One-pot Green Synthesis Research Articles

Evaluation of Antibacterial Mechanism of Action, Tyrosinase Inhibition, and Photocatalytic Degradation Potential of Sericin-Based Gold Nanoparticles.

In recent times, numerous natural materials have been used for the fabrication of gold nanoparticles (AuNPs). Natural resources used for the synthesis of AuNPs are more environment friendly than chemical resources. Sericin is a silk protein that is discarded during the degumming process for obtaining silk. The current research used sericin silk protein waste materials as the reducing agent for the manufacture of gold nanoparticles (SGNPs) by a one-pot green synthesis method. Further, the antibacterial effect and antibacterial mechanism of action, tyrosinase inhibition, and photocatalytic degradation potential of these SGNPs were evaluated. The SGNPs displayed positive antibacterial activity (8.45-9.58 mm zone of inhibition at 50 μg/disc) against all six tested foodborne pathogenic bacteria, namely, Enterococcus feacium DB01, Staphylococcus aureus ATCC 13565, Listeria monocytogenes ATCC 33090, Escherichia coli O157:H7 ATCC 23514, Aeromonas hydrophila ATCC 7966, and Pseudomonas aeruginosa ATCC 27583. The SGNPs also exhibited promising tyrosinase inhibition potential, with 32.83% inhibition at 100 μg/mL concentration as compared to 52.4% by Kojic acid, taken as a reference standard compound. The SGNPs also displayed significant photocatalytic degradation effects, with 44.87% methylene blue dye degradation after 5 h of incubation. Moreover, the antibacterial mode of action of the SGNPs was also investigated against E. coli and E. feacium, and the results show that due to the small size of the nanomaterials, they could have adhered to the surface of the bacterial pathogens, and could have released more ions and dispersed in the bacterial cell wall surrounding environment, thereby disrupting the cell membrane and ROS production, and subsequently penetrating the bacterial cells, resulting in lysis or damage to the cell by the process of structural damage to the membrane, oxidative stress, and damage to the DNA and bacterial proteins. The overall outcome of the current investigation concludes the positive effects of the obtained SGNPs and their prospective applications as a natural antibacterial agent in cosmetics, environmental, and foodstuff industries, and for the management of environmental contagion.

One-pot green synthesis of magnetic adsorbent via Anabaena sphaerica and its performance towards Remazol Red dye removal from aqueous media

A simple one-pot green approach was adopted for synthesizing novel surface-modified Anabaena sphaerica biomass of various functional groups with the superparamagnetic Fe3O4. The preparation strategy was based on the reduction of iron-precursor by the antioxidants released from Anabaena sphaerica during the solvothermal process. The prepared materials were applied for Remazol Red F3B (RR) dye removal. The adsorptive material prepared by 1:3 Anabaena sphaerica to Fe-precursor weight ratio as starting materials heated at 200 °C/48 h removed ∼ 98% of RR dye (10 mg/L) after only 15 min at pH 3. The reusability of the best sample was confirmed for five consecutive runs. Langmuir best described the adsorption equilibrium data, while Elovich's kinetic model best fitted the experiment data even at low adsorbent dosage. Conclusively, the prepared magnetic biosorbents were demonstrated as good adsorbents for water decontamination.

Facile One-Pot Green Synthesis of Magneto-Luminescent Bimetallic Nanocomposites with Potential as Dual Imaging Agent

Nanocomposites serving as dual (bimodal) probes have great potential in the field of bio-imaging. Here, we developed a simple one-pot synthesis for the reproducible generation of new luminescent and magnetically active bimetallic nanocomposites. The developed one-pot synthesis was performed in a sequential manner and obeys the principles of green chemistry. Briefly, bovine serum albumin (BSA) was exploited to uptake Au (III) and Fe (II)/Fe (III) ions simultaneously. Then, Au (III) ions were transformed to luminescent Au nanoclusters embedded in BSA (AuNCs-BSA) and majority of Fe ions were bio-embedded into superparamagnetic iron oxide nanoparticles (SPIONs) by the alkalization of the reaction medium. The resulting nanocomposites, AuNCs-BSA-SPIONs, represent a bimodal nanoprobe. Scanning transmission electron microscopy (STEM) imaging visualized nanostructures with sizes in units of nanometres that were arranged into aggregates. Mössbauer spectroscopy gave direct evidence regarding SPION presence. The potential applicability of these bimodal nanoprobes was verified by the measurement of their luminescent features as well as magnetic resonance (MR) imaging and relaxometry. It appears that these magneto-luminescent nanocomposites were able to compete with commercial MRI contrast agents as MR displays the beneficial property of bright luminescence of around 656 nm (fluorescence quantum yield of 6.2 ± 0.2%). The biocompatibility of the AuNCs-BSA-SPIONs nanocomposite has been tested and its long-term stability validated.

One-pot strategy to fabricate conductive cellulose nanocrystal-polyethylenedioxythiophene nanocomposite: Synthesis mechanism, modulated morphologies and sensor assembly

Simple preparation, good conductivity, and excellent hydrophilicity are in urgent demand due to fast growth of wearable intelligent devices. Cellulose nanocrystal-polyethylenedioxythiophene (CNC-PEDOT) nanocomposites with modulated morphology were prepared through Iron (III) p-toluenesulfonate hydrolysis of commercialized microcrystalline cellulose (MCC) and in situ polymerization of 3,4-ethylenedioxythiophene monomers (EDOT) through one-pot green synthesis, where preparation and modification of CNC were obtained for uses as templates to anchor PEDOT nanoparticles. The resultant CNC-PEDOT nanocomposite gave well-dispersed PEDOT nanoparticles with sheet-like structure on the CNC surface, possessing higher conductivity and improved hydrophilicity or dispersibility. Subsequently, a wearable non-woven fabrics (NWF) sensor was successfully assembled by dipping the conductive CNC-PEDOT, and showed excellent sensing response for multiple signals (subtle deformation from various human activities and temperature). This study provides a feasible and large-scale production of CNC-PEDOT nanocomposites and their applications in wearable flexible sensors and electronic devices.

One-pot green synthesis of silver nanoparticles using brittle star Ophiocoma scolopendrina: Assessing biological potentialities of antibacterial, antioxidant, anti-diabetic and catalytic degradation of organic dyes

In the current study, aqueous extract of O. scolopendrina (OSE) was used to synthesize AgNPs in a simple and environmentally friendly manner. The biosynthesized OSE-AgNPs were also assessed for its catalytic, antibacterial, anti-diabetic, antioxidant and dye degradation properties. The techniques like UV–visible spectroscopic examinations, TEM, SEM, TGA, zeta potential and FT-IR were used in the characterization investigations. The bioproduction of OSE-AgNPs was preliminary confirmed by UV–visible spectroscopic based investigation followed by microscopic visualization. The synthesized OSE-AgNPs exhibited a reddish brown colour and nearly spherical forms with sizes between 5 and 50 nm quantified by TEM and SEM. The attendance of functional groups like –OH and –NH present in OSE caps on the AgNPs surface was confirmed by FTIR analysis. Interestingly, in the presence of OSE-AgNPs, the degradation of dyes (CV, 95% and EY, 96% in 15 min) were noticeably accelerated. Further, OSE-AgNPs demonstrated substantial antibacterial activity; robust antioxidant properties andnotable anti-diabetic activities. This is the first account on the biosynthetic process of AgNPs using the aqueous extract of O. scolopendrina.

One-pot green synthesis of gold nanoparticles using Sarcophyton crassocaule, a marine soft coral: Assessing biological potentialities of antibacterial, antioxidant, anti-diabetic and catalytic degradation of toxic organic pollutants

Marine bio-resources are being extensively researched as a priceless supply of substances with therapeutic potential. This work report the first time attempt made towards the green synthesis of gold nanoparticles (AuNPs) using the aqueous extract of marine soft coral (SCE), Sarcophyton crassocaule. The synthesis was conducted under optimized conditions and the visual coloration of reaction mixture changed from yellowish to ruby red at 540 nm. The electron microscopic (TEM, SEM) studies exhibited spherical and oval shaped SCE-AuNPs in the size ranges of 5–50 nm. The organic compounds present in SCE were primarily responsible for the biological reduction of gold ions validated by FT-IR while the zeta potential confirmed the overall stability of SCE-AuNPs. The synthesized SCE-AuNPs exhibited variety of biological efficacies like antibacterial, antioxidant and anti-diabetic in nature. The biosynthesized SCE-AuNPs demonstrated remarkable bactericidal efficacy against clinically significant bacterial pathogens with inhibition zones of mm. Additionally, SCE-AuNPs exhibited greater antioxidant capacity in terms of DPPH: 85 ± 0.32% and RP: 82 ± 0.41%). The ability of enzyme inhibition assays to inhibit α-amylase (68 ± 0.21%) and α-glucosidase (79 ± 0.2%) was quite high. The study also highlighted the spectroscopic analysis of the biosynthesized SCE-AuNPs' catalytic effectiveness of 91% in the reduction processes of the perilous organic dyes, exhibiting pseudo-first order kinetics.

One-Pot Green Synthesis of Novel 1H-Pyrrole(Furan, Thiophene)-Conjugated Pyrazolo[3,4-b]quinolin-5-one Derivatives

One-Pot Green Synthesis of Novel 1H-Pyrrole(Furan, Thiophene)-Conjugated Pyrazolo[3,4-b]quinolin-5-one Derivatives

Ionic liquid-enhanced lemon biomass carbon dots with sustainable use in bionic antibody microspheres for urea capture and ethyl carbamate inhibition

Herein, we reported the room-temperature fabrication of ionic liquid-modified carbon dots encapsulated in bionic antibodies (IL-modified CDs@BAs) by one-pot green synthesis. In order to enhance the fluorescence intensity of CDs, imidazole ILs and lemon rich in heteroatoms were selected as CDs modifiers and sources. The resulting IL-modified CDs@BAs showed good selectivity and capture toward urea and obviously induced fluorescence quenching by template-binding. The inhibition rate ofIL-modified CDs@BAs on the urea pathway of ethyl carbamate was about 29.07% in the simulated Huangjiu system, indicating a good inhibitory effect. The IL-modified CDs@BAs system was also reproducible after five consecutive uses, thus reducing the economic cost. This research would expand the application fields of BAs-based optical sensing system from the perspectives of energy conservation, environmental protection and resource recovery, focusing on their application in the field of food safety control.

Ionic Liquid Modified SPION@Chitosan as a Novel and Reusable Superparamagnetic Catalyst for Green One-Pot Synthesis of Pyrido[2,3-d]pyrimidine-dione Derivatives in Water

In this paper, the chitosan-functionalized ionic liquid is modified with superparamagnetic iron oxide nanoparticles to form a novel and reusable catalyst (SPION@CS-IL), which was carried out using an ultrasonic promoted approach. Transmission electron microscopy (TEM), vibrating-sample magnetometer (VSM), energy-dispersive X-ray spectroscopy (EDX), Fourier transform infrared spectroscopy (FT-IR), X-ray powder diffraction (XRD), energy-dispersive X-ray spectroscopy (EDX), and thermogravimetric analysis (TGA) are some of the techniques that are used to fully characterize SPION@CS-IL. The created nanoparticles were discovered to be a reusable heterogeneous superparamagnetic catalyst for the environmentally friendly one-pot synthesis of pyrido[2,3-d]pyrimidine derivatives using a simple three-component reaction approach involving thiobarbituric acid, 4-hydroxy coumarin, and various aromatic aldehydes. The method is studied by performing the reaction under ultrasonic irradiation, while the approach is a “green” method, it uses water as the solvent. The isolated yields of the synthesized products are very advantageous. The catalyst has outstanding reusability and is easily removed from the products via filtration (5 runs). Short reaction times, low catalyst loadings, the nanocatalyst’s capacity to be recycled five times, and the absence of harmful chemical reagents are all significant benefits of this environmentally benign process.

One-pot green synthesis of chitosan biguanidine nanoparticles for targeting M. tuberculosis

Tuberculosis (TB) is considered as one of the most fatal infectious diseases nowadays. Several traditional anti-tuberculosis drugs like isoniazid have been largely applied; however, they are associated with toxicity and poor anti-TB treatment. So, the fabrication of new alternative anti-TB drugs containing natural biopolymers for TB treatment has attracted great attention in recent years because of their remarkable features: biodegradability, biocompatibility and non-toxicity. Therefore, their medicine is very effective with low side effects compared with synthetic drugs. Our current work intends to engineer chitosan biguanidine (ChBG) nanoparticles as a new safe and high-efficient anti-TB drug using one-pot, green, cost-effective ionic gelation method. The chemical structure of as-formed materials was chemically confirmed using various analysis techniques: H-NMR, FTIR, SEM, and TEM. TEM results have proved the formation of uniformly well-distributed ChBG nanoparticles with a small particle size of ~38 nm. The inhibitory activity of these prepared nanoparticles was investigated against the growth of three different M. tuberculosis pathogens such as sensitive, MDR, and XDR, and in a comparison with the isoniazid drug as a standard anti-tuberculosis drug. The antituberculosis assay results showed that ChBG NPs attained MIC values of 0.48, 3.9, 7.81 μg/mL for inhibiting the growth of sensitive, MDR, and XDR M. tuberculosis pathogens compared to bare Ch NPs (15.63, 62.5 > 125 μg/mL) and the isoniazid drug (0.24, 0, 0 μg/mL), respectively. Moreover, cytotoxicity of the ChBG NPs was examined against normal lung cell lines (Wi38) and was found to have cell viability of 100 % with the concentration range of 0.48–7.81 μg/mL.

A trinuclear cobalt coordination complex constructed using novel triazine ligandsviaone-pot green synthesis: structural properties and biological evaluation

A triazine-based trinuclear cobalt complex, synthesisedviaa one-pot green synthesis process, exhibits unique structural behaviours and excellent biological activities.

One-pot green bio-assisted synthesis of highly active catalytic palladium nanoparticles in porcine gastric mucin for environmental applications

Palladium nanoparticles were synthesized using one-pot synthesis utilizing porcine gastric mucin glycoproteins as reducing and capping agents. These were further utilized as efficient catalysts.

Eco-friendly synthesis of MnO2 nanoparticles using Saraca asoca leaf extract and evaluation of in vitro anticancer activity

Manganese oxide nanoparticles (MnO2 NPs) were synthesized through a simple one-pot green synthesis method using Saraca asoca leaves extract (SA-MnO2 NPs), and their physicochemical properties were characterized using various analytical techniques, including electron microscopy (FESEM and TEM), X-ray diffraction (XRD), and electron diffracted X-ray spectroscopy (EDAX). The as-synthesized MnO2 NPs had a highly crystalline structure with a calculated crystalline size of approximately 18 nm and a d-spacing value of 0.216 nm. The morphology of the SA-MnO2 NPs was like stacked cubes with high elemental purity, as confirmed by the EDAX spectrum. Further, confirming the as-obtained crystalline size and d-spacing value from the XRD analysis, the samples were subjected to anti-cancer activities to evaluate their reactance against cancer cell lines. The in vitro anti-cancer activity of the synthesized material was assessed against two breast cancer cell lines, namely MCF7 and MDA-MB-231. The results showed that SA-MnO2 NPs exhibited significantly lower levels of cytotoxicity against these cell lines, indicating their potential as an effective anticancer agent. Further, the IC50 value of SA-MnO2 NPs at 24 h was greater than 20 μg/mL. Therefore, the synthesized SA-MnO2 NPs could be a promising candidate for developing novel breast cancer treatment therapies.

Polyethylene glycol (PEG-400) as a recyclable and biodegradable reaction medium for green synthesis of 2-amino-4H-chromenes

A helpful manufactured course to the one-pot green synthesis of 2-amino-4H-chromenes through a tandem Knoevenagel-Michael cyclocondensation reaction of aldehydes, malononitrile, and resorcinol in polyethylene glycol (PEG-400) as accessible and biodegradable media have been detailed. All responses are completed in a brief time and the items are gotten in fabulous yields. The striking highlights of this eco-friendly approach are biodegradable media, fabulous yields, simple work-up without requires for column chromatographic separation, and no poisonous organic solvents, evasion of harmful reagents, one-pot strategy, and effortlessness of operation. Additionally, PEG-400 is exceedingly steady and can be reused for four sequential runs without major basic changes or misfortune of movement, which has been exceptionally advantageous in tending to natural concerns.

Barium silicate nanoparticles, an efficient catalyst for one-pot green synthesis of α-benzyl amino coumarin derivatives as potential chemotherapeutic agents.

A new, simple, and efficient method for synthesis of α-benzyl amino coumarin and its derivatives (1-24) is described via a one-pot, three-component condensation of aromatic aldehydes, amine, and 4-hydroxycoumarin under green chemistry conditions: water as a solvent and BaSiO3 nanoparticles as catalyst. BaSiO3 nanoparticles and all synthesized derivatives were characterized by multiple methods including; XRD, NMR, and FE-SEM. This method which gives higher yields, is also less expensive, and more environmentally friendly compared with other methods in the literature. In silico physicochemical and pharmacokinetics analyses were done on all synthesized compounds and indicated that these α-benzyl amino coumarins would be effective scaffolds for the future development of chemotherapeutic agents.

Microwave-assisted commercial copper-catalyzed aerobic oxidative synthesis of AChE quinazolinone inhibitors under solvent free conditions.

A facile and green one-pot synthesis of AChE quinazolinone inhibitors was developed using microwave irradiation under solvent free conditions. Quinazolinones were synthesized from 2-aminobenzamide derivatives and various alcohols such as benzyl alcohol derivatives and butanol using economical commercially available copper as a catalyst in the presence of base, Cs2CO3. The desired products were achieved in moderate to high yields with up to 92% isolated yield. These quinazolinone products were then evaluated for acetylcholinesterase inhibition so that they can be developed as promising anti-acetylcholinesterase agents.

Green one-pot synthesis of bimetallic Pd–Pt nanosponges using biomolecules with enhanced catalytic activity for hydrogen evolution reactions

Green one-pot synthesis of bimetallic nanoparticles of Pd and Pt using RNA molecules as the capping/stabilizing agent and ascorbic acid as the reducing agent was described.

An efficient and eco-compatible multicomponent synthesis of 2,4,5-trisubstituted imidazole derivatives using modified-silica-coated cobalt ferrite nanoparticles with tungstic acid.

The aim of this study has been to offer a method for the synthesis of 2,4,5-trisubstituted imidazole derivatives based on green chemistry principles. Therefore, a one-pot multicomponent cyclocondensation reaction through aldehyde interaction with ammonium acetate and 1,2-diketone under solvent-free conditions was utilized as an eco-effective synthetic route using CoFe2O4@SiO2@(-CH2)3OWO3H NPs as the catalyst. The stabilized tungstic acid on 3-chloropropyl-anchored SiO2-coated CoFe2O4 magnetic nanoparticles was designed, prepared, and applied as a recyclable heterogeneous acid catalyst to attain high product yield in a short reaction time. The nanocatalyst structure was confirmed using FT-IR, Raman, XRD, FE-SEM, EDX, VSM, and TGA techniques, and the organic product structures were examined by melting point, FT-IR and 1H NMR analyses.

Trimesic acid-modified magnetic gum as a highly efficient and recyclable biocatalyst for the one-pot green synthesis of condensation reactions

In this work, a novel and efficient magnetic biocatalyst was designed, prepared and identified using cherry tree gum as a biopolymer functionalized with 1,3,5-benzenetricarboxylic acid (gum@Fe3O4@BTA). The obtained biocatalyst was prepared using available and cheap materials in an easy process. This biocatalyst was used as an efficient catalyst with high catalytic activity for the synthesis of a three-component one-pot protocol and four-component one-pot protocol of tetrahydro-4H-chromene derivatives and polyhydroquinoline derivatives in EtOH green solvent under reflux conditions, respectively. The synthesized heterogeneous biocatalysts were identified and analyzed by FT-IR, EDS, FESEM, TGA and XRD techniques. The synthesis of tetrahydro-4H-chromene and polyhydroquinoline derivatives by using this biocatalyst has advantages such as high efficiency, short reaction time, simple work method, absence of dangerous solvents, environmentally friendly conditions, easy separation of the biocatalyst by an external magnet, and the ability reuse for five periods without significant decrease in catalytic activity.

One-Pot Synthesis of Degradable and Renewable Cellulose-Based Packaging Films

Among all of the plastic pollutants, cling packaging films pose a particularly complex problem due to their high consumption, poor reusability, difficulty in recycling, and nondegradability. Despite many efforts by researchers to develop alternatives to plastic cling films, none of the alternatives have been satisfactory. Here, cellulose-based active packaging films that are degradable, renewable, and reusable were prepared by one-pot green synthesis of silver-based metal–organic frameworks on carboxymethyl cellulose (Ag-2MI@CMC). The preparation process is simple (water solvent system with normal temperature and normal pressure). The Ag-2MI@CMC composite film exhibits better performance than commercial PE films, including (1) better mechanical properties and antifog performance, Ag-2MI@CMC film has a high tensile strength of about 61 MPa, while that of commercial PE films is only about 35 MPa, (2) excellent antimicrobial properties, including bacteria and mold, while commercial PE films did not exhibit any antibacterial properties, (3) better fruit preservation than commercial PE cling films, (4) high natural degradability (complete degradation takes only about 45 days, during which time the commercial PE film does not degrade at all), and (5) renewable and reusable more than five times, the recycled Ag-2MI@CMC film still maintains good mechanical strength and fruit preservation effect. Given the low raw material cost and superior performance of the composite film, one-pot green synthesis of cellulose-based active packaging films may be a suitable solution to solve the environmental challenges brought by the high volume of the plastic packaging films.