In this paper, we propose a novel anti-disturbance attitude control law for combined spacecraft with an improved closed-loop control allocation scheme. More specifically, a saturated approach is adopted to guarantee the global asymptotic stability under control input saturation. To enhance the robustness of the system, a nonlinear disturbance observer is constructed to compensate the disturbances caused by inertial parameter uncertainty and unmodeled dynamics. Next, the quadratic programming algorithm is used to obtain an optimal open-loop control allocation scheme, where both energy consumption and actuator saturation have been considered in the allocation of the virtual control command. Then, a modified closed-loop control allocation scheme is proposed to reduce the allocation error under the actuator uncertainty. Finally, stability analysis of the closed-loop system with the proposed allocation scheme is provided. Simulation results confirm the effectiveness of the proposed control scheme.