Numerous Health Disorders Research Articles

Icariin as a Treatment Proposal in Mammalian Reproduction.

Icariin (ICA), one of the main active components of Herba Epimedii, is a natural prenylated flavonol glycoside that possesses a wide range of pharmacological effects, including antioxidant, antiosteoporotic, anti-aging, neuroprotective, immunomodulatory, antitumor, and aphrodisiac effects, and prevents numerous health disorders, such as cardiovascular diseases, osteoporosis, cancer, sexual dysfunction, menstrual disorders, neurodegenerative diseases, asthma, chronic inflammation, and diabetes. In the reproductive system, it has been observed that ICA may play a role in preserving fertility by regulating different signalling pathways, such as PI3K/AKT, which improves ovarian function, and ERα/Nrf2, which enhances testicular function and prevents ROS generation. In contrast, regulating the NF/kB signalling pathway causes anti-inflammatory effects, reducing spontaneous abortions. In this study, we review and examine the relevant literature on the therapeutic potential of ICA in reproduction, highlight the various mechanisms of action and limitations for the therapeutic applications of ICA, and summarise and highlight the existing preclinical research on its effects on male and female reproduction.

Association of predicted body composition with occurrence of atrial fibrillation.

Body mass index (BMI) is insufficient evidence as a risk factor for numerous health disorders. Body composition may be more appropriate for confirming the association with cardiovascular diseases, including atrial fibrillation (AF). This study aimed to examine the association between body composition and the occurrence of AF. A total of 2,673,108 participants (48.6% women) without AF at baseline from the Korean national health insurance data were included. Body composition including appendicular skeletal muscle mass, body fat mass, and lean body mass were indirectly measured through validated anthropometric prediction equations. The diagnosis of AF and comorbidities were defined. With a median of 9.5 (interquartile range 9.2-10.1) years' follow-up, 25,841 (0.96%) cases of incident AF were included. In multivariable analysis, higher appendicular skeletal muscle was related to low risk of AF [hazard ratio (HR) 0.829, 95% confidence interval (CI) 0.753-0.912 for men (fifth quintile) and HR 0.888, 95% CI 0.792-0.995 for women (fifth quintile)]. In contrast, a higher body fat mass [HR 1.345, 95% CI 1.221-1.483 for men (fifth quintile) and HR 1.420, 95% CI 1.274-1.591 for women (fifth quintile)] and lean body mass [HR 2.241, 95% CI 2.182-2.303 for men (fifth quintile) and HR 1.516, 95% CI 1.368-1.667 for women (fifth quintile)] were associated with the occurrence of AF. In this study, body composition parameters were associated with the occurrence of AF. It should be noted that when appendicular skeletal muscle mass decreases and body fat mass and lean body mass increase, the risk of AF may be increased in general population except underweighted BMI group.

Recent insights about pyrrolidine core skeletons in pharmacology.

To overcome numerous health disorders, heterocyclic structures of synthetic or natural origin are utilized, and notably, the emergence of various side effects of existing drugs used for treatment or the resistance of disease-causing microorganisms renders drugs ineffective. Therefore, the discovery of potential therapeutic agents that utilize different modes of action is of utmost significance to circumvent these constraints. Pyrrolidines, pyrrolidine-alkaloids, and pyrrolidine-based hybrid molecules are present in many natural products and pharmacologically important agents. Their key roles in pharmacotherapy make them a versatile scaffold for designing and developing novel biologically active compounds and drug candidates. This review aims to provide an overview of recent advancements (especially during 2015-2023) in the exploration of pyrrolidine derivatives, emphasizing their significance as fundamental components of the skeletal structure. In contrast to previous reviews that have predominantly focused on a singular biological activity associated with these molecules, this review consolidates findings from various investigations encompassing a wide range of important activities (antimicrobial, antiviral, anticancer, anti-inflammatory, anticonvulsant, cholinesterase inhibition, and carbonic anhydrase inhibition) exhibited by pyrrolidine derivatives. This study is also anticipated to serve as a valuable resource for drug research and development endeavors, offering significant insights and guidance.

Investigating the effects of long-term Aroclor 1260 exposure on fatty liver disease in a diet-induced obesity mouse model.

Polychlorinated biphenyls (PCBs) are persistent environmental toxicants that have been implicated in numerous health disorders including liver diseases such as non-alcoholic fatty liver disease (NAFLD). Toxicant-associated NAFLD, also known as toxicant-associated fatty liver disease (TAFLD), consists of a spectrum of disorders ranging from steatosis and steatohepatitis to fibrosis and hepatocellular carcinoma. Previously, our group demonstrated that 12-week exposure to the PCB mixture, Aroclor 1260, exacerbated steatohepatitis in high-fat diet (HFD)-fed mice; however, the longer-term effects of PCBs on TAFLD remain to be elucidated. This study aims to examine the longer-term effects of Aroclor 1260 (>30 weeks) in a diet-induced obesity model to better understand how duration of exposure can impact TAFLD. Male C57BL/6 mice were exposed to Aroclor 1260 (20 mg/kg) or vehicle control by oral gavage at the beginning of the study period and fed either a low-fat diet (LFD) or HFD throughout the study period. Aroclor 1260 exposure (>30 weeks) led to steatohepatitis only in LFD-fed mice. Several Aroclor 1260 exposed LFD-fed mice also developed hepatocellular carcinoma (25%), which was absent in HFD-fed mice. The LFD+Aroclor1260 group also exhibited decreased hepatic Cyp7a1 expression and increased pro-fibrotic Acta2 expression. In contrast, longer term Aroclor 1260 exposure in conjunction with HFD did not exacerbate steatosis or inflammatory responses beyond those observed with HFD alone. Further, hepatic xenobiotic receptor activation by Aroclor 1260 was absent at 31 weeks post exposure, suggesting PCB redistribution to the adipose and other extra-hepatic tissues with time. Overall, the results demonstrated that longer-term PCB exposure worsened TAFLD outcomes independent of HFD feeding and suggests altered energy metabolism as a potential mechanism fueling PCB mediated toxicity without dietary insult. Additional research exploring mechanisms for these longer-term PCB mediated toxicity in TAFLD is warranted.

In Vitro Antioxidant and Bioactive Component Analysis of Himalayan Spice Faran (Allium Stracheyi)

Reactive oxygen species (ROS), a group of highly reactive molecules derived from oxygen metabolism, have been implicated in numerous health disorders. As a result, there has been growing interest in the potential of antioxidant-based drugs and natural antioxidants for treating complex diseases. This study aimed to assess the antioxidant potential of the Himalayan spice Faran (Allium Stracheyi) by determining the presence of phytochemicals such as phenols and flavonoids and evaluating its in vitro antioxidant activity using various assays. Chloroform, petroleum ether, and aqueous extracts of Allium Stracheyi leaves were tested using DPPH radical scavenging assays, ferric reducing antioxidant power, total antioxidant capacity and reducing power assay. The Chloroform extracts demonstrated significantly higher (p≤0.05) levels of phytochemicals and superior antioxidant activity compared to the other extracts. These findings suggest that Faran could be a promising candidate for developing nutraceuticals to treat diseases such as diabetes and cancer.

Evaluation of salivary alkaline phosphatase levels in tobacco users to determine its role as a biomarker in oral potentially malignant disorders

Background: Saliva, a widely obtainable oral fluid, has gained acceptability as a screening medium in numerous health disorders in recent years. It has the capacity to discern initial epithelial alterations in tobacco abusers and people with OPMD since it is in direct contact with the lesion. Although few reports have been conducted on the use of concentration of alkaline phosphatase (ALP) enzyme in serum as well as saliva of OSCC patients as a biomarker, more research is needed in OPMD.Aims and Objectives: The study's major goals were to measure S-ALP levels in smokers, nonsmokers, and people with OPMD. and to compare S ALP levels in smokers, nonsmokers, and people with OPMD.Materials and Methods: The 84 participants in the study ranged in age from 18 to 75 years old, and they were divided into four groups:Category One – People who don't smoke or chew tobacco and don't have any lesions on intraoral inspection (n = 24).

Syzygium samarangense leaf extract exhibits distinct antidiabetic activities: Evidences from in silico and in vivo studies

The wax apple, Syzygium samarangense , is widely used in traditional medicine. We have previously described a plethora of biological activities from its leaf extract. These include antioxidant, anti-inflammatory, antiulcer, antitrypanosomal and hepatoprotective effects. Here, we explored the antidiabetic activities from the bioactive leaf extract in silico on two crucial receptors involved in the management of diabetes disease namely peroxisome proliferator activated receptor gamma (PPARɣ) and glucagon like peptide-1 (GLP-1) and in vivo against streptozotocin-induced diabetic rats. Altogether, 457 secondary metabolites belonging to 10 classes (phenolic acids (86 compounds), flavonoids (139 compounds), anthocyanins (61 compounds), alkylphenols (17 compounds), chalcone (15 compounds), stilbenes (9 compounds), lignans (29 compounds), tannins (29 compounds), tyrosols (13 compounds), and terpenes and others (59 compounds), were docked into the active site of PPARɣ and GLP-1 receptors. From the PDB codes used for each receptor, the co-crystallized ligand was extracted and docked together with a known reference ligand. This was done simultaneously with docking the extract’s compounds to serve as references for comparative purposes. Out of the docked candidates, the top 30 compounds affording the best docking scores were compiled for further inspection and they appeared to exhibit better scores than the respective co-crystallized and reference ligands, highlighting the antidiabetic potential of the tested extract. Nine compounds exhibited highly negative scores on both receptors, demonstrating their high probability of being potent antidiabetic agents through forming stable ligand-receptor complexes. These activities were also confirmed in STZ diabetic rats where the extract reduced the elevated levels of serum glucose and lipid peroxides and increased the declined serum insulin hormone level. Taking all together, S. samarangense can be a potential candidate for further investigations for the treatment of numerous health disorders including diabetes.

HAND-ARM VIBRATION IN DIFFERENT OPERATING CONDITIONS WITH A CHAINSAW

The mechanization of forest harvesting is a trend in Brazil. However, small and medium-sized companies in the forestry sector, even today, opt for semi-mechanized harvesting, using chainsaws for the harvesting and sectioning of trees. Despite technological advances, when operated continuously, chainsaws may cause damage to the operator’s body, acting as a stressor, and vibration excess is responsible for numerous health disorders, among them the Raynaud syndrome. In this sense, this study aimed to determine the vibration levels to which a chainsaw operator is subjected, during the transversal cut (tracing) of the wood, in different forest species and cutting sets. The treatments consisted of three forest species (Eucalyptus grandis, Eucalyptus dunnii and Acacia mearnsii De Wild) and two cutting sets, consisting of square tooth chains of the semi-chisel and chisel types. The vibration assessment was based on the criteria established by the Regulatory Standards NR15, NHO10 and ISO 2631-4. The results of vibration levels were higher than the reference limits established by ISO 2631-4, and, for both cutting sets, the highest vibration levels occurred on the “x” axis. After the data processing, the acceleration values resulting from the normalized exposure to hand-arm vibrations showed significant differences for the “y” and “z” axes. Therefore, it can be inferred that the chainsaw operation is a stressor, potentially capable of causing damage to workers' health.

An Overview of Evidence that Mercury from Dental Fillings may be an Etiological Factor in Many Health Disorders

Aim: The purpose of this paper is to summarize the research regarding the toxic health effects caused by mercury dental amalgams. Method: The study involved summarizing scientific articles in journals regarding health effects of dental amalgam mercury. Results: The science strongly suggests dental amalgam mercury may be an etiological factor in numerous health disorders. Mental health seems to be affected the most including such conditions as depression, anger, and irritability. Studies have also associated it with schizophrenia and bipolar disorders. The cardiovascular system also is affected including high blood pressure, heart rate, hemoglobin, hematocrit, and red blood cells. Subjects with amalgams have a decreased T lymphocyte percentage compared to a control, and the immunoglobins IgG, IgA, and IgE correlated with the number of amalgams. Myopia is reduced in amalgam bearing subjects but amalgam mercury is constricting the visual field. When comparing total health disorders of subjects with amalgams compared to those without, they suffered 45% more health disorders. Urine and hair mercury levels were significantly higher in subjects with amalgams compared to those without. The scientific evidence strongly suggests that amalgam mercury is associated with Alzheimer’s disease, multiple sclerosis, and amytrophic lateral sclerosis. Research has shown when amalgams are removed many health conditions improve. Conclusion: The evidence is overwhelming that mercury from dental amalgam is an etiological factor in many health disorders.

Antioxidant and antimicrobial effects of Geranium extracts as flavoring agents in some prepared foods

Thesis Abstract Background: Essential oils and their fragrance compounds are a very important part of industry. Geranium extracts are used in numerous health disorders and medical conditions and has been validated as commercial exploitation in many industrial branches. Aim: Test the effect of geranium extract against spoilage and pathogenic bacteria, and test if it can be used for the development of novel systems for food preservation. Materials and Methods: Geranium steam extract and geranium n-Butanol extract were used as a natural flavor in food products. Results: The selected Geranium extracts were used as natural sanitizers to reduce and control pathogen contamination or the growth of native microflora. The inclusion of geranium extracts altered the antioxidant properties of the ice cream and jelly candy samples. Due to some limitations of the extract impacting on texture and color of the product, the extract was recommended to use at the lowest level. Conclusion: Geranium was found to be a good source of alternative for the future flavors of ice cream and jelly candy.

Overcommitment to work as a mediator of the association between effort-reward imbalance and insomnia among shift working nurses

IntroductionToday, approximately one fifth of employees in the European Union works in the shift system. Insomnia is one of the most common consequences of occupational stress and shift work. Identifying factors contributing to poor sleep quality among shift workers, especially in healthcare professions, is important because insomnia increases the risks for numerous health disorders and impacts work ability.ObjectivesThe aim of this research was to investigate to what extend does an inability to withdraw from work influences the link between occupational stress and insomnia among shift workers. We operationalized occupational stress within the Effort-Reward Imbalance Model (ERI). An imbalance between individual effort and reward obtained at work leads to experiencing a stressful work environment.Methods153 shift working female nurses completed a short questionnaire about work schedule, the Effort-Reward Imbalance questionnaire with the Overcommitment (OC) scale and the Insomnia Severity Index (ISI). To estimate the mediating effect of OC on the association between ERI and ISI, we conducted a mediation analysis using PROCESS v3.4 macro in SPSS.ResultsThe model including ERI and OC accounted for 12.25% of the variance in ISI scores. ERI significantly predicted OC and OC significantly predicted insomnia. The direct effects of ERI on ISI remained significant after controlling for the effects of overcommitment. 35.07% of the effect of ERI on ISI was through OC.ConclusionsAbility to detach from work-related thoughts during leisure time is crucial for successful recovery from occupational stress. The research is supported by a grant no. 2019/33/N/HS6/02572 from the National Science Center in Poland.DisclosureNo significant relationships.

Effects of cooking on phytochemical and antioxidant properties of pigmented and non-pigmented rare Indian rice landraces

Ever since a positive correlation between rice consumption and reduced risk of developing chronic diseases was recognized, numerous researches on native indigenous rice landraces have been carried out. In the present investigation, ten pigmented and non-pigmented rare Indian rice landraces were analyzed for their total phenolic content (TPC), total flavonoid content (TFC), total protein, total anthocyanin, and antioxidant potential. Three different parameters in raw, cooked, strained cooking water were taken into consideration and phytochemical analysis revealed that pigmented rice varieties displayed higher levels of bioactive compounds as compared to the non-pigmented cultivars. Higher TPC (398 ± 0.23 mg GAE/100 g), TFC (1308 ± 0.04 mg QE/100 g), total anthocyanin (13.36 ± 0.00 mg/100 g), total protein (2590 ± 0.03 mg/100 g), total antioxidant activity (316 ± 0.03 mg AAE/100 g) was recorded with the pigmented varieties. A strong correlation was found between the antioxidant activity and the phenolic, flavonoid content in pigmented rice cultivars. Further, the phytochemical composition and antioxidant activities in cooked rice and strained cooking water were lower as compared to raw. Among the tested landraces, navara was found to be superior in terms of higher phytochemical contents and antioxidant activity. Our study revealed the various health-promoting properties of pigmented rice over non-pigmented rice. It was also found that pressure cooking without straining away the water would be ideal to retain the nutrients and pigmented rice can alleviate numerous health disorders upon regular consumption.

Small Molecule Compound Nerolidol attenuates Hypertension induced hypertrophy in spontaneously hypertensive rats through modulation of Mel-18-IGF-IIR signalling

BackgroundCardiovascular diseases are caused by multitudes of stress factors like hypertension and their outcomes are associated with high mortality and morbidity worldwide. Nerolidol, a naturally occurring sesquiterpene found in several plant species, embodies various pharmacological benefits against numerous health disorders. However, their effects on hypertension induced cardiac complications are not completely understood. PurposeThe present study is to elucidate the efficacy of nerolidol against hypertension related cardiac hypertrophy in spontaneously hypertensive rats (SHRs). Study DesignFor preliminary in vitro studies, H9c2 cardiomyoblasts cells were challenged with 200 nM Angiotensin-II (AngII) for 12 h and were then treated with nerolidol for 24 h. The hypertrophic effect in H9c2 cells were analyzed by actin staining and the modulations in hypertrophic protein markers and mediators were determined by Western blotting analysis. For in vivo experiments, sixteen week-old male Wistar Kyoto (WKY) and SHRs were segregated into five groups (n = 9): Control WKY, hypertensive SHRs, SHRs with low dose (75 mg/kg b.w/day) nerolidol, SHRs with high dose (150 mg/kg b.w/day) nerolidol and SHR rats treated with an anti-hypertensive drug captopril (50 mg/kg b.w/day). Nerolidol treatment was given orally for 8 weeks and were analysed through Echocardiography. After euthanasia, hematoxylin and eosin staining, Immunohistochemical analysis and Western blotting was performed on left ventricle tissue. ResultsWestern blotting analysis revealed that nerolidol significantly attenuates AngII induced expression of hypertrophic markers ANP and BNP in H9c2 cardiomyoblasts. In addition, actin staining further ascertained the potential of nerolidol to ameliorate AngII induced cardiac hypertrophy. Moreover, nerolidol administration suppressed the hypertrophic signalling mediators like calcineurin, GATA4, Mel-18, HSF-2 and IGFIIR in a dose-dependent fashion. In silico studies also ascertained the role of Mel-18 in the ameliorative effects of nerolidol. Further, these intriguing in vitro results were further confirmed in in vivo SHR model. Oral neraolidol in SHRs efficiently reduced blood pressure and ameliorated hypertension induced cardiac hypertrophic effects by effectively reducing the levels of proteins involved in cardiac MeL-18-HSF2-IGF-IIR signalling. ConclusionCollectively, the data reveals that the cardioprotective effect of nerolidol against hypertension induced hypertrophy involves reduction in blood pressure and regulation of the cardiac Mel-18-IGFIIR signalling cascade.

Wearable Smart Health Advisors: An IMU-Enabled Posture Monitor

Unhealthy life habits are associated with a large number of chronic conditions in our modern lifestyle. Many commercialized wearable solutions have already been developed for monitoring and prevention purposes, while recent design efforts aim for more user-friendly and reliable solutions. In this context, due to the increased periods of sitting at work or home, improper sitting posture is related to numerous health disorders of the musculoskeletal system. Therefore, continuous stance monitoring can be used to improve users' sitting habits. In this article, we present an overview of wearable self-care devices and describe a monitoring system for a sitting posture that utilizes wireless motion sensors attached to the user's back. The developed prototype relies on inertial measurement units able to track the angle deviation from the optimal position which is learned during a training phase. Additionally, in order to support stance visualization and track the user's performance over time, our framework utilizes a cloud-native mobile application. The proposed system is experimentally evaluated resulting in an accurate everyday solution that prevents chronic improper posture.

Individual differences in biological regulation: Predicting vulnerability to drug addiction, obesity, and other dysregulatory disorders.

Physiological regulation is so fundamental to survival that natural selection has greatly favored the evolution of robust regulatory systems that use both reactive and preemptive responses to mitigate the disruptive impact of biological and environmental challenges on physiological function. In good health, robust regulatory systems provide little insight into the typically hidden complex array of sensor-effector interactions that accomplish successful regulation. Numerous health disorders have been traced to defective regulatory mechanisms, and generations of scientists have worked to discover ways to correct these defects and restore normal physiological function. Despite progress, numerous chronic health disorders remain resistant to treatment, and indeed for some disorders the incidence is increasing. We propose that an individual's susceptibility to acquire certain persistent dysregulatory disorders can be traced to interindividual variation in how that individual's regulatory system responds to challenges. Preexisting reliable individual differences among regulatory systems are typically unrecognized until appropriate regulatory challenges (e.g., exposure to a drug of abuse) lead to dysregulation (e.g., drug addiction). Specific characteristics of an individual's regulatory responsiveness may include etiological factors that participate in the acquisition, escalation and maintenance of health disorders characterized by dysregulation. By appropriately challenging a healthy individual's regulatory systems to identify its underlying characteristics, it is possible to ascertain whether an individual has an elevated risk for acquiring a dysregulated health condition and thereby enable strategies designed to prevent, rather than treat, the condition. This model is applied to drug addiction, and in addition we relate this approach to other dysregulated conditions such as obesity. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

Homeostasis and dysbiosis of the gut microbiome in health and disease

The human gastrointestinal tract (GIT) harbors taxonomically and functionally complex microbial ecosystem. The composition of the microbial species in the GIT ecosystem varies among individuals and throughout development. Both environmental factors as well as host genetics influence the composition and homeostasis of GIT microbiome. Intrinsic GIT microbiome can be characterized in terms of diversity, richness, dynamics and resilience. In healthy individual, microbial communities maintain homeostatic equilibrium and are resistant against perturbations. The resilience and resistance to perturbations of the GIT microbial ecosystem are robust but not absolute. Several factors can affect the homeostatic equilibrium of GIT microbiome and lead to dysbiotic microbiome configuration. Taxonomic and/or functional dysbiosis in the GIT microbiome is associated with numerous health disorders like inflammatory bowel disease (IBD), malnutrition, metabolic disorders, asthma and neurodegenerative diseases. In this review, we discuss our current understanding of homeostasis and dysbiosis of the microbial ecology in the human gut and health disorders that are associated with the microbiome dysbiosis.

Erratum: Effect of Nigella sativa (Kalozira) oil on pain in Long Evans rats. J Bangladesh Soc Physiol 2018, June;13(1):1-7

The author of this article brought attention to publishers that there were errors on page 1,3,4,5 published in previous issue. These errors have been corrected to enhance credibility to readers and the whole corrected article has been published in this issue of JBSP.
 The online version of the original article can be found at doi:http:/ /dx.doi.org/10.3329/jbsp,v13i1.37840(http://banglajol.info/ index.php/JBSP/article/view/37840)
 Background: For thousands of years, Nigella sativa has been used in many countries as a spice as well as a protective and curative remedy for numerous health disorders. Nigella sativa oil (NSO) suppressed pain in animal models.
 Objective: To assess the effects of Nigella sativa oil on pain after single administration with three increasing doses in rat models.
 Methods: This experimental study was conducted in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, from March 2016 to February 2017. For this, 20 (twenty) Long Evans rats (200±20) of both sexes were divided into control ( 10 ml/kg of 1% solution of Tween 20) and experimental groups (NSO 0.5, with 0.5 ml/kg NSO; NSO 1, with 1 ml/kg NSO; NSO 1.5, with 1.5 ml/kg NSO) with 5 rats in each group. To assess nociceptive pain, central analgesic system and inflammatory pain early phase (1st-5th minutes); inter phase (6th-15th minutes) and late phase (16th-60th minutes) of formalin test respectively were observed. All the agents were given intraperitoneally in a single dose just one hour before the formalin test. In all phases, total frequency of jerking and total duration of flexing and licking of right hind paw were counted after administration of subcutaneous formalin (50 mL, 2.5%) injection. Statistical analysis was done by ANOVA, followed by Bonferroni’s post hoc test.
 Results: In early phase, NSO significantly reduced the jerking (p ≤0.001, in all doses) and flexing and licking (p ≤0.001, in higher 2 doses). In interphase, jerking was significantly (p ≤0.01) lowered after 1.5 ml/kg of NSO but flexing and licking significantly lowered by all 3 doses (p ≤0.05, p ≤ 0.001, p≤ 0.001). In addition, in late phase jerking and flexing and licking was reduced by higher 2 doses (p ≤0.001) and all 3 doses respectively (p ≤ 0.001, in all doses).
 Conclusion: From this study, it may be concluded that, NSO possess analgesic effect and higher two doses were more effective than lower doses.
 J Bangladesh Soc Physiol. 2018, December; 13(2): 84-90

Effect of Nigella Sativa (Kalozira) Oil on Pain in Long Evans Rats

Background: For thousands of years, Nigella sativa has been used in many countries as a spice as well as a protective and curative remedy for numerous health disorders. Nigella sativa oil (NSO) suppressed pain in animal models.Objective: To assess the effects of Nigella sativa oil on pain after single administration with three increasing doses in rat models.Methods: This experimental study was conducted in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, from March 2016 to February 2017. For this, 20 (twenty) Long Evans rats (200±20) of both sexes were divided into control ( 10 ml/kg of 1% solution of Tween 20) and experimental groups (NSO 0.5, with 0.5 ml/ kg NSO; NSO 1, with 1 ml/kg NSO; NSO 1.5, with 1.5 ml/kg NSO) with 5 rats in each group.. To assess nociceptive pain, central analgesic system and inflammatory pain ,early phase (1st-5th minutes); inter phase (6th-15th minutes) and on late phase (16th-60th minutes) of formalin test respectively were observed. All the agents were given intraperitoneally in a single dose just one hour before the formalin test. In all phases, total frequency of jerking and total duration of flexing and licking of right hind paw were counted after administration of subcutaneous formalin (50 µL, 2.5%) injection. Statistical analysis was done by ANOVA, followed by Bonferroni’s post hoc test.Results: In early phase, NSO significantly reduced the jerking (p ≤0.001, in all doses) and flexing and licking (p≤0.001, in higher 2 doses). In interphase, jerking was significantly (p ≤ 0.01) lowered after 1.5 ml/kg of NSO but flexing and licking were significantly lowered by at all 3 doses (p ≤0.05, p ≤0.001, p ≤0.001,). In addition, in late phase jerking and flexing and licking were reduced by higher 2 doses (p ≤0.001, ) and all 3 doses respectively (p ≤0.001, in all doses).Conclusion: From this study, it may be concluded that, NSO possess analgesic effect and higher two doses were more effective than lower doses.J Bangladesh Soc Physiol. 2018, June; 13(1): 1-7

Diabetic data analysis in healthcare using Hadoop architecture over big data

Owing to the increasing developments in this digitised era, it is necessary to move from paper health records to digital by handling the large volume of healthcare data for analysis, and using them for efficient treatment will be a crucial issue. Diabetes Mellitus (DM) is one of the Non-Communicable Diseases (NCD). It is a major health hazard in developing countries and associated with long-term complications and numerous health disorders. The main idea of this project is to integrate massive unstructured diabetic data from various sources which need to be normalised into a proper scale to get optimised solution for medicinal field using Hadoop. Although the traditional database management systems can handle data effectively, processing the high volume of unstructured data at a reasonable time becomes very challenging. This paper uses the predictive analysis algorithm in the Hadoop/MapReduce environment to predict the DM complexities and the type of treatment to be adopted. Based on the analysis, this system provides an efficient way to cure patients with better outcomes.

Diabetic data analysis in healthcare using Hadoop architecture over big data

Owing to the increasing developments in this digitised era, it is necessary to move from paper health records to digital by handling the large volume of healthcare data for analysis, and using them for efficient treatment will be a crucial issue. Diabetes Mellitus (DM) is one of the Non-Communicable Diseases (NCD). It is a major health hazard in developing countries and associated with long-term complications and numerous health disorders. The main idea of this project is to integrate massive unstructured diabetic data from various sources which need to be normalised into a proper scale to get optimised solution for medicinal field using Hadoop. Although the traditional database management systems can handle data effectively, processing the high volume of unstructured data at a reasonable time becomes very challenging. This paper uses the predictive analysis algorithm in the Hadoop/MapReduce environment to predict the DM complexities and the type of treatment to be adopted. Based on the analysis, this system provides an efficient way to cure patients with better outcomes.