Detailed understanding of the membrane application is essential for the treatment of wastewater to remove organic and inorganic pollutants. Even though the membrane bioreactor (MBR) has been widely used for the removal of oil and grease (O&G) and chemical oxygen demand (COD) from wastewater, the use of MBR to remove the organic and inorganic pollutants from oilfield-produced water (OPW) needs to be verified. This study used two submerged MBRs to remove the COD, O&G, NH3 and PO43- pollutants from OPW by considering two variables of NaCl content and C/N/P ratio in the analysis of experimental data. The results show the use of the MBR system to remove COD, O&G and NH3 reaching at an efficiency of higher than 90%. The efficiency of the MBR system to remove PO43- increases by 14.95% for the treatment of OPW with salt content of 10 gNaCl L-1 and by 15.71% for that with salt content of 17.5 gNaCl L-1. Despite of the change in C/N/P ratio from 100/10/1 to 100/2/1 shows a decrease in the sludge volume index by 61.27% for the treatment of OPW with salt content of 10 gNaCl L-1 and by 61.43% for that with salt content of 17.5 gNaCl L-1, the occurrence of membrane fouling could be due to the growth of filamentous bacteria in OPW when conditioned with 17.5 gNaCl L-1. A valuable insight into the practical design of MBR technology can be obtained from this study to contribute to the future development of OPW treatment process.