In this paper, we investigate the solution to a class of symmetric non-homogeneous two-dimensional fractional integro-differential equations using both analytical and numerical methods. We first show the differences between the Caputo derivative and the symmetric sequential fractional derivative and how they help facilitate the implementation of numerical and analytical approaches. Then, we propose a numerical approach based on the operational matrix method, which involves deriving operational matrices for the differential and integral terms of the equation and combining them to generate a single algebraic system. This method allows for the efficient and accurate approximation of the solution without the need for projection. Our findings demonstrate the effectiveness of the operational matrix method for solving non-homogeneous fractional integro-differential equations. We then provide examples to test our numerical method. The results demonstrate the accuracy and efficiency of the approach, with the graph of exact and approximate solutions showing almost complete overlap, and the approximate solution to the fractional problem converges to the solution of the integer problem as the order of the fractional derivative approaches one. We use various methods to measure the error in the approximation, such as absolute and L2 errors. Additionally, we explore the effect of the derivative order. The results show that the absolute error is on the order of 10−14, while the L2 error is on the order of 10−13. Next, we apply the Laplace transform to find an analytical solution to a class of fractional integro-differential equations and extend the approach to the two-dimensional case. We consider all homogeneous cases. Through our examples, we achieve two purposes. First, we show how the obtained results are implemented, especially the exact solution for some 1D and 2D classes. We then demonstrate that the exact fractional solution converges to the exact solution of the ordinary derivative as the order of the fractional derivative approaches one.