Number Of Notifications Research Articles

Review article: Comparison of cosmetic regulatory policies in various countries toward consumer protection

Cosmetics are various products that enhance physical appearance and care for the skin, hair, and body. Cosmetic regulation refers to the rules and regulations imposed by a country's government or health regulatory agencies to regulate the production, marketing, and use of cosmetic products. The purpose of writing this journal is to compare the regulation of cosmetic products in Indonesia with the regulation of cosmetic products abroad, and it is hoped that people will be more aware and understand the regulation of cosmetic products that have been established. The literature method is used to conduct a review article, and the criteria chosen are based on the originality and relevance of the reading. The result of this writing is that the requirements regarding labeling in various countries are similar, such as composition, country of manufacture, product name, instructions for use, full name and address of the owner of the notification number (manufacturer), manufacturing batch number, expiration date, and special precautions that must be considered when using. Consumers must consider different regulations for cosmetic products in each country. These must be considered when making or selling cosmetic products: import and export regulations, limited ingredients, and safety testing of cosmetic products. Keywords: Cosmetics, Export, Import, Labelling, Regulation

PACIFIC

To be useful and widely accepted, automated contact tracing schemes (also called exposure notification) need to solve two seemingly contradictory problems at the same time: they need to protect the anonymity of honest users while also preventing malicious users from creating false alarms. In this paper, we provide, for the first time, an exposure notification construction that guarantees the same levels of privacy and integrity as existing schemes but with a fully malicious database (notably similar to Auerbach et al. CT-RSA 2021) without special restrictions on the adversary. We construct a new definition so that we can formally prove our construction secure. Our definition ensures the following integrity guarantees: no malicious user can cause exposure warnings in two locations at the same time and that any uploaded exposure notifications must be recent and not previously uploaded. Our construction is efficient, requiring only a single message to be broadcast at contact time no matter how many recipients are nearby. To notify contacts of potential infection, an infected user uploads data with size linear in the number of notifications, similar to other schemes. Linear upload complexity is not trivial with our assumptions and guarantees (a naive scheme would be quadratic). This linear complexity is achieved with a new primitive: zero knowledge subset proofs over commitments which is used by our "no cloning" proof protocol. We also introduce another new primitive: set commitments on equivalence classes, which makes each step of our construction more efficient. Both of these new primitives are of independent interest.

Epidemiological evolution of dengue in the pre-pandemic to post-pandemic periods in the Americas and Brazil

Introduction: Dengue is an asymptomatic infection or present symptoms like low fever to disabling high fever, severe headache, retroocular, muscle and joint pain, in addition to skin rashes, and if associated with COVID-19, it can worsen the illness condition. Objective: investigate the epidemiological evolution of dengue in the pre-pandemic, pandemic and post-pandemic periods from an American and Brazilian perspective. Methodology: descriptive study, based on the search for information in epidemiological bulletins, data from DATASUS and the Pan American Health Organization/World Health Organization, in addition to articles available in databases provided by SciELO, ScienceDirect and Pubmed. Results: In the period before the pandemic, the high number of notifications was due to the DENV2 serotype, causing a large epidemic. In the years 2020-2021 there was a drop in the number of notifications due to the introduction of social and public health measures, misdiagnosis between the signs/symptoms of dengue and COVID-19, inaccurate serological tests and underreporting. In 2022 and 2023, the epidemiological scenario again points to increasing notification of dengue cases, mainly due to changes in routine vector control during the pandemic, combined with favorable environmental factors, such as increased rainfall. Conclusion: the neglect of both dengue fever and other diseases has negatively impacted the population today, since in order to mitigate the damage caused by the pandemic, actions to promote and prevent the health of endemic diseases in our territory, when placed in the background, have caused the underreporting of cases, influenced by changes in the political, economic and health spheres of society.

Parenting, Child Maltreatment, and Social Disadvantage: A Population-Based Implementation and Evaluation of the Triple P System of Evidence-Based Parenting Support.

Child Maltreatment (CM) is a widespread public health problem, with adverse outcomes for children, families, and communities. Evidence-based parenting support delivered via a public health approach may be an effective means to prevent CM. The Every Family 2 population trial applied a public health approach to delivering evidence-based parenting support to prevent CM in disadvantaged communities. Using a quasi-experimental design, 64 matched low socioeconomic communities in the Australian states of Queensland and New South Wales received either the full multi-level Triple P system (TPS) of parenting support, or Care as Usual (CAU). Two population indicators of CM, the number of substantiated cases of CM, and the number of notifications of CM to protective services were compared using Welch's t-test to evaluate intervention effectiveness. After two years of intervention, medium to large effect sizes favoring TPS communities were found for substantiations (d = 0.57, p < .05) and notifications (d = 1.86, p < .001). These findings show the value of the TPS, deployed using a public health approach, in efforts to prevent CM in socially disadvantaged communities. A number of uncontrolled contextual factors are described that may have contributed to some of the differences detected between TPS and CAU communities.

Impact of the COVID-19 pandemic on infectious diseases reporting.

COVID-19 pandemic had impacted the reporting of notifiable communicable diseases. Since the beginning of the pandemic and the introduction of relate public health measures, notifications for most notifiable diseases have declined compared to previous years. In this study, we aim to quantify the changes in the incidences of notifiable infectious diseases during and after the pandemic in Siracusa Local Health Authority, Italy. We collected and analysed the infectious disease notifications made in two different three-years periods, 2017-2019 and 2020-2022 in Siracusa Local Health Authority, Italy. Descriptive statistics were used to find the percentages and the 95% confidence interval (CI). Exact "F-tests" was performed to compare the mean values between the studied periods to evaluate the hypothesis that the number of reported cases would not differ significantly between the two periods. Significance was assessed at the p < 0.05 level. The total number of notifications significantly decreased by 69.3% in the pandemic period compared to the pre-pandemic one, with the highest reduction of air-borne transmission diseases (-86.5%), followed by food-borne diseases (-68.2%) and sexually transmitted diseases (-39.3%). Conversely, an increase in number of notifications was found only for legionellosis. The COVID-19 pandemic had the potential to influence communicable disease reporting at multiple points. While the effects could vary considerably, the results would be expected to reduce the number and the detection of notifiable cases. Included would be changes in exposures, diagnostic testing, reporting to public health agencies, and public health investigations.

Drastic reduction in the notification of acute cases of Chagas disease in the Northeast region of Brazil. Epidemiological evaluation in the period 2001–2021

Chagas disease (CD), caused by the protozoan Trypanosoma cruzi (T. cruzi), is a neglected disease endemic to some Latin American countries, including Brazil. Soon after infection, individuals develop an acute phase, which in most cases is asymptomatic and may go undetected. However, when CD is detected early, notification in the Notifiable Diseases Information System (SINAN), is mandatory. This study aimed to evaluate the information registered in the SINAN database and to determine the epidemiological profile of acute CD in Northeast Brazil, an endemic region, from 2001 to 2021. According to this survey, 1,444 cases of acute CD were reported in the Northeastern region of Brazil during this period. During the first six years, referred to as period 1, 90.24% of the notifications were registered, while the number of notifications significantly decreased in the subsequent years, referred to as period 2. Most individuals diagnosed with acute CD were Afro-Brazilian adults. All known routes of infection by the parasite were reported. Vector-borne transmission was predominant during period 1 (73.29%) and oral transmission during period 2 (58.87%). All nine states in Northeast Brazil reported cases in both periods. A higher incidence of disease was reported in Rio Grande do Norte (RN) during period 1, and in Maranhão (MA) during period 2. Our results show that CD remains a significant public health challenge.

Epidemiological Profile of Meningitis Reports in Brazilian Regions between 2007 and 2015

Abstract Meningitis is an inflammation that affects meninges of the nervous system and can cause severe sequelae, which makes it important to understand the epidemiological profile of the disease to aid in control policies. The objective of this study was to describe the epidemiological profile of meningitis in different Brazilian regions from 2007 to 2015. We did a descriptive observational study of all 184,868 reports of meningitis cases made by SUS in DATASUS between 2007 and 2015 in Brazil. It was observed that most case occurred in male and white persons. In general, the etiology was viral and bacterial. About 50% of the cases occurred in children up to 9 years old, but with higher lethality in the elderly. There was a nearly 40% drop in the number of notifications from 2007 to 2014, but with more lethality. We conclude that the decrease in cases is due to the success of control policies, but we need to keep our attention to the notifications due to the increase in lethality. Keyword: Meningitis, Public health, Neglected disease.

Emergency services response to eCall System alerts: Observations from 2016–2022 in the National Fire and Rescue System

Objective Analysis of interventions by fire protection units in road traffic incidents alerted by the eCall system between 2016 and 2022. Materials and Methods Data from the State Fire Service Decision Support System (SFS DSS), provided by the Operational Planning Office, were used. Events from January 1, 2016, 00:00 to December 31, 2022, 23:59 were analyzed. Quantitative data were described using mean (Mean) and standard deviation (SD). Correlations and differences at a significance level of p < 0.05 were considered statistically significant. The analysis is anonymous for both victims and officers involved in the interventions. Results Between 2016 and 2022, firefighters were alerted by the e-call system 896 times. The shortest average intervention time was 47 ± 37 min and was recorded in 2021. In the comparative analysis of intervention time and factors conditioning the use of the eCall system, it was shown that this time was significantly statistically dependent on the number of cars involved in the incident (p < 0.001), the number of injured persons (p < 0.001), the type of intervention (p < 0.001),), and the occurrence of fuel leakage (p < 0.001). Conclusions ECall is a relevant system for reporting accidents and collisions on the road. While it proves reliable in road incidents, a significantly high number of false alarms initiated from eCall requires system refinement to avoid accidental alarms and user education about the possibility of unintentionally sending an alarm signal. The authors predict that as the number of vehicles with the eCall system introduced to the roads increases, so will the number of notifications from this system. Data from the analysis of false reports suggest that mechanics and electricians in facilities performing repairs and maintenance of vehicles with the eCall system may lack the necessary knowledge of the need to deactivate the system before starting work. The number of injured people had no impact on the intervention time, which may prove that the rescue services were properly prepared.

Phule Satwik (NIAW 3170): A soft bread wheat variety for North Western Plains and Peninsular Zone of India

Wheat is an important crop that plays major role in a food grain production in the country.It is a lone source for industries involved in the manufacturing of bread, biscuits, flakes, cakes etc. These industries rely on quality parameters viz.,grain hardness index, biscuit spread factor, bread quality score, and bread loaf volume. Bread wheat variety Phule Satwik (NIAW 3170) is developed at Agricultural Research Station, Niphad has been released and notified by Central Sub Committee on Crop Standards, India for cultivation in North Western Plains Zone and Peninsular Zone under restricted irrigation conditions vide notification number S.O. 3482 (E) dated 7th October, 2020. The variety has high yield potential under restricted irrigation conditions along with disease resistance and superior grain quality parameters. It was the softest grain variety among all the genotypes having a biscuit spread factor of more than 10. With good nutritional and quality parameters, it will be a promising variety for bakery industries.

Epidemiological and sociodemographic description of snakebite envenoming cases in Paraguay reported between 2015 and 2021

IntroductionSnakebite envenoming (SBE) is a public health problem in Paraguay where the presence of 15 medically important snake species has been reported. Blessed with large forested areas, its economy largely...

Evaluation of rapid alert system for food and feed (RASFF) data for mycotoxin contaminated dried figs originating from Türkiye

In this study, the Rapid Alert System for Food and Feed (RASFF) database was analysed to assess mycotoxin hazards in Turkish dried figs during the production years from 2002 to 2019. A comprehensive evaluation of influencing factors, such as weather conditions, agricultural and processing practices, as well as non-product related elements such as export quantities and regulatory changes, was carried out while analysing yearly and monthly notification trends. Years marked by drought conditions recorded the highest number of notifications. Notably, the years 2007 and 2012 corresponded with peaks in notifications (104 and 117, respectively), suggesting a potential relationship between drought conditions and increased notifications – a finding supported by existing literature on mycotoxin contamination. The mean total aflatoxin (AF) concentrations ranged from 13 μg/kg to 44 μg/kg. However, the considerable variability in the annual number of notifications (ranging from 2 to 106) and the presence of outliers in certain years limit the usefulness of mean total AF concentration data for trend analysis. Weather-related factors, along with agricultural practices, processing and storage conditions, can influence mycotoxin contamination of dried figs, highlighting the need for integrated and comprehensive control strategies. The observed correlation between specific weather conditions, such as drought, and RASFF notifications, and, consequently, mycotoxin contamination, warrants further exploration to better understand and predict this relationship. This study significantly contributes to the mycotoxin literature by providing a comprehensive analysis of mycotoxin hazards in Turkish dried figs. By examining the complex interplay of factors, from weather conditions to agricultural and processing practices and changes in export quantities and regulations, it addresses a crucial gap in the current understanding of mycotoxin risks and offers insights on the historical evolution of safety protocols within Turkish dried fig production. It thus provides a solid foundation for improving food safety practices and developing more effective policy frameworks.

Primeiros relatos de leishmaniose canina no noroeste do Rio Grande do Sul

ABSTRACT This research aimed to carry out an epidemiological investigation of dogs with canine leishmaniasis in an area of Rio Grande do Sul with no history of notification of the disease. Leishmaniasis is considered an endemic zoonosis in different countries. In Brazil, it occurs mainly in the Southeast and Midwest regions, having drastically increased the number of notifications in recent years. In the state of Rio Grande do Sul, there are reports of the disease in the metropolitan region of Porto Alegre and in the border region in the west of the state, as well as in the central region. The investigation was conducted in 100 dogs from the municipalities of Frederico Westphalen and region. Whole blood was collected for immunochromatographic testing (TR DPP® Canine Visceral Leishmaniasis) and lymph node aspiration. Positives were confirmed by ELISA test and indirect immunofluorescence test with total dilution or immunohistochemistry after skin biopsy. Two animals were diagnosed with visceral leishmaniasis, considered the first reported cases of the disease in the canine population in the region. Therefore, it becomes necessary to research and control the potential presence of sandflies in the area. There is a hypothesis that the animals were contaminated in other regions of the country, remaining as a reservoir until the moment of diagnosis.

Brown spiders (Loxosceles) are taking hold in Pernambuco, Brazil: a case series, 2018-2022.

To describe accidents involving brown spider (genus Loxosceles) bites notified by the Pernambuco Poison Information and Care Center (CIATox-PE), Brazil, from January 2018 to December 2022. This was a case series study of brown spider bites notified by the CIATox-PE. The study included 22 cases with median age of 35 years, the majority being female (13); the cases occurred in rural and urban areas (12 versus 10), at night (10); Petrolina was the municipality with the highest number of notifications (6); spider bites occurred mainly in the lower (11) and upper (9) limbs, almost exclusively inside households (21); specific serum therapy was not indicated for 8 cases because the time for its effectiveness had already elapsed. Loxoscelism cases occurred more frequently in females, in both rural and urban areas and mainly at home, with delays in seeking medical care. The 22 cases described represent an alert for the presence of a venomous species not reported in previous studies in Pernambuco. The severity of cases may be associated with delays in seeking medical care, especially due to the population's lack of information. Identify the presence of brown spiders in households in the region and the potential severity of poisonings. Alert health professionals to recognize the clinical picture with a view to appropriate early treatment. Develop research on poisoning by venomous animals and educational actions alerting the population to prevent these accidents and updating health professionals on care.

Group A streptococcal infection in the United Kingdom: an emerging threat

Within group A Streptococcus (GAS), only Streptococcus pyogenes exhibits clinical significance. GAS is typed serologically based on unique surface proteins and critical virulence factors, such as a hyaluronic acid capsule that shields GAS from phagocytosis. The burden of GAS was estimated in the last five years as 14,000 to 25,000 cases of the invasive group A streptococcal disease in the USA with an estimated death from 1,500 to 2,300 cases per year. Early in the summer of 2022 in England, there was more scarlet fever than was anticipated. Early in the current season, the number of notifications rose to unusual heights. The analysis of invasive GAS (iGAS) isolate typing data shows that this season has seen a wide variety of encoding mature M protein (emm) gene sequence types found. Therefore, public health authorities should think about initiatives to increase clinicians’ and the general public’s awareness of GAS infections and to promote their quick diagnosis, molecular testing and antibiotic susceptibility testing, and standard treatment.

A comparative study between the top 10 origin countries involved in the EU RASFF notifications on aflatoxins from 1997 to 2022

Aflatoxin B1 (AFB1), is among the most carcinogenic and genotoxic food and feed contaminants and there is no acceptable level of their intake. An analysis of the top 10 countries of origin notifications on aflatoxins (AFs) involved in the EU RASFF database over the last 26 years was undertaken. A risk assessment was estimated for simulating the worst-case scenario for the serious notifications of the mostly notified products as well. Out of 12,400 notifications on AFs over the period between 1997 and 2022, of which 10,340 (83.39 %) concerned Iran which was the most frequently notified country (21.56 %), followed by Turkey (20.48), China (9.99 %), India (7.88 %), the USA (7.74 %), Argentina (5.82 %), Egypt (3.94 %), Brazil (3.05 %), Pakistan (1.52 %), and Nigeria (1.41 %). Germany was the most notifying country, followed by the Netherlands. Among all notifications, 53.3 % have been border rejected. Nuts, nuts products, and seeds were the highest notified product category followed by fruits and vegetables. The highest serious risk decision in terms of notification number was taken for contaminated dried fig from Turkey, followed by pistachio from Iran. The estimated margin of exposure (MOE) values for the mostly notified products i.e., pistachio, dried fig, and peanut were <10,000 which is not safe and represents a health concern.

Comparative study between the top six heavy metals involved in the EU RASFF notifications over the last 23 years

From the Rapid Alert System for Food and Feed (RASFF) database, a total of 4728 notifications regarding the six most frequently notified heavy metals (i.e., arsenic, cadmium, lead, mercury, chromium, and nickel) were tracked from January 1, 2000, to December 31, 2022, and analyzed based on year, notification classification, notifying countries, countries of origin, product types, product categories, risk decision, and action taken. Human risk assessment owing to consumption of mercury- and cadmium-contaminated seafood was estimated as well. Results revealed that the highest numbers of notifications were on mercury (36.6%), cadmium (25.1%), and lead (14.1%). Interestingly, the number of total notifications was at its peak between 2011 and 2014; from 2015 onward, it started to decrease considerably. Alert, border rejection, and information notifications represented 29.6%, 21.9%, and 48.5% of the total notifications, respectively. Chromium and nickel resulted in 33.8% and 23.3% of border rejection notifications, respectively. About 52.0% of the alert notifications were on mercury. Serious notifications represented 34.9% of the total notifications. Mercury and cadmium notifications accounted for 54.9% and 25.8% of serious notifications, respectively. Italy was the most notifying country, recording the highest number of notifications on cadmium (29.0%), mercury (52.6%), chromium (81.0%), and nickel (78.7%). China was the most notified origin country with regards to arsenic (18.7%), cadmium (12.8%), lead (27.6%), chromium (71.2%), and nickel (66.9%) notifications. Notifications on food, food contact materials (FCM), and feed represented 71.9%, 23.4%, and 4.7%, respectively, of the total notifications. About 91.5% of mercury notifications were on fish and fish products; 24.3% of arsenic notifications related to fruits and vegetables; and 20.1% of cadmium notifications corresponded to cephalopods and products thereof. Notified products were largely withdrawn from the markets according to arsenic (20.3%), lead (17.9%), and mercury (18.0%) notifications and re-dispatched because of cadmium (20.5%), chromium (42.1%), and nickel (49.5%) notifications. The target hazard quotient (THQ) values for mercury in swordfish, sharks, and tuna and cadmium in squid were all also below the threshold value of 1, implying that there is no significant risk for consumers. Overall, media coverage of RASFF alerts and actions may raise awareness of heavy metal contamination among the general public and industry professionals. The primary dietary advice of our study is to stay away from species with high mercury contents. Also, identifying the most dangerous heavy metals (HMs) and the most polluting products can help researchers prioritize their efforts in finding sustainable solutions for them.

Impact of the COVID-19 pandemic on the infectious disease epidemiology.

COVID-19 pandemic has exerted a huge impact on different aspects of public health. Mandatory notifications are a fundamental tool to have a general picture of infection disease spread in a population. The aim of this study was to evaluate the impact the COVID-19 pandemic had on infectious disease epidemiology. We collected and analyzed all the infectious disease notifications made in the pre-pandemic (2017-2019) and the pandemic (2020-2022) three-years periods in the provincial territory of Messina, Italy. The total number of notifications significantly decreased by 41% in the pandemic period compared to the pre-pandemic one, with very high reduction of certain disease notifications such as measles and varicella. Similarly, other airborne infections, such as meningococcal meningitis and tuberculosis, underwent an important decrease. Conversely, an increase was found for some infections such as syphilis and, especially, scabies that reported a percentage value of +159.9%. The COVID-19 pandemic, reducing the possibility of microbial spread following to the lockdown and, in addition, to the constant use of face masks and other personal protective equipment, the frequent hand-washing, more ventilation of the living locals, and less gathering, surely reduced the occasions and the possibility to get many infections. On the other hands, the pandemic had a negative impact on scabies diffusion probably due to different causes among which the worsening of some poor realities, the restrictions that forced people to live in strict contact and, especially, the worsening of the conditions of the elderly living in care homes.

Notifications of work-related injuries and diseases: an observational study on a mining disaster

IntroductionAccidents at work are events that endanger the health and life of workers. They are considered a public health problem, being the object of studies and actions in the Brazilian health system. The collapsed of the ore tailings dam in the municipality of Brumadinho, Brazil, in January 2019, shocked the world due to the proportion of environmental and human damage caused. In this context, concern for the health of workers gained prominence. This paper evaluated the impact of the collapse of the mining tailings dam in Brumadinho, on notifications of occupational health problems before and after the disaster.MethodsAn observational, longitudinal and retrospective study, of the time series type with a statistical approach was carried out on notifications of work-related injuries and diseases, available in the local database of the Notifiable Diseases Information System between January 2017 and December 2021.ResultsDuring the study period, 520 notifications of work-related injuries and conditions were registered. Of this total, 67.3% were serious work accidents, 26.0% mental disorders, 12.3% accidents with biological material and 2.9% repetitive strain injuries/musculoskeletal disorders, occupational dermatoses and induced hearing loss by noise. Occurrences were more frequent in 2019, the year in which the mining disaster occurred, recording 65.2% of total notifications. Regarding the volume of notifications after the disaster, there was a statistically significant reduction (p < 0.001) for accidents with biological material; significant increase for severe work accident and mental disorder. The average time between the occurrence of the injury and the notification showed a statistically significant reduction for accidents involving biological material (p = 0.001) and a significant increase for serious accidents at work (p = 0.016).ConclusionsIt was demonstrated that there were changes in the number of notifications when comparing the period before and after the mining disaster, with a consequent impact on the health of workers, which may persist over the years.

Foodborne botulism in Poland in 2018-2021.

The aim of this study is to assess the epidemiological situation of foodborne botulism in Poland in 2018-2021, compared to previous years. The assessment is based on an analysis of aggregated surveillance data from the annual bulletin "Infectious Diseases and Poisons in Poland" from 2013-2021, as well as botulism case reports collected by sanitary-epidemiological stations and sent to the Department of Epidemiology of Infectious Diseases and Surveillance of the NIPH NIH - NRI or provided by EpiBase. A total of 54 foodborne botulism cases were registered between 2018 and 2021, including 31 (57.4%) cases of laboratory-confirmed botulism intoxication. Most cases (46 cases, 85.2%) were sporadic. The declining trend in the number of notifications continued throughout the time period, and the incidence recorded in 2021 (0.02 per 100,000 population) was the lowest since the introduction of mandatory reporting and registration of botulism in Poland. The highest median annual incidence was recorded in the Warmisko-Mazurskie (0.18), but many voivodeships reported only single notifications or none. The decreasing trend in rural areas relative to the level of incidence in urban areas continued. Men (incidence in men more than twice that of women) and people aged 50-59 predominated. All patients were hospitalized. According to the State Sanitary Inspection, there were 3 deaths (mortality of 5.6%). In 2018-2021, the downward trend in the number of foodborne botulism notifications in Poland continued. At the same time, the considerable proportion of cases reported by physicians without laboratory confirmation and not meeting the definition of botulism adopted in other EU countries is noteworthy. The incidence in rural areas decreases to the level of incidence in urban areas, and the previously observed geographical distribution of cases diminishes.

Increased Amazon carbon emissions mainly from decline in law enforcement.

The Amazon forest carbon sink is declining, mainly as a result of land-use and climate change1-4. Here we investigate how changes in law enforcement of environmental protection policies may have affected the Amazonian carbon balance between 2010 and 2018 compared with 2019 and 2020, based on atmospheric CO2 vertical profiles5,6, deforestation7 and fire data8, as well as infraction notices related to illegal deforestation9. We estimate that Amazonia carbon emissions increased from a mean of 0.24 ± 0.08 PgC year-1 in 2010-2018 to 0.44 ± 0.10 PgC year-1 in 2019 and 0.52 ± 0.10 PgC year-1 in 2020 (±uncertainty). The observed increases in deforestation were 82% and 77% (94% accuracy) and burned area were 14% and 42% in 2019 and 2020 compared with the 2010-2018 mean, respectively. We find that the numbers of notifications of infractions against flora decreased by 30% and 54% and fines paid by 74% and 89% in 2019 and 2020, respectively. Carbon losses during 2019-2020 were comparable withthose of the record warm El Niño (2015-2016) without an extreme drought event. Statistical tests show that the observed differences between the 2010-2018 mean and 2019-2020 are unlikely to have arisen by chance. The changes in the carbon budget of Amazonia during 2019-2020 were mainly because of western Amazonia becoming a carbon source. Our results indicate that a decline in law enforcement led to increases in deforestation, biomass burning and forest degradation, which increased carbon emissions and enhanced drying and warming of the Amazon forests.