Oil Delivery Research Articles

Synthesis and Characterization of Novel Patchouli Essential Oil Loaded Starch-Based Hydrogel.

Starch hydrogels are highly available, biocompatible and biodegradable materials that have promising applications in medical and pharmaceutical industries. However, their applications are very limited due to their poor mechanical properties and fragility. Here, we investigated, for the first time, conventional corn and waxy corn starch-based hydrogels for loading patchouli essential oil. The essential oil extracted by supercritical carbon dioxide with a yield reached 8.37 ± 1.2 wt.% (wet sample) at 80 °C temperature and 10 MPa pressure. Patchouli essential oil exhibited a 23 to 28 mm zone of inhibition against gram-positive and gram-negative bacteria. Waxy starch hydrogels had better properties in term of viscosity, water evaporation stability and the delivery of essential oil than conventional starch hydrogels. The viscosity and spreadability of a 6% waxy starch sample were 15,016 ± 59 cP and 4.02 ± 0.34 g·cm/s, respectively, compared with those of conventional starch hydrogel (13,008 ± 29 cP and 4.59 ± 0.88 g·cm/s). Waxy starch-based hydrogels also provided slower in vitro biodegradation behavior and sustained release of essential oil compared with conventional starch hydrogels. All the samples were biocompatible and non-cytotoxic to fibroblast cells; the addition of patchouli essential oil enhances the proliferation of the cells. The enhanced viscosity, good antibacterial and improved biocompatibility results of prepared hydrogels confirm their suitability for wound healing applications.

Development of Biodegradable, Cellulose-Based, Essential Oil and Chitosan Drug Delivery Systems for Cosmetic Mask Applications

The goal of this research was the development of cellulose-based biodegradable drug delivery systems solutions for cosmetic mask applications. Cellulose-based materials derived from natural renewable sources provide a sustainable alternative to nonwoven cosmetic masks derived from nondegradable fossil-based raw materials. An experimental design was executed to assemble the 3D cellulose fibres matrix and the water in oil emulsion comprising the active molecules from Mentha piperita L. Two types of biopolymeric additives were used, one derived from a nano/micro fibrillated cellulose pulp and another one including chitosan. A 3D computational simulation study was performed to enhance porosity and strength properties. The results indicated that the cosmetic face mask optimized prototypes, made from a biodegradable 3D matrix of cellulose fibres and active molecules, are suitable for dermic use.
 Keywords: biopolymers, dermic application, drug delivery systems (DDS), essential oil, Mentha piperita

Review on Security Analysis in Cyber Physical Systems

Cyber-Physical Systems (CPS) have seen a dramatic increase in research and real-world application in recent years. Many parts of our everyday lives have been affected, including electrical power systems, oil and gas delivery, transportation networks, medical equipment, home appliances, and a host of other areas. For example, many critical infrastructure and life support equipment are relying on these kinds of systems. As a result, they are required to be completely secure and resistant to all forms of assaults, which is almost unachievable for any real-world system. This paper focuses on security analysis in CPSs, whereby security in CPSs, security threats in CPSs, and security challenges in CPSs, have been discussed

Enhanced Delivery of Sesame Oil through Nanoformulation: Edible Protein Excipients and Nanotechnology as Protagonists

For decades, researchers have gained a lot of interest for lignans-rich sesame oil due to its potent antioxidative and anti-inflammatory properties. But its potential could not be fully achieved through traditional means of delivery due to the poor aqueous solubility of lipophilic bioactives. To eliminate the unsatisfactory outcome of conventional delivery strategies and to corroborate the perception of manufacturing the bio-compatible vehicle for therapeutic delivery, present-day researches are vigorously attempting to develop nanocarrier systems with food-grade excipients.

Fibrous palygorskite clays as versatile nanocarriers for skin delivery of tea tree oils in efficient acne therapy

This paper presents a facile approach to develop palygorskite (Pal), a fibrous clay mineral, as a delivery system of tea tree oil (TTO) for topical acne therapy. The obtained TTO-Pal composite showed an efficient loading of TTO (27.4%) with a selective accumulation of terpine-4-ol and 1,8-cineole (two major antimicrobial TTO constituents), sustained release of TTO at skin physiological conditions (pH5.4, 32 °C) and superior skin sebum (2.2 g/g) absorbability. In vitro toxicological assessments showed that the Pal incorporation strategy significantly reduced the acute contact toxicity of TTO. The antimicrobial results revealed a preferable bacteriostatic effect for the TTO-Pal system towards opportunistic dermal pathogens (Escherichia coli, Staphylococcus aureus and Propionibacterium acnes) over the beneficial bacterium (Staphylococcus epidermis). Moreover, TTO-Pal based formulations exhibited pronounced clinical therapeutic efficacy in treating facial acne by rapidly reducing inflamed lesions, modulating skin sebum overproduction and restoring barrier function. This is the first report of using fibrous clay as a biocompatible nanocarrier system for topical delivery of essential oils in efficient management of facial acne with both in vitro and in vivo evidences, which may open perspectives for fibrous clay-drug delivery system in topical application and expand the high added value development of this mineral resource in the advanced healthcare fields.

Development of recyclable pH-responsive magnetic nanospheres via RAFT polymerization and their application in Pickering emulsions

A controllable and efficient method for the preparation of dual-stimulus-responsive magnetic nanospheres (IO/P) as particle emulsifiers via reversible surface addition and fragmentation chain transfer (RAFT) polymerization was described. FTIR, TGA, TEM and VSM were used to prove that the grafting reaction proceeded successfully. The interfacial properties of the magnetic nanospheres at pH from 2 to 12 were characterized by interfacial tension meter. The IO/P Pickering emulsion had dual-responsiveness of pH and magnetic, which was stable at pH 8–10, and could be rapidly broken by changing pH value or under the action of an external magnetic field. The emulsion could undergo at least 5 emulsification-demulsification cycles, which were triggered by changing pH value. The stabilization/destabilization of IO/P Pickering emulsions was triggered by the synergistic effect of applied magnetic field, surface wettability, and zeta potential, which led to the adsorption/exfoliation of IO/P on the water-oil interface. In addition, the effects of polymer segment length, particle concentration, water-oil ratio, and oil phase polarity on emulsion stability were investigated in detail. pH and magnetic stimuli-responsive Pickering emulsifier provided opportunities for oily wastewater treatment, water-oil separation, and design of crude oil delivery systems.

Structure of whey protein hydrolysate used as emulsifier in wet and dried oil delivery systems: Effect of pH and drying processing

The secondary structure of whey protein concentrate hydrolysate (WPCH), used as an emulsifier in oil delivery systems, was investigated using Synchrotron Radiation Circular Dichroism (SRCD). The effect of pH on the conformation of peptides in solution and adsorbed at the oil/water interface, as well as the thermal stability of the systems was studied. Furthermore, oil-loaded microcapsules were produced by spray-drying or electrospraying to investigate the influence of encapsulating agents (glucose syrup, maltodextrin) and drying technique on the secondary structure of WPCH at the oil/water interface. Enzymatic hydrolysis resulted in peptides with a highly unordered structure (∼60% turns and unordered regions) in solution. However, WPCH adsorption onto the oil/water interface increased the α-helical content resulting in an improved thermal stability. The encapsulating agents and spray-drying process did not modify the conformation of WPCH at the oil/water interface. Nonetheless, electrospraying affected the SRCD spectra obtained for WPCH adsorbed at the oil/water interface.

Pharmacodynamics, toxicology and toxicokinetics of ropivacaine oil delivery depot

BackgroundRopivacaine oil delivery depot (RODD) can be used to treat postoperative incision pain. The aim was to study pharmacodynamics, toxicity and toxicokinetics of RODD.MethodsThe base research of RODD were conducted. Thirty rabbits were randomly divided into saline, solvent, ropivacaine aqueous injection (RAI) 0.9 mg, RODD 0.9 mg and RODD 3 mg groups. The sciatic nerve of rabbits were isolated, dripped with RODD and the effect of nerve block were observed. In toxicity study, the rats were divided into saline, solvent and RODD 75, 150 and 300 mg/kg groups, 30 rats per group. In toxicokinetics, rats were divided into RODD 75, 150 and 300 mg/kg groups, 18 rats per group. The rats were subcutaneously injected drugs.ResultsThe analgesic duration of RODD 3 mg and RAI 0.9 mg blocking ischiadic nerve lasted about 20 h and 2 h, respectively, and their blocking intensity was similar. The rats in RODD 75 mg/kg did not show any toxicity. Compared with saline group, in RODD 150 mg/kg group neutrophils and mononuclear cells increased, lymphocytes decreased and albumin decreased(P < 0.05), and pathological examination showed some abnormals. In RODD 300 mg/kg group, 10 rats died and showed some abnormalities in central nerve system, hematologic indexes, part of biochemical indexes, and the weights of spleen, liver, and thymus. However, these abnormal was largely recovered on 14 days after the dosing. The results of toxicokinetics of RODD 75 mg/kg group showed that the Cmax was 1.24 ± 0.59 µg/mL and the AUC(0-24 h) was 11.65 ± 1.58 h·µg/mL.ConclusionsSubcutaneous injection RODD releases ropivacaine slowly, and shows a stable and longer analgesic effect with a large safety range.

Selecting assets supplier for coal mining company

The approach to selecting a supplier for the coal industry is considered in the framework of the cost&ndash;time concept. The proposed approach uses the Pareto analysis and the BOFa method (decision-making among a set of multiple-attribute alternatives) which allow gradual elimination of less attractive options and selection of the best supplier according to the set of criteria. It is possible to change the list of suppliers with the introduction of a risk factor. This article is related to the justification of approaches to selecting an assets supplier for a coal mining company. The research object is the activity of Kuzbassrazrezugol JSC&rsquo;s branch in Bachaty in terms of motor oil delivery from companies in the Kemerovo and Novosibirsk Regions and in the Altai Krai. The article describes the company&rsquo;s activity dynamics and the structure of coal production and supply per open pit coal mines. The criteria for selecting suppliers are the price of an asset, availability of prepayment, as well as the method and distance of delivery which directly form the cost of the purchased asset. It is noted that the specific features of a certain company determine the multivariance of both formulation of a multi-criteria optimization problem with the criteria of different levels of significance and possible solutions of the problem. A two-stage supplier evaluation using the Pareto analysis and the BOFa method is proposed. The Pareto analysis to create a set of alternatives recognizes the best alternative as an alternative which is equal or better than the other alternative based on the selected criteria; the goal is to exclude the least attractive option from the list. The ranking is based on the relationship between the cost&ndash;time parameters, and the price factors are preferable as they are insensitive to a buyer&rsquo;s influence while governing a company&rsquo;s performance. The next stage is selecting a supplier based on a set of criteria using the BOFa method which is invariant to the number and type of particular criteria and alternatives. This method is used to rank the criteria and to determine their weights, as well as the weights and ranks of alternatives are determined for each criterion, including the normalized alternatives, which finally enable calculation of a generalized criterion for each company. The option of adding the list with a new supplier which the best (averaged) parameters as compared with the listed supplier is considered; due to the lack of any experience of cooperation with such supplier, the latter is assigned a high level of risk. The proposed approach can be used by any company regardless industry classification.

Multi-Tunnel Triboelectric Nanogenerator for Scavenging Mechanical Energy in Marine Floating Bodies

The ocean has an abundant reserve of wave energy, which is considered to be a clean, widely distributed and inexhaustible resource. Triboelectric nanogenerators (TENGs) have been regarded as a reliable technology for harvesting wave energy due to its robustness and efficiency in scavenging random mechanical energy. In this study, a wave energy harvesting multi-tunnel TENG (MT-TENG) has been proposed, which could be integrated easily with ocean buoys. The MT-TENG consists of polytetrafluoroethylene (PTFE) balls and a multi-tunnel frame, which could convert wave energy into electrical energy. The multi-tunnel design also avoids possible mutual obstruction of the PFTE balls during the movement. Compared with the flat type structure, the multi-tunnel structure could enhance output performance obviously. With an agitation frequency of 2 Hz and vibration amplitude of 130 mm, the MT-TENG has a peak power density of 8.3 W/m3, which is five times that of the flat type structure TENG. By integrating with a life buoy and floating pipe line, the MT-TENG could harvest wave energy to light LEDs continuously, which could provide a new solution for maritime rescue and night offshore oil delivery warning.

Multifunctional Role of Silica in Pharmaceutical Formulations.

Due to the high surface area, adjustable surface and pore structures, and excellent biocompatibility, nano- and micro-sized silica have certainly attracted the attention of many researchers in the medical fields. This review focuses on the multifunctional roles of silica in different pharmaceutical formulations including solid preparations, liquid drugs, and advanced drug delivery systems. For traditional solid preparations, it can improve compactibility and flowability, promote disintegration, adjust hygroscopicity, and prevent excessive adhesion. As for liquid drugs and preparations, like volatile oil, ethers, vitamins, and self-emulsifying drug delivery systems, silica with adjustable pore structures is a good adsorbent for solidification. Also, silica with various particle sizes, surface characteristics, pore structure, and surface modification controlled by different synthesis methods has gained wide attention owing to its unparalleled advantages for drug delivery and disease diagnosis. We also collate the latest pharmaceutical applications of silica sorted out by formulations. Finally, we point out the thorny issues for application and survey future trends pertaining to silica in an effort to provide a comprehensive overview of its future development in the medical fields. Graphical Abstract.

Chemical Stabilization behind Cardamom Pickering Emulsion Using Nanocellulose

Cardamom essential oil (EO) is a rare oil of high scientific and economic interest due to its biofunctionality. This work aims to stabilize the EO by Pickering emulsions with nanocellulose, in the form of nanocrystals (CNC) or nanofibers (CNF), and to investigate the stability and chemical and physical interactions involved in the process. The emulsions were characterized by droplet size, morphology, stability, surface charges, Fourier transform infrared spectroscopy, FT-Raman, nuclear magnetic resonance, and scanning electron microscopy. Stable emulsions were prepared with cellulose morphologies and CNCs resulted in a 34% creaming index, while CNFs do not show instability. Emulsions indicate a possible interaction between nanocellulose, α-terpinyl acetate, and 1,8-cineole active essential oil compounds, where α-terpinyl acetate would be inside the drop and 1,8-cineole is more available to interact with cellulose. The interaction intensity depended on the morphology, which might be due to the nanocellulose’s self-assembly around oil droplets and influence on oil availability and future application. This work provides a systematic picture of cardamomum derived essential oil Pickering emulsion containing nanocellulose stabilizers’ formation and stability, which can further be extended to other value-added oils and can be an alternative for the delivery of cardamom essential oil for biomedical, food, cosmetics, and other industries.

Liquid crystalline lipid nanoparticles for combined delivery of curcumin, fish oil and BDNF: In vitro neuroprotective potential in a cellular model of tunicamycin-induced endoplasmic reticulum stress

We develop multidrug-loaded cubosome and spongosome lipid nanoparticles for targeting of endoplasmic reticulum stress as a potential emerging therapeutic strategy against neuronal degeneration. The multicompartment organization of the liquid crystalline nanoparticles (LCNPs), fabricated by self-assembly, was characterized by cryogenic transmission electron microscopy (cryo-TEM) and small-angle X-ray scattering (SAXS). Monoolein-based cubosome and spongosome LCNPs co-encapsulated the natural plant-derived antioxidant curcumin, fish oil rich in ω-3 polyunsaturated fatty acids (PUFA), and the neurotrophin brain-derived neurotrophic factor (BDNF), which is of vital need for neurogenesis. The neuroprotective properties of the nanoparticles were in vitro investigated in a cellular model of tunicamycin-induced endoplasmic reticulum (ER) stress using differentiated human neuroblastoma SH-SY5Y cells deprieved from serum. The intracellular accumulation of aggregates of misfolded proteins, typical for the ER stress process, was analyzed by fluorescence microscopy co-localization imaging and ER staining. The performed cellular bioassays established that the BDNF-loaded LCNPs enhanced the neuronal cell survival. The diminution of the tunicamycin-induced ER stress upon internalization of neuroprotective nanoparticles was quantified via the changes in the Thioflavin T fluorescence, which is a sensitive marker of protein aggregation. LCNPs with multi-drug loading appear to be promising candidates to face the challenges in neuroprotective nanomedicine development by exploiting ER-stress targeting mechanisms.

“Act Quickly and Correctly, in the Austrian Way”: Delivering Compensation from Austria to the USSR, 1955—1963

This article examines the delivery of Austrian compensation and oil to the USSR from the signing of the relevant treaty on 15 May 1955 to 1963. The article&amp;apos;s aim is to analyse the formation of bilateral economic relations between the Soviet Union and Austria during the post-war socioeconomic and political transformations of European space. The course and mechanisms of compensation delivery are analysed, as is their meaning in Soviet and Austrian perceptions. It is concluded that the personal diplomacy of Austrian and Soviet politicians was important in the formation of friendly relations between the two countries, which came into being despite the stark confrontation between the blocs during the Cold War.

Numerical Analysis of Two-Phase Flow in High-Speed Rotating Circular Tube

With the accelerating global adoption of electric vehicles, the automotive industry is about to reach a major turning point. In this context, we focused on centrifugal force and agitation for stable lubrication and delivery of oil inside the drive unit, which is indispensable to achieve the compact and high-speed motor technology that is so important. We quantitatively measured the ratio of the oil supply to the oil discharge by placing three discharge holes at each point of the circular tube. Based on the experiments, Ansys Fluent was used to reproduce the gas-liquid two-phase flow using the VOF method, and the rotational expression was analyzed numerically on a periodic boundary using MRF with fixed mesh and considering centrifugal and Coriolis forces. The percentage of discharge flow rate at each hole was evaluated for every 1000 [rpm] of rotation at different temperatures and different number of discharge holes. As a result, the results could not be perfectly reproduced because it was not clear whether the oil temperature in the high-temperature range was strictly controlled under the experimental environment, but the trend could be captured as the discharge from the first discharge hole became dominant at high rpm for both the 2-hole and 4-hole models. The trend could be captured.

Development of Topical Nanoemulgel Using Combined Therapy for Treating Psoriasis.

This study focuses on the development of topical formulation of methoxsalen using Babchi oil as formulation component that can be applied at body surfaces providing sustained delivery and enhanced penetration of methoxsalen leading to significant epidermal localization and better anti-psoriatic activity. The combination of psoralens, that is, methoxsalen (synthetic) and Babchi oil (natural) has been developed into nanoemulgel formulations. A total of four nanoemulsion formulations was developed using Babchi oil as oil phase and Tween 80 as surfactant by high-pressure homogenization method. The prepared nanoemulsions were characterized for entrapment efficiency, mean droplet size, and zeta potential. Based on characterization results, the optimized nanoemulsion formulation(s) were incorporated into the carbopol gel base to make a nanoemulgel. The prepared nanoemulgel formulations were analyzed for pH, drug content determination, spreadability, viscosity, ex vivo skin permeation, and in vivo studies. The nanoemulsions showed droplet size between 51.3 and 146.7 nm, entrapment efficiency of 92.76%-98.10%, and zeta potential of -28.1 to -54.89 mev. The nanoemulsions showed varied in vitro drug release. In ex vivo skin permeation, nanoemulgel (NG2) showed increased penetration and localized accumulation of methoxsalen across the skin compared with plain gel. Ex vivo results were substantiated by in vivo results showing significant amelioration of hyperproliferative skin symptoms. The promising results suggested that nanoemulgel system is a suitable carrier for the topical delivery of methoxsalen-Babchi oil.

Investigating Antiarthritic Potential of Nanostructured Clove Oil (Syzygium aromaticum) in FCA-Induced Arthritic Rats: Pharmaceutical Action and Delivery Strategies.

The combined application of clove oil in a lipid nanocarrier opens a promising avenue for bone and joints therapy. In this study, we successfully developed a tunable controlled-release lipid platform for the efficient delivery of clove oil (CO) for the treatment of rheumatoid arthritis (RA). The ultra-small nanostructured lipid carriers co-loaded with CO (CONCs) were developed through an aqueous titration method followed by microfluidization. The CONCs appeared to be spherical (particle size of 120 nm), stable (zeta potential of −27 mV), and entrapped efficiently (84.5%). In toluene:acetone:glacial acetic acid (90:9:1 percent v/v/v) solvent systems, high-performance thin layer chromatography (HPTLC) analysis revealed the primary components in CO as eugenol (RF = 0.58). The CONCs greatly increased the therapeutic impact of CO in both in vitro and in vivo biological tests, which was further supported by excellent antiarthritic action. The CONC had an antiarthritic activity that was slightly higher than neat CO and slightly lower than standard, according to our data. The improved formulation inhibited serum lysosomal enzymes and proinflammatory cytokines while also improving hind leg function. This study provides a proof of concept to treat RA with a new strategy utilizing essential oils via nanodelivery.

Essential Oil Delivery Route: Effect on Broiler Chicken's Growth Performance, Blood Biochemistry, Intestinal Morphology, Immune, and Antioxidant Status.

Simple SummaryMuch research is devoted to the search for potent alternatives to antibiotic growth promoters in the poultry industry. It is hypothesized that the efficacy of potential alternatives could be influenced by their type and the delivery strategy utilized. Consequently, this study evaluated the efficacy of a commercial essential oil blend across different delivery routes as a potent alternative to in-feed antibiotics in broiler chickens using selected biochemical, immune, and performance parameters. The results provide evidence that the successive delivery of essential oils via in ovo and in-water routes in broiler chickens offers the potential to improve broiler chicken biochemical and antioxidant status. However, the in ovo delivery of essential oil at 0.2 mL dosage (saline + essential oil, dilution ratio—2:1) suffers the limitations of reduced hatchability.This study evaluated the effect of an essential oil blend and its delivery routes on broiler chicken growth performance, blood biochemistry, intestinal morphology, and immune and antioxidant status. Eggs were incubated and allotted to 3 groups: non-injected group, in ovo saline group, and in ovo essential oil group. On day 18 of incubation, essential oil in saline or saline alone was injected into the amnion. At hatch, chicks were assigned to post-hatch treatment combinations (1) in ovo essential oil + in-water essential oil (in ovo + in-water EO); (2) in ovo essential oil (in ovo EO); (3) in ovo saline; (4) in-water essential oil; (5) in-feed antibiotics (Bacitracin methylene disalicylate) and (6) a negative control (NC; corn-wheat-soybean diet) in 8 replicate cages (6 birds/cage) and raised for 28 day. The in ovo EO group reduced (p < 0.05) chick length and hatchability, all groups recorded no difference in growth performance at 0–28 day. The in ovo + in-water EO treatment reduced (p < 0.05) blood creatine kinase and aspartate aminotransferase levels whilst increasing (p < 0.05) total antioxidant capacity in birds. The in ovo + in-water delivery of EO might represent a potential antibiotic reduction strategy for the poultry industry but more research is needed to address the concern of reduced hatchability.

The Use of Porous Silica Particles as Carriers for a Smart Delivery of Antimicrobial Essential Oils in Food Applications.

The objective of this study was to design, develop, and quantify the effectiveness of a simple method to facilitate the smart delivery of antimicrobial essential oils (EOs) via their absorption into a chemically bound high surface area support material. To this end, Santa Barbara Amorphous 15 (SBA-15) was functionalized by means of a post-synthetic reaction using (3-aminopropyl)triethoxysilane (APTES) to create an amine-terminated SBA-15 (SBA-APTES), and functionalization was confirmed by FTIR, TGA, and N2 isotherm analysis. Amine-modified SBA-15 was then grafted to a 3-glycidyloxypropyltrimethoxysilane (GPTS)-modified silicon (Si) surface (Si-GPTS), and subsequent attachment to the GPTS-modified surface was confirmed through XPS, dynamic contact angle, and SEM analysis. The smart delivery devices (SBA-15 and SBA-APTES) were then loaded with antimicrobial oregano essential oil (OEO) and the antimicrobial activity was assessed against common food spoilage microorganisms Escherichia coli, Bacillus cereus, Staphylococcus aureus, and Pseudomonas fluorescens. Antimicrobial activity results indicate that both SBA-OEO and SBA-APTES-OEO have good antimicrobial activity and that functionalization of bare SBA-15 with APTES has no effect on antimicrobial activity (P > 0.05) compared to SBA-OEO. Moreover, it appears that direct surface coating of the modified SBA to a surface substrate may not provide a significant quantity of oil needed to elicit an antimicrobial response. Nevertheless, given the strong absorption properties of SBA materials, good antimicrobial activity, and the GRAS nature of SBA-OEO and SBA-APTES-OEO, the results found in this study open potential applications of the functionalized carrier materials.

Definition and analysis of overall heat-transfer coefficient at the sections of “hot” export petroleum pipeline operating in northern winter conditions

Background. Receiving information on overall heat-transfer coefficient of pipeline pumping down the heat oil is required for resolving a number of process challenges: definition of specific cooling-off intensity of delivered petroleum, optimization of delivery processes, insulation efficiency assessment of pipeline sections etc. Aim. The actual values of the heat transfer coefficients are the most reliable basis for the implementation of optimization and technological calculations during thermohydraulic modeling and development of measures (a) to save energy during hot pumping and (b) to increase the reliability of the “hot” pipeline in order to exclude the possibility of its self-stopping and “freezing”. In the context of assessing the technological reliability of pumping, the determination and analysis of the total heat transfer coefficient for the sections of the oil pipeline were carried out and the capabilities of this methodological approach were demonstrated. Materials and methods. In the article, by the example of 266-kilometer long export pipeline (Ø 300 mm), functioning in «hot» delivery mode is presented the calculation process of defining the actual values of overall heat-transfer coefficient in route sections, and is done the analysis of this coefficient values, operation heating mode of the pipeline and their related factors of technological reliability of oil delivery process. Results. The difference in the values of the overall heat transfer coefficient at the sections of the pipeline is shown, which allows us to come to a practical conclusion about the different intensities of the thermal processes occurring in its different linear sections (aboveground, underground with intersection of marshy soils and rivers, with and without thermal insulation, operating in non-isothermal and isothermal modes). Conclusions. The proposed approach to determining the actual values of the total heat transfer coefficient for sections of the “hot” oil pipeline in combination with the analysis of the data obtained provides opportunities that are largely in demand from a methodological point of view and extremely important from a practical standpoint.