ORCID Research Articles

Histopathological study of scaly plaque over palm and sole in patients attending a tertiary care Hospital in Kathmandu

Background: Dermatoses of palms and soles are frequently encountered as palms and soles have non-hairy skin. Scaling skin could be a symptom of many medical conditions including psoriasis, eczema, contact dermatitis, ichthyosis, actinic keratosis, lichen planus, tinea, etc. Psoriasis must be differentiated from its non-psoriatic lesions. Histopathological examination often serves as a confirmative part of the diagnosis. Materials and methods: This was a hospital-based retrospective study carried out in the Department of Pathology and Department of Dermatology of Nepal Medical College Teaching Hospital. A total of 139 cases of scaly plaque skin lesions of the palm and sole from January 2020 to December 2022 were included in the study. The histopathological diagnosis was correlated with the clinical diagnosis. Results: Among 139 persons presenting with scaly lesions, the median age was 36 years with an age range from 15 years to 80 years. A female preponderance (59%) was observed. The odds of Psoriasis were 2.5 times higher (OR CI: 1.21 to 5.17) among those aged 36 years and above (P value 0.011). There was a significant association between age categories and histological diagnosis of scaly lesions. The agreement was significant between the clinical and histological diagnosis for psoriatic (63.0%) and non-psoriatic lesions (76.3%) with a Cohen’s kappa coefficient of 0.38 (SE: 0.084), P value < 0.0001. Conclusions: Both psoriatic and non-psoriatic lesions can present as scaly plaque skin lesions, hence the knowledge of these clinical mimickers is important for the proper diagnosis. The histopathological examination will give the confirmatory diagnosis.

Resistance and collaboration within the panoptivarsity: differing views of ORCID in Ireland

PurposeORCID is well recognised as a Persistent Identifier (PID) amongst the global academic community. The international literature is generally extremely positive towards this development. A minority of vociferous critics however have continued to dispute its benefits. Particular concerns have been noted around the potential for ORCID to be used as a tool for evaluation and surveillance by University management structures. This research sought to critically evaluate in-depth perceptions of ORCID in the Technological University (TU) sector in Ireland.Design/methodology/approachThis study involved ten semi-structured interviews with academics and five with librarians in the TU sector. Reflexive thematic analysis informed by Heideggerian hermeneutic phenomenological principles was used to explore transcribed interview data.FindingsThe results demonstrate a clear difference in perceptions concerning ORCID, with library staff being very positive and uncritical, even arguing for mandatory adoption. Although some academics were using ORCID IDs in a performative manner, most were suspicious of, or resigned to their use. Concerns about ORCID ranged across various issues including employer surveillance, a lack of institutional autonomy and its inappropriateness for the sector. It is argued that academics in the TU sector have so far not had an opportunity to fully explore and articulate their vision for the future. In its current form ORCID represents a foreign, imposed and inappropriate tool that may facilitate willing or unwilling inclusion in the inequitable and crude “game” of global university league tables.Originality/valueThe paper offers an in-depth and critical analysis of ORCID adoption in Ireland based on perceptions amongst two stakeholder groups: academics and librarians.

A calculator for musculoskeletal injuries prediction in surgeons: a machine learning approach

BackgroundSurgical specialists experience significant musculoskeletal strain as a consequence of their profession, a domain within the healthcare system often recognized for the pronounced impact of such issues. The aim of this study is to calculate the risk of presenting musculoskeletal injuries in surgeons after surgical practice.MethodsCross-sectional study carried out using an online form (12/2021–03/2022) aimed at members of the Spanish Association of Surgeons. Demographic variables on physical and professional activity were recorded, as well as musculoskeletal pain (MSP) associated with surgical activity. Univariate and multivariate analysis were conducted to identify risk factors associated with the development of MSP based on personalized surgical activity. To achieve this, a risk algorithm was computed and an online machine learning calculator was created to predict them. Physiotherapeutic recommendations were generated to address and alleviate each MSP.ResultsA total of 651 surgeons (112 trainees, 539 specialists). 90.6% reported MSP related to surgical practice, 60% needed any therapeutic measure and 11.7% required a medical leave. In the long term, MSP was most common in the cervical and lumbar regions (52.4, 58.5%, respectively). Statistically significant risk factors (OR CI 95%) were for trunk pain, long interventions without breaks (3.02, 1.65–5.54). Obesity, indicated by BMI, to lumbar pain (4.36, 1.84–12.1), while an inappropriate laparoscopic screen location was associated with cervical and trunk pain (1.95, 1.28–2.98 and 2.16, 1.37–3.44, respectively). A predictive model and an online calculator were developed to assess MSP risk. Furthermore, a need for enhanced ergonomics training was identified by 89.6% of surgeons.ConclusionsThe prevalence of MSP among surgeons is a prevalent but often overlooked health concern. Implementing a risk calculator could enable tailored prevention strategies, addressing modifiable factors like ergonomics.

Relation between serum sclerostin and CTRP3 levels and bone mineral density in diabetic postmenopausal women

BackgroundOsteoporosis (OP) is a common finding in diabetic patients especially high-risk populations such as postmenopausal women. Sclerostin is a glycoprotein chiefly secreted by mature osteocytes and is considered a main regulator of bone formation. The C1q/TNF-Related Protein 3 (CTRP3) was found to be significantly associated with OP in postmenopausal women. The effect of type 2 diabetes mellitus (T2DM) on sclerostin and CTRP3 levels in postmenopausal women is rarely investigated. The present study aimed to assess the impact of T2DM on sclerostin and CTRP3 levels and their relation to OP in postmenopausal women.MethodsThe study included 60 postmenopausal women with T2DM and 60 age-matched postmenopausal non-diabetic women. Bone mineral density (BMD) was assessed using dual energy X-ray absorptiometry (DEXA). Serum levels of sclerostin and CTRP3 were assessed using enzyme-linked immunosorbent assay (ELISA) technique.ResultsDiabetic group expressed significantly higher serum levels of sclerostin when compared with non-diabetic group (110.0 ± 29.0 versus 51.5 ± 23.2 ng; p < 0.001). Oppositely, CTRP3 were significantly lower in the diabetic group (3.5 ± 3.5 versus 9.9 ± 3.7 ng/ml, p < 0.001). Multivariate logistic regression analysis identified HbA1c levels [OR (95% CI): 0.49 (0.26–0.93), p = 0.028], sclerotin levels [OR (95% CI): 1.06 (1.0-1.012), p = 0.041] and CTRP3 levels [OR (95%) CI: 1.64 (1.0-2.68), p = 0.047] as significant predictors of OP in diabetic patients.ConclusionsSclerostin and CTRP3 levels are involved in OP in postmenopausal diabetic patients.

Mendelian randomization study on causal association of TEF and circadian rhythm with pulmonary arterial hypertension

BackgroundPrevious research has revealed the potential impact of circadian rhythms on pulmonary diseases; however, the connection between circadian rhythm-associated Thyrotroph Embryonic Factor (TEF) and Pulmonary Arterial Hypertension (PAH) remains unclear. We aim to assess the genetic causal relationship between TEF and PAH by utilizing two sets of genetic instrumental variables (IV) and publicly available Pulmonary Arterial Hypertension Genome-Wide Association Studies (GWAS).MethodsTotal of 23 independent TEF genetic IVs from recent MR reports and PAH GWAS including 162,962 European individuals were used to perform this two-sample MR study. Gain- and loss-of-function experiments were used to demonstrate the role of TEF in PAH.ResultsOur analysis revealed that as TEF levels increased genetically, there was a corresponding increase in the risk of PAH, as evidenced by IVW (OR = 1.233, 95% CI: 1.054–1.441; P = 0.00871) and weighted median (OR = 1.292, 95% CI for OR: 1.064–1.568; P = 0.00964) methods. Additionally, the up-regulation of TEF expression was associated with a significantly higher likelihood of abnormal circadian rhythm (IVW: P = 0.0024733, β = 0.05239). However, we did not observe a significant positive correlation between circadian rhythm and PAH (IVW: P = 0.3454942, β = 1.4980398). In addition, our in vitro experiments demonstrated that TEF is significantly overexpressed in pulmonary artery smooth muscle cells (PASMCs). And overexpression of TEF promotes PASMC viability and migratory capacity, as well as upregulates the levels of inflammatory cytokines.ConclusionOur analysis suggests a causal relationship between genetically increased TEF levels and an elevated risk of both PAH and abnormal circadian rhythm. Consequently, higher TEF levels may represent a risk factor for individuals with PAH.

ASSESSMENT OF QUALITY-OF-LIFE INDICATORS IN OPERATED AND NON-OPERATED PATIENTS WITH PRIMARY HYPERPARATHYROIDISM IN A COMPARATIVE ASPECT AT DIFFERENT TIMES

ВЕСТНИК СОВРЕМЕННОЙ КЛИНИЧЕСКОЙ МЕДИЦИНЫ 2024 Том 17, вып. 4 127ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ © K.К. Nasirova, N.T. Rikhsieva, Y.M. Urmanova, G.D. Narimova, O.К. Saitmuratova, R.T. Кhаydarova, 2024 УДК:7696.332-796.422.12/16:796.92-519.63 DOI: 10.20969/VSKM.2024.17(4).127-134 ASSESSMENT OF QUALITY-OF-LIFE INDICATORS IN OPERATED AND NON-OPERATED PATIENTS WITH PRIMARY HYPERPARATHYROIDISM IN A COMPARATIVE ASPECT AT DIFFERENT TIMES NASIROVA KHURSHIDAХON К., ORCID ID: 0000-0002-8104-5037, Dr. sc. med., Head of the Department of Endocrinology, Pediatric Endocrinology, Tashkent Pediatric Medical Institute, 223 Bogishamol str., 100140 Tashkent, Uzbekistan. E-mail: hursh77@mail.ru RIKHSIEVA NAZIRA T., ORCID ID: 0000-0001-9790-1208, Cand. sc. med., Associate Professor at the Department of Endocrinology, Pediatric Endocrinology, Tashkent Pediatric Medical Institute, 223 Bogishamol str., 100140 Tashkent, Uzbekistan. E-mail: nazirarikhsieva1507@gmail.com URMANOVA YULDUZ M., ORCID ID: 0000-0001-9776-053X, Dr. sc. med., Professor at the Department of Endocrinology, Pediatric Endocrinology, Tashkent Pediatric Medical Institute, 223 Bogishamol str., 100140 Tashkent, Uzbekistan. E-mail: yulduz.urmanova@mail.ru NARIMOVA GULCHEHRA D., ORCID ID: 0000-0002-1831-3633, Dr. sc. med., Head of the Department of Integrative and Preventive Endocrinology, Deputy Chief Physician, Republican Specialized Scientific and Practical Medical Center of Endocrinology named after Acad. Yo. Kh. Turakulov, 103 Mirzo Ulugbek str., Mirzo Ulugbek District, 100047 Tashkent, Uzbekistan. E-mail: mail@tashpmi.uz SAITMURATOVA OGULDZHAN Kh., ORCID ID: 0000-0002-7807-9463, Dr. sc. med., Professor at the Department of Histology and Pathological Physiology, Tashkent Pediatric Medical Institute, 223 Bogishamol str., 100140 Tashkent, Uzbekistan. E-mail: oguljon@inbox.ru KHAIDAROVA RAVSHANOY T., ORCID ID: 0009-0000-0173-5162, Cand. sc. med., Associate Professor at the Department of Endocrinology, Center for Developing Medical Professionals’ Vocational Qualifications at the Health Ministry of the Republic of Uzbekistan, 51 Parkent str., 100007 Tashkent, Uzbekistan. E-mail: mail@tashpmi.uz Abstract. Introduction. The clinical picture of primary hyperparathyroidism has changed over the past decades, mainly due to the early detection of hypercalcemia, and often occurs as an asymptomatic or oligosymptomatic disease. Aim. This study aims to evaluate the quality-of-life indicators in operated and non-operated patients with primary hyperparathyroidism in a comparative aspect at various times. Materials and Methods. The present study deals with the results of treatment of children who applied to the clinic of the specialized scientific and practical medical center of endocrinology in 2012-2022, 103 children with suspected primary hyperparathyroidism were examined according to anamnesis, outpatient cards, and detailed procedure reports. From among them, 90 children and adolescents with primary hyperparathyroidism were selected, where 50 patients are in the 1st group (after surgery) and 40 children and adolescences with primary hyperparathyroidism are in the 2nd group (no surgery). Numerical values obtained as a result of scientific research were statistically processed using MS Excel, arithmetic mean (M), mean standard error (m), standard deviation (Ϭ), relative values (% agreement), and Student’s t-test (t). Results and Discussion. It was found that the quality-of-life indicators in patients with primary hyperparathyroidism were significantly lower than in the control group, to a greater extent due to pain, general health, social functioning, and vitality (p&lt;0.05). Thus, in patients with primary hyperparathyroidism before surgery, a significant violation of both: the physical and mental components of the quality-of-life was established. Further, in the 1st group of patients with surgical treatment, in dynamics after 3 and 6 months, all quality-of-life indicators according to SF-36 were significantly closer to the control group in all domains. In the 2nd group of patients with conservative treatment in dynamics after 3, 6, 12 months and 10 years, all quality- of-life indicators according to SF-36 remained significantly lower than in the control group in all domains and did not change significantly. Conclusions. The results obtained demonstrate the positive effect of surgical treatment from the patient’s point of view and confirm the feasibility of assessing the quality of life both at the decision-making stage when choosing a surgical approach, and as part of a comprehensive assessment of the therapy effectiveness in determining the recovery degree of various functioning aspects in patients after surgery.

Metabolic syndrome in personnel of TUMS☆ and its association with types of occupations: A cross-sectional study

BackgroundMetabolic syndrome (MetS) causes an increased risk of cardiovascular disease and death. Hospital staff as an influential segment of the population are at risk of developing MetS. This study aimed to determine the occupational distribution of MetS in hospital staff and to examine the association between the type of occupation and the likelihood of developing MetS. MethodsIn this cross-sectional study we recruited 3128 personnel of TUMS, including healthcare workers, office workers and supportive workers of Tehran's University Teaching Hospitals during 2020–2022. Demographic, anthropometric indices and laboratory tests were recorded. MetS was determined using three definitions including ATP III recommendations, IDF and regional IDF criteria. Statistical analysis was performed using SPSS 26. ResultsMetS was observed in 641 (20.5%) subjects according to ATP III recommendations, 923 (29.5%) based on IDF and 713 (22.8%) using regional IDF criteria. Using regional IDF criteria, age, gender and occupational status were associated with the MetS occurrence (all p < 0.0001). Adjusting for the age and gender of participants, healthcare workers were less likely to develop MetS compared to both office workers (OR = 0.66, 95%CI for OR: 0.55–0.80, p < 0.0001) and supportive workers (OR = 0.72, 95%CI for OR: 0.58–0.90, p = .003). However, office workers and supportive workers did not differ significantly regarding this parameter (p = .44). ConclusionRegardless of the MetS definition criteria, the findings indicated an alarming MetS prevalence, particularly among supportive workers and office workers. Considering the significant role of hospital staff in patients’ health promotion, effective management is essential.

LUNG CANCER - RISK FACTORS AND PREVENTION STRATEGIES - OVERVIEW OF THE LITERATURE

Europäische Wissenschaftliche Gesellschaft Home About the Journal Peer Review Editorial Board For Authors Reviewer Recognition Archive Contact Impressum EWG e.V. Elektronische Zeitschriftbibliotek Logo Bielefeld Academic Search Engine Logo Erfolgreich durch internationale Zusammenarbeit ONCOLOGY Cite as: Archiv EuroMedica. 2024. 14; 3. DOI 10.35630/2024/14/3.344 Received 25 April 2024; Accepted 15 June 2024; Published 19 June 2024 LUNG CANCER - RISK FACTORS AND PREVENTION STRATEGIES - OVERVIEW OF THE LITERATURE Jakub Rybak1email orcid id logo, Barbara Magiera2orcid id logo, Karol Magiera1orcid id logo, Martyna Grabowska-Szczurek3orcid id logo, Alicja Grabarczyk4 orcid id logo, Piotr Bator1 orcid id logo, Michał Razik1 orcid id logo, Patrycja Rozwadowska1 orcid id logo, Karol Wielgus5 orcid id logo 1Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland 2Prof. K. Gibiński University Clinical Center of the Medical University of Silesia in Katowice, Poland 3The Hospital of the Bonifratres of St. John Grand in Cracow, Poland 4Students’ Scientific Society, Department of Gynecology and Obstetrics in Katowice, Medical University of Silesia, Katowice, Poland 5Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, Poland download article (pdf) rybakjak@gmail.com ABSTRACT Introduction and purpose: Lung cancer is the second most common cancer worldwide. The aim of this study is to analyze the key modifiable and non-modifiable risk factors associated with the development of lung cancer and to discuss existing prevention strategies. Materials and methods: A literature review was conducted using the "PubMed" database with the keywords "lung cancer", "lung cancer risk factors", "lung cancer prevention”. Results: Lung cancer risk factors can be divided into two groups: modifiable and non-modifiable. Modifiable risk factors include: smoking, radon, diet, chronic lung diseases, asbestos and diesel fumes. Non-modifiable risk factors include: age, race, genetic factors and gender. In primary prevention of lung cancer it is important to reduce exposure to risk factors, especially cigarette smoke. Screening using low-dose computed tomography plays a major role in secondary prevention. Conclusion: Lung cancer is one of the most frequent malignant tumors. Over the years, enormous progress has been made in the fight against lung cancer. Despite a large reduction in smoking prevalence, cigarette smoking remains the most important risk factor of lung cancer. Several other factors have been identified, with e.g. asbestosis exposure and air pollutants being among top-5 risk factors with the highest impact. Effective methods of primary and secondary prevention such as health campaigns and screening tests have led to a reduction in the incidence of lung cancer. Smoking cessation and low-dose chest CT screening were proven to be the most effective in the lung cancer prevention. However, lung cancer remains the most common cause of death in cancer patients so further research and effective and practical public health policy are crucial in decreasing incidence and mortality.

Diuretic response after neonatal cardiac surgery: a report from the NEPHRON collaborative.

Multicenter early diuretic response (DR) analysis of single furosemide dosing following neonatal cardiac surgery is lacking to inform whether early DR predicts adverse clinical outcomes. We performed a retrospective cohort study utilizing data from the NEPHRON registry. Random forest machine learning generated receiver operating characteristic-area under the curve (ROC-AUC) and odds ratios for mechanical ventilation (MV) and respiratory support (RS). Prolonged MV and RS were defined using ≥ 90th percentile of observed/expected ratios. Secondary outcomes were prolonged CICU and hospital length of stay (LOS) and kidney failure (stage III acute kidney injury (AKI), peritoneal dialysis, and/or continuous kidney replacement therapy on postoperative day three) assessed using covariate-adjusted ROC-AUC curves. A total of 782 children were included. Cumulative urine output (UOP) metrics were lower in prolonged MV and RS patients, but DR poorly predicted prolonged MV (highest AUC 0.611, OR 0.98, sensitivity 0.67, specificity 0.53, p = 0.006, 95% OR CI 0.96-0.99 for cumulative 6-h UOP) and RS (highest AUC 0.674, OR 0.94, sensitivity 0.75, specificity 0.54, p < 0.001, 95% CI 0.91-0.97 UOP between 3 and 6h). Secondary outcome results were similar. DR had fair discrimination for kidney failure (AUC 0.703, OR 0.94, sensitivity 0.63, specificity 0.71, 95% OR CI 0.91-0.98, p < 0.001, cumulative 6-h UOP). Early DR poorly discriminated patients with prolonged MV, RS, and LOS in this cohort, though it may identify severe postoperative AKI phenotype. Future work is warranted to determine if early DR or late postoperative DR later, in combination with other AKI metrics, may identify a higher-risk phenotype.

Increasing Antibiotic-Resistant Infections With Inpatient Endoscopic Retrograde Cholangioscopies (ERCP) Is Associated With Higher Mortality in the United States: A Cross-sectional Cohort Study.

This study aims to investigate associated mortality with inpatient endoscopic retrograde cholangiopancreatography (ERCP) with and without resistant infections. The co-primary objective compares frequencies of inpatient ERCP with resistant infections to overall hospitalizations with resistant infections. The risks of inpatient antibiotic-resistant organisms are known, but the associated mortality for inpatient ERCP is unknown. We aim to use a national database of hospitalizations and procedures to understand trends and mortality for patients with antibiotic-resistant infections during inpatient ERCP. The largest publicly available all-payer inpatient database in the United States (National Inpatient Sample) was used to identify hospitalizations associated with ERCPs and antibiotic-resistant infections for MRSA, VRE, ESBL, and MDRO. National estimates were generated, frequencies were compared across years, and multivariate regression for mortality was performed. From 2017 to 2020, national weighted estimates of 835,540 inpatient ERCPs were generated, and 11,440 ERCPs had coincident resistant infections. Overall resistant infection, MRSA, VRE, and MDRO identified at the same hospitalization of inpatient ERCPs were associated with higher mortality (OR CI(95%): Overall: 2.2(1.77-2.88), MRSA: 1.90 (1.34-2.69), VRE: 3.53 (2.16-5.76), and MDRO: 2.52 (1.39-4.55)). While overall hospitalizations with resistant infections have been decreasing annually, there has been a yearly increase in admissions requiring ERCPs with simultaneous resistant infections ( P =0.001-0.013), as well as infections with VRE, ESBL, and MDRO ( P =0.001-0.016). Required Research Practices for Studies Using the NIS scoring was 0, or the most optimal. Inpatient ERCPs have increasing coincident resistant infections and are associated with higher mortality. These rising infections during ERCP highlight the importance of endoscopy suite protocols and endoscopic infection control devices.

Discontinuity between journals' registration and submission requirements for Open Researcher and Contributor ID (ORCID)

Discontinuity between journals' registration and submission requirements for Open Researcher and Contributor ID (ORCID)

Low HDL-C and the Risk of Hospitalisation in Children with COVID-19.

To investigate high-density lipoprotein cholesterol (HDL-C) levels in children with COVID-19. Descriptive study. Place and Duration of the Study: Goztepe Professor Suleyman Yalcin City Hospital, Istanbul, Turkiye, between 2020 and 2022. The hospital data were examined to find children (<18 years) who presented with COVID-19. The associations between HDL-C, inflammatory biomarkers, hospital admission requirements, and prolonged hospital stays in children with COVID-19 were analysed. During the study period, 1,056 children were diagnosed with COVID-19. Lipid levels were measured in 193 patients during outpatient clinic visits from the same hospital records. One hundred and twenty-seven (65.5%) patients displayed low HDL-C levels. One hundred and nine (86.5%) of the patients with low HDL-C and 33 (50.0%) of the patients with normal HDL-C were hospitalised (p=0.012). Patients with lower HDL-C exhibited higher triglyceride (median 124 vs. 81 mg/dl, p<0.001), glucose (median 116 vs. 101 mg/dl, p=0.001), lactate dehydrogenase (LDH) (median 343 vs. 251 mg/dl, p<0.001), C-reactive protein (CRP) (median 0.6 vs. 0.5 mg/L, p=0.009), D-dimer (median 1.3 vs. 0.3 mcg/mL, p<0.001), ferritin (median 127 vs. 40 µg/L, p<0.001), and uric acid (median 5.5 vs. 4.5 mg/dL, p=0.002) levels compared to children with normal HDL-C. Logistic regression (LR) analysis showed that age (OR = 0.87, CI for OR 0.80-0.94, p < 0.001), ferritin (OR = 1.004, CI for OR 1.001-1.006, p = 0.003), and D-dimer (OR = 2.171, CI for OR 1.183-3.984, p = 0.012) were associated with lower HDL-C level in children with COVID-19. Low HDL-C levels were common in children with COVID-19. Children with COVID-19 and low HDL-C were more frequently hospitalised and had higher inflammatory biomarkers of COVID-19 than children with COVID-19 and normal HDL-C levels. HDL-C, HDL-C levels in children, COVID-19, Children with COVID-19.

ScienceOpen

ScienceOpen is a free aggregator database for scientific literature, including open access and preprint publications. The inclusion of altmetrics and linked citations will be of interest to scholars tracking their own author impact and/or conducting systematic reviews. Additional levels of access, including peer reviews and commenting, are available to users who provide their ORCID ID and link publications.

Developing systems to encourage FAIR and secure research data

Welcome to first issue of IASSIST Quarterly for 2024; this is Volume 48 of the journal (IQ 48(1) 2024). The three papers in this issue represent different aspects of researchers’ use of data archives. Experts from three major data archives (ICPSR, IPUMS, and GESIS) share their experiences developing systems to make research resources in their archives more findable, accessible, and usable. Lafia, Million, and Hemphill in their article “Exploratory and directed search strategies at a social science data archive” investigate search strategies of users of a large social science data archive. In an effort to understand how users search for curated research data, the authors analyze data queries issued through the Inter-University Consortium for Political and Social Research (ICPSR) website’s search box. The study is meant to inform archives and repositories of their users’ experience and help develop systems that encourage dataset findability, accessibility and reuse. The authors identify two types of data searches, exploratory and directed searches. They find that while users that issued exploratory queries were able to navigate the ICPSR website successfully and refine their searches, they may benefit from more explicit support for query reformation. The authors suggest ways development of tools and training could improve users’ experience. In the article “Stewarding our resources: Building a sustainable IPUMS archival document access system” Daina Magnuson describes IPUMS experience building a web interface to support exploration and dissemination of archival materials associated with IPUMS International (IPUMS-I). Ancillary materials, including thousands of unique pieces of census and survey documentation were obtained by IPUMS-I during data acquisition efforts. This rich source material was curated and preserved by archival staff. Magnuson describes in details the development of a system that would make these resources findable, searchable and downloadable to internal users as well as IPUMS researchers. Strategies describe may inform other data archives considering developing similar tools. Deborah Wiltshire in her article “Developing canonical ‘Safe Researcher’ training materials for Trusted Research Environment” describes the development of training materials for researchers applying to access restricted data through Trusted Research Environment (TRE). The increased use of a virtual desktop environment, as opposed to physical safe rooms, offers researchers easier and more flexible access to restricted data; however, it offers fewer physical safeguards. Attending a mandatory ‘Safe Researcher’ training is one of the principles of the Five Safe Framework[i] developed by the UK’s Office for National Statistics to bridge this gap and assure the safe use of sensitive data. The process described in the article could be easily adapted by other TREs according to their needs and settings (e.g., in-person vs. online training). In the spirit of making information findable, accessible and reusable, we’re happy to share that the Open Journal System platform from the University of Alberta has enabled author linking to ORCID. This means that IQ authors are now able to connect their ORCID iDs to their IQ publications, so that their ORCID profiles will automatically update with those citations as their articles are published. For existing IQ account holders, log into your account at the upper right of the IQ page, and go to Profile &gt; Public. Then click “Create or Connect your ORCID iD” (just below the Homepage URL field). For details, see this video walkthrough of profile authentication. New IQ users will automatically be prompted to link (or create) their ORCID iDs during IQ account creation. Authors are also encouraged to note their ORCID iD link with their affiliation and contact information in an endnote when submitting a manuscript for publication. We hope to see many of you at the 49th Annual IASSIST Conference in Halifax, Nova Scotia, Canada, May 28-31, 2024! Ofira Schwartz and Michele Hayslett, March 2024

THE ROLE OF THE NATIONAL CONSORTIUM ORCID UKRAINE IN ADVANCING OPEN SCIENCE POLICY

This article explores the pivotal role played by the National Consortium ORCID Ukraine in effectively implementing the Open Science Policy within the Ukrainian research landscape. . The article delves into the strategies employed by the consortium to promote ORCID iDs (Open Researcher and Contributor IDs) and their integration into various research processes to enhance research transparency, streamline collaboration, and establish a robust foundation for open science practices. Emphasizing the significance of ORCID iDs in uniquely identifying researchers, the discussion also highlights their impact on reducing authorship ambiguity and ensuring accurate attribution of scholarly contributions. Furthermore, the article explores the broader implications of promoting open science in Ukraine, emphasizing the positive correlation between research transparency and economic development. It is shown that by facilitating a more transparent and collaborative research environment, the National Consortium ORCID Ukraine generates high-quality research outputs, fosters innovation, and attracts investment. The experiences and successes of the consortium in advocating for open science principles, along with the challenges encountered and lessons learned, are detailed. Particularly, it highlighted the challenges and the technical complexity associated with using the ORCID Affiliation Manager tool by Ukrainian research institutes and ensuring compatibility and seamless data transfer between the digital repository system DSpace and the editorial workflows of the publishing platform OJS. The article concludes by underscoring the critical role that initiatives like the National Consortium ORCID Ukraine play in shaping a research ecosystem that not only adheres to open science principles but also stimulates economic growth through knowledge dissemination and collaboration.

Discrepancies in Publication Volume Per Matched-Applicant Between Sex, Geographic Regions and Program Affiliation in the 2023 Orthopaedic Surgery Residency Match

Objective: This study aims to examine potential gender-based publication disparities among 2023 orthopaedic surgery matched-applicants, investigate variations in research emphasis based on program affiliation and assess publication differences across different geographic regions. Methods: Orthopaedic surgery residency programs participating in the 2023 NRMP with a publicly available incoming resident class were identified using the NRMP database. Each resident was searched using PubMed and ORCID identifiers for publications. Each program was designated as “university-based”, “community-based”, “community-based/university affiliated” or “other” using the American Medical Association’s FRIEDA database. Results: In total, 763 residents were identified with a mean and median number of publications of 6.1 (SD=10.0) and 3.0 (IQR=1.0-7.0) respectively. There was no significant difference in the median number of publications between males (2.0) and females (3.0, p=0.2315). Those who matched to “community-based/university affiliated” (median=2.0) programs had a lower median number of publications than those who matched to “university-based” (median=3.0, p&lt;0.0001) or “other” (median=6.0, p=0.0006). Geographically, applicants in the West-South Central region (median=1.0) had the lowest publication median compared to those in the New England (median=4.0, p=0.0010) or Pacific (median=4.0, p=0.0015) regions. Conclusion: There lies a perceived increase in significance of research publications for competitiveness in the orthopaedic surgery match. This largely follows the elimination of objective Step-1 scoring to help stratify potential applicants. Research remains an objective manner to stratify applicants; however, new data lacks on recent analysis of the 2023 match pool. There was not a significant difference in the number of publications between male vs female matched-applicants. The program category “other” and the New England and Pacific regions had the highest median number of publications. Keywords: Orthopaedics; Medical Residency; Graduate Medical Education; Medical School; Residency Match; Orthopaedic Education; Orthopaedic Residency

Analisis Faktor Risiko Kejadian Musculoskletal Disorders (MSDS) Pada Pekerja Officer dan Welder Menggunakan Metode Nordic Body Map di PT XYZ Kota Batam

Musculoskeletal Disorders (MSDS) is an occupational risk characterized by complaints in the muscles. MSDS occurs due to incorrect body posture while working which causes muscles to stretch too hard over a long period of time. PT. Officer and welder workers are at risk of MSDS occurring which is caused by many factors. This research is descriptive analytical with a total population of 30 officers and welders. The sampling technique uses saturated samples and primary and secondary data sources. Data collection methods are field observation, questionnaires and interviews. The research instrument was a checklist using the Nordic Body Map (NBM), a list of question items and interview guidelines. The research results show that there is an influence of work period, length of work and work attitude on the incidence of MSDS. Based on the results of the simple logistic regression test, the length of service variable was p=0.027 and OR 10.00 CI 95% (0.994-100.612). The length of work variable obtained a value of p=0.010 and OR CI 95% 13.71 (1.381-136.212) and the work attitude variable had a value of p=0.003 CI 95% 18.66 (1.879-185.399).

Relationship between Subclinical Hypothyroidism and Uremic Pruritis in Hemodialysis Patients.

Uremic pruritus (UP) is one of the most distressing symptoms in hemodialysis (HD) patients. Subclinical hypothyroidism (SCH) is a biochemical condition with high prevalence in HD patients. The present multicentric study aimed to assess the relationship between UP and SCH in HD patients. The present cross-sectional study included 328 HD patients. All patients were submitted to careful history through clinical examination and standard laboratory assessment. Pruritis was evaluated using the pruritis visual analog scale (VAS). Patients were diagnosed with SCH if they had TSH levels above the upper limit of the normal reference range in association with normal free thyroxine (FT4) levels. Among the studied patients, there were 196 patients (59.8 %) with UP. Comparison between patients with UP and patients without revealed that patients in the former group had significantly longer HD duration (median (IQR): 47.5 (27.0-72.5) versus 36.0 (23.0-50.5) months, p < 0.001) and lower Kt/v (median (IQR): 1.4 (1.09-1.7) versus 1.54 (1.12-1.91), p = 0.009). Moreover, they had significantly higher ferritin (median (IQR): 653.0 (526.0-800.0) versus 628.0 (470.8- 716.0) ng/mL), hsCRP (median (IQR): 12.0 (8.0-14.0) versus 8.0 (6.0-9.0) mg/dL, p < 0.001) and TSH levels (median (IQR): 4.34 (1.98-5.2) versus 3.34 (1.9-4.85) μIU/ml) with a significantly higher frequency of SCH (45.9 % versus 28.8 %, p = 0.002). Logistic regression analysis identified hemodialysis duration (OR (95%) CI): 1.02 (1.009-1.028), p < 0.001), ferritin levels (OR (95% CI): 1.002 (1.001-1.003), p < 0.001), and SCH (OR (95% CI): 0.54 (0.32-0.89), p = 0.016) as significant predictors of UP. The present study suggested a possible link between SCH and the development of UP in HD patients.

Synthesis of Acetylsalicylic Acid – An Environmentally Friendly Approach

Background: The aim of this study was to compare the yields of acetylsalicylic acid synthesis based on the traditional approach and green chemistry approach. Green chemistry is one of the most important approaches in pharmaceutical sustainability. The reagents used for the acetylsalicylic acid synthesis can be environmentally harmful, so there is a need for a better and safer alternative. Methods: We conducted five syntheses based on the traditional approach and five syntheses based on the green chemistry approach. The synthesis process was identical except for one part – traditional synthesis used sulfuric acid and green chemistry synthesis used phosphoric acid. After synthesis, theoretical and experimental yields were calculated. The obtained products were tested using high performance liquid chromatography.Main findings: The theoretical yield of acetylsalicylic acid in both reactions was determined as 3.896 g. Traditional synthesis gave us a mean yield of 3.113 g (79.8%). Green chemistry synthesis gave us a mean yield of 3.104 g (79.4%). The quality of both products was confirmed by the above-mentioned chromatography method. There was no statistically significant difference between the means of the product masses (p=0.8220).Principal conclusions: Phosphoric acid can be used as a safe alternative to acetylsalicylic acid synthesis instead of sulfuric acid. As phosphoric acid is much safer than sulfuric acid in terms of environmental impact, these findings can be used in the pharmaceutical industry setting to obtain a better, cleaner and safer alternative to acetylsalicylic acid synthesis.Key words: acetylsalicylic acid, synthesis, green chemistry, medicinal chemistryArticle processing history:Received July 19, 2023 Revised November 7, 2023 Accepted November 21 , 2023 ORCID IDs of the authors: L.G. 0009-0005-9137-6218M.K. 0000-0003-3904-4994Corresponding author:Assistant Professor Martin Kondža, PhD; Faculty of Pharmacy, University of Mostar, Matice hrvatske bb, 88000Mostar, Bosnia and HerzegovinaE‒mail: martin.kondza@farf.sum.baCite this article as: Golemac L, KondžaM. Synthesis of acetylsalicylic acid –an environmentally friendly approach. Annals of Biomedical and Clinical Research. 2023;2:100 -108 . https://doi.org/Copyright © School of Medicine, University of Mostar 2023

Cancer rates and characteristics of thyroid nodules with macrocalcification.

The aim of this study was to determine the malignant potential of thyroid nodules with macrocalcifications and to evaluate the role of other sonographic findings in the diagnosis of malignancy in thyroid nodules besides macrocalcifications. The findings of 8250 patients who applied to our outpatient clinic and underwent thyroid ultrasonography(US) between 2008 and 2021 were retrospectively reviewed. We included a total of 296 patients with 296 macrocalcified nodules (macrocalcification group) and an age- and sex matched group of 300 patients (control group) with the cytopathologic and/or histopathologic data of fine-needle aspiration biopsy (FNAB) of thyroid nodules without calcification. Demographic characteristics of these patients, US characteristics of the nodules, and thyroid function tests were recorded. Cytopathological data of FNAB were classified according to BETHESDA. The malignancy rate was 14.2% (42/296) in the macrocalcification group and 5.3% (16/300) in the control group (p < 0.001). There was no significant relationship between interrupted peripheral calcification and malignancy. Hypoechoic or markedly hypoechoic appearance, irregular border, solid structure, presence of accompanying pathological lymphadenopathy on sonographic examination and upper and middle zone localization were other sonographic features that increased the risk of malignancy of a nodule. The presence of autoimmunity was not found to be associated with the risk of malignancy. TSH and calcitonin levels of malignant nodules were higher than benign nodules. There was no significant difference between gender and malignancy. In the univariate analysis, it was found that the presence of macrocalcification increased the risk of malignancy 2.935 times. (OR:2.935, p < 0.001.95% CI for OR 1.611-5.349) In addition, being younger, being in the high TIRADS category, and being in the upper and middle zones were factors that increased the risk of malignancy. Gender, TSH level, nodule volume and structure were not associated with malignancy. However, after multivariate analysis, factors that significantly increased the risk of malignancy were younger age, higher TIRADS category, and nodule localization. In our study, the malignancy rate was higher in the macrocalcification group than in the control group. However, no correlation was found after multivariate analysis. In the multivariate analysis, younger age, higher TIRADS category, and nodules located in the upper and middle zone were other factors associated with malignancy. There was no association between peripheral interrupted calcification and malignancy risk.