Nerve injuries leads to loss of function from different organs of patient. It is caused due to dysfunction of neural cell. This dysfunction can occur by different ways like of genetics, protein accumulation in neural cell or any of the sudden accident. The nerve consist of various parts and one axon. The same nerve divides as CNS part and PNS part. The regeneration of nerve axon in PNS can be possible to function but the CNS part of axon cannot be regenerated. This regeneration takes place takes place with injured cell. This injury leads to pain referred as neuropathic pain. The nerve cell injury can be putted into three categories as of Neuropraxia, Axonotmesis and Neurotmesis. The injured neural cell leads to neurodegeneration. There are several treatments available on the basis of nutrients and constituents taken from herbal medicinal plants. Nutraceuticals is a branch known by its food supplements and nutrients of any herbal plant which have positive effect towards patient health and management of related disease. Nutraceuticals have less side and adverse effect towards patient. There are some medications which is derived from herbal medicinal plant such as Ginseng, Ashwagandha, Bacopa monnieri, Ginkgo biloba, Centella asiatica. Some compounds belong to as class of flavonoids, celastrol, trehalose, lycopene, sesamol, resveratrol and curcumin are showing high positive impression. The present scenario demands for the herbal medicinal treatment and for the fulfilment of this need the approach towards nutraceutical are raising high. Neuroprotection mechanism also shown by these nutrients. Apart from neuro regeneration, neuroprotective effect the nutraceutical also show antioxidant, anti-inflammatory effect. Polyphenol compound help to increase neural function.