The Fukushima Daiichi Nuclear Power Plant accident, triggered by the Great East Japan Earthquake and the tsunami, has had a major impact on societies across the world. The subsequent focus on decommissioning efforts has attracted worldwide attention. It has been consistently asserted since the aftermath of the accident that the decommissioning of the Fukushima Daiichi Nuclear Power Plant will take approximately 30 to 40 years. The promotion of decommissioning work means that we will continue to face the problems with uncertainties in the work, as sometimes referred to as Unknown Unknowns. Typical elemental technologies required in remotely operated robotic systems for decommissioning include mobile mechanisms and their control, handling mechanisms and their control, information communication, operation interface (information presentation and command input), shielding (radiation resistance) and so on. Although many tasks using remotely operated robotic systems have been carried out with noteworthy results, there are lingering issues yet to be clarified. To ensure the safe and effective execution of various types of decommissioning tasks over a period of several decades, continuous research and development of each elemental technology are imperative, and these technologies must be integrated into a system appropriately to the assumed tasks. In addition, human resource development and the transfer of knowledge and experience are also important issues. From such viewpoint, this special issue is titled “Robotic, Mechatronic and Information Systems for Decommissioning.” It contains papers and development reports on robotics, mechatronics, information processing, and information systems technologies relevant to decommissioning work. It also features recent activities of nuclear emergency response organizations. We hope this special issue will acquaint readers with the latest research and development results and organizational activities related to decommissioning. At the same time, we hope that we were able to provide readers interested in robots, mechatronics, and information technology with an opportunity to become aware of the issues and necessary perspectives related to decommissioning and nuclear disasters. Lastly, we would like to thank the editorial board of the Journal of Robotics and Mechatronics, the editorial team of Fuji Technology Press, and the reviewers for their support in the planning and publication of this special issue. Their dedicated efforts are deeply appreciated.