Open Access Research Articles

On becoming an electronic-only, diamond open access journal, through the lens of a managing editor

On becoming an electronic-only, diamond open access journal, through the lens of a managing editor

Peningkatan Motivasi Berprestasi Bagi Santri Melalui Metode Peer Teaching di Pondok Pesantren Ar-Rohmah Grobogan

Learning motivation has a position that is quite urgent in supporting the success of the learning process. In general, the problems faced by students who study in two educational institutions such as the world and pesantren, in the case raised in the community service, are low motivation to learn and low time management. Learning activities using the Peer Teaching method turned out to make a positive contribution to improving achievement motivation among students of the Ar-Rohmah Grobogan Islamic Boarding School. Education that involves peers as supervisors and supervisors can also create a conducive and pleasant learning environment. However it is not without challenges at all. Mass media such as television and increasingly open internet access are problems that must be solved in the future so that the atmosphere of santri learning can be better conditioned

Bexotegrast Shows Dose-dependent Integrin αvβ6 Receptor Occupancy in Lungs of Participants with Idiopathic Pulmonary Fibrosis: A Phase 2, Open-Label Clinical Trial.

Rationale: Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive disease characterized by dyspnea and loss of lung function. Transforming growth factor-beta (TGF-β) activation mediated by αv integrins is central to the pathogenesis of IPF. Bexotegrast (PLN 74809) is an oral, once-daily, dual-selective inhibitor of αvβ6 and αvβ1 integrins under investigation for the treatment of IPF. Positron emission tomography (PET) using an αvβ6-specific PET tracer could confirm target engagement of bexotegrast in the lungs of participants with IPF. Objectives: This Phase 2 study (NCT04072315) evaluated αvβ6 receptor occupancy in the lung, as assessed by changes from baseline in αvβ6 PET tracer uptake, following single dose administration of bexotegrast to participants with IPF. Methods: In this open-label, single-center, single-arm study, adults with IPF received up to 2 single doses of bexotegrast, ranging from 60 to 320 mg with or without background IPF therapy (pirfenidone or nintedanib). At baseline and approximately 4 hours after each orally administered bexotegrast dose, a 60-minute dynamic PET/CT scan was conducted following administration of an αvβ6-specific PET probe ([18F]FP-R01-MG-F2). αvβ6 receptor occupancy by bexotegrast was estimated from the changes in PET tracer uptake following bexotegrast. Pharmacokinetics, safety, and tolerability of bexotegrast were also assessed. Results: Eight participants completed the study. Total and unbound plasma bexotegrast concentrations increased in a dose-dependent manner, and regional PET volume of distribution (VT) values decreased in a dose- and concentration-dependent manner. The VT data fit a simple saturation model, producing an unbound bexotegrast EC50 estimate of 3.32 ng/mL. Estimated maximum receptor occupancy was 35%, 53%, 71%, 88%, and 92% following single 60, 80, 120, 240, and 320-mg doses of bexotegrast, respectively. No treatment-emergent adverse events related to bexotegrast were reported. Conclusions: Dose- and concentration-dependent αvβ6 receptor occupancy by bexotegrast was observed by PET imaging, supporting once-daily 160 to 320 mg dosing to evaluate efficacy in clinical trials of IPF. Trial registration number: NCT04072315 Primary source of funding: Pliant Therapeutics, Inc. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Analyzing Data Sharing Policies in Library and Information Science: Journal Metrics, Open Access Status, and Publisher Volume

The objective of this study is to explore the prevalence and characteristics of data sharing policies in library and information science (LIS) journals, focusing on their relationship with journal metrics, publisher volume (number of journals managed by the publisher), and open access (OA) status. The study examined the link between data sharing policies and journal metrics in LIS journals indexed in Scopus. Using secondary data from the SJR portal and qualitative data from author guidelines, the study revealed several key findings: First, a positive relationship existed between publisher volume and the presence of data sharing policies, with high-volume publishers consistently implementing such policies. Second, 50.2% of LIS journals lacked data sharing guidelines, indicating a significant gap. Third, journals that encouraged or required data sharing under certain conditions tended to perform better in metrics such as quartiles, h-index, and citation impact. Fourth, data sharing policies were more common in higher-ranked journals and were linked to better journal metrics. Fifth, higher-ranked journals were more likely to include details on data statements, DOIs, and repositories than lower-ranked journals. Lastly, non-OA journals were more likely to encourage practices such as including data repositories and supplementary files in submissions, compared to OA journals, revealing unexpected disparities. In conclusion, data sharing policies in LIS journals showed associations with journal ranking and publisher volume, with non-OA journals showing higher presence of certain data sharing practices.

Towards Understanding Nomophobia: A Systematic Review of Its Prevalence, Causes, and Effects in Educational Settings

This article analyzes the causes and consequences of excessive mobile device use among university students and its impact on mental health and academic performance through a review of studies published between 2018 and 2023. Articles were selected from Scopus and Web of Science databases that included "nomophobia" and "education" in the title, abstract, or keywords, and that were open access. The final analysis included 30 articles organized into 14 thematic categories. The most addressed topics were consequences, causes, levels, and factors that determine nomophobia. It was found that excessive mobile device use is mainly due to the constant need to stay connected and the fear of missing out on social media information. This technological dependence manifests in symptoms such as anxiety, stress, nervousness, and physical health problems, such as thumb and wrist pain, visual fatigue, and sleep disturbances. Nomophobia negatively impacts academic performance by interfering with the attention and concentration necessary for learning. Although educational technology does not seem to be a risk factor, it is crucial to promote a balanced use of mobile devices. Family intervention and education on the risks of excessive mobile use are essential to mitigate these effects and foster healthy technology use. Received: 2 August 2024 / Accepted: 30 October 2024 / Published: 05 November 2024

Asthma and COVID-19: Unveiling Outcome Disparities and Treatment Impact Based on Distinct Endotypes.

Epidemiologic studies on asthmatics and in vitro data suggest a protective role of T2 inflammation in SARS-CoV-2 infection. Using a large, multisite cohort, we studied clinical outcomes following SARS-CoV-2 infection in multiple asthma endotypes and examined the effects of T2-directed biologics in infected asthmatics.in Methods: The National COVID Cohort Collaborative (N3C) Data Enclave was used to identify and stratify asthmatic patients by endotype to include non-T2 and T2 asthmatics, as well as exposure to T2-directed biologic therapy. We evaluated the risk of hospitalization, invasive mechanical ventilation, and 90-day mortality by endotype and exposure to biologics. For this study, 402,376 patients met inclusion criteria, of which 138,142 (34%) were characterized as non-T2 and 264,234 (66%) as T2 asthmatics, a group further divided into 104,823 (26%) atopic, 84,440 (21%) eosinophilic, and 74,971 (19%) T2-high asthmatic endotypes. Compared to non-T2 asthmatics, atopic and T2-high asthmatics experienced decreased odds of hospitalization, and 90-day mortality. Conversely, eosinophilic asthmatics experienced higher odds of hospitalization, intubation, and 90-day mortality. Exposure to T2-directed biologic therapies did not alter outcomes after propensity score matching. In contrast, maximum eosinophil count and recent systemic corticosteroid use were directly correlated with increased odds of all outcomes. COVID-19 outcomes differ depending on asthma endotype, with atopic asthmatics experiencing lower odds and eosinophilic asthmatics experiencing higher odds of deleterious outcomes. T2-directed biologic treatment did not alter these outcomes but recent systemic corticosteroid use predisposes all asthmatics patients to adverse outcomes. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Antimicrobial Prescribing Patterns in GP Practices in Northern Ireland

Introduction: Antimicrobial resistance (AMR) is a global health threat requiring immediate attention as it is set to cause ten million deaths worldwide by 2050, overtaking that of cancer. Continuation of overuse and/or misuse of these crucial medicines will prevent future generations from reaping the benefits, as the pandemic of AMR spirals out of control. Aims: The primary aim of this study was to investigate antimicrobial prescribing patterns in General Practices throughout Northern Ireland. A secondary aim was to analyse the impact of the COVID-19 pandemic on antimicrobial prescribing and consumption patterns in GP practices in Northern Ireland. Methods: A retrospective, cross-sectional quantitative study was designed to measure, analyse, and evaluate the antimicrobial prescribing patterns within GP practices in Northern Ireland, using open access Business Services Organisation (BSO) data. Results: A total of 3,168.78 kg of antibacterial drugs were prescribed in primary care throughout the duration of the study. Penicillins were the most prescribed class (59.79%), followed by tetracyclines (10.68%) and macrolides (9.53%). Access group antibiotics were the most frequently prescribed (79.35%), followed by Watch group antibiotics (20.64%), with Reserve group antibiotics equating to nearly 0% despite being prescribed. The Derry GP Federation prescribed and dispensed the greatest amount of antibiotics overall in Northern Ireland (10.90%). Despite there being no significant difference in antibiotic prescribing amongst GP federations prior to and during the COVID-19 pandemic (unpaired t-test, p > 0.05), there were differences in prescribing of individual drug classes throughout this period. Conclusions: Despite meeting World Health Organisation (WHO) targets, GP practices within Northern Ireland must achieve more to further reduce antimicrobial consumption. Although antibiotic prescribing rates here are on the decline, there was no significant difference in prescribing amongst GP federations pre- and midst-COVID-19 pandemic, thus sufficient strategies such as increased communication between colleagues and supportive measures must be implemented within GP practices to enhance antimicrobial stewardship (AMS) across Northern Ireland.

Unveiling Frequency-Specific Microstate Correlates of Anxiety and Depression Symptoms.

Electroencephalography (EEG) microstates are canonical voltage topographies that reflect the temporal dynamics of brain networks on a millisecond time scale. Abnormalities in broadband microstate parameters have been observed in subjects with psychiatric symptoms, indicating their potential as clinical biomarkers. Considering distinct information provided by specific frequency bands of EEG, we hypothesized that microstates in decomposed frequency bands could provide a more detailed depiction of the underlying neuropathological mechanism. In this study, with a large open access resting-state dataset (n = 203), we examined the properties of frequency-specific microstates and their relationship with anxiety and depression symptoms. We conducted clustering on EEG topographies in decomposed frequency bands (delta, theta, alpha and beta), and determined the number of clusters with a meta-criterion. Microstate parameters, including global explained variance (GEV), duration, coverage, occurrence and transition probability, were calculated for eyes-open and eyes-closed states, respectively. Their ability to predict the severity of depression and anxiety symptoms were systematically identified by correlation, regression and classification analyses. Distinct microstate patterns were observed across different frequency bands. Microstate parameters in the alpha band held the best predictive power for emotional symptoms. Microstates B (GEV, coverage) and parieto-central maximum microstate E (coverage, occurrence, transitions from B to E) in the alpha band exhibited significant correlations with depression and anxiety, respectively. Microstate parameters of the alpha band achieved predictive R-square of 0.100 for anxiety scores, which is much higher than those of broadband (R-square = -0.026, p < 0.01). Similar results were found in classification of participants with high and low anxiety symptom scores (68% accuracy in alpha vs. 52% in broadband). These results suggested the value of frequency-specific microstates in predicting emotional symptoms.

Visibility of Russian university journals in the systems of national and international scientific and technical information

Current limitations of access to some international journal platforms and bibliographic systems for Russian researchers result in increased role of national journals for communication and knowledge spreading both at domestic and international levels. Consequently, correct information on Russian journals indexation in various bibliographic systems including underestimated open access databases seems to be topical. The analyzed sample includes journals published by Russian universities as the less studied ones compared to serials published by research institutes. We studied journals published by three types of Russian universities, i.e. Federal, National Research and Basic. Rapid increase in the number of new journals in recent years is demonstrated caused by financial support under different programs. Indexing of journals in Web of Science, Scopus, Dimensions and Lens was studied over a period of 2018–2022. In the Dimensions and Lens we also studied the completeness of indexing as these databases index content using other approaches as compared to Web of Science and Scopus. A share of journals indexed by authoritative Russian journal lists Russian Science Citation Index and White List was revealed. The best positions were detected among journals published by National Research universities. However, Basic universities demonstrate positive growth, as well. The obtained results enabled us to conclude that journals published by Russian universities can be regarded as significant strategic information resource for representing Russian research results to international community.

The Economics of Capital Allocation in Firms: Evidence from Internal Capital Markets

We analyze a unique chief financial officer (CFO) survey data set to examine capital allocation in firms. Top management is aware of agency and information problems at the divisional level and organizes the budgeting process to counteract managerial opportunism, employing systems of interconnected measures, including layers of approval, divisional budgets, reporting requirements, and compensation schemes. When making funding decisions, top management relies heavily on top-level nonfinancial information, such as the assessment of divisional managers’ abilities. However, substantial parts of the capital budget do not require top management approval as firms trade off the benefits and costs of decentralization, thereby deviating from the traditional paradigm of decentralized project initiation but centralized project approval. Even firms with active internal capital markets tilt capital allocation toward relatively even distributions, reflecting the use of capital allocation as a credible communication device. We also find that within-firm agency problems may result in capital rationing, that is, divisions’ restricted access to internal capital. CFOs also believe that integrating multiple businesses into an internal capital market results in tangible financial benefits, predominantly lower costs of capital and higher debt capacities. Thus, our findings also support coinsurance arguments suggesting that internal capital markets may improve access to external financing. This paper was accepted by Victoria Ivashina, finance. Funding: This work was supported by the BBBank Karlsruhe, Wissenschaftsförderung der Sparkassen-Finanzgruppe, and Karlsruher Institut für Technologie (Karlsruhe House of Young Scientists). Publishing fees were supported by the “Funding Programme Open Access Publishing” of the University of Hohenheim. Supplemental Material: The online appendices and data files are available at https://doi.org/10.1287/mnsc.2021.02755 .

Global Health Priority Box─Proactive Pandemic Preparedness.

The coronavirus pandemic outbreak of 2019 highlighted the critical importance of preparedness for current and future public health threats (https://www.mmv.org/mmv-open/global-health-priority-box/about-global-health-priority-box). While the main attention for the past few years has been on COVID-19 research, this focus has reduced global resources on research in other areas, including malaria and neglected tropical diseases (NTDs). Such a shift in focus puts at risk the hard-earned progress in global health achieved over the past two decades (https://www.who.int/news-room/spotlight/10-global-health-issues-to-track-in-2021). To address the urgent need for new drugs to combat drug-resistant malaria, emerging zoonotic diseases, and vector control, Medicines for Malaria Venture (MMV) and Innovative Vector Control Consortium (IVCC) assembled a collection of 240 compounds and, in August 2022, launched the Global Health Priority Box (GHPB). This collection of compounds has confirmed activity against emerging pathogens or vectors and is available free of charge. This valuable tool enables researchers worldwide to build on each other's work and save precious time and resources by providing a starting point for the further development of treatments and insecticides. Furthermore, this open access box aligns with two of the many priorities outlined by the World Health Organization (WHO) (https://www.who.int/news-room/spotlight/10-global-health-issues-to-track-in-2021).

CattleReview

This Cattle Review examines two recent Open Access papers in preventive veterinary medicine, which assess the current status of Johne's disease control in Great Britain's dairy herds.

High-Q terahertz chirality enhancement using elliptical hole metasurface

Circular dichroism (CD) technology has garnered significant attention due to its extensive applications in ultra-sensitive biosensing and spin-selective optical frequency conversion. However, existing terahertz chiral structures are constrained by linewidth, which limits their effectiveness in narrowband signal processing. In this study, we propose the notion of quasi-bound states in the continuum (quasi-BIC) within a planar elliptical hole all-silicon terahertz metasurface that exhibits broken mirror symmetry. This approach achieves a CD value as high as 0.97, with a linewidth below 0.5 GHz and a Quality (Q)-factor reaching up to 107 in the 1.3 THz to 1.55 THz band, thereby enabling ultra-narrowband terahertz chirality. This method significantly enhances the Q-factor of optical resonant systems, reduces linewidth, and achieves strong CD while addressing the trade-off between high Q-factor and high CD observed in existing structures. The theoretical foundations for achieving ultra-narrow linewidth are established through band structure calculations and far-field polarization analysis. Additionally, the Q-factor of quasi-BIC can be flexibly optimized through parameter tuning, rendering it more practical than perfect BIC in real-world applications. This study presents a novel solution for terahertz narrowband chirality and optical filters, potentially advancing technologies in related fields.© 2024 Optica Publishing Group under the terms of the Optica Publishing Group Open Access Publishing Agreement.

Spatiotemporal Moisture Field

For monitoring capillary moisture conduction, the most important parameter is the moisture conductivity coefficient, which is a material characteristic; however, its use in practical calculations is not very common. For further development in the field of liquid moisture propagation, an automated measuring apparatus has been developed and granted a European patent. Its essence lies in detecting the liquid water content based on a well-known physical phenomenon: electromagnetic radiation in the microwave range. The determination of the spatiotemporal moisture field is the first and fundamental step for describing transportation phenomena. The moisture field thus created allows for the viewing of the moisture conductivity coefficient, which is one of the most important parameters in describing transportation phenomena as a function of moisture. The presence of water in building materials can significantly affect their physical properties, such as mechanical or thermal–technical characteristics. This may lead to unacceptable consequences, which might only manifest after a certain period of time. In the case of multi-layered structures, moisture can transfer from one material to another. Therefore, it is essential to address this process. The advantage of the software solution described by the methodology is the use of an open communication protocol in the form of a synchronized array, which is not common in typical applications of this type. The principle of separating hardware modules is also unusual for devices of this type, as it requires the independent communication of each module with the control software. Mutual communication is handled exclusively at the software level, making it possible to modify, optimize, or parameterize the procedures as needed. Upon closer examination of the wetting curves of various materials, anomalies were revealed in some of their structures. This can be advantageously utilized in the research of newly developed composite materials. The assembled system of measuring instruments, their software integration, and control provide a foundation for the practical application of the described procedures and methods for determining the moisture field of building materials. The parameterization of individual processes, as well as the open access to data, allows for the optimization of the methodology, as materials of entirely different characteristics may require an individual approach, which will certainly contribute to the advancement of science and research in this area. Currently, this work is being followed by further extensive studies, not yet published by the authors, focusing on the application of the described moisture field to evaluate the moisture conductivity coefficient as a function dependent on the material’s mass moisture content. Their application requires specific mathematical and programming approaches due to the significant volume of data involved.

Open science practices among authors published in complementary, alternative, and integrative medicine journals: An international, cross-sectional survey.

Open science practices aim to increase transparency in research and increase research availability through open data, open access platforms, and public access. Due to the increasing popularity of complementary, alternative, and integrative medicine (CAIM) research, our study aims to explore current open science practices and perceived barriers among CAIM researchers in their own respective research articles. We conducted an international cross-sectional online survey that was sent to authors that published articles in MEDLINE-indexed journals categorized under the broad subject of "Complementary Therapies" or articles indexed under the MeSH term "Complementary Therapies." Articles were extracted to obtain the names and emails of all corresponding authors. Eight thousand seven hundred eighty-six researchers were emailed our survey, which included questions regarding participants' familiarity with open science practices, their open science practices, and perceived barriers to open science in CAIM with respect to participants' most recently published article. Basic descriptive statistics was generated based on the quantitative data. The survey was completed by 292 participants (3.32% response rate). Results indicate that the majority of participants were "very familiar" (n = 83, 31.68%) or "moderately familiar" (n = 83, 31.68%) with the concept of open science practices while creating their study. Open access publishing was the most familiar to participants, with 51.96% (n = 136) of survey respondents publishing with open access. Despite participants being familiar with other open science practices, the actual implementation of these practices was low. Common barriers participants experienced in implementing open science practices include not knowing where to share the study materials, where to share the data, or not knowing how to make a preprint. Although participants responded that they were familiar with the concept of open science practices, the actual implementation and uses of these practices were low. Barriers included a lack of overall knowledge about open science, and an overall lack of funding or institutional support. Future efforts should aim to explore how to implement methods to improve open science training for CAIM researchers.

Escape behavior of rocky‐reef fish reveals the impact of spearfishing across different management regimes

AbstractFlight initiation distance (FID), the distance at which an organism begins to flee from an approaching threat, is a major component of antipredator escape behavior and a potential indicator of threat perception in fishes. In this study, we analyzed the FID of three important rocky‐reef fish species targeted by spearfishers, which are of commercial and recreational importance. We tested predictions that FID to a diver threat increases with the following factors: (1) fish body size, (2) less restricted access regimes, and (3) increased historical fishing pressure. We studied three size ranges of three rocky‐reef fish species, in three different access regimes (i.e., open access, territorial user rights for fishery areas, no‐take marine protected areas), and in two regions (northern and central region with different levels of fishing pressure depending on the species). We conducted an ANOVA to analyze pairwise interactions. We used the mean square criterion to select the models that best explained the variation of our response variable. Our findings indicate that FID can be distinctly elucidated by factors such as individual size, species, access regimes, and regions. Additionally, our models show that interactions involving regions and either species or size further contribute to explain FID variability. FID was higher in larger fishes and those of higher commercial value, outside marine reserves and in the region with the highest historical fishing pressures (based on landings data). This study supports the predictions that increased FID is associated with the threat posed by spearfishing activities. Furthermore, our findings indicate that spearfishing may already be altering the behavior of rocky‐reef fishes on the north‐central coast of Chile.

Utilization of percutaneous closure devices for large bore arterial access in patients with genetic aortopathy does not result in increased rates of access site complications

ObjectivePercutaneous closure devices for arterial sheaths of sufficient caliber to deliver aortic endografts have a published success rate of 90-95%. Despite this, they are frequently avoided in patients with genetic aortopathy due to concern for high failure rates and increased complications in the setting of compromised tissue integrity. This study aims to compare rates of access site complications following large bore percutaneous access among patients with and without confirmed genetic aortopathy. MethodsAll patients undergoing endovascular aortic procedures requiring large bore (≥9Fr) femoral sheath access between 2019-2023 were identified. The specific mutation, demographics, comorbidities, and operative details including maximum sheath size were recorded. Outcomes including unplanned femoral cutdown, access site complications and reinterventions were evaluated. These factors were then compared between patients with and without a laboratory confirmed mutation associated with genetic aortopathy. A supplemental analysis was then performed on all patients with genetic aortopathy from 2014-2023. ResultsAmong the 404 patients identified, 33 (8%) had confirmed genetic aortopathy. Among these, 7 patients (21%) had Marfan syndrome, 7 (21%) had Loeys-Dietz syndrome, and 3 (9%) had vascular Ehlers-Danlos. Also represented were ACTA2, PRKG1, FOXE3, and LOX mutations. The genetic aortopathy group was significantly younger (median genetic aortopathy: median 52 years; non-genetic aortopathy: 71 years; p<0.001). TEVAR was most frequent in the genetic aortopathy group (52%), followed by Zone II arch replacement with frozen elephant trunk (21%); the most frequent operation among the non-genetic aortopathy group was F/BEVAR(43%), followed by TEVAR (25%). Both groups had a median sheath size of 20 Fr; the patients with genetic aortopathy had higher rates of both prior open (genetic aortopathy: 27%; non-genetic aortopathy: 12%; p=0.015) and prior percutaneous ipsilateral access (genetic aortopathy: 58%; non-genetic aortopathy: 39%; p=0.041). Rates of unplanned cutdowns (genetic aortopathy: 0%; non-genetic aortopathy: 6%) and access site complications (genetic aortopathy: 0%; non-genetic aortopathy: 8%) did not significantly differ between groups (p=0.160 and p=0.096, respectively). In supplementary analysis, there was one patient with genetic aortopathy who required unplanned cutdown, yielding an overall technical success rate of 97% for percutaneous closure over a 10-year period. ConclusionsPercutaneous access is safe and effective in patients with confirmed genetic aortopathy with similar rates of unplanned cutdown as those in patients without genetic aortopathy. Given the high rates of staged, repeat aortic procedures in this patient population, percutaneous closure should be attempted to avoid an obligate femoral incision, thereby reducing the potential for wound complications and increasing the ease of future procedures.

First Complete Genome Sequence of Nigrospora osmanthi: A Fundamental Resource for Studying the Plant Pathogenic Fungus

Nigrospora osmanthi strain Z1 is a potential bioherbicide for the biological control of water lettuce, one of the most common invasive weeds. Here, the first high-quality genome assembly of N. osmanthi was obtained by a combination of PacBio and Illumina sequencing technologies. Twelve contigs representing the nuclear genome and one mitochondrial DNA were generated, with a total length of 45.94 Mb, an N50 equal to 6.99 Mb, and a GC content of 57.91%; 9 of the 12 nuclear contigs represented chromosomes from telomere to telomere characterized by telomeric-like repeats. A total of 11,051 genes were predicted using a combination of gene prediction tools, including 336 noncoding RNAs, 1,298 genes encoding secretory proteins, 1,735 genes encoding carbohydrate-active enzymes, 1,955 fungal virulence factors, and 50 putative secondary metabolite gene clusters. This complete genome sequence can serve as a valuable resource for future comparative genomic studies of the fungus Nigrospora for effective application in the biocontrol of invasive species and the discovery of fungal secondary metabolites. [Formula: see text] Copyright © 2024 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license .

PP186 Topic: AS16–Medical, Nursing and AHP Workforce &amp; Education: Staff Education and Development/Equity, Diversity, Inclusion/Other: DEVELOPMENT OF OPEN ACCESS APRN PEDIATRIC CRITICAL CARE CURRICULUM AT BOSTON CHILDREN’S HOSPITAL

PP186 Topic: AS16–Medical, Nursing and AHP Workforce &amp; Education: Staff Education and Development/Equity, Diversity, Inclusion/Other: DEVELOPMENT OF OPEN ACCESS APRN PEDIATRIC CRITICAL CARE CURRICULUM AT BOSTON CHILDREN’S HOSPITAL

Evaluation of ComBat Harmonization for Reducing Across-Tracer Differences in Regional Amyloid PET Analyses.

Differences in amyloid positron emission tomography (PET) radiotracer pharmacokinetics and binding properties lead to discrepancies in amyloid-β uptake estimates. Harmonization of tracer-specific biases is crucial for optimal performance of downstream tasks. Here, we investigated the efficacy of ComBat, a data-driven harmonization model, for reducing tracer-specific biases in regional amyloid PET measurements from [18F]-florbetapir (FBP) and [11C]-Pittsburgh compound-B (PiB). One hundred thirteen head-to-head FBP-PiB scan pairs, scanned from the same subject within 90 days, were selected from the Open Access Series of Imaging Studies 3 (OASIS-3) dataset. The Centiloid scale, ComBat with no covariates, ComBat with biological covariates, and GAM-ComBat with biological covariates were used to harmonize both global and regional amyloid standardized uptake value ratios (SUVR). Variants of ComBat, including longitudinal ComBat and PEACE, were also tested. Intraclass correlation coefficient (ICC) and mean absolute error (MAE) were computed to measure the absolute agreement between tracers. Additionally, longitudinal amyloid SUVRs from an anti-amyloid drug trial were simulated using linear mixed effects modeling. Differences in rates-of-change between simulated treatment and placebo groups were tested, and change in statistical power/Type-I error after harmonization was quantified. In the head-to-head tracer comparison, ComBat with no covariates was the best at increasing ICC and decreasing MAE of both global summary and regional amyloid PET SUVRs between scan pairs of the same group of subjects. In the clinical trial simulation, harmonization with both Centiloid and ComBat increased statistical power of detecting true rate-of-change differences between groups and decreased false discovery rate in the absence of a treatment effect. The greatest benefit of harmonization was observed when groups exhibited differing FBP-to-PiB proportions. ComBat outperformed the Centiloid scale in harmonizing both global and regional amyloid estimates. Additionally, ComBat improved the detection of rate-of-change differences between clinical trial groups. Our findings suggest that ComBat is a viable alternative to Centiloid for harmonizing regional amyloid PET analyses.