Obturation Material Research Articles

Application of Copper Nanoparticles in Dentistry.

Nanoparticles based on metal and metallic oxides have become a novel trend for dental applications. Metal nanoparticles are commonly used in dentistry for their exclusive shape-dependent properties, including their variable nano-sizes and forms, unique distribution, and large surface-area-to-volume ratio. These properties enhance the bio-physio-chemical functionalization, antimicrobial activity, and biocompatibility of the nanoparticles. Copper is an earth-abundant inexpensive metal, and its nanoparticle synthesis is cost effective. Copper nanoparticles readily intermix and bind with other metals, ceramics, and polymers, and they exhibit physiochemical stability in the compounds. Hence, copper nanoparticles are among the commonly used metal nanoparticles in dentistry. Copper nanoparticles have been used to enhance the physical and chemical properties of various dental materials, such as dental amalgam, restorative cements, adhesives, resins, endodontic-irrigation solutions, obturation materials, dental implants, and orthodontic archwires and brackets. The objective of this review is to provide an overview of copper nanoparticles and their applications in dentistry.

The Efficacy of Two Novel Retreatment Systems in the Removal of Root Canal Obturating Materials (An In vitro Study)

BACKGROUND: The complete removal of root filling material is one of the main goals of non-surgical endodontic retreatment. Thus, the development of new techniques and instruments aiming to promote this task presents clinical significance. AIM: The purpose of the study was to assess the amount of residual root canal filling materials (gutta-percha/sealer) after using two different endodontic retreatment systems and ultrasonic tip. METHODS: Forty-five mandibular premolar teeth were mechanically instrumented and obturated. Retreatment was performed using two different Endostar RE (Group 2), Rogin retreatment system (Group 3), and ultrasonic tip (Group 1). Roots were separated buccolingually into two halves. A digital camera connected to the stereomicroscope captured images to each half. Image-J software was used to evaluate and measure the areas with remaining filling material in each third (cervical, middle, and apical). RESULTS: Data analysis revealed significant differences between the groups in the coronal, middle, and apical thirds (p < 0.05). The ultrasonic retreatment tips (G1) were significantly more efficient in removing the gutta-percha and sealers compared to the Rogin (G3) and Endostar (G2) retreatment endodontic kits. CONCLUSIONS: All the file systems left some filling material in the canals. Ultrasonic retreatment tip had maximum efficacy for the removal of filling materials in comparison with the retreatment file systems under investigation.

Non surgical management of trauma induced root resorption and large periapical lesion using bioactive material- A case report

Multiple root resorption with a huge periapical lesion is considered as a great challenge in daily endodontic practice. The anterior teeth are easy victim to traumatic injuries, and thereby a common site for huge lesions of the jaw. Considering hard tissue loss in surgical intervention, the non-surgical modality with triple antibiotic paste (TAP) and Mineral Trioxide Aggregate (MTA) as an obturation material is gaining popularity in managing such lesions. The present case shows successful healing outcome of a large periapical lesion with inflammatory root resorption in mandibular anterior teeth with non-surgical endodontic modalities. Key-words: External root resorption, Triple antibiotic paste, MTA, CBCT

Comparative evaluation of zinc oxide-eugenol and zinc oxide with Neem oil in root canal treatment of primary teeth: Split-mouth study with 12 months follow-up.

Various root canal filling materials are used to preserve pulp tissue involved carious the primary tooth. A single material that fulfills all the requirements of an ideal root canal filling material for primary teeth is yet unavailable. Hence, this study was initiated to evaluate clinically and radiographically, the efficacy of two obturating materials - zinc oxide eugenol (ZOE) and zinc oxide mixed with Neem oil (ZON) for 12 months. To assess the success rate of a mixture of zinc oxide and neem oil in comparison to zinc oxide-eugenol paste, as an obturating material in primary molars. To compare the efficacy of ZON as an obturating material at the various time interval of 3, 6, 9, and 12 months postoperatively. This split-mouth, double-blind study was performed on 24 children aged 5-7 years, who presented with bilaterally infected primary molars. Total 48 infected primary molars were divided into two groups for pulpectomy followed by obturation with ZOE and ZON, respectively. Randomization with the chit-pick method, for the control and experimental drug, was performed. A follow-up for 12 months was performed. The Chi-square test was used for inter-group comparison and the Z test was used for the analysis of data over a period of time. Overall clinical findings in this study revealed 91.7% results in ZOE compared with 100% results in the ZON group. The radiographical findings revealed 91.7% results in ZOE compared with 100% success in the ZON group. ZON demonstrated excellent effectiveness as an obturating material in the 12-month follow-up period as compared to ZOE in primary teeth. The efficacy elicited in this study could be a basis to recommend ZON as herbal alternative obturation material.

Obturating Materials for Primary Teeth – A Review

If an infected tooth can be repaired and is disease-free, it should be managed and kept in the dental arch as a natural space maintainer. The care given to deciduous teeth differs from that given to permanent teeth. There have been a number of obturating materials developed for use in primary teeth's root canal fillings, but none have been able to meet all of the material's desirable qualities. The major objective of the medical professional should be to fill the root canal with a substance that may best fulfill the ideal qualities' strictest requirements. In light of this, the purpose of this review is to outline several obturation materials utilized in routine clinical practice.

The thermoplastic techniques or single-cone technique on the quality of root canal filling with tricalcium silicate-based sealer: An integrative review.

BackgroundThe filling of the root canal system (RCS) is an important step in endodontic treatment and aims to obtain a three-dimensional sealing of the root canal spaces to prevent bacterial contamination. For this, the selection of an appropriate sealer must be performed synchronously with the choice of the root canal filling technique. This study aims, through an integrative review, to evaluate the quality of root canal filling by comparing thermoplastic and single-cone (SC) techniques. Material and MethodsThe Medline/PubMed, Scopus, Web of Science and Virtual Health Library (VHL) databases were used to find articles published until November 2021. The eligibility criteria comprised articles that evaluating the quality of root canal filling comparing thermoplastic techniques with the SC technique using tricalcium silicate-based sealer. Studies that evaluated primary teeth, endodontic retreatment or perforations, different outcomes, and studies that considered artificial teeth or different sealer and material for obturation of different techniques were excluded. For articles that were not available for access, an additional contact with authors were considered. A total of 1699 articles were found. After duplicate removal, the title and abstract of 828 articles were screened. Sixteen articles were considered for full-text analysis, but only ten articles met the eligibility criteria. Data extracted from the studies were discussed and tabulated to allow the comparison of desired factors. ResultsConcerning the formation of gaps/voids, the thermoplastic techniques showed better results than the SC technique in 3 articles. On the other hand, 2 articles reported no statistical difference between the tested techniques. In addition, about the penetration of tricalcium silicate-based sealer in the dentinal tubules, of the 5 articles selected, in 4 there was no significant difference between the tested techniques and only one study showed better penetration of the sealer when using thermoplastic techniques. ConclusionsThe thermoplastic technique was better in most selected studies regarding gaps and voids, but regarding the penetration of the sealer into the tubules, both techniques were effective. Key words:Root canal filling, thermoplastic techniques, tricalcium silicate.

A study to evaluate and compare the apical sealing ability of MTA, Biodentine, and TotalFill BC RRM Putty in simulated immature teeth

Background: Adequate seal of the root canal is necessary to prevent recontamination and ensure long-term clinical success. The aim of this study was to evaluate the sealing ability of ProRoot mineral trioxide aggregate (MTA), Biodentine, and Total Fill Bioceramic Root Repair Material Putty as the root canal obturation materials using the dye penetration test. Materials and Methods: In this in vitro study, a total of All 68 human teeth were mounted on an experimental setup. Teeth were randomly divided into four groups: Group 1 – A 4 mm apical plug of premixed TotalFill BC RRM Putty; Group 2 – A 4 mm apical plug of hand-mixed MTA; Group 3 – A 4 mm apical plug of mechanically mixed MTA was placed; and Group 4 – A 4 mm apical plug of mechanically mixed Biodentine was placed. Results: There is a statistically significant difference between Group II and Group III along the root canal wall (P < 0.05). There is no significant difference between Group I and Group IV along the root canal walls (P > 0.05). The lowest mean value of microleakage was recorded by Group I, whereas the highest mean value of microleakage was shown by Group II. Conclusion: Within the limitation of this study, none of the root-end filling materials were free from microleakage. Among these materials, TotalFill BC RRM Putty showed the least microleakage along the root canal walls. However, the validity of this in vitro study could be appreciated only through further clinical trials.

Dissolving efficacy of xylene on epoxy resin-based and bioceramic-based root canal sealers

Background: Epoxy resin-based and bioceramic-based root canal sealers are used in endodontic treatment as root canal obturation materials because they are considered to have many advantages. The complete removal of these materials during root canal retreatment is crucial in order to ensure adequate disinfection. Due to the difficulty in accessing root canal ramifications, removal of these filling materials without damaging the teeth can be successfully achieved using endodontic solvents. Objective: The aim of this study was to evaluate the solubility of two types of root canal sealers in xylene used in endodontics. Methods: A total of 34 epoxy resin and bioceramic samples were stored for 72 h in an incubator to set. The samples were then immersed for 2 min in 1 mL of xylene. The excess xylene on the samples was drained with an absorbent paper and stored in an incubator for 24 h to dry. The pre- and post-immersion weight of the samples was measured using a digital analytical scale, then the weight difference between the groups was analyzed using the independent t test at a 5% significance level. Results: No significant difference was observed between the epoxy resin-based root canal sealer group and the bioceramic-based root canal sealer group (P ≥ 0.05). Conclusion: Xylene endodontic solvent has a similar efficacy for removing epoxy resin-based and bioceramic-based root canal sealers in in vitro study.

FOREIGN BODY ON RIGHT LATERAL BORDER OF TONGUE THAT MIMICKS VARIX: A CASE REPORT

Foreign body impaction in the oral cavity either due to traumatic injury or iatrogenically is not uncommon. Most commonly encountered iatrogenic foreign bodies is restorative materials such as amalgam, obturation materials, broken instruments and needles. Majority of foreign bodies are impacted in tonsils, base of tongue, maxillary sinus and vallecula. However, foreign bodies impaction in the mobile tongue is rare. We present a case of unusual foreign body impaction on the right lateral border of tongue appeared as bluish mass. A 40-year-old female military personnel came to Oral and Maxillofacial Surgery Department of 94 Armed Forces Hospital Terendak Camp complaining of bluish, painless mass on the right side of her tongue for 4 years. Excisional biopsy has been done and histopathological examination reveals foreign body impaction, likely amalgam tattoo. Amalgam tattoo can sometimes be confused with other foreign body pigmentations, being then biopsied. Once amalgam tattoos have been established, the removal of lesions is not necessary, except for esthetic reasons.

Evaluation of a Triple Antibiotic Paste as a Root Canal Obturating Material for Deciduous Teeth: A Study Protocol

Background: Teeth with infected root canals, secondary to endodontic infections are a common problem in primary as well as permanent dentition. The key to successful endodontic treatment is seen only after the complete removal of infection from root canals. Systemic antibiotics have limited reach to endodontic spaces. In pediatric dentistry, difficulties in antimicrobial control require the development of a new root canal obturating paste with broad antimicrobial activity, minimal tissue toxicity, and high safety index. In this experimental study, a new Triple Antibiotic Obturating Paste (TAOP) will be developed and its efficacy will be evaluated.
 Methods and Design: This is a pre-clinical in-vitro microbiological and in-vivo animal study, utilizing laboratory-grown white Wistar rats aged 2-3 months and weighing 200-300 grams. The antibiotic sensitivity test (AST) will be conducted using 21 standard aerobic and anaerobic microbial strains for determining potency through serial dilution and agar diffusion assay. The systemic and local tissue toxicity will be assessed by inserting the test and control materials into the dorsal connective tissues of the experimental rats. The antimicrobial efficacy of triple antibiotic obturating paste [thermo-modulated in-situ polymeric hydrogel matrix of TAOP, containing chitosan-carbopol and poloxamer blended with clindamycin (5%), metronidazole (5%), and doxycycline (1%)] will be evaluated against Metapex [Ca(OH)2-Iodoform paste] on endodontic microflora. The microbiological study data will be evaluated through One-way ANOVA trailed by ‘Tuckey’s post hoc test’ for intergroup as well as, t-test for intragroup comparison. The animal study data will be evaluated through One-way ANOVA for intergroup and ‘paired t-test’ for intragroup comparison.
 Results: The newly developed bio-degradable obturating material will be more suitable than the conventionally used one, to eliminate resistant endodontic pathogens from root canal systems, along with good pharmacokinetic and pharmacodynamic responses as well as minimal local and systematic tissue toxicity when used in primary teeth.
 Conclusion: The application of such novel multi-antibiotic formulation as an obturating material not only will achieve efficient disinfection of the endodontic spaces but also increase chances of therapeutic success due to the elimination of side effects associated with cytotoxicity and material properties as it contains most of the bioresorbable organic ingredients.

Effect of solvent on root canal filling material removal by two different rotary file systems in C-shaped root canals.

This study compared the percentage reduction of total obturation materials, gutta-percha and sealer, using two rotary file systems with/without solvent in retreating C-shaped root canals and to evaluate the effect of the solvent on instrument separation. C-shaped root canals were scanned using micro-CT to identify the root canal morphology and randomly assigned to four groups (n = 12). Retreatment was performed using ProTaper Universal Retreatment (PTUR) or XP-endo systems with/without solvent. The number of separated instruments were recorded. The samples were scanned pre- and post-retreatment. The percentage reduction of total obturation materials, gutta-percha and sealer, were calculated. The percentage reduction of gutta-percha in the PTUR without solvent group was significantly lower than the other groups (P = 0.018). The number of separated instruments in the solvent groups were significantly lower than the no solvent groups (P < 0.05). Solvent increased gutta-percha removal, when using PTUR and decreased the occurrence of separated instruments for both systems.

Resorbable Collagen Barrier Impeding the Extrusion of Obturating Material in Primary Molars Undergoing Resorption - A Randomized Clinical Trial.

To evaluate the effectiveness of placing a resorbable collagen barrier in impeding the extrusion of obturation material in primary molars undergoing resorption. All the 94 canals in 47 mandibular molars were allocated to 2 groups- Group 'A'- 47 canals with collagen barrier (Test group) and Group 'B'- 47 canals without collagen barrier (Control group) based on randomization protocol. Pulpectomy was performed and obturation of both test and control canals were radiographically assessed. Pearson's chi - square test was applied to analyze the results. The significance level was predetermined at p < 0.05. Among the test group, 93.6% of the canals showed no extrusion while, 6.4% showed visible extrusion of the material outside the apex. In the control group, 83% showed no extrusion whereas 17% of the canals showed visible extrusion outside the apex. But no significant difference was noted (p>0.05). The placement of resorbable collagen barrier in the apical third of the canal prevented the extrusion of obturating material beyond the apex in resorbing primary molars.

The Effect of Ultrasonic Agitation on the Porosity Distribution in Apically Perforated Root Canals Filled with Different Bioceramic Materials and Techniques: A Micro-CT Assessment.

The present study evaluated the effect of ultrasonic agitation on the porosity distribution of BioRoot RCS/single gutta-percha cone (BR/SC) and MTA Flow (MF) root canals fillings used as apical plugs in moderately curved and apically perforated roots. Eighty mesial root canals of mandibular first molars were enlarged up to ProTaper NEXT X5 rotary instrument 2 mm beyond the apical foramen, simulating apical perforations. Specimens were randomly divided into four experimental groups (20 canals per group) according to the material and technique used for root canal obturation: BR/SC, BR/SC with ultrasonic agitation (BR/SC-UA), MF and MF with ultrasonic agitation (MF-UA). The ultrasonic tip was passively inserted into the root canal after the injection of flowable cement and activated for 10 s. The specimens were scanned before and after obturation with a high-resolution micro-computed tomography scanner, and the porosity of the apical plugs was assessed. The differences between groups were analyzed using the Kruskal-Wallis and Mann-Whitney tests, with the significance level set at 5%. None of the obturation materials and techniques used in this study was able to provide a pore-free root canal filling in the apical 5 mm. Considerably higher percentages of open and closed pores were observed in the MF and MF-UA groups, with the highest porosity being in the MF-UA group (p < 0.05). No significant differences were observed between the BR/SC and BR/SC-UA groups, where the quantity of open and closed pores remained similar (p > 0.05).

The Sealing Ability of Guttaflow2 Sealer in Comparison to AH Plus Sealer Using Dye Penetration Method

The aim of this study was to evaluate the apical sealing ability of GuttaFlow2 obturation material using dye penetration method. Palatal roots of forty five extracted maxillary first molars were instrumented with ProTaper rotary files to size F4. The teeth were divided into three experimental groups according to type of sealer used, group1: root obturated with AH Plus sealer and single cone technique, group2: root obturated with GuttaFlow2 sealer and single cone technique, group3: root obturated with GuttaFlow2 sealer only. Results: Data was subjected to statistical analysis. P-Value

Biocompatibility of glass-ionomer cements in dentistry

Biocompatibility takes into account the ability of a material to elicit a specific biological response after administration to a living organism. The concept does not define only one quality of the material, but reflects a complex of interactions with the biological environment in which it is placed. Over time, the definition of biocompatibility has gradually changed. Dental cements are the main clinical obturating materials. First created by Wilson and Kent in 1969, glass ionomer (polyalkenoate) cements have become widely used in medicine and dentistry. The purpose of this review is to discuss the biocompatibility of glass ionomer cements. Scientific databases - PubMed and SCOPUS were used to find appropriate studies in English on the topic of this article, with the following keywords - biocompatibility, glass ionomer cements, dentistry. A time period of 2000-2021 was set to screen articles and track the progress of the biocompatibility of dental cements in the new millennium. In addition to the cited scientific databases and articles such as clinical trials, review articles, meta-analyzes, writing of the report included information from Bulgarian and foreign textbooks in English on the subject. After applying the screening criteria, 61 results were displayed in SCOPUS and 215 in PubMed. From them, selected articles that describe experimental productions with testing the properties of cements, incl. to living cells, were reviewed. Science has found that by modifying the composition of the powder and the liquid of the cement, properties and biocompatibility can be affected. Modifications with the addition of nanoparticles hydroxylapatite and silica, carbon nanocompounds, zinc ions, cellulose microfiber and nanocrystals, amorphous calcium phosphate, chlorhexidine, collagen type 1 and peptides have been reported. Cement liquid has also been improved, which changes its properties. In the given time period between 2000-2021 there is a rapid rise of development and improvement of the properties of already synthesized cements. Efforts are being made to study the biocompatibility of materials and their properties to help tissue regeneration. There is also a wider use of materials and their implementation into various fields of medicine and dentistry.

Comparative evaluation of sealing ability of three bioactive obturation materials

Aim: The aim of this study was to evaluate and compare the sealing ability of three obturating materials used with single-cone technique: C Point/Endosequence BC sealer, gutta-percha/Endoseal MTA and gutta-percha/GuttaFlow bioseal using bacterial leakage model with Enterococcus faecalis. Materials and Methods: Seventy-six extracted human single-rooted mandibular premolars with straight canals prepared using Hyflex CM up to 45/04 and assigned to 3 experimental groups according to the root canal filling material as Group A - C Point/Endosequence BC sealer; Group B - guttapercha/Endoseal MTA; Group C - guttapercha/GuttaFlow bioseal. Split-chamber bacterial leakage model was prepared and microleakage analysis was made every 24 h for up to 9 weeks. The presence of E. faecalis was confirmed by light microscopy and Gram staining. Results: A survival analysis was performed using Kaplan–Meier plots and a log-rank test and it was found that Group A showed the best apical seal followed by Group C and then Group B at the end of the observational period. The difference in bacterial leakage among Group A and C versus Group B was statistically significant (P &lt; 0.05), but there was no significant difference between Group A and Group C. Conclusion: C Point/Endosequence BC sealer and GP/Guttaflow bioseal sealer has shown better apical seal with single-cone technique as compared to GP/Endoseal MTA.

Regenerative Therapy Modality for Treatment of True Combined Endodontic-Periodontal Lesions: A Randomized Controlled Clinical Trial.

The aim of this in-vivo study was to evaluate/compare the clinical periodontal parameters in patients with true combined endo-perio lesions (EPL), treated with gutta-percha (GP) and mineral trioxide (MTA) as an obturation material alone and with addition of bone grafting in such lesions. 120 Saudi patients (mean age = 41yrs) diagnosed with true combined EPL participated in this study. Group I (control group, n = 30) was treated with conventional endodontic treatment using GP for obturation. Group II (n = 30) was treated with conventional endodontic treatment using MTA for obturation. Group III (n = 30) was treated with conventional endodontic treatment using GP for obturation + grafting procedure to fill the bony defect. Group IV (n = 30) was treated with conventional endodontic treatment using MTA for obturation + grafting procedure to fill the bony defect. Clinical parameters (Pocket depth (PD); Clinical attachment loss (CAL); keratinized tissue width (KTW); gingival phenotype (G.Ph.) and Cone Beam Computed Tomography Periapical Index (CBCTPAI)) were recorded and compared at baseline, 3, 6, 12 months’ interval. For the groups III and IV, CBCTPAI showed significant difference (p < 0.0001) with the other groups at 6 months and 1-year interval. The group with MTA + bone graft showed 76% and 90% patients with 0 score at 6 months and 1-year follow-up, respectively. Comparison of mean values of PD among study groups at 3 months, 6 months and 1 year showed significant difference at 3 months, whereas the mean PD values of subjects in GP + bone graft showed significantly higher PD values than other 3 groups (p = 0.025). Use of GP and MTA for root canal obturation along with periodontal therapy and bone augmentation helps in resolving complex endo-perio lesions. Bone grafting in addition to obturation with MTA was found to be the best treatment strategy in management of EPL cases and is recommended for clinicians who are treating EPL patients.

What’s new for the clinician? - Excerpts from and summaries of recently published papers

Choosing an endodontic sealer clinical use is a decision that contributes to the long-term success of non-surgical root canal treatment. Sealers are used as a thin tacky paste which function as a lubricant and luting agent during obturation, allowing the core obturation material, such as gutta-percha points or other rigid materials, to slide in and become fixed in the canal. Sealers can fill voids, lateral canals, and accessory canals where core obturation materials cannot infiltrate. If the sealer does not perform its function, microleakage may cause root canal failure via clinically undetectable passage of bacteria, fluids, molecules or ions between the tooth and restorative material. It has been reported that extrusion of the sealer during root canal filling has cytotoxic effects on periapical tissues, causing periapical inflammation, necrosis and pain. Endodontic sealers are categorized by composition based on setting reaction and composition: zinc oxide eugenol, salicylate, fatty acid, glass ionomer, silicone, epoxy resin, tricalcium silicate, and methacrylate resin sealer systems. Aslan &amp; Özkan (2021) reported on a trial that sought to evaluate the effect of two calcium silicate-based root canal sealers, Endoseal MTA and EndoSequence BC Sealer, on postoperative pain following single-visit root canal treatment on molar teeth compared to their epoxy/ amine resin-based counterpart AH Plus. The null hypotheses tested in this study were as follows:1. The type of sealer used would not change the incidence and the intensity of post-treatment endodontic pain2. The analgesic intake of patients following single-visit root canal treatment

Debris Extrusion Using Reciproc Blue and XP Endo Shaper Systems in Root Canal Retreatment.

This study aimed at assessing the performance of Reciproc Blue (RB) and XP Endo Shaper (XPS), used for canal retreatment on extracted teeth, in terms of debris extrusion and obturating materials removal. Thirty mandibular premolars were prepared to ProTaper X2 file, obturated using warm vertical compaction, and then incubated for 28 days at 100% humidity at 37°C. Teeth were randomly assigned into two groups, according to the system used for retreatment (RB and XPS). During retreatment, debris extruded beyond the apex was collected in preweighed Eppendorf tubes, and the retreatment time was measured. Afterward, the teeth were longitudinally sectioned to assess the remaining obturating materials. Data were statistically analyzed using the Mann–Whitney test and chi-square test at a 95% confidence level. All the samples had extruded debris at varying weights ranging from 0.125 mg to 3.680 mg. XPS extruded less debris than RB, but no difference was detected (Mann–Whitney test; P > 0.05). RB and XPS required 54.9 ± 17.9 and 22.3 ± 9.3 seconds to perform retreatment procedures, respectively (Mann–Whitney test; P < 0.05). The sealer was found in all the samples. Compared to the RB group, fewer samples with remaining gutta-percha were found in the XPS group (Chi-square test; P < 0.05). None of the files fractured during the retreatment procedure. The tested files appear to extrude debris beyond the apex. Although XPS was able to remove the gutta-percha completely from the majority of the canals, it was unable to remove the sealer.

Root Canal Filling Quality Comparison of a Premixed Calcium Silicate Endodontic Sealer and Different Carrier-Based Obturation Systems.

Background: The number of voids within the root canal obturation is a relevant parameter to describe the quality of the technique, as well as to predict long-term prognosis. The aim of this study was to evaluate the quality of root canal obturation in curved root canals filled with Thermafil, GuttaCore, GuttaFusion and lateral compaction with AH Plus and EndoSequence BC sealer, by means of percentage of gutta-percha and sealer filled area. Methods: 200 curved canals of mandibular molars were divided in five groups (n = 40). Each specimen was evaluated at 3, 6 and 9 mm from the apex. A total of 600 samples were analyzed. Obturation was performed with either Thermafil (TH), GuttaCore (GC), GuttaFusion (GF) or lateral compaction (LC), using AH Plus as sealer. In another group EndoSequence BC sealer (BC) was used. Subgroups (n = 20) were made depending on the use of sonic activation during the placement of the sealer. The percentage of total obturation material was analyzed as an indirect measurement of percentage of voids. Results: GF showed a better performance at the apical level, while GC showed the higher percentage of total obturation at the coronal area. No differences were observed for the activation of sealers in any of the groups. Statistical analysis was performed by using two-way ANOVA. Statistical significance was set at CI: 95% (p < 0.05). Conclusions: Sonic activation of sealers did not show any benefit to avoid the presence of voids within obturation of curved canals. Following the manufacturer recommendations, we found that TH did not show benefits when applied to curved canals.