With the access to a large number of intermittent and fluctuating new energy sources in the low-voltage distribution network, the complex relationship between producers and consumers makes the node voltage stability and other problems in the power system increasingly prominent. Aiming at the voltage stability problem caused by the intermittent and fluctuation of the new power system, based on the high-precision measurement data of PMU, this article used the model predictive control algorithm to realize regional voltage optimization and improve the stability of node voltage. First, the voltage sensitivity matrix is calculated using PMU measurement data and grid structure state information. Second, active power, reactive power, and voltage were taken as the input of the MPC algorithm, and the optimal compensation voltage instruction was obtained by rolling optimization, and the node voltage was compensated by SVG and SVC. Finally, a simulation experiment was carried out on the MATLAB/Simulink simulation platform, and the experimental results verified the correctness and effectiveness of the proposed control method.