The article presents the results of a study of the homogeneity of rectangular optical radiation fluxes for different versions of the initial sections of the light guide nozzles. When conducting a significant part of laser exposure in medicine, pathological areas of biological tissue or their projections located on the surface of the body are covered with light spots with contours, as a rule, in the form of flat geometric shapes.
 The variability of the implementation of light spots in shape (circle, square, rectangle, triangle, rhombus, etc.) and linear dimensions of the cross section allows you to select the shape and size of the light spot, covering a specific pathological surface with minimal capture of intact tissues. At the same time, regardless of the shape and linear dimensions, the light spots should be as uniform as possible. To date, of particular interest is the provision of optical uniformity of rectangular light spots.
 Firstly, similar forms of spots are widely used under the influence of laser medicine. Secondly, in the original optical stages of laser equipment and the light guides connected to them, first of all, optical fibers of a cylindrical shape with a rounded cross section of the optical flow at the output are used. The purpose of this work is to optimize the parameters of light guide nozzles of medical laser equipment with rectangular output optical radiation fluxes by evaluating the uniformity of the power density distribution for various options for the output sections of the nozzles. In the work, optical flows at the output of three versions of the distal sections of light guides were studied. The light guides were formed by optical fibers, including the use of microlenses at the output ends, and were apertured by channel optical waveguides in the form of rectangular parallelepipeds.
 The experimental results obtained at the stage of physical modeling show the promise of using spherical micro-optical elements at the initial ends of optical fibers in combination with rectangular apertures in the form of channel optical waves to obtain rectangular light spots with a high level of optical homogeneity.
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