The spatiotemporal patterns of late Quaternary lake evolution, along with their responses to climatic changes and glacial meltwater in the westerlies-dominated Central Asia, remain unclear primarily due to the lack of well-dated records spanning across glacial and interglacial cycles. In this study, we investigated five well-preserved paleolake shoreline sequences, 15–27 m above the modern lake basin of the now-dry Manas Lake, a representative terminal lake in the Junggar Basin of arid Central Asia. Both single aliquot and single-grain K-feldspar post-infrared infrared stimulated luminescence (pIRIR) dating protocols were applied to 26 shoreline samples to reconstruct a lake level variation for Manas Lake over the past 90 kyr. The reliability of the K-feldspar pIRIR dating was tested through assessment of luminescence characteristics and comparison of single-grain and single-aliquot K-feldspar pIRIR Des. The results indicate that the highest water levels (∼25 m deep) occurred during late Marine Isotope Stage (MIS) 5 (∼80 ka) and MIS 3 (31–27 ka). A lake level 20 m above modern lake basin (a.m.l.b.) occurred from the last deglaciation to the early Holocene (14–10 ka) and again in the late Holocene (3.4–0.3 ka). The lake level changes of Manas Lake are decoupled from observed Westerlies precipitation changes over the past 90 kyr. This decoupling suggests enhanced glacial meltwater sourced from the high Tianshan Mountains, triggered by higher mean summer temperatures, worked together with Westerlies precipitation drove periods of lake level highstand in Manas Lake during late MIS 5, late MIS 3, and early Holocene periods.