This paper presents a virtual toolchain for the optimal concept and prototype dimensioning of 48 V hybrid drivetrains. First, this toolchain is used to dimension the drivetrain components for a 48 V P0+P4 hybrid which combines an electric machine in the belt drive of the internal combustion engine and a second electric machine at the rear axle. On an optimal concept level, the power and gear ratios of the electric components in the 48 V system are defined for the best fuel consumption and performance. In the second step, the optimal P0+P4 drivetrain is simulated with a prototype model using a realistic rule-based operating strategy to determine realistic behavior in legal cycles and customer operation. The optimal variant shows a fuel consumption reduction in the Worldwide harmonized Light Duty Test Cycle of 13.6 % compared to a conventional vehicle whereas the prototype simulation shows a relatively higher savings potential of 14.8 %. In the prototype simulation for customer operation, the 48 V hybrid drivetrain reduces the fuel consumption by up to 24.6 % in urban areas due to a high amount of launching and braking events. Extra-urban and highway areas show fuel reductions up to 11.6 % and 4.2 %, respectively due to higher vehicle speed and power requirements. The presented virtual toolchain can be used to combine optimal concept dimensioning with close to reality behaviour simulations to maximise realistic statements and minimize time effort.