Evaluation of salivary alkaline phosphatase levels in tobacco users to determine its role as a biomarker in oral potentially malignant disorders

Abstract

Background: Saliva, a widely obtainable oral fluid, has gained acceptability as a screening medium in numerous health disorders in recent years. It has the capacity to discern initial epithelial alterations in tobacco abusers and people with OPMD since it is in direct contact with the lesion. Although few reports have been conducted on the use of concentration of alkaline phosphatase (ALP) enzyme in serum as well as saliva of OSCC patients as a biomarker, more research is needed in OPMD.Aims and Objectives: The study's major goals were to measure S-ALP levels in smokers, nonsmokers, and people with OPMD. and to compare S ALP levels in smokers, nonsmokers, and people with OPMD.Materials and Methods: The 84 participants in the study ranged in age from 18 to 75 years old, and they were divided into four groups:Category One – People who don't smoke or chew tobacco and don't have any lesions on intraoral inspection (n = 24).