REVIEW OBJECTIVES/QUESTION The objective of this systematic review is to synthesize the best available evidence regarding the effectiveness of interventions delivered in advance practice nurse-led clinics on mortality in adult (19 years of age and older) patients with heart failure. The review question is: in adult patients,19 years of age and older, diagnosed with heart failure, what is the effectiveness of the interventions provided in advanced practice nurse-led heart failure clinics on all-cause mortality rates compared to usual care? INCLUSION CRITERIA Types of participants The review will consider studies that include patients who are 19 years of age or older, diagnosed with heart failure, regardless of gender, ethnicity, other co-existing health conditions, level of education, income or health insurance. Participants must have been assessed using an established classification or categorization system by a primary care provider (i.e. Advanced practice nurses, physician or cardiologist) at the beginning of the research study to determine their severity of symptoms or physical activity limitations. The New York Heart Association Functional Classification and the American Heart Association Stages of Heart Failure are two of the most widely used instruments. Types of intervention(s) The review will consider studies that evaluated evidence-based interventions delivered in Advanced practice nurses-led Heart Failure clinics compared to usual care. Usual care refers to all non-Advanced practice nurses-led Heart Failure clinics, care approaches including care provided by primary care physicians, or cardiology clinics and physician-led Heart Failure clinics. Advanced practice nurses-led Heart Failure clinics are defined as TRUNCATED AT 250 WORDS