Radiomics, or quantitative image analysis from radiographic image data, borrows the suffix from other emerging -omics fields of study, such as genomics, proteomics, and metabolomics. This report provides an overview of the general principles of how radiomic features are computed, describes major types of morphological, first order, and texture features, and the applications, challenges, and opportunities of radiomics as applied in veterinary medicine. Some advantages radiomics has over traditional semantic radiological features include standardized methodology in computing semantic features, the ability to compute features in multi-dimensional images, their newfound associations with genomic and pathological abnormalities, and the number of perceptible and imperceptible features available for regression or classification modeling. Some challenges in deploying radiomics in a clinical setting include sensitivity to image acquisition settings and image artifacts, pre- and post-image reconstruction and calculation settings, variability in feature estimates stemming from inter- and intra-observer contouring errors, and challenges with software and data harmonization and generalizability of findings given the challenges of small sample size and patient selection bias in veterinary medicine. Despite this, radiomics has enormous potential in patient-centric diagnostics, prognosis, and theragnostics. Fully leveraging the utility of radiomics in veterinary medicine will require inter-institutional collaborations, data harmonization, and data sharing strategies amongst institutions, transparent and robust model development, and multi-disciplinary efforts within and outside the veterinary medical imaging community.
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