NURSING'S AGENDA CALLS on us to lead evidence-based practice (EBP) for quality care. 1 Auerbach D. Martsolf G. Pearson M.L. et al. The DNP by 2015: A study of the institutional, political, and professional issues that facilitate or impede establishing a post-baccalaureate doctor of nursing practice program. http://www.aacnnursing.org/Portals/42/DNP/DNP-Study.pdf?ver=2017-08-01-105854-190Date: 2015 Date accessed: June 26, 2018 Google Scholar , 2 Institute of Medicine Leadership Commitments to Improve Value in Healthcare: Finding Common Ground: Workshop Summary. National Academies Press, Washington, DC2009 Google Scholar , 3 Melnyk B.M. Fineout-Overholt E. Gallagher-Ford L. Kaplan L. The state of evidence-based practice in US nurses: Critical implications for nurse leaders and educators. J Nurs Adm. 2012; 42: 410-417 Crossref PubMed Scopus (355) Google Scholar The Institute of Medicine set a goal for 90% of health care to be evidence-based by 2020, yet clinicians and organizations are struggling to achieve this goal. 2 Institute of Medicine Leadership Commitments to Improve Value in Healthcare: Finding Common Ground: Workshop Summary. National Academies Press, Washington, DC2009 Google Scholar Growing and sustaining programs to promote evidence-based health care remain elusive. Commitment to building programs and infrastructures that promote EBP and continuous learning in health care are essential, yet few exemplars and little research is available as a guide. 4 Institute of Medicine Best Care at Lower Cost: The Path to Continuously Learning in Health Care in America. National Academies Press, Washington DC2013 Google Scholar , 5 Stetler C.B. Ritchie J.A. Rycroft-Malone J. Charns M.P. Leadership for evidence-based practice: Strategic and functional behaviors for institutionalizing EBP. Worldviews Evid Based Nurs. 2014; 11: 219-226 Crossref PubMed Scopus (76) Google Scholar , 6 Warren J.I. McLaughlin M. Bardsley J. et al. The strengths and challenges of implementing EBP in healthcare systems. Worldviews Evid Based Nurs. 2016; 13: 15-24 Crossref PubMed Scopus (84) Google Scholar , 7 Williams B. Perillo S. Brown T. What are the factors of organisational culture in health care settings that act as barriers to the implementation of evidence-based practice? A scoping review. Nurse Educ Today. 2015; 35: e34-e41 Abstract Full Text Full Text PDF PubMed Scopus (110) Google Scholar , 8 Wilson M. Sleutel M. Newcomb P. et al. Empowering nurses with evidence-based practice environments: Surveying Magnet®, Pathway to Excellence®, and non-magnet facilities in one healthcare system. Worldviews Evid Based Nurs. 2015; 12: 12-21 Crossref PubMed Scopus (66) Google Scholar Expanding nurse-led EBP remains a journey, not a destination. 9 Cullen L. Hanrahan K. Journey to evidence-based healthcare. Reflections Nurs Leadersh. 2018; (Available at:)https://www.reflectionsonnursingleadership.org/features/more-features/journey-to-evidence-based-healthcareDate accessed: June 25, 2018 Google Scholar , 10 Melnyk B.M. Gallagher-Ford L. Zellefrow C. et al. The first U.S. study on nurses' evidence-based practice competencies indicates major deficits that threaten healthcare quality, safety, and patient outcomes. Worldviews Evid Based Nurs. 2018; 15: 16-25 Crossref PubMed Scopus (159) Google Scholar Best evidence and decades of work have created a path forward with solutions for integrating EBP improvements in daily care. However, programs and resources require piloting, evaluation, and revision to match local context. Core elements will be described that create a climate and capacity that empowers nurses to lead EBP within their span of influence. Laura Cullen, DNP, RN, FAAN, Office of Nursing Research, Evidence-Based Practice & Quality Department of Nursing Services and Patient Care, University of Iowa Hospitals and Clinics, Iowa City, IA.