Abstract
Bacterial diseases and reactive oxygen species can cause dental caries and oral cancer. Therefore, the present review analyzes and discusses the antibacterial and antioxidant properties of synthetic and plant-derived substances and their current and future patents to formulate dental products. The reviewed evidence indicates that chlorhexidine, fluorides, and hydrogen peroxide have adverse effects on the sensory acceptability of oral care products. As an alternative, plant-derived substances have antimicrobial and antioxidant properties that can be used in their formulation. Also, adding plant metabolites favors the sensory acceptability of dental products compared with synthetic compounds. Therefore, plant-derived substances have antibacterial, antioxidant, and flavoring activity with the potential to be used in the formulation of toothpaste, mouth rinses, dentures cleansers-fixatives, and saliva substitutes.
Highlights
Oral diseases are a significant health burden for many countries, causing pain, discomfort, deformity, and even death; it is estimated that these affect nearly 3.5 billion people [1].According to the Global Burden of Disease, untreated dental caries in permanent teeth is the most common health condition [2]
[33,34]. in hydrogen peroxide thermore, it has beenand reported that the increase free radicals the environment causes is a type of produced by some bacteria, such as Lactobacillus acidophilus, Bifidobacterium damage to cellular structures and promotes mutations related to cardiovascular disease adolescentis, andthere
Oral diseases are related to the proliferation of pathogenic bacteria, mainly S. mutans, and the expression of virulence factors
Summary
Oral diseases are a significant health burden for many countries, causing pain, discomfort, deformity, and even death; it is estimated that these affect nearly 3.5 billion people [1]. Controlling harmful bacteria and oxidative stress in the oro-dental area is a severe concern for global health authorities Some synthetic substances, such as chlorhexidine and fluorides, among other compounds, have antibacterial activity against S. mutans; they have been incorporated into different dental products, such as pastes and mouthwashes [11]. Glycosyltransferases use their carboxyl-terminal bind glycanbinding proteins (GbpA, GbpB, GbpC, GbpD) found in the bacterial cell wall, allowing cell-cell adhesion [7,24] This process produces cells and glucans accumulation, generating biofilms on dental surfaces (Figure 2) [9]. Glycosyltransferases use their carboxyl-terminal domain to bind glycan-binding proteins (GbpA, GbpB, GbpC, GbpD) found in the bacterial cell wall, allowing cell-cell adhesion [7,24]
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