BackgroundDiabetic retinopathy is a complication of diabetes that affects the eyes and can lead to blindness if not adequately managed. No national or population-based estimates of diabetic retinopathy in Palestine exist. High-quality ophthalmic services are not available at the primary health care level for patients with diabetes in all sectors. Specialised eye centres are lacking. St John of Jerusalem Eye Hospital Group, which consists of five facilities in the West Bank and Gaza Strip, is the only provider of expert eye care in Palestine. The aim of this study was to determine the population prevalence of diabetic retinopathy among people with diabetes aged 50 years and older in Palestine. MethodsThis survey was part of a larger population-based survey using the rapid assessment of avoidable blindness (RAAB) methodology to estimate prevalence of vision impairment, blindness, and disability in individuals aged 50 years and older in Palestine. It was a nationally representative, cross-sectional, population-based survey in Gaza Strip and West Bank. Based on an expected prevalence of blindness of 3·4% in individuals aged 50 years and older, 20% precision level, 95% confidence level, 10% non-response rate, and a design effect of 1·4 to account for clustering, a sample size of 4224 participants aged 50 years and older was determined. 69 clusters in the West Bank and 52 clusters in the Gaza Strip were selected with probability proportionate to size from a list of areas from the Palestinian Central Bureau of Statistics population and housing census of 2017. Within each cluster, 35 people aged 50 years or older were randomly selected for examination in their homes. Three teams collected data; each consisted of a nurse and an ophthalmologist. Dilated fundus examination and Scottish diabetic retinopathy grading were done by the ophthalmologist in each team. Participants were classified as having diabetes if they had been diagnosed by a health professional, or if their random blood glucose (RBG) was 200 mg/dL or above on the day of data collection, as measured by a portable glucometer. Ethical approval was obtained from the St John of Jerusalem Eye Hospital Group and the London School of Hygiene & Tropical Medicine ethics committees. Informed oral witnessed consent was obtained from all participants. FindingsThe survey was conducted between July, 2018, and April, 2019. 4224 individuals were asked to participate, of whom 376 did not, leaving 3848 participants. The number of previously diagnosed and newly diagnosed patients with diabetes was 1176 (486 male, 690 female) and 103 (55 male, 48 female), respectively. The overall prevalence of diabetes across West Bank and Gaza was 33·2% (95% CI 31·5–34·9; 1279 of 3848 participants). The prevalence was higher in women (738 of 2047 [36·1%, 95% CI 33·6–38·5]) than in men (541 of 1801 [30·0%, 27·9–32·2), and in Gaza Strip (639 [35·8%] of 1783) than in West Bank (640 [31·0%] of 2065; p=0·002). Only 539 (46·3%) of 1164 patients with diagnosed diabetes who consented to blood blucose measurement had controlled blood glucose (RBG <200 mg/dL). 483 (41·1%) of 1176 patients with previously diagnosed diabetes had never had an eye check-up or had not been checked in the 2 years before the survey. 327 (25·6%) of 1279 patients with diabetes refused dilated fundus examination; 952 patients did undergo this examination, and 457 (48·0%, 95% CI 43·5–52·6) had diabetic retinopathy or maculopathy. Vision impairment was more common in those with diabetes (428 [33·5%] of 1279) than in those without (652 [25·4%] of 2569). 43 (3·4%) of 1279 participants with diabetes had blindness, compared with 65 (2·5%) of 2569 patients without diabetes. The principal cause of blindness in Gaza Strip was diabetic retinopathy (23 [32·4%] of 71) and in West Bank was untreated cataract (19 [51·4%] of 37). Diabetic retinopathy was the main cause of blindness, severe visual impairment, and moderate visual impairment among patients with diabetes. InterpretationDiabetes and diabetic retinopathy are substantial health problems in Palestine. Earlier detection and proper management at primary health care clinics and by outreach clinics for marginalised populations could be key. Referral networks between health-care sectors and specialised eye centres might provide the necessary infrastructure. FundingFred Hollows Foundation, Australia, German Federal Ministry for Economic Cooperation and Development.