Estrogen Cream Research Articles

Office gynecology. Relieving dyspareunia.

Effective treatment of dyspareunia can be a simple matter of reassuring the patient or conferring with her sexual partner. Or it may require vaginal dilation, use of lubricant or estrogenic cream, or surgery. Psychogenic dyspareunia is relatively uncommon.

A microbiological study of pediatric vaginitis

Summary The vaginal microbiological organisms of premenarchal girls were studied in an effort to determine the etiology of vaginitis and to determine the changes that occur in the prevalence of these organisms when the child is under the influence of an estrogenic substance. Neisseria gonorrhoeae occurred in 21 per cent of the patients and could definitely be incriminated as etiologically related to vaginitis. The chisquare test of significance supported this conclusion. The gonococcus was not recovered in girls who received an estrogenic cream which was applied topically to the vulvar region and in whom an adult-type of vaginal epithelium developed with a concurrent establishment of Doderlein's bacillus and a pH of 4. Trichomonas vaginalis occurred in 5.2 per cent of the patients, but not at all in the control children. This organism is believed to be etiologically related to the vaginitis observed in these cases. The chi-square test, however, did not support this conclusion. It is believed that the sample of data was too small to obtain statistical support of the clinical impression. Estrogenic cream had no effect on the course of infection with this organism. The occurrence of coagulase-positive strains of M. pyogenes var. aureus was similar in both patient and control groups and could not be correlated with the observed vaginitis. No enteropathogenic strains of E. coli were isolated from vaginitis patients. The organism, H. vaginalis , was not recovered from any of the premenarchal patients. A large number of species of various bacteria were isolated from vaginitis patients and from normal control girls in approximately equal percentages. These data when subjected to the chisquare test indicated that the probability of such observations occurring by chance was high and, therefore, any one of these organisms had little significance to the obscrved vaginitis. These data are in keeping with those of other investigators who call such cases “nonspecific” vaginitis. The hypothesis is made that some viral agent or agents e.g., the echo, adenovirus, Coxsackie, or possibly some other as yet unrecognized virus, may be responsible for the clinical entity called “nonspecific” vaginitis.

Estrogens in urine and cytology of vaginal smears after the use of an estrogenic cream: Eidelsberg, Joseph: Am. J. M. Sc. 214: 630, 1947

Estrogens in urine and cytology of vaginal smears after the use of an estrogenic cream: Eidelsberg, Joseph: Am. J. M. Sc. 214: 630, 1947

The use of an estrogenic cream in the treatment of senile vaginitis

In this investigation 123 patients received dienestrol in a cream base for the treatment of atrophic changes occurring in the vaginal mucosa. All of these patients, with the exception of two children and two adults, were over 40 years of age. In 68.3 per cent of the cases, after receiving this type of therapy, the vaginal mucosa appeared healthy and the patients had no complaints. Those patients who returned to the Clinic at the end of one week of treatment showed rapid improvement. Although 25.2 per cent of the cases were classified as un-improved, it must be noted that some of this group showed either symptomatic or clinical improvement. Relief of symptoms had to be accompanied by clinical response before the patient was considered improved. Further topical application of the estrogenic cream was prescribed if symptoms recurred. The average healthy vagina was maintained in some instances by using dienestrol one to three times a week over a period of months. No untoward effects were noted.