The evolution of the treatment technologies in dentistry is remarkable. However, despite the advancement of science and therapeutic agents, they have not been able to overcome dental caries, periodontal disease [1], nor alveolar pyorrhea [2]. We are attempting to eliminate hundreds of oral bacteria, partly because we are fighting indigenous oral bacteria [3]. Currently, although many patients are trained in proper oral hygiene, including teeth brushing, flossing, and use of mouthwash daily, many still suffer from periodontal diseases, such as gingivitis [1]. Despite training and the abundance of oral healthcare products [4] widely available, including fluorides, chlorhexidine, and triclosan, oral health diseases remain a prominent issue. Beyond periodontal disease and gingival inflammation, extremely problematic conditions [1], such as periodontal abscesses [1] and alveolar pyorrhea [2], are some of the potential problems for patients and dentists. The most problematic condition is alveolar pyorrhea [2], advanced conditions of gingival inflammation [1], with symptoms including painful chewing, swollen or puffy gums, gum bleeding, and pus in the gums. These symptoms gradually appear, and in untreated conditions, lead to tooth loss. The advent and development of antibiotics have greatly impacted the treatment of bacterial infections. However, local bacterial infection lesions in various parts, such as dental fistulae [5], have not yet been overcome. The emergence of resistant strains is also a problem; the peculiarity of the conditions, such as fistula-like sites and infected wounds, is still a major obstacle to bacterial infections. These periodontal and gingival diseases [1] are treated with systemic antibiotics during the acute phase [4], but they are not always completely cured. It should be noted that bacterial infections in the oral cavity remain unresolved issues.