We introduce non-associative Ore extensions, S = R[X; σ, δ], for any nonassociative unital ring R and any additive maps σ, δ: R → R satisfying σ(1) = 1 and δ(1) = 0. In the special case when δ is either left or right R δ -linear, where R δ = ker(δ), and R is δ-simple, i.e. {0} and R are the only δ-invariant ideals of R, we determine the ideal structure of the nonassociative differential polynomial ring D = R[X; id R , δ]. Namely, in that case, we show that all non-zero ideals of D are generated by monic polynomials in the center Z(D) of D. We also show that Z( D ) = R δ [p] for a monic p ∈ R δ [X], unique up to addition of elements from Z(R) δ . Thereby, we generalize classical results by Amitsur on differential polynomial rings defined by derivations on associative and simple rings. Furthermore, we use the ideal structure of D to show that D is simple if and only if R is δ-simple and Z(D) equals the field R δ ∩ Z(R). This provides us with a non-associative generalization of a result by Oinert, Richter and Silvestrov. This result is in turn used to show a non-associative version of a classical result by Jordan concerning simplicity of D in the cases when the characteristic of the field R δ ∩ Z(R) is either zero or a prime. We use our findings to show simplicity results for both non-associative versions of Weyl algebras and non-associative differential polynomial rings defined by monoid/group actions on compact Hausdorff spaces.