A graphene-oxide-coated interferometric microfiber-sensor-based polarization-maintaining optical fiber is proposed for highly sensitive detecting for ethanol vapor concentration at room temperature in this paper. The strong sensing capability of the sensor to detect the concentration of ethanol vapor is demonstrated, taking advantage of the evanescent field enhancement and gas absorption of a graphene-oxide-coated microfiber. The transmission spectrum of the sensor varies with concentrations of ethanol vapor, and the redshift of the transmission spectrum has been analyzed for the concentration range from 0 to 80ppm with sensitivity as high as 0.138nm/ppm. The coated graphene oxide layer induces the evanescent field enhancement and gas selective adsorption, which improves sensitivity and selectivity of the microfiber gas sensor for ethanol vapor detection.