In order to improve the overall level and long-term development of YTO Express, according to the development strategy and planning of YTO Express logistics, this paper puts forward the construction of Hub-and-Spoke air logistics transport network with core hub airport, and optimizes YTO Express transport network. Firstly, the cluster analysis function of SPSS is used to divide the region of the air node, and then the center of gravity method is used to select the regional hub point, and the core hub airport and the regional hub airport are determined, so as to design the final transport network, which is conducive to the sustainable development of YTO Express, and improve the proportion of YTO Express in the air field.