of palm morphology.