Onset Of Acne Research Articles

LAMA PENGGUNAAN MASKER TIDAK MEMENGARUHI TIMBULNYA JERAWAT PADA PEREMPUAN USIA 15-60 TAHUN

Acne is an inflammatory dermatosis of the pilosebaceous follicular unit. Many factors influence the onset of acne, including facial skin hygiene and skin moisture. The use of masks can have an impact on increasing facial skin moisture and pressure on the skin. This study aims to determine relationship between length use of masks and appearance of acne and factor influencing in women age 15-60 years old. A cross sectional design was conducted on respondents with inclusion criteria of women aged as mentioned previously. Data was collected using a google form questionnaire. The relationship between variables were analyzed statistically with Spearman test with p <0,05 and Chi Square test with p <0,05 significantly different. Total of 225 respondents participated in this study. Respondents used masks for 3 hours and more are 190 (84.5%) respondents. Respondents reported the occurrence of acne after using the mask are 143 (63.5%). Statistical analysis did not find a significant relationship between the duration of using a mask and the onset of acne (p=0.391). Factors that showed a significant relationship with the onset of acne were age, menstrual cycle, education level, facial care, and washing face more often. The duration of using a mask is not related to the appearance of acne in women of reproductive age. Factors influencing with the appearance of acne are age, menstrual cycle, education level, facial care, and washing face more often.

N07 JAKne: JAK inhibitor associated acne, a real-life single-center experience

Abstract Background Three Janus kinase (JAK) inhibitors, tofacitinib (TFC), filgotinib (FIL) and upadacitinib (UPA), have been approved for treatment of Crohn’s disease (CD) and/or ulcerative colitis (UC). During the IBD registrational trials, acne was reported as adverse event (AE) in 5-7% of UPA treated patients, but not in the FIL and TFC programs. Hence, we assessed the prevalence of JAK inhibitor associated acne in a real-life cohort. Methods All patients initiating JAK inhibitors for active moderate-to-severe CD or UC at our center were included. Patients were prospectively monitored at prespecified timepoints, and specifically assessed for AEs including acne. Affected patients completed a visual analogue scale (VAS) to assess the impact of acne on their quality of life. All pictures of skin lesions were assessed by a dermatologist specialized in inflammatory skin diseases. Results In total, 46 patients initiated TFC, 40 FIL and 79 UPA. None of the TFC or FIL treated patients reported new onset of acne. Instead, 17 (21.5%) patients (9 CD, 8 UC; median [IQR] age 28.2 [25.2-45.0]; 47.1% female) spontaneously reported acne during UPA therapy. Most (89.5%) reported new onset of acne, while 2 (10.5%) mentioned a deterioration of existing acne during UPA induction. Previous acne during adolescence was reported by 46.2%. Lesions were present in the face (82.3%), back (23.5%), chest (23.5%) and scalp (11.8%). The acne phenotype included inflammatory papules in all patients, but also pustules (66.7%), nodules (33.3%), cysts (11.1%) and comedones (11.1%) were observed. A median VAS score of 5.5 [5.0-7.0] highlighted the impact on the patient’s quality of life, though no patient interrupted UPA due to acne. Six (35.2%) patients were referred to a dermatologist for acne. Most patients (82.4%) received topical skin therapy during UPA induction based on a standard operation procedure approved by the dermatologist and communicated via the IBD nurses. Three patients (17.6%) received antibiotics during UPA induction because of acne. During UPA maintenance, 5 patients (29.4%) reported resolution of skin problems with only 1 requiring continued skin therapy. Ten patients (58.7%) continued topical skin therapy during maintenance, with 4 of them requiring continued antibiotic treatment for at least 3 months. A single patient was deescalated from UPA 30mg to 15mg QD because of severe acne, with little improvement. Conclusion In this real-world experience, JAK inhibitor associated acne was uniquely linked to UPA, occurring in one fifth of patients. This is more prevalent than observed in the registrational trials. Awareness and patient education are therefore important, as well as early referral to the dermatologist for appropriate treatment.

The Relationship of Facial Skin Personal Hygiene to The Onset of Acne (Acne Vulgaris) in Adolescent Boys

The Relationship of Facial Skin Personal Hygiene to The Onset of Acne (Acne Vulgaris) in Adolescent Boys

RESEARCH ON THE PREVALENCE, CLINICAL CHARACTERISTICS, AND RELATED FACTORS IN ACNE VULGARIS PATIENTS WITH DEMODEX INFECTION IN CAN THO CITY FROM 2021 TO 2023

Background: Acne is a common disorder, associated with inflammation of the sebaceous and bacterial hair follicle units and has diverse clinical manifestations. The most commonly mentioned causes and factors associated with the onset of acne in adulthood are hormones, antibiotic-resistant bacteria, and the use of drugs and cosmetics. In particular, the increase in the number of Demodex mites due to the habit of using cosmetics of unknown origin, has caused complicated clinical symptoms and difficulties in the treatment of acne today. Objectives: To determine the prevalence, clinical characteristics and some related factors in patients with acne vulgaris superinfected with Demodex. Materials and methods: A cross-sectional descriptive study with analysis was conducted on 154 acne vulgaris patients visiting medical facilities in Can Tho city in 2021-2023. Results: The study included 154 acne vulgaris patients with an average age of 22.16 ± 6.739 years old, with males constituting the majority. Among the patients, 29.87% had Demodex infestation, and 9.74% of them had a Demodex density of 5 or more mites. The majority of acne cases were of moderate or higher severity, with the most severe cases accounting for 85.7% of those with Demodex presence. Clinical features observed in patients with Demodex infestation included closed comedones (97.8%), open comedones (93.5%), papules (63%), pustules (60.9%), and cystic nodules (52.2%). Additionally, 93.5% and 91.3% of patients reported symptoms of peeling skin, but only 50% reported a feeling of ants, which appeared to be related to Demodex infection in acne patients. Furthermore, habits such as sharing towels, makeup, and wearing masks for more than 8 hours were identified as risk factors for Demodex infection. Conclusions: The presence of Demodex in acne patients is associated with a variety of clinical manifestations, including acne accompanied by skin peeling, scaling, and itching sensation. The relationship between Demodex infestation and the sensation of ants requires further investigation. Additionally, papules, pustules, and crawling sensations were also found to be related to Demodex infection. Moreover, certain habits, such as sharing towels, using makeup, and wearing masks for prolonged periods, appear to be risk factors for Demodex infection in acne patients

Gut microbiota and acne: A Mendelian randomization study.

Prior observational studies have identified a relationship between the composition of gut microbiota and the onset of acne. To ascertain the causal relationship underlying this association, we adopted the Mendelian randomization (MR) method, which offers a powerful approach to causal inference. Summary statistics on gut microbiota and acne were obtained from the MiBioGen and FinnGen consortium, respectively. The causal relationship was assessed using multiple methods in a two-sample framework, including MR Egger, weighted median, inverse variance weighted (IVW), and weighted mode. Furthermore, the heterogeneity and horizontal pleiotropy analyses were conducted, along with the leave-one-out method. The IVW estimation indicated that Allisonella (odds ratio [OR]=1.42, 95% confidence interval [CI]=1.18-1.70, p=0.0002) and Bacteroides (OR=2.25, 95% CI=1.48-3.42, p=0.0001) have adverse effects on acne. By contrast, Ruminococcus torques group (OR=0.41, 95% CI=0.25-0.65, p=0.0002) showed a beneficial effect on acne. In addition, Candidatus soleaferrea (OR=0.75, 95% CI=0.60-0.95, p=0.0149), Eubacterium coprostanoligenes group (OR=0.67, 95% CI=0.47-0.95, p=0.0230), Fusicatenibacter (OR=0.71, 95% CI=0.52-0.97, p=0.02897), and Lactobacillus (OR=0.72, 95% CI=0.58-0.90, p=0.0046) showed suggestive associations with acne. The present investigation suggests a causal effect of gut microbiota on acne.

Factors related to the onset of acne after adolescence and traditional Chinese medicine treatment

Factors related to the onset of acne after adolescence and traditional Chinese medicine treatment

Myths, misconceptions and attitudinal trends among patients with acne.

Background Despite acne being a common dermatological problem, there is a paucity of literature addressing the knowledge, attitude and practice about it. Aims/Objectives To find out what patients know about acne, its cause and treatment, as well as myths, misconceptions and attitude towards it. Methods A cross-sectional, descriptive questionnaire-based study on acne patients at Maharana Bhupal Hospital, RNT Medical College, Udaipur, Rajasthan, India. Results Most (84.8%) patients belonged to the age group of 16-25 years. The majority (63.9%) presented 12 months after the onset of acne. More than half had average knowledge, a positive attitude and good practices, related significantly to gender and education. Limitations A standardized questionnaire suitable for all dialects and regional languages would have yielded more uniform results. Conclusion Study revealed that acne patients still need to acquire accurate, adequate and easily accessible information to seek timely and appropriate treatment, and alleviate their psychological suffering.

Prevalence and Associated Factors of Mask-Induced Acne (Maskne) in the General Population of Jeddah During the COVID-19 Pandemic.

Background: COVID-19 is a newly emerged coronavirus (SARS-CoV2) infectious disease pandemic that originated in Wuhan, China at the end of 2019. The first documented case in Saudi Arabia was on March 2, 2020. Soon after, the World Health Organization declared the outbreak a global pandemic. The ministry of health in Saudi Arabia mandated the wearing of facial masks for the general population, among other methods of protection from the spread of this highly contagious virus.It was observed that the continuous and prolonged wearing of facial masks has led to the development of multiple skin complications and facial dermatosis, including new-onset acne as well as flares of pre-existing acne in the general population and especially healthcare workers.Methodology: This cross-sectional study was conducted during the COVID-19 pandemic from January to September 2021 in Jeddah, Saudi Arabia. A self-administered electronic survey was distributed to residents of Jeddah city using multiple social media platforms to assess the prevalence and the factors attributed to the development of mask-induced acne.Result: A total of 630 participants were enrolled. 470 (74.6%) were females and 160 (25.4%) were males, and the predominant age group was 18-30 years old, 374 (59.4%). The majority of participants wore a mask for five to seven days per week, 272 (43.2%), and for less than four hours per day, 378 (60%). The surgical masks were the most frequently used masks, with 597 (94.8%). Three hundred and seventy-nine (60.2%) participants had no previous skin disease on their faces. Only 251 (39.8%) of the participants had pre-existing skin diseases affecting the face. Of those, acne was the most frequent skin condition, 217 (86.4%), followed by atopic dermatitis, 12 (4.8%).Ninety-seven (23.5%) participants without a prior history of acne reported the new onset of acne during the pandemic with the use of a face mask or face shield. Thirty people (59.9%) who had acne on their faces before the pandemic said that their acne got worse when they wore face masks or face shields for a long time during the pandemic.Conclusion: This study demonstrated a significant association between the new onset of acne or worsening of pre-existing acne and the frequent and prolonged usage of facial masks. Thus, certain measures should be applied to prevent the development of new or worsening of prior acne while maintaining effective protection using facial masks.

Ribotype‐dependent growth inhibition and promotion by erythritol in Cutibacterium acnes

The close balance between Cutibacterium acnes and the skin flora, particularly between C.acnes phylotypes, has been suggested to play an important role in the onset of acne. C.acnes has been classified into ribotypes (RTs) based on polymorphisms in its 16S rRNA sequence, with RT4 and RT5 being associated with the onset of acne and RT6 with healthy skin. The present study investigated the impact of erythritol on the growth of C.acnes strains classified into different RTs and attempted to elucidate the molecular mechanisms underlying its effects. Culturing tests were performed on several RTs of C.acnes with or without erythritol. A transcriptional analysis of HM554 (RT6) and HM514 (RT5) was also conducted. The growth of RT2 and RT6, RTs associated with healthy skin, was significantly promoted in a medium containing 10% (W/W) erythritol, whereas that of RT1, RT3, RT4, RT5, and RT8, RTs associated with the development of acne, was inhibited. A RNA-seq analysis of HM554 showed that the expression of six genes (EIGs) potentially involved in carbohydrate metabolism was strongly induced by the presence of 10% erythritol (Log2 fold change >2.0 and p-value <0.05). A comparative expression analysis by qPCR revealed that EIGs other than g3pD were strongly induced by erythritol in HM514, similar to HM554, whereas g3pD was only slightly induced. Erythritol inhibited the growth of RTs associated with acne and promoted that of RTs associated with healthy skin. The enzyme encoded by g3pD may play an important role in the metabolism of erythritol and the dissolution of its growth inhibitory effects on C.acnes.

Acne and insulin resistance: A systematic review and meta-analysis

To the Editor: Acne is more common in westernized societies, suggesting that environmental factors likely contribute to acne pathogenesis.1Cordain L. Lindeberg S. Hurtado M. Hill K. Eaton S.B. Brand-Miller J. Acne vulgaris: a disease of western civilization.Arch Dermatol. 2002; 138: 1584-1590Crossref PubMed Google Scholar Metabolic abnormalities may influence key factors in the development of acne, such as the proliferation of basal keratinocytes in the sebaceous-pilosebaceous unit and abnormal desquamation of follicular corneocytes.2Del Prete M. Mauriello M.C. Faggiano A. et al.Insulin resistance and acne: a new risk factor for men?.Endocrine. 2012; 42: 555-560Crossref PubMed Scopus (50) Google Scholar Therefore, we hypothesized that patients with acne would demonstrate higher levels of insulin resistance. In this systematic review and meta-analysis, we examined the relationship between insulin resistance and acne, as it may have important therapeutic and diagnostic implications, such as exploring insulin modifiers as an adjunctive acne treatment and screening acne patients for metabolic syndrome. PubMed and Embase were systematically searched for studies published prior to March 17, 2021 that evaluated insulin resistance in patients with acne. In PubMed and Embase (acne OR acne vulgaris) AND (insulin resistance OR diabetes OR blood glucose) were searched as Medical Subject Heading terms and keywords, respectively. Only clinical studies measuring values for Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), a validated laboratory measure of insulin resistance, in acne patients and control subjects were included.3Muniyappa R. Madan R. Assessing insulin sensitivity and resistance in humans.in: Feingold K.R. Anawalt B. Boyce A. Endotext [Internet]. MDText.com, Inc, 2000Google Scholar Studies were excluded if they were unpublished, abstracts, not written in English, or included patients with polycystic ovarian syndrome in order to exclude hyperandrogenism as a potential confounding variable. Database searches yielded 136 unique results. Thirteen articles met inclusion criteria and were included in the analysis (Supplementary Fig 1, available via Mendeley at https://data.mendeley.com/datasets/bfrm4wbdrz/2). The following data were extracted from each article: number of acne subjects, mean age of acne subjects, mean body mass index of acne subjects, acne severity, other acne qualifiers (postadolescent acne or treatment nonresponders), control subjects, mean HOMA-IR value in both acne and control groups, and quality assessment score (Supplementary Table 1, available via Mendeley at https://data.mendeley.com/datasets/bfrm4wbdrz/2). Meta-analysis compared the differences between acne and control patients. Hedges' g standardized mean difference between HOMA-IR values in acne patients and controls was calculated as the summary statistic. Results are reported from a random effects model. An I2 statistic was calculated to estimate heterogeneity across studies.4Egger M. Davey Smith G. Schneider M. Minder C. Bias in meta-analysis detected by a simple, graphical test.BMJ. 1997; 315: 629-634Crossref PubMed Scopus (32351) Google Scholar Moderating variables were studied in a mixed-effects model. Statistical analyses were conducted with R statistical software (version 4.0.5) using the meta package.5Balduzzi S. Rücker G. Schwarzer G. How to perform a meta-analysis with R: a practical tutorial.Evid Based Ment Health. 2019; 22: 153-160Crossref PubMed Scopus (952) Google Scholar Acne patients had higher HOMA-IR values than controls (standardized mean difference = 0.60; 95% CI, 0.33-0.88; P < .001) (Supplementary Fig 2, available via Mendeley at https://data.mendeley.com/datasets/bfrm4wbdrz/2). Onset of acne in the postadolescent period, average age of participants, sex of participants, average body mass index, publication year, or quality score were not significant modifying variables in our model. There was heterogeneity between studies (P < .001), which was a limitation of our study. Publication bias was assessed visually using a funnel plot and quantitatively with Egger's regression test of asymmetry (Supplementary Fig 3, available via Mendeley at https://data.mendeley.com/datasets/bfrm4wbdrz/2). Although some asymmetry exists, the large effect size of study 13 appears to mitigate the asymmetry (P = .47). However, due to the small number of studies with a large variation in effect sizes and standard errors, we do not have enough evidence that publication bias does not exist in this study. Dermatologists should be aware of the potential relationship between acne and insulin resistance and consider referring acne patients to primary care for further evaluation. Early treatment of insulin resistance can prevent the development of diabetes and cardiovascular disease. None disclosed.

Caesarean delivery and pubertal timing in boys and girls: A Danish population-based cohort study.

There is considerable public and scientific interest in the declining age of pubertal timing. Prenatal and postnatal stress has been proposed to relate with earlier pubertal timing, but it remains unknown whether intrapartum stress may affect pubertal timing as well. This study aims to examine the potential effect of caesarean delivery on pubertal timing in boys and girls. This study was based upon the nationwide Puberty Cohort nested within the Danish National Birth Cohort (DNBC) from 2000 to 2003. A total of 15,731mother-child pairs with complete information on delivery mode and puberty were included in the main analysis. The delivery mode was categorised into non-instrumental vaginal delivery (reference), instrumental vaginal delivery, elective caesarean delivery before labour, emergency caesarean delivery during labour and un-specified caesarean delivery. Children's pubertal development were self-reported in web-based questionnaires from 11years of age and every 6months throughout puberty (2012-2019), including Tanner stages 2-5, menarche, voice break, first ejaculation, axillary hair growth and the onset of acne. Regression models for censored, normally distributed time-to-event data were used to estimate mean monthly differences in age at attaining the different pubertal milestones and the average of all these estimates for each sex (a combined indicator of pubertal timing). A total of 2810 participants were born by caesarean delivery (17.9%). Neither elective nor emergency caesarean delivery was associated with earlier age at achieving the pubertal milestones in boys or in girls. For the combined indicator, the mean age differences for elective caesarean delivery and emergency caesarean delivery were 0.1 (95% CI -1.1, 1.4) months and -0.7 (95% CI -2.0, 0.5) months in boys and 0.7 (95% CI -0.7, 2.0) and 0.2 (95% CI -1.3, 1.7) in girls. This study does not suggest a clinically important effect of caesarean delivery on children's pubertal timing.

Факторы риска поздних акне у женщин

Acne is the most common skin disorder, affecting almost 90 % of young people under the age of 20. Modern research also indicates an increase in the incidence in adulthood. According to Russian and foreign literature, the incidence of acne in women aged 25–55 years ranges from 3 to 40 % Moreover, in recent years, more often in women, the onset of acne occurs at the age of over 25 years. Localization of rashes on the face, considered by women as a cosmetic defect, in almost all patients leads to the formation of various psychoemotional disorders, causes difficulties in social and professional adaptation, while in adult women these disorders are more pronounced than at puberty. The article discusses the etiopathogenesis and therapy of late acne and their consequences in women. The results of studies of the effectiveness of methods of treating late acne in women, depending on the factors of their occurrence, are presented, the use of hormone replacement therapy is substantiated. The authors have shown the high efficiency and compliance of the combination therapy of late acne in women

Lityum kullanımına bağlı gelişen akne: bir olgu sunumu.

Lithium is the drug of choice in the treatment of bipolar mood disorders. Lithium, which causes neutrophilic infiltration, can have negative consequences on the skin. Dermatological side effects such as acne, psoriasis, hair loss, thinning hair, itching, folliculitis and maculopapular rash may occur during lithium use. Acne, especially due to lithium use, is one of the most frequently reported dermatological side effects. However, these side effects may not be questioned or noticed in clinical practice. Regarding the diagnosis of lithium-induced acne development, the history of drug intake, the sudden onset and an unusual age of onset, as well as the initiation of lithium therapy, the drug dose, the duration of the treatment, the absence of other triggering factors, and the clinical relationship between the administration of the drug and the onset of acne should be examined in detail. In our study, a 27-year-old female patient with bipolar disorder using lithium treatment and who developed widespread acne as a result of increasing the drug dose was presented in the light of literature findings. Acne development due to lithium use may be a problem for patients and may affect treatment compliance. Clinicians are advised to carefully monitor dermatological side effects in patients receiving lithium therapy.

Risk Factors for Acne Vulgaris Development

Acne vulgaris is a disease of pilosebaceous unit that is most commonly seen during adolescence . Increasing pubertal age, seborrhea, the premenstrual phase, mental stress, and sweet and oily foods were recognized as risk factors for moderate to severe acne. Also gender, spicy foods, and smoking were not associated with acne severity This case-control study included 50 participants; 30 patients suffering from moderate and severe acne vulgaris, in addition to 20 apparently healthy, age and sex matched individuals . Present history including age of onset of acne, disease duration, course of the disease and risk factors (diet, sun exposure , smoking, stress) family histories were obtained from all patients. logistic regression analysis was conducted for prediction of acne vulgaris development, using age, gender, smoking, risk factors,. Positive FH, smoking, higher frequency sun exposure, high caloric diet, excess stress, were associated with risk of acne vulgaris occurrence in univariable analysis. Estimation of risk factors including Positive FH, smoking, higher frequency sun exposure, high caloric diet, excess stress are important in prediction and management of acne vulgaris .

Acne in pregnancy: A prospective multicenter, cross-sectional study of 295 patients in Turkey.

There are only a few studies on acne in pregnancy. This study was aimed to investigate the demographic, clinical, and familial characteristics of acne in pregnancy, triggering factors including endocrine diseases, and association of these findings with acne in different trimesters of pregnancy. Pregnant women aged 18years and older with acne at any stage of pregnancy were consecutively interviewed at the participating centers during the study period from 2016 to 2019. Acne severity was evaluated using the Comprehensive Acne Severity Scale. A total of 295 pregnant women with acne were included, with 167 (56.6%) patients showing mild, 87 (29.5%) moderate, six (12.2%) severe, and five (1.7%) very severe acne. Truncal acne was significantly higher in the third trimester than in the other stages (P<0.001). Onset of acne before pregnancy, prepubertal, pubertal or adult onset, or acne history in previous pregnancies did not influence acne severity in pregnancy. Women with irregular menstruation before pregnancy, polycystic ovary syndrome, hirsutism, and higher body weight index tended to show severe acne in pregnancy. Severe acne during pregnancy is generally uncommon, while severity of facial acne, truncal acne, and hirsutism is higher in the third trimester than in other trimesters. Acne in pregnancy shares many characteristics with female adult acne. Substantial changes in different kinds of hormones play a more complex role in acne during pregnancy, but the pathogenesis remains to be determined.

A Morphological Study of Acne Scarring and Its Relationship between Severity and Treatment of Active Acne.

Background:Scarring is one of the most dreadful complications of acne for which patients seek surgical treatment.Objective:The aim of this research was to study the morphological features of acne scarring and the relationship between severity of acne and its treatment with type and severity of acne scars.Materials and Methods:This was a hospital-based, noninterventional, cross-sectional study carried out over a period of 1 month on 100 patients with post-acne scarring. A morphological evaluation of the types, sites, and severity of acne scars was done, and details of the severity and treatment of acne were recorded.Results:Of 100 patients included in the study, 61 were male and 39 were females. Females had an earlier onset of acne (15.8 years) as compared to males (16.5 years). The mean duration of active acne was longer in males (99.3 months) than that in females (74.4 months). Male patients had more severe acne vulgaris as compared to females (P = 0.0001). Of 100 patients, 52 started treatment 1 year after the onset of acne, and 18 patients had never taken any anti-acne medication. Morphologically, majority of post-acne scars were ice pick scars in 94% patients, followed by rolling scars in 86%, boxcar scars in 54%, and keloidal scars in 10% patients. Male patients had more severe acne scarring than females (P < 0.05). Of 54 patients with severe acne, 22 progressed to moderate grade and 32 patients progressed to severe grade of acne scarring. Significant reduction in the severity of acne scarring was observed in patients who received isotretinoin as compared to that in patients who received oral antibiotics.Conclusion:Majority of patients with active acne delay treatment, which leads to increased acne scarring. Ice pick scars are the most common type of acne scars, and keloidal scars are more common in males. Males have a longer duration of acne, they delay treatment, and have more severe acne scarring. Early introduction of oral isotretinoin may help to reduce the severity of acne scarring. Public education is essential to urge patients to seek early and appropriate treatment of acne that can reduce the incidence and severity of acne scarring and its psychosocial consequences.

FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN KEJADIAN ACNE VULGARIS (JERAWAT) PADA REMAJA DI SMK TARUNA PEKANBARU TAHUN 2014

Acne vulgaris is a chronic inflammatory disease of the follicles pilosebaseous, characterized by comedones, papules, pustules, and nodules.The main causes of acne as yet known with certainty, but there is strong suspicion is a multifactorial disease, including heredity, hormonal balance, diet, skin condition and hygiene. Acne is a skin disease that is often found in adolescents by (85%).. Based on the results of the survey in 5 SMK Pekanbaru on class X , obtained the highest number of cases of acne that is in SMK Taruna Pekanbaru many as 113people. This study aims to determine the factors associated with the incidence of acne vulgaris in adolescents in SMK Taruna Pekanbaru 2014. The research is quantitative cross-sectional study research design that was held on 5-9 May 2014, in SMK Taruna Pekanbaru. The population this is the entire student SMK Taruna Pekanbaru class X at 302 people, and obtained a large sample of 117people, with rendom systematic sampling technique using a questionnaire measuring instruments. Data analiysis of univariate and bivariate using chi square test.The results showed that there is a relationship of knowledge obtainable, (p value = 0,006 dan POR = 3,06, 95%CI : 1,43-6,75), foods that can emergence the onset of acne obtainable (p value = 0,009 and POR = 2,88, 95%CI : 1,35-6,14, the frequency of facial wash (cleaning) obtainable (p value = 0,009 and POR = 2,88, 95%CI : 1,35-6,14) and the condition of facial skin obtainable (p value = 0,005, POR = 3,12 , 95%CI : 1,46-6,68) with incidence of acne vulgaris. It is recommended for adolescents to avoid foods that can emergence the onset of acne, skin treatment to reduce excess oil production by applying frequency facial wash (cleaning) on a regular basis.

Involvement of adenosine triphosphate-binding cassette subfamily B member 1 in the augmentation of triacylglycerol excretion by Propionibacterium acnes in differentiated hamster sebocytes.

An onset of acne, a common inflammatory skin disease, is associated with excess sebum production and secretion in sebaceous glands. Because Propionibacterium acnes has been reported to augment intracellular sebum accumulation in sebaceous glands in hamsters, it remains unclear whether P. acnes influences sebum secretion from differentiated sebocytes. Both P. acnes culture media (Acnes73-CM) and formalin-killed P. acnes (F-Acnes73) dose-dependently increased the extracellular levels of triacylglycerol (TG), a major sebum component, and Rhodamine 123, a substrate of adenosine triphosphate-binding cassette (ABC) transporter, from differentiated hamster sebocytes (DHS). In addition, the gene expression of the ABC subfamily B member 1 (ABCB1) was dose-dependently augmented by adding Acnes73-CM and F-Acnes73 into DHS. Furthermore, the F-Acnes73-induced increase of TG excretion was suppressed by PSC833, a selective ABCB1 inhibitor. On the other hand, peptidoglycan (PGN), which is a Toll-like receptor 2 (TLR2) ligand in P. acnes, increased extracellular TG levels, transporter activity and ABCB1 mRNA expression in DHS. The PGN-augmented TG excretion was suppressed by PSC833. Thus, these results provide novel evidence that P. acnes facilitates sebum secretion due to the activation of ABCB1 concomitantly with the increased ABCB1 expression, which may result from the activation of the TLR2 pathway in DHS. Therefore, the ABCB1 inhibitor is likely to become a candidate as a possible therapeutic for the treatment of acne.

Heredity of acne in Korean patients.

Acne is a chronic inflammatory disease of the pilocebaceous unit that presents with various spectrum and severity. Genetic backgrounds and environmental factors are also considered to be relevant, but few studies have focused on Korean patients. A cross-sectional epidemiologic study on family history of Korean acne patients was performed to analyze family history of acne, and to compare the severity and characteristics of acne in association with family history. A total of 221 patients were enrolled, 98 male (44.3%) and 123 female (55.7%). Patients were grouped as patients with (A+) or without (A-) family history of acne. In a second analysis, patients with any experience of acne treatment were evaluated. Severity of acne was measured with Burton's grading system and Korean Acne Grading System (KAGS). Female patients had a higher tendency to have family history than males (P=0.002). Group A+ had statistically significant earlier onset of acne (P=0.002). In inexperienced patients, patients with family history showed a relatively earlier onset (P=0.084). This study confirmed the role of heredity in acne. Family history of acne is associated with earlier onset of the disease, and more non-inflammatory lesions.

The influence of united psychosomatic factors on clinical features of acne vulgaris

Acne is a chronic inflammatory disorder of the pilosebaceal unit. Dermatological disorders are often associated with a variety of psychological problems which the patient have. Psichodermatologic disorders (acne) are associated with skin problems that are not directly connected to the mind, but that react to emotional states, such as stress. The aim of this article is to show if there is any psychological characteristic which are common for the whole group of ill-patients from acne, as well as whether there is correlation between any type of acne and psychological parameters. Own exploration consist at thirty patients with three clinical type of acne. Personality test-Kornel index were used for identification and diagnostic psychosomatic disorders. The results are: neurastenic parameters, parameters of conversion and parameters of psychopathy in different percent at both sex, and different clinical features. We show correlation united 2-6 psichosomatic disorders in male sex with softly type of acne. In female sex with any type of acne are responsible 7-12 united findings. The association of several psychosomatic factors could possibly be responsible for the onset of acne at any type.