In this session, we explore current techniques and problem areas in the use of computers to manage newborn screening and follow-up. Certain genetic/metabolic disorders (for example, PKU), if untreated, have serious consequences such as severe mental retardation and death. Laboratory tests for PKU were first available over 25 years ago. More sophisticated testing procedures for PKU and other conditions have developed since. Newborn screening for various disorders has now been mandated by every state. Testing on this scale generates large amounts of data. Not only test results, but also data on demographics, follow-up, and quality control must be maintained, and results must be returned to practitioners in an accurate and timely fashion. Previous systems of manual record-keeping proved inadequate for the task, even when the region of service was small. In addition, statewide or regional coordination and quality control was difficult. Use of computerized systems in statewide or regional centers has developed to provide for efficient data handling and standardization of quality control. The first paper, by Meaney, introduces the topic of newborn screening. It provides a review of developments and the future of computers in assuring quality newborn screening programs. Mordaunt, Cunningham, and Kan discuss the on-line computer system employed in California to manage their statewide newborn screening program. The automated newborn screening follow-up program in Illinois is examined in the paper by Kling, Nash, and Jones. The Pacific Northwest regional newborn screening program has some unique geographic problems because its region of service covers Oregon, Idaho, Nevada, and Alaska. The paper by Tuerck and Buist examines the computerized quality control, monitoring, and tracking system for this region.