Self-regulation is an important marker of both cognitive and socio-emotional competency. This exploratory study examined the role of the indoor home environment on two components of self-regulation: emotional dysregulation and independence. We used growth curve modelling to explore the trajectories of self-regulation among 13,774 children from the Millennium Cohort Study, followed at ages three, five and seven years. Disorganisation, quiet and calm were related to both components of self-regulation. Additionally, damp, second-hand smoke and TV noise predicted emotional dysregulation. Our other measures of the home environment (overcrowding, home traffic, presence of open fires and garden access) were unrelated to self-regulation. Our results suggest that the atmosphere and maintenance of the home may directly impact self-regulation in early and middle childhood.