This paper investigates trajectory tracking control of the Autonomous Underwater Vehicle (AUV) with the general uncertainty consisting of model uncertainties and unknown ocean current disturbances. A full prescribed performance control strategy based on disturbance observer is developed, which ensures that the tracking error, the velocity error, and the observation error are all constrained. First, under the case of unmeasurable AUV acceleration, a fixed-time observer is constructed to estimate the general uncertainty, which constrains the observation error within the prescribed accuracy by a prescribed performance observer. Then, based on the performance function and corresponding error transformation, a prescribed performance protocol is designed to realize the trajectory tracking control, so that the observation error, the tracking error, and the velocity error are all constrained within the prescribed accuracy range. Simulation results demonstrate the efficiency of the full prescribed performance control strategy while the AUV tracking control with full state constraints is feasible. Moreover, compared with the other two relevant works, this study improves the observation performance by at least 10 %, both in case of deepwater disturbances and near-surface disturbances.