The purpose of this research is to analyze sociodemographic factors that influence the quality of life of tuberculosis sufferers with diabetes mellitus in Medan City, 2023. The approach in this research is cross sectional. The number of tuberculosis patients in Medan City who are still undergoing treatment from January to July 2023 is 357 patients. Sample for this research is 172 respondents. Data analysis used in this research used univariate, bivariate, and multivariate analysis. The results of the research show that education has a relationship with the quality of life of tuberculosis sufferers with diabetes mellitus in Medan City, 2023. Age, gender, occupation, and income have no relationship on the quality of life of tuberculosis sufferers with diabetes mellitus in Medan City, 2023. Age and education influence the quality of life of tuberculosis sufferers with diabetes mellitus in Medan City, 2023. Gender, occupation, and income have no effect on the quality of life of tuberculosis sufferers with diabetes mellitus in Medan City, 2023. Keywords: Education, Age, Gender, Occupation, Income, Quality of Life