Oral Pregabalin Research Articles

Pregabalin Versus Duloxetine on Postoperative Analgesic Requirement Following Lower Extremity Trauma Surgeries: A randomised, Clinical Trial.

The use of pregabalin versus duloxetine in postoperative lower limb traumatic pain has not been compared. The aim of this study was to evaluate the response rate of rescue analgesic requirement with perioperative pregabalin versus duloxetine in lower limb trauma surgeries. In this randomised, clinical trial, 60 patients of American Society of Anesthesiologists physical status I-II undergoing lower limb trauma surgery were randomised to receive oral pregabalin 150 mg day-1 or duloxetine 60 mg day-1, 2 hours prior to surgery and then once daily for next 2 days postoperatively. The surgery was performed under standardised spinal anaesthesia technique. The investigator was blinded to the study drug, oral paracetamol 1 g every 6 hours and intravenous diclofenac 75 mg was a rescue analgesic. The primary outcome of the study was response rate in terms of rescue analgesia requirement. Secondary outcomes included total rescue analgesia, visual analogue scale at rest and on movement, haemodynamics, anxiety depression score, and patient satisfaction score and adverse effects. In group pregabalin, 60% of patients required the first dose of rescue analgesia versus 50% in group duloxetine for 72 hours postoperatively. In group pregabalin, 6.6% of patients required the second dose of rescue analgesia after a mean duration of 24 hours, and 10% of patients in group duloxetine required the second dose after a mean duration of 40 hours. The visual analogue scale scores, time to first rescue, and cumulative rescue analgesic were comparable in both the groups. Equivalent rate-responsive rescue analgesia was required in patients receiving pregabalin or duloxetine following lower limb trauma surgery.

A Randomized, Double-Blind, Prospective Study to Evaluate the Effect of Oral Pregabalin in Upper Limb Surgeries Under Brachial Plexus Block

ContextThe oral pregabalin administration preoperatively has been reported to reduce acute postoperative pain and prolong the duration of anesthesia produced by single-injection peripheral nerve blockade.AimTo study the effect of single dose pregabalin on duration of brachial plexus blockSettings and designProspective, randomised, double blind, comparative studyMaterial and methodsPatients were divided into two groups (groups A and B), with each group having 50 patients. In group A, the patient received a pregabalin capsule of 300 mg orally two hours before surgery with a sip of water. Group B received a placebo (vitamin B complex capsule) orally two hours before surgery. Brachial plexus block was performed, and data was collected.Statistical analysisData analysis was done using SPSS version 21.0 statistical analysis software. Demographic data and clinical variables were compared using the student's t-test, chi-square test, and Mann-Whitney U test.ResultsThe requirement of the first dose of analgesia was significantly earlier in group B as compared to group A (4:56±0:20 vs. 8:01±0:30 hours). Group B patients, as compared to group A patients, had significantly higher levels of pain after two hours of surgery (0.32±0.47 vs. 0.00±0.00) and at four hours of surgery (2.42±0.50 vs. 0.34±0.59).ConclusionsOral pregabalin prolongs analgesia from brachial plexus block without significant effect on the motor block. In addition, premedication with oral pregabalin increases the sensory block of brachial plexus block.

Oral pregabalin as preemptive analgesia and reduces the dose of diclofenac consumption during the postoperative period of gynaecological operation under spinal anaesthesia- a randomized, placebo-controlled study

Oral pregabalin as preemptive analgesia and reduces the dose of diclofenac consumption during the postoperative period of gynaecological operation under spinal anaesthesia- a randomized, placebo-controlled study

Analgesic Efficacy of Pre-Operative Oral Pregabalin in Dacryocystorhinostomy Surgery

Background: External dacryocystorhinostomy (DCR) is still considered the golden standard for lacrimal surgery. It is a painful procedure that involves intra- and extra-ocular dissection with a high prevalence post-operative nausea and vomiting (PONV). Aims: This study was designed to evaluate the effects of preoperative oral pregabalin on postoperative pain and analgesic requirements in patients undergoing DCR surgery. Design: A prospective randomized double-blind clinical trial. Patients and methods: 100 American Society of Anesthesiologists (ASA) physical classes I and II patients in an age ranging from 18 to 65 years of either sex, had DCR surgery. Patients were divided randomly into two equal groups (each = 50). In pregabalin group, they received two capsules of pregabalin (one at the night of the surgery, the other at 2 hours before the surgery), while patients in control group received two identical placebo capsules. Hemodynamics were monitored, postoperative VAS scores, the time of first analgesic request, total pethidine requirements, and the incidence of PONV were recorded as well. Statistical analysis: A prospective analysis of the collected data was performed using the SPSS program for Windows (version 22). Results: The pregabalin group exhibited a significant lower incidence of postoperative pain, pethidine consumption and nausea, without any statistically significant differences regarding hemodynamic parameters in comparison to control group. Conclusion: Preoperative oral administration of pregabalin can be a promising modality for alleviation of postoperative pain and reduction in postoperative opioid consumption.

Analgesic Efficacy of Pre-Operative Oral Pregabalin in Dacryocystorhinostomy Surgery

Analgesic Efficacy of Pre-Operative Oral Pregabalin in Dacryocystorhinostomy Surgery

Post-operative Analgesic and Opioid-sparing Effect of a Single-dose Pre-operative Oral Pregabalin in Gynaecological Surgeries.

Post-operative pain treatment is a major challenge in our environment. Opioids may cause respiratory depression post-operatively. Therefore, any combination of opioid and non-opioid analgesics that provides quality post-operative pain control and reduces opioid consumption with its attendant side effects will be highly desirable. The aim of this article is to evaluate analgesic benefits and opioid-sparing effects of pre-operative oral pregabalin in patients who undergo abdominal gynaecological surgeries. A prospective randomized double-blind placebo-controlled study is carried out at University of Ilorin Teaching Hospital, Kwara State, Nigeria. Eighty-two patients scheduled for gynaecological surgeries were randomized into two equal groups. The patients in the control and study groups received a placebo drug and oral pregabalin 150 mg, respectively, 1 h before induction of general anaesthesia. Post-operative pain intensity using a five-point Verbal Rating Scale, time to first request for analgesia, and 24 h post-operative pethidine consumptions were assessed. Mean values were compared using Student's t-test. Categorical data were compared with the χ 2 test. Level of significance was set at 5% (0.05) and power of the study was 80%. Demographic characteristics were comparable between the two groups. The median pain score was 0-2 (no pain-moderate pain) throughout the study. Post-operative static and dynamic pain scores at 1, 4, and 12 h were significantly higher in the placebo group (<0.001). Twenty-four hours post-operatively, there were no significant differences in static and dynamic pain scores between the two groups (P=0.131 and P=0.384, respectively). Time to first analgesic requirement and total pethidine consumed within 24 h post-operative were 47 ± 19 vs. 258 ± 137 min (P=0.001) and 326.19 ± 62.70 vs. 192.86 ± 55.84 mg (P=0.001) in the control and study groups, respectively. The pre-operative use of pregabalin reduced post-operative opioid requirement by 40.9% in the study group. Nausea and vomiting were more common in the placebo group, whereas dizziness, blurring of vision, and sedation were more common in the pregabalin group. A single pre-operative dose of 150 mg oral pregabalin had significantly greater analgesic effects compared with placebo and reduced post-operative opioid requirements in patients undergoing myomectomy or total abdominal hysterectomy. It should be considered an adjuvant in multimodal pain management regimens following gynaecological surgeries.

Comparison of lidocaine and ropivacaine stellate ganglion blockade in treating upper limb postherpetic neuralgia.

To provide a basis for treating postherpetic neuralgia (PHN), we compared the efficacy of lidocaine and ropivacaine stellate ganglion block (SGB) in PHN treatment in the upper limbs.Data from 252 patients with upper-limb PHN were retrospectively analyzed. The lidocaine group (n = 118) was treated with oral pregabalin capsules 75 mg twice a day, tramadol hydrochloride sustained release tablets 100 mg twice a day, and amitriptyline 25 mg once at night combined with ultrasound-guided lidocaine SGB; the ropivacaine group (n = 134) was orally administered the same medicines combined with ultrasound-guided ropivacaine SGB. The visual analog scale (VAS), self-rating anxiety scale (SAS), and adverse reactions were compared between the groups before treatment and at 1 week, 1 month, and 3 months after treatment.There were no significant differences between the lidocaine and ropivacaine groups in terms of sex, age, height, weight, and pain duration (P > .05). There was no significant difference between the groups in VAS and SAS scores before treatment (P > .05). At 1 week, 1 month, and 3 months after ultrasound-guided SGB treatment, the VAS and SAS scores were significantly lower in the ropivacaine group than in the lidocaine group (P < .05). There were no significant differences between the groups in terms of adverse reactions (P > .05).For ultrasound-guided SGB treatment of upper limb PHN, ropivacaine is superior to lidocaine. Ultrasound-guided ropivacaine SGB is safe and effective for the treatment of upper limb PHN.

COMPARISON OF THE EFFECTS OF PRE-EMPTIF ANALGESIA PREGABALINE 75 WITH 150 MG ON THE GRADE OF PAIN AND CAESARIAN SECTION SEDATION SCORE WITH SUBARAKHNOID BLOCK

In recent years, many studies have been carried out on the pre-emptive analgesia of pregabalin for various types of surgery with varying results. Preemptive analgesia in caesarean section (SC) usually uses pregabalin at a dose of 150 mg, and there have been no studies using low doses (75 mg) Objective This study aimed to determine the effects of pregabalin 75 mg vs 150 mg doses for controlled pain, their sedation score in patients after C-section under spinal anesthesia. Methods This study was a double-blind randomized trial study examining 20 samples of patients who underwent elective C-sections under spinal anesthesia and divided into 2 equal groups, P75 (who received oral pregabalin 75 mg) and P150 (who received pregabalin 150 mg). The Results There were no significant differences in NRS between the 75 vs 150 mg group (p&gt;0.05), and there were significant differences in Ramsay sedation score between the 75 vs 150 mg group on 2 and 6 hours after surgery(p&lt;0.05) and there were no significant differences about the need for fentanyl rescue between 75 vs 150 mg group (p&gt;0.05). Pregabalin has an opioid-sparing effect and larger doses of pregabalin may increase its efficacy. The sedative effect that arises is due to the mechanism of action of pregabalin which binds potently to the 2δ subunit calcium channel and modulates calcium influx at nerve endings, thereby reducing the release of several excitatory neurotransmitters (glutamate), such as the mechanism of action of various intravenous and inhaled anesthetic agents. Preemptive administration of pregabalin 75 mg is recommended for C-section surgery because it might reduce NRS and the need for fentanyl rescue with minimal sedation side effects.

Taste masking of oral pregabalin liquid preparation by using ion exchange resins

The purpose of this study was to use cation exchange resins to mask Pregabalin's unpleasant taste. Dowex-50, a crosslinked polystyrene backbone, was employed. DRCs were synthesised in batches with drug-to-resin ratios of 1:1, 1:2, and 1:3. The optimal drug-to-resin ratio as well as the time required for maximum complexation were discovered. In this work, an attempt was made to develop a taste-masked Pregabalin solution using a simple, rapid, and cost-effective flavour masking approach, such as complexation among ion exchange resin, that could be acceptable to industries. To mask the flavour, researchers used a combination of ion-exchange resins such as doshion P 542, Tulsion 344, Indion 234, Indion 204, and Kyron T 114, as well as formulation into a solution. The generated suspensions were tested for taste, drug content, particle size, viscosity, sedimentation volume, drug release, and accelerated stability. Kyron T 114 has been shown to effectively disguise the drug among the various resins. The newly developed formulation also has the benefit of simplifying the manufacturing process and being cost-effective. According to drug release studies, the entire medicament was released within 20 minutes.

Comparison of effect of preemptive use of oral gabapentin and pregabalin for acute postoperative pain after Partial Thyroidectomy

Background and Aims: Preemptive analgesia is defined as a treatment that is initiated before surgery in order to prevent the establishment of central sensitization evoked by the incisional and inflammatory injuries occurring during surgery and postoperative period. Pregabalinas considered in abolishing neuropathie component of acute nociceptive pain of surgery. Materials and methods: A study was done to know the effect of oral gabapentin and pregabalinath control group for post-operative analgesia. Materials and Methods: A total of 90 ASA grade I and II patients posted for elective Partial thyroidectomy were randomized into 3 groups (group A, B and C of 30 patients each). One hour before surgery the blinded drug selected for the study was given with a sip of water. Group C- received identical placebo tablet, Group B- received 800 mg of gabapentin tablet and Group A - received 150 mg of pregabalinablet . VAS score recorded for initial rescue analgesia, total duration of analgesia and total requirement of rescue analgesia were observed as primary outcome. Hemodynamics andside effects were recorded as secondary outcome in patients. Results: The analgesic requirement in both Pregabalinand Gabapentin groups are lower than the control group.

Comparative evaluation of the hemodynamic effects of inclusion versus exclusion of dexmedetomidine to pregabalin and fentanyl premedication regimen during airway instrumentation in laparoscopic abdominal surgeries

Background: Airway instrumentation leads to an aggravated hemodynamic response due to increased sympathetic activity, imposing a risk of myocardial ischemia. A premedication regimen using fentanyl and pregabalin blunts the pressure response but not the rate response. Objective: To compare the effects of pregabalin and fentanyl regimen versus pregabalin, fentanyl, and dexmedetomidine regimen on the hemodynamic pressor response during airway instrumentation in laparoscopic abdominal surgery (LAS). Methods: Sixty patients (ASA I and II), undergoing elective LASunder general anesthesia, were randomly divided into 2 groups - Group A (n=30) premedicated with oral pregabalin (150mg) and IV fentanyl (2μg/kg) and Group B (n=30) premedicated with IV dexmedetomidine (0.25μg/kg) in addition to pregabalin-fentanyl regimen. Both groups were managed with the same anesthetic protocol. The preoperative sedation level was assessed before induction. The heart rate (HR), systolic and diastolic BP (SBP, DBP), and mean arterial pressure (MAP) were recorded at baseline as well as preoperatively, prior to intubation and at 1, 3, 5, 10, and 15 min after intubation. Results: Both groups had similar distribution of age, weight, gender, physical status, sedation level as well as intra-operative fentanyl and postoperative analgesic requirements.

Prevention of Opioid Induced Hyperalgesia Following Remifentanil Infusion: A Case Report

Remifentanil, a potent µ-opioid agonist, is useful in anesthesia because of its rapid onset and short duration of action. However, the same traits that make remifentanil useful can also lead to increased pain sensation when it is discontinued. Nociceptive sensitization following opioids is termed opioid-induced hyperalgesia (OIH). Proposed preventative treatments for remifentanil-induced OIH run the spectrum of cost and feasibility. This case report will discuss the use of and rationale for readily available techniques aimed at preventing OIH. These techniques include intravenous ketamine, inhaled nitrous oxide, oral pregabalin, and gradual cessation of remifentanil infusion.

A prospective, randomized clinical study for evaluation of pregabalin for post-operative analgesia in infraumbilical surgeries

Background: Preemptive analgesia is about the administration of an analgesic agent before the initiation of noxious stimulus, aiming of preventing sensitization of the neural system to successive stimulus that could intensify pain perception. Pregabalin is derivative of gabapentinoid which exhibits analgesic properties. Aims and Objectives: This clinical study designed to evaluate the effectiveness of pregabalin for post-operative analgesia in infraumbilical surgeries. Materials and Methods: This prospective clinical study was conducted in a medical college hospital of central India after obtaining approval from institutional ethics committee and informed written consent from the selected patients over the period of 1 year. A total of 60 patients between the ages of 20 and 40 years of ASA Grade I/II were randomly assigned into two groups (n=30, each) using an online randomization tool. Patients in Group P received oral Pregabalin 150 mg and Group D received oral Diazepam 10 mg, 1 h before induction of anesthesia. Both the groups uniformly received Tablet Paracetamol 1 gm, 2 h after completion of surgery. Patients experiencing pain with visual analogue scale (VAS) score ≥3, were injected Inj. Tramadol 100 mg, as rescue analgesia. Outcome variables such as need for rescue analgesia, sedation, VAS score, and other adverse events were noted at time intervals of 2, 4, 6, 12, and 24 h. Results: The mean VAS scores in patients of Group P were significantly lower than Group D (P&lt;0.0001), over 24 h of post-operative period. In Group P, rescue analgesic Inj. Tramadol was given after 12.33±3.47 h as compared to 3.47±8.19 h in Group D (P&lt;0.0001) with total need of 133.56±49.27 mg and 210.73±63.35 mg over 24 h in patients of Groups P and D, respectively (P&lt;0.0001). Conclusion: Pregabalin 150 mg in pre-operative period provides superior post-operative analgesia and considerably reduces need of rescue analgesia postoperatively.

Comparison of Oral Clonidine with Oral Pregabalin Premedication for the Attenuation of Pressor Response to Direct Laryngoscopy and Tracheal Intubation in Elective Surgery: A Prospective Randomized Study

Background: Laryngoscopy and intubation has adverse effects like tachycardia, hypertension, myocardial ischemia and cerebral hemorrhage. There are many studies on various pharmacological agents to attenuate pressor response. Aim of the study was to compare efficacy and safety of oral clonidine versus oral pregabalin premedication to attenuate stress response in patients undergoing elective surgery.&#x0D; Methods: 106 patients of American Society of Anesthesiologist (ASA) class I, aged between 18-60 years of either sex scheduled for elective surgery were randomized into two groups. Group A received oral clonidine 0.2mg and group B received oral pregabalin 150mg, 90 minutes before surgery. Primary objectives of the study heart rate(HR), systolic blood pressure(SBP) diastolic blood pressure(DBP) and mean blood pressure(MBP) were noted baseline, before induction, immediately after intubation (0) and at 1, 3, 5, 10 and 15 minutes after intubation. sedation, postoperative pain scores and any adverse effects were also noted.&#x0D; Results: The demographic data were comparable in group A and group B. There was no significant difference at baseline for mean (SD) HR, SBP, DBP, and MBP in both groups (p&gt;0.05). The mean (SD) HR was significantly lower in group A as compared to group B, before induction and at 1, 3, 5, 10 and 15 minutes (p &lt;0.05). The mean (SD) SBP, MBP was significantly lower in group A as compared to group B, before induction immediately after intubation and at 1, 3, and 5 minutes (p &lt;0.05). The mean (SD) DBP was significantly lower in group A as compared to group B, before induction (p 0.012). but post-operative analgesia was better in pregabalin group. Bradycardia was more in clonidine group and sedation was more with the use of pregabalin.&#x0D; Conclusion: We concluded that oral premedication with either clonidine or pre.gabalin attenuates hemodynamic response to laryngoscopy and tracheal intubation, but Clonidine is superior to pregabalin.

Comparative study of gabapentin versus pregabalin as a premedication in patients undergoing FESS under general anaesthesia

Introduction: Functional endoscopic sinus surgery (FESS) is a minimally invasive procedure which is usually done under general anaesthesia. Laryngoscopy and tracheal intubation may induce an intense sympathetic hemodynamic response which is dangerous in patients with comorbidities. So an effective and safe premedication drug to attenuate this response is very much necessary. Objectives: The present study was designed to compare the effects of oral gabapentin and oral pregabalin as a premedication to produce sedation and attenuate haemodynamic response to laryngoscopy and endotracheal intubation in patients undergoing FESS under general anaesthesia. Methods: This prospective, randomized study was undertaken in ENT operation theatre in a Government teaching hospital, Karnataka between July 2020 and June 2021. Group A received gabapentin 600 mg and Group B received pregabalin 150 mg orally one hour prior to induction of general anaesthesia. Results: Patients in both group A and group B were sedated after premedication but the degree of sedation achieved in group B was higher compared to group A (p &lt;0.05). Attenuation of HR and MAP was also higher in group B compared to group A (p &lt;0.05). Conclusion: Premedication with both oral pregabalin 150mg and oral gabapentin 600mg, given 1 hour before general anaesthesia in patients undergoing FESS produce sedation and attenuate hemodynamic response to laryngoscopy and intubation. But premedication with oral pregabalin 150 mg is more effective than oral gabapentin 600 mg in producing sedation and attenuating the hemodynamic responses to laryngoscopy and intubation. Keywords: gabapentin; pregabalin; FESS; anaesthesia

Treatment Outcomes in Patients with PHN: A Controlled Trial of Capsaicin 8% Versus Oral Pregabalin

AIM OF INVESTIGATION: Pregabalin and High Concentration Capsaicin 8% Topical System (HCCTS) are both established treatments for PHN (Hadley et al, 2016). This investigation compares treatment outcomes of HCCTS and Pregabalin in a subgroup of patients with PHN from the ELEVATE study (Haanpää et al., 2016). Methods ELEVATE was an 8-week, open label, randomized, multicentre, non-inferiority trial. Eligible patients with PHN had pain 6 or more months after shingles vesicle crusting and were naïve to, or had received inadequate treatment with, Gabapentin or Pregabalin.

Treatment Outcomes in Patients with Post-Surgical Neuropathic Pain (PSNP): Capsaicin 8% vs. Pregabalin

AIM OF INVESTIGATION: PSNP is peripheral neuropathic pain (PNP) following surgery. Treatments for PNP include systemic and local treatments such as Pregabalin or High Concentration Capsaicin 8% Topical System (HCCTS). In this post-hoc analysis in a subgroup of patients with PSNP of the ELEVATE study, treatment outcomes of HCCTS and Pregabalin are compared (Haanpää et al., 2016). Methods In an eight-week, open-label, randomized, multicenter, non-inferiority trial eligible patients with PSNP were randomized to HCCTS or an optimized dose of oral Pregabalin.

Our 15-year experience of complications of Chow’s technique for endoscopic carpal tunnel releasing

ABSTRACT Purpose Our objective in this study was to summarize our 15-year experience treating carpal tunnel syndrome released with Chow technique, focusing on the complications and how to avoid them. Method We systematically evaluated the postoperative complications in 211 patients who underwent endoscopic carpal tunnel release (ECTR) with Chow technique. We recorded the incidence of complex regional pain syndrome type I (CRPS I), median nerve and digital nerve injury, superficial palmar arch injury, and tendon injury. Result The overall incidence of complications was 5.6%, and involved 10 cases of CRPS I, 1 case of median nerve trunk injury, and 1 case of superficial palmar arch injury. No other complication occurred. We used oral pregabalin and neurotropin to relieve CRPS I symptoms, and performed second operations for the other two complications. Conclusions Our study revealed that ECTR could reduce structural and cutaneous complications, but increase the incidence of nerve injury. we speculated that the incidence of CRPS I may be higher in the Asian population.

Evaluation of the postoperative morphine-sparing effect of oral premedicants used as pre-emptive analgesics in breast-conserving cancer surgeries: A randomised placebo-controlled trial.

Background and Aims:Breast cancer surgeries are associated with both nociceptive and neuropathic pain, requiring strong analgesics. We aimed to evaluate the postoperative morphine-sparing effect of pre-emptive oral premedication with tramadol versus pregabalin in patients undergoing breast-conserving cancer surgeries (BCCS).Methods:This prospective, randomised, placebo-controlled trial was carried out at tertiary care centre on 90 patients undergoing BCCS randomised into three groups of 30 each. Group C received placebo, Group T received tramadol 100 mg and Group P received pregabalin 75 mg as oral premedication, 1 hour before surgery. General anaesthesia was administered. Postoperatively morphine 1 mg.h-1 through intravenous PCA was started at a visual analogue scale score ≥4. Total morphine consumption in 24 hours was calculated and its sparing effect was evaluated as the primary outcome.Results:The median with interquartile range (IQR) of total postoperative morphine consumed in 24 hours, was found to be 22 mg (IQR 0-25.77), 15 mg (IQR 0-16) and 17.50 mg (IQR 0-19.25) in groups C, T, P respectively, (P = 0.000, 0.003, 0.060). The median duration of analgesia in group C was 5.40 hours (IQR 3.30-11.40), 11.6 hours (IQR 9.30-24.0) in group T and 8.60 hours (IQR 6.97-16.27) in group P (P value C/T = 0.000, C/P = 0.007, T/P = 0.002). The postoperative side effects were comparable.Conclusion:Oral tramadol 100 mg and oral pregabalin 75 mg as premedication reduced the 24 hours postoperative morphine requirement as compared to placebo in BCCS. However, tramadol 100 mg provided superior analgesia for longer duration than pregabalin 75 mg and was associated with more side effects.

ARTROSKOPİK OMUZ CERRAHİSİNDE PREEMPTİF PREGABALİN YÖNETİMİNİN POSTOPERATİF VE POSTOPERATİF ANKSİYETE VE POSTOPERATİF ANALJEZİ ÜZERİNE ETKİNLİĞİ: PROSPEKTİF, RANDOMİZE, ÇİFT KÖR, PLASEBO KONTROLLÜ BİR KLİNİK ÇALIŞMA

Aim: Few studies have investigated pregabalin use as preemptive analgesia in the management of acute pain and anxiety following arthroscopic shoulder surgery. We hypothesized that the preemptive use of oral pregabalin might decrease pain and postoperative anxiety on arthroscopic shoulder surgery pain during the initial 48 hours. Patients and methods: In this prospective, randomized, double-blind, placebo-controlled study, 65 eligible patients were randomly divided into two groups, the preemptive pregabalin 150 mg (group P) and the control group (group C). The primary outcomes were pain levels measured both rest and during active motion based on a visual analog scale (VAS). Secondary outcomes were the level of anxiety (STAI-S and STAI-T), patient satisfaction, and complications. Results: Group P showed lower pain (p &amp;lt; 0.001), better opioid consumption (p &amp;lt; 0.001), longer time to first requirement of analgesia (p &amp;lt; 0.001), and lower rescue analgesic dose (p &amp;lt; 0.001) than the control group at postoperative 48 h follow-up. Also, group P showed less preoperative and postoperative anxiety (p &amp;lt; 0.001) and greater patient satisfaction (p &amp;lt; 0.001) than group C. The rate of postoperative adverse effects was similar between the groups (p &amp;gt; 0.05). Conclusion: The preemptive use of oral pregabalin received 150 mg daily for 2 days before surgery provided postoperative analgesia in both rest and active motion, and improved preoperative and postoperative anxiety levels and greater patient satisfaction in patients undergoing arthroscopic surgery.