ASSESSMENT OF QUALITY-OF-LIFE INDICATORS IN OPERATED AND NON-OPERATED PATIENTS WITH PRIMARY HYPERPARATHYROIDISM IN A COMPARATIVE ASPECT AT DIFFERENT TIMES

Abstract

ВЕСТНИК СОВРЕМЕННОЙ КЛИНИЧЕСКОЙ МЕДИЦИНЫ 2024 Том 17, вып. 4 127ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ © K.К. Nasirova, N.T. Rikhsieva, Y.M. Urmanova, G.D. Narimova, O.К. Saitmuratova, R.T. Кhаydarova, 2024 УДК:7696.332-796.422.12/16:796.92-519.63 DOI: 10.20969/VSKM.2024.17(4).127-134 ASSESSMENT OF QUALITY-OF-LIFE INDICATORS IN OPERATED AND NON-OPERATED PATIENTS WITH PRIMARY HYPERPARATHYROIDISM IN A COMPARATIVE ASPECT AT DIFFERENT TIMES NASIROVA KHURSHIDAХON К., ORCID ID: 0000-0002-8104-5037, Dr. sc. med., Head of the Department of Endocrinology, Pediatric Endocrinology, Tashkent Pediatric Medical Institute, 223 Bogishamol str., 100140 Tashkent, Uzbekistan. E-mail: hursh77@mail.ru RIKHSIEVA NAZIRA T., ORCID ID: 0000-0001-9790-1208, Cand. sc. med., Associate Professor at the Department of Endocrinology, Pediatric Endocrinology, Tashkent Pediatric Medical Institute, 223 Bogishamol str., 100140 Tashkent, Uzbekistan. E-mail: nazirarikhsieva1507@gmail.com URMANOVA YULDUZ M., ORCID ID: 0000-0001-9776-053X, Dr. sc. med., Professor at the Department of Endocrinology, Pediatric Endocrinology, Tashkent Pediatric Medical Institute, 223 Bogishamol str., 100140 Tashkent, Uzbekistan. E-mail: yulduz.urmanova@mail.ru NARIMOVA GULCHEHRA D., ORCID ID: 0000-0002-1831-3633, Dr. sc. med., Head of the Department of Integrative and Preventive Endocrinology, Deputy Chief Physician, Republican Specialized Scientific and Practical Medical Center of Endocrinology named after Acad. Yo. Kh. Turakulov, 103 Mirzo Ulugbek str., Mirzo Ulugbek District, 100047 Tashkent, Uzbekistan. E-mail: mail@tashpmi.uz SAITMURATOVA OGULDZHAN Kh., ORCID ID: 0000-0002-7807-9463, Dr. sc. med., Professor at the Department of Histology and Pathological Physiology, Tashkent Pediatric Medical Institute, 223 Bogishamol str., 100140 Tashkent, Uzbekistan. E-mail: oguljon@inbox.ru KHAIDAROVA RAVSHANOY T., ORCID ID: 0009-0000-0173-5162, Cand. sc. med., Associate Professor at the Department of Endocrinology, Center for Developing Medical Professionals’ Vocational Qualifications at the Health Ministry of the Republic of Uzbekistan, 51 Parkent str., 100007 Tashkent, Uzbekistan. E-mail: mail@tashpmi.uz Abstract. Introduction. The clinical picture of primary hyperparathyroidism has changed over the past decades, mainly due to the early detection of hypercalcemia, and often occurs as an asymptomatic or oligosymptomatic disease. Aim. This study aims to evaluate the quality-of-life indicators in operated and non-operated patients with primary hyperparathyroidism in a comparative aspect at various times. Materials and Methods. The present study deals with the results of treatment of children who applied to the clinic of the specialized scientific and practical medical center of endocrinology in 2012-2022, 103 children with suspected primary hyperparathyroidism were examined according to anamnesis, outpatient cards, and detailed procedure reports. From among them, 90 children and adolescents with primary hyperparathyroidism were selected, where 50 patients are in the 1st group (after surgery) and 40 children and adolescences with primary hyperparathyroidism are in the 2nd group (no surgery). Numerical values obtained as a result of scientific research were statistically processed using MS Excel, arithmetic mean (M), mean standard error (m), standard deviation (Ϭ), relative values (% agreement), and Student’s t-test (t). Results and Discussion. It was found that the quality-of-life indicators in patients with primary hyperparathyroidism were significantly lower than in the control group, to a greater extent due to pain, general health, social functioning, and vitality (p<0.05). Thus, in patients with primary hyperparathyroidism before surgery, a significant violation of both: the physical and mental components of the quality-of-life was established. Further, in the 1st group of patients with surgical treatment, in dynamics after 3 and 6 months, all quality-of-life indicators according to SF-36 were significantly closer to the control group in all domains. In the 2nd group of patients with conservative treatment in dynamics after 3, 6, 12 months and 10 years, all quality- of-life indicators according to SF-36 remained significantly lower than in the control group in all domains and did not change significantly. Conclusions. The results obtained demonstrate the positive effect of surgical treatment from the patient’s point of view and confirm the feasibility of assessing the quality of life both at the decision-making stage when choosing a surgical approach, and as part of a comprehensive assessment of the therapy effectiveness in determining the recovery degree of various functioning aspects in patients after surgery.