Since the onset of the Coronavirus Disease 2019 (COVID-19) pandemic, many vaccine research studies have started. Changes in the demographic characteristics of the patients hospitalized from the emergency room to the intensive care unit due to COVID-19 has caught our attention since the vaccination program began in Turkey. The purpose of this study is to investigate whether our investigation is scientifically valid and meaningful. Thus, it will be helpful to investigate the effect of priority ordering in vaccination programs in future pandemics. Demographic characteristics and hospitalization processes of patients hospitalized in the intensive care unit before and after vaccination were compared. For comparison, Charlson Comorbidity Index (CCI) and Acute Physiologic Assessment and Chronic Health Evaluation (APACHE) scores, as well as intensive care unit duration of stay and mortality were used. While age [mean (SD); 70,8 (12,2) vs 66,2 (15,2), p=0,032] and duration of intensive care stay [day; mean (SD); 6,4 (6,3) vs 9,4 (7,4); p<0,001] increased in the post-vaccination group, a statistically significant decrease was observed in APACHE [mean (SD); 26,9 (9,2) vs 20,9 (9,0); p=0,008] and CCI scores [mean (SD); 4,3 (2,2) vs 3,6 (2,7); p<0,001]. Regulating the priorities of those to be vaccinated causes rapid changes in the patient population. For this reason, vaccination of vulnerable groups will contribute to the operation of the health system properly.